A study of single nucleotide polymorphisms of GRIN2B in schizophrenia from Chinese Han population

Neuroscience Letters

Volumn 630, Issue , 2016, Pages 132-135

  Guo, Zhenming ^a   Niu, Weibo ^a   Bi, Yan ^a   Zhang, Rui ^a   Ren, Decheng ^a   Hu, Jiaxin ^a   Huang, Xiaoye ^a   Wu, Xi ^a   Cao, Yanfei ^a   Yang, Fengping ^a   Wang, Lu ^a   Li, Weidong ^a   Li, Xingwang ^a   Xu, Yifeng ^a   He, Lin ^a,b,c   Yu, Tao ^a   He, Guang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c Chinese Academy of Sciences   (China)

Author keywords

Case control study; GRIN2B; Schizophrenia; Single nucleotide polymorphisms

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NR2B NMDA RECEPTOR;

3' UNTRANSLATED REGION; ADULT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; DSM-IV; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; GENETIC MODEL; HAN CHINESE; HAPLOTYPE; HUMAN; INTERRATER RELIABILITY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; GENE FREQUENCY; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, N-METHYL-D-ASPARTATE; SCHIZOPHRENIA;

EID: 84979889729     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2016.07.038     Document Type: Article

References (27)

1. [1] Howes, O.D., Murray, R.M., Schizophrenia: an integrated sociodevelopmental-cognitive model. Lancet 383 (2014), 1677–1687.
2. [2] van Os, J., Kapur, S., Schizophr. Lancet 374 (2009), 635–645.
3. [3] Sullivan, P.F., Kendler, K.S., Neale, M.C., Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch. Gen. Psychiatry 60 (2003), 1187–1192.
4. [4] Akashi, K., Kakizaki, T., Kamiya, H., Fukaya, M., Yamasaki, M., Abe, M., Natsume, R., Watanabe, M., Sakimura, K., NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses. J. Neurosci. 29 (2009), 10869–10882.
5. [5] Cull-Candy, S., Brickley, S., Farrant, M., NMDA receptor subunits: diversity, development and disease. Curr. Opin. Neurobiol. 11 (2001), 327–335.
6. [6] Gonzalez-Burgos, G., Lewis, D.A., NMDA receptor hypofunction, parvalbumin-positive neurons, and cortical gamma oscillations in schizophrenia. Schizophr. Bull. 38 (2012), 950–957.
7. [7] Tsai, G., Coyle, J.T., Glutamatergic mechanisms in schizophrenia. Annu. Rev. Pharmacol. Toxicol. 42 (2002), 165–179.
8. [8] Coyle, J.T., Balu, D.T., Puhl, M.D., Konopaske, G.T., History of the concept of disconnectivity in schizophrenia. Harv. Rev. Psychiatry 24 (2016), 80–86.
9. [9] Mandich, P., Schito, A.M., Bellone, E., Antonacci, R., Finelli, P., Rocchi, M., Ajmar, F., Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12. Genomics 22 (1994), 216–218.
10. [10] Gareeva, A.E., Zakirov, D.F., Khusnutdinova, E.K., Association polymorphic variants of GRIN2B gene with paranoid schizophrenia and response to common neuroleptics in Russians and Tatars from Bashkortostan Republic. Genetika 49 (2013), 1106–1113.
11. [11] Yang, Y., Li, W., Zhang, H., Yang, G., Wang, X., Ding, M., Jiang, T., Lv, L., Association study of N-Methyl-D-Aspartate receptor subunit 2B (GRIN2B) polymorphisms and schizophrenia symptoms in the han chinese population. PLoS One, 10, 2015, e0125925.
12. [12] Cherlyn, S.Y., Woon, P.S., Liu, J.J., Ong, W.Y., Tsai, G.C., Sim, K., Genetic association studies of glutamate, GABA and related genes in schizophrenia and bipolar disorder: a decade of advance. Neurosci. Biobehav. Rev. 34 (2010), 958–977.
