Stem-cell based engineered immunity against HIV infection in the humanized mouse model

Journal of Visualized Experiments

Volumn 2016, Issue 113, 2016, Pages

  Zhen, Anjie ^a   Rezek, Valerie ^a   Youn, Cindy ^a   Rick, Jonathan ^a   Lam, Brianna ^a   Chang, Nelson ^a   Zack, Jerome ^a   Kamata, Masakazu ^a   Kitchen, Scott ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Chimeric antigen receptor; Hematopoietic stem cells; HIV; Human leukocyte antigen; Humanized BLT mouse; Issue 113; Medicine; Non obese diabetic

Indexed keywords

ANIMAL; DISEASE MODEL; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOUSE; NONOBESE DIABETIC MOUSE; SCID MOUSE;

ANIMALS; DISEASE MODELS, ANIMAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HIV INFECTIONS; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID;

EID: 84979917763     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/54048     Document Type: Article

References (25)

1. Karpel, M. E., Boutwell, C. L., & Allen, T. M. BLT humanized mice as a small animal model of HIV infection. Current opinion in virology. 13, 75-80, (2015).
2. Zhen, A., & Kitchen, S. Stem-cell-based gene therapy for HIV infection. Viruses. 6 (1), 1-12, (2014).
3. Goulder, P. J. R., & Watkins, D. I. HIV and SIV CTL escape: implications for vaccine design. Nature Reviews: Immunology. 4 (8), 630-640, (2004).
4. Kitchen, S. G., Bennett, M., et al. Engineering Antigen-Specific T Cells from Genetically Modified Human Hematopoietic Stem Cells in Immunodeficient Mice. PloS one. 4 (12), e8208, (2009).
5. Goulder, P. J. R., & Watkins, D. I. HIV and SIV CTL escape: implications for vaccine design. Nature Reviews: Immunology. 4 (8), 630-640, (2004).
6. Kitchen, S. G. S., Levin, B. R. B., et al. In vivo suppression of HIV by antigen specific T cells derived from engineered hematopoietic stem cells. PLoS Pathogens. 8 (4), e1002649-e1002649, (2012).
7. Yang, O. O., Tran, A. C., Kalams, S. A., Johnson, R. P., Roberts, M. R., & Walker, B. D. Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells. PNAS. 94 (21), 11478-11483, (1997).
8. Zhen, A., Kamata, M., et al. HIV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells. Molecular Therapy. 23 (8) 1358-1367, (2015).
9. Barrett, D. M., Singh, N., Porter, D. L., Grupp, S. A., & June, C. H. Chimeric Antigen Receptor Therapy for Cancer. Annual Review of Medicine. 65 (1), 333-347, (2014).
10. Pejchal, R., Doores, K. J., et al. A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield. Science. 334 (6059), 1097-1103, (2011).
11. Caskey, M., Klein, F., et al. Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC 117. Nature. 522 (7557), 487-491, (2015).
12. West, A. P., Scharf, L., Scheid, J. F., Klein, F., Bjorkman, P. J., & Nussenzweig, M. C. Structural insights on the role of antibodies in HIV-1 vaccine and therapy. Cell. 156 (4), 633-648, (2014).
13. Lan, P., Tonomura, N., Shimizu, A., Wang, S., & Yang, Y.-G. Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation. Blood. 108 (2), 487-492, (2006).
14. Melkus, M. W., Estes, J. D., et al. Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1. Nature medicine. 12 (11), 1316-1322, (2006).
15. Shultz, L. D., Brehm, M. A., Garcia-Martinez, J. V., & Greiner, D. L. Humanized mice for immune system investigation: progress, promise and challenges. Nature Reviews: Immunology. 12 (11), 786-798, (2012).
16. Vatakis, D. N., Bristol, G. C., et al. Using the BLT humanized mouse as a stem cell based gene therapy tumor model. Journal of visualized experiments: JoVE (70), e4181, (2012).
17. De Rosa, S. C., Brenchley, J. M., & Roederer, M. Beyond six colors: a new era in flow cytometry. Nature medicine. 9 (1), 112-117, (2003).
18. Shimizu, S., Hong, P., et al. A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model. Blood. 115 (8), 1534-1544, (2010).
19. Denton, P. W., Olesen, R., et al. Generation of HIV latency in humanized BLT mice. Journal of virology. 86 (1), 630-634, (2012).
20. Zhou, J., Zhang, Y., et al. Embryoid bodies formation and differentiation from mouse embryonic stem cells in collagen/Matrigel scaffolds. Journal of Genetics and Genomics. 37 (7), 451-460, (2010).
21. Vatakis, D. N., Arumugam, B., Kim, S. G., Bristol, G., Yang, O., & Zack, J. A. Introduction of Exogenous T-cell Receptors Into Human Hematopoietic Progenitors Results in Exclusion of Endogenous T-cell Receptor Expression. Molecular Therapy. 21 (5), (2013).
22. Ito, R., Takahashi, T., Katano, I., & Ito, M. Current advances in humanized mouse models. Cellular & Molecular Immunology. 9 (3), 208-214, (2012).
23. Martinez-Torres, F., Nochi, T., Wahl, A., Garcia, J. V., & Denton, P. W. Hypogammaglobulinemia in BLT humanized mice--an animal model of primary antibody deficiency. PloS one. 9 (10), e108663-e108663, (2014).
24. McCune, J. M. Development and applications of the SCID-hu mouse model. Seminars in Immunology. 8 (4), 187-196, (1996).
25. Srivastava, S., & Riddell, S. R. Engineering CAR-T Cells: Design Concepts. Trends in immunology. 36 (8), (2015).