Cigarette smoke-induced epithelial expression of WNT-5B: Implications for COPD

European Respiratory Journal

Volumn 48, Issue 2, 2016, Pages 504-515

  Heijink, Irene H ^a   De Bruin, Harold G ^a   Dennebos, Robin ^a   Jonker, Marnix R ^a   Noordhoek, Jacobien A ^a   Brandsma, Corry Anke ^a   Van Den Berge, Maarten ^a   Postma, Dirkje S ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CIGARETTE SMOKE; FIBRONECTIN; GELATINASE A; GELATINASE B; MESSENGER RNA; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; WNT5B PROTEIN; CYTOKINE; MIGRATION STIMULATING FACTOR, HUMAN; MMP2 PROTEIN, HUMAN; MMP9 PROTEIN, HUMAN; SMAD3 PROTEIN, HUMAN; SNAI1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SNAIL; WNT PROTEIN; WNT5B PROTEIN, HUMAN;

ADULT; AGED; AIRWAY REMODELING; ARTICLE; BEAS 2B CELL; BRONCHUS MUCOSA; CELL CULTURE TECHNIQUE; CELL LINE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; EPITHELIUM CELL; FEMALE; FIBRONECTIN GENE; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; LUNG PARENCHYMA; MALE; MATRIX METALLOPROTEINASE 2 GENE; MMP 9 GENE; PATHOGENESIS; PRIMARY BRONCHIAL EPITHELIAL CELL; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SMOKING; SNAII GENE; UPREGULATION; BRONCHUS; CASE CONTROL STUDY; CHEMICALLY INDUCED; CYTOLOGY; EPITHELIUM; INFLAMMATION; LUNG; METABOLISM; MIDDLE AGED; PATHOLOGY; RESPIRATORY MUCOSA; SMOKE; TOBACCO; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BRONCHI; CASE-CONTROL STUDIES; CYTOKINES; EPITHELIAL CELLS; EPITHELIUM; FEMALE; HUMANS; INFLAMMATION; LUNG; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SMOKE; SNAIL FAMILY TRANSCRIPTION FACTORS; TOBACCO; TOBACCO PRODUCTS; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEINS;

EID: 84980009706     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/13993003.01541-2015     Document Type: Article

References (37)

