Aptamer-Based Proteomic Profiling Reveals Novel Candidate Biomarkers and Pathways in Cardiovascular Disease

Circulation

Volumn 134, Issue 4, 2016, Pages 270-285

  Ngo, Debby ^a,b   Sinha, Sumita ^b   Shen, Dongxiao ^b   Kuhn, Eric W ^c   Keyes, Michelle J ^b   Shi, Xu ^b   Benson, Mark D ^b,d   O'Sullivan, John F ^b   Keshishian, Hasmik ^c   Farrell, Laurie A ^b   Fifer, Michael A ^b   Vasan, Ramachandran S ^e   Sabatine, Marc S ^b,d   Larson, Martin G ^f,g   Carr, Steven A ^c   Wang, Thomas J ^h   Gerszten, Robert E ^b,c,i  

^a Division of Pulmonary and Critical Care Medicine   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f BOSTON UNIVERSITY   (United States)

^g FRAMINGHAM HEART STUDY   (United States)

^h VANDERBILT UNIVERSITY   (United States)

ⁱ BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

aptamer, nucleotides; cardiovascular diseases; mass spectrometry; myocardial infarction; proteomics

Indexed keywords

AMINOACYLASE; ANGIOGENIN; APOLIPOPROTEIN E; APTAMER; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CADHERIN; CALPHOBINDIN II; CELL CYCLE PROTEIN 37; CHYMASE; COLLAGENASE 3; CREATINE KINASE MB; DICKKOPF RELATED PROTEIN 4; EPIDERMAL GROWTH FACTOR RECEPTOR; FATTY ACID BINDING PROTEIN; FIBROBLAST GROWTH FACTOR 18; HISTONE H2AZ; INTERLEUKIN 11; INTERLEUKIN 34; INTERLEUKIN 5; INTERLEUKIN 6; LAMININ; MACROPHAGE ELASTASE; MALATE DEHYDROGENASE; MATRIX METALLOPROTEINASE 16; MYOGLOBIN; STROMAL CELL DERIVED FACTOR 1; TRANSKETOLASE; TRIOSEPHOSPHATE ISOMERASE; TROPONIN I; UNCLASSIFIED DRUG; PLASMA PROTEIN; SINGLE STRANDED DNA;

ADULT; ANTIBODY AFFINITY; ARTICLE; BLOOD SAMPLING; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY SINUS; FEMALE; FRAMINGHAM RISK SCORE; HEART CATHETERIZATION; HEART DEVELOPMENT; HEART INFARCTION; HEART MUSCLE INJURY; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; IMMUNOASSAY; LIMIT OF DETECTION; MALE; MASS SPECTROMETRY; MIDDLE AGED; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEOMICS; WNT SIGNALING PATHWAY; ACUTE CORONARY SYNDROME; BLOOD; COMPLICATION; LIQUID CHROMATOGRAPHY; LONGITUDINAL STUDY; METABOLISM; MYOCARDIAL INFARCTION; PHENOTYPE; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

ACUTE CORONARY SYNDROME; ADULT; APTAMERS, NUCLEOTIDE; BIOMARKERS; BLOOD PROTEINS; CARDIOMYOPATHY, HYPERTROPHIC; CHROMATOGRAPHY, LIQUID; DNA, SINGLE-STRANDED; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PHENOTYPE; PROTEOMICS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84979971046     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.116.021803     Document Type: Article

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