Polymorphisms in MicroRNA Genes and Genes Involving in NMDAR Signaling and Schizophrenia: A Case-Control Study in Chinese Han Population

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Zhang, Yanxia ^a   Fan, Mei ^a   Wang, Qingzhong ^a   He, Guang ^a   Fu, Yingmei ^a   Li, Huafang ^a   Yu, Shunying ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3' UNTRANSLATED REGION; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CAMK2G PROTEIN, HUMAN; GRIN3A PROTEIN, HUMAN; MICRORNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N-METHYL D-ASPARTATE RECEPTOR SUBTYPE 2A; NR2B NMDA RECEPTOR;

3' UNTRANSLATED REGION; ADULT; ALLELE; ASIAN CONTINENTAL ANCESTRY GROUP; CASE CONTROL STUDY; CHEMISTRY; CHINA; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HEK293 CELL LINE; HUMAN; MALE; METABOLISM; MIDDLE AGED; ODDS RATIO; REPORTER GENE; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

3' UNTRANSLATED REGIONS; ADULT; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CASE-CONTROL STUDIES; CHINA; FEMALE; GENE FREQUENCY; GENES, REPORTER; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEK293 CELLS; HUMANS; MALE; MICRORNAS; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, N-METHYL-