1. Pauwels RA, Buist AS, Calverley PM, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med 2001; 163: 1256-1276.
2. Takizawa H, Tanaka M, Takami K, et al. Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med 2001; 163: 1476-1483.
3. Milara J, Peiró T, Serrano A, et al. Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke. Thorax 2013; 68: 410-420.
4. Baarsma HA, Spanjer AI, Haitsma G, et al. Activation of WNT/β-catenin signaling in pulmonary fibroblasts by TGF-β1 is increased in chronic obstructive pulmonary disease. PLoS One 2011; 6: e25450.
5. Königshoff M, Eickelberg O. WNT signaling in lung disease: a failure or a regeneration signal? Am J Respir Cell Mol Biol 2010; 42: 21-31.
6. Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006; 127: 469-480.
7. Arnsdorf EJ, Tummala P, Jacobs CR. Non-canonical Wnt signaling and N-cadherin related beta-catenin signaling play a role in mechanically induced osteogenic cell fate. PLoS One 2009; 4: e5388.
8. Ma L, Wang HY. Mitogen-activated protein kinase p38 regulates the Wnt/cyclic GMP/Ca2+ non-canonical pathway. J Biol Chem 2007; 282: 28980-28990.
9. Crosby LM, Waters CM. Epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol 2010; 298: L715-L731.
10. Königshoff M, Kramer M, Balsara N, et al. WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest 2009; 119: 772-787.
11. Heijink IH, de Bruin HG, van den Berge M, et al. Role of aberrant WNT signalling in the airway epithelial response to cigarette smoke in chronic obstructive pulmonary disease. Thorax 2013; 68: 709-716.
12. Kneidinger N, Yildirim AO, Callegari J, et al. Activation of the WNT/beta-catenin pathway attenuates experimental emphysema. Am J Respir Crit Care Med 2011; 183: 723-733.
13. Wang R, Ahmed J, Wang G, et al. Down-regulation of the canonical Wnt β-catenin pathway in the airway epithelium of healthy smokers and smokers with COPD. PLoS One 2011; 6: e14793.
14. Hackett TL, Shaheen F, Johnson A, et al. Characterization of side population cells from human airway epithelium. Stem Cells 2008; 26: 2576-2585.
15. Heijink IH, Postma DS, Noordhoek JA, et al. House dust mite-promoted epithelial-to-mesenchymal transition in human bronchial epithelium. Am J Respir Cell Mol Biol 2010; 42: 69-79.
16. Heijink IH, Brandenburg SM, Postma DS, et al. Cigarette smoke impairs airway epithelial barrier function and cell-cell contact recovery. Eur Respir J 2012; 39: 419-428.
17. Wang Q, Wang H, Zhang Y, et al. Activation of uPAR is required for cigarette smoke extract-induced epithelial-mesenchymal transition in lung epithelial cells. Oncol Res 2013; 21: 295-305.
18. Brajer B, Batura-Gabryel H, Nowicka A, et al. Concentration of matrix metalloproteinase-9 in serum of patients with chronic obstructive pulmonary disease and a degree of airway obstruction and disease progression. J Physiol Pharmacol 2008; 59: Suppl. 6, 145-152.
19. Vernooy JH, Lindeman JH, Jacobs JA, et al. Increased activity of matrix metalloproteinase-8 and matrix metalloproteinase-9 in induced sputum from patients with COPD. Chest 2004; 126: 1802-1810.
20. Annoni R, Lan?as T, Yukimatsu Tanigawa R, et al. Extracellular matrix composition in COPD. Eur Respir J 2012; 40: 1362-1373.
21. Baraldo S, Bazzan E, Zanin ME, et al. Matrix metalloproteinase-2 protein in lung periphery is related to COPD progression. Chest 2007; 132: 1733-1740.
22. Gohy ST, Hupin C, Fregimilicka C, et al. Imprinting of the COPD airway epithelium for dedifferentiation and mesenchymal transition. Eur Respir J 2015; 45: 1258-1272.
23. Hackett TL, Warner SM, Stefanowicz D, et al. Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1. Am J Respir Crit Care Med 2009; 180: 122-133.
24. Bakin AV, Rinehart C, Tomlinson AK, et al. p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration. J Cell Sci 2002; 115: 3193-3206.
25. Hayashi H, Sakai T. Biological significance of local TGF-β activation in liver diseases. Front Physiol 2012; 3: 12.
26. Heijink IH, Noordhoek JA, Timens W, et al. Abnormalities in airway epithelial junction formation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2014; 189: 1439-1442.
27. Sohal SS, Reid D, Soltani A, et al. Evaluation of epithelial mesenchymal transition in patients with chronic obstructive pulmonary disease. Respir Res 2011; 12: 130.
28. Yang L, Yang X, Ji W, et al. Effects of a functional variant c.353T>C in snai1 on risk of two contextual diseases. Chronic obstructive pulmonary disease and lung cancer. Am J Respir Crit Care Med 2014; 189: 139-148.
29. Kato S, Hayakawa Y, Sakurai H, et al. Mesenchymal-transitioned cancer cells instigate the invasion of epithelial cancer cells through secretion of WNT3 and WNT5B. Cancer Sci 2014; 105: 281-289.
30. Kim MK, Maeng YI, Sung WJ, et al. The differential expression of TGF-β1, ILK and wnt signaling inducing epithelial to mesenchymal transition in human renal fibrogenesis: an immunohistochemical study. Int J Clin Exp Pathol 2013; 6: 1747-1758.
31. Bhowmick NA, Zent R, Ghiassi M, et al. Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity. J Biol Chem 2001; 276: 46707-46713.
32. Nicenboim J, Malkinson G, Lupo T, et al. Lymphatic vessels arise from specialized angioblasts within a venous niche. Nature 2015; 522: 56-61.
33. O'Connell MP, Marchbank K, Webster MR, et al. Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2. Cancer Discov 2013; 3: 1378-1393.
34. Jiang L, Zhang J, Monticone RE, et al. Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis. Hypertension 2012; 60: 1192-1199.
35. Yang IA, Relan V, Wright CM, et al. Common pathogenic mechanisms and pathways in the development of COPD and lung cancer. Expert Opin Ther Targets 2011; 15: 439-456.
36. Gauldie J, Kolb M, Ask K, et al. Smad3 signaling involved in pulmonary fibrosis and emphysema. Proc Am Thorac Soc 2006; 3: 696-702.
37. Durham AL, McLaren A, Hayes BP, et al. Regulation of Wnt4 in chronic obstructive pulmonary disease. FASEB J 2013; 27: 2367-2381.