13. [13] Qin, S., Zhao, X., Pan, Y., Liu, J., Feng, G., Fu, J., Bao, J., Zhang, Z., He, L., An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray. Eur. J. Human Genetics: EJHG 13 (2005), 807–814.
14. [14] Shi, Y.Y., He, L., SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 15 (2005), 97–98.
15. [15] Barrett, J.C., Fry, B., Maller, J., Daly, M.J., Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005), 263–265.
16. [16] Cui, Y., Jin, J., Zhang, X., Xu, H., Yang, L., Du, D., Zeng, Q., Tsien, J.Z., Yu, H., Cao, X., Forebrain NR2B overexpression facilitating the prefrontal cortex long-term potentiation and enhancing working memory function in mice. PLoS One, 6, 2011, e20312.
17. [17] Tang, Y.P., Shimizu, E., Dube, G.R., Rampon, C., Kerchner, G.A., Zhuo, M., Liu, G., Tsien, J.Z., Genetic enhancement of learning and memory in mice. Nature 401 (1999), 63–69.
18. [18] Brigman, J.L., Daut, R.A., Wright, T., Gunduz-Cinar, O., Graybeal, C., Davis, M.I., Jiang, Z., Saksida, L.M., Jinde, S., Pease, M., Bussey, T.J., Lovinger, D.M., Nakazawa, K., Holmes, A., GluN2B in corticostriatal circuits governs choice learning and choice shifting. Nat. Neurosci. 16 (2013), 1101–1110.
19. [19] Dalton, G.L., Wu, D.C., Wang, Y.T., Floresco, S.B., Phillips, A.G., NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear. Neuropharmacology 62 (2012), 797–806.
20. [20] Berg, L.K., Larsson, M., Morland, C., Gundersen, V., Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses. Neuroscience 230 (2013), 139–150.
21. [21] Monaco, S.A., Gulchina, Y., Gao, W.J., NR2B subunit in the prefrontal cortex: a double-edged sword for working memory function and psychiatric disorders. Neurosci. Biobehav. Rev. 56 (2015), 127–138.
22. [22] Di Maria, E., Gulli, R., Begni, S., De Luca, A., Bignotti, S., Pasini, A., Bellone, E., Pizzuti, A., Dallapiccola, B., Novelli, G., Ajmar, F., Gennarelli, M., Mandich, P., Variations in the NMDA receptor subunit 2B gene (GRIN2B) and schizophrenia: a case-control study. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 128B (2004), 27–29.
23. [23] Beveridge, N.J., Gardiner, E., Carroll, A.P., Tooney, P.A., Cairns, M.J., Schizophrenia is associated with an increase in cortical microRNA biogenesis. Mol. Psychiatry 15 (2010), 1176–1189.
24. [24] Schizophrenia, C., Psychiatric Genome-Wide Association study, Genome-wide association study identifies five new schizophrenia loci. Nat. Genet. 43 (2011), 969–976.
25. [25] Murai, K., Sun, G., Ye, P., Tian, E., Yang, S., Cui, Q., Sun, G., Trinh, D., Sun, O., Hong, T., Wen, Z., Kalkum, M., Riggs, A.D., Song, H., Ming, G.L., Shi, Y., The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model. Nat. Commun., 7, 2016, 10965.
26. [26] Strazisar, M., Cammaerts, S., van der Ven, K., Forero, D.A., Lenaerts, A.S., Nordin, A., Almeida-Souza, L., Genovese, G., Timmerman, V., Liekens, A., De Rijk, P., Adolfsson, R., Callaerts, P., Del-Favero, J., MIR137 variants identified in psychiatric patients affect synaptogenesis and neuronal transmission gene sets. Mol. Psychiatry 20 (2015), 472–481.
27. [27] Zhang, Y., Fan, M., Wang, Q., He, G., Fu, Y., Li, H., Yu, S., Polymorphisms in MicroRNA genes and genes involving in NMDAR signaling and schizophrenia: a case-control study in chinese han population. Sci. Rep., 5, 2015, 12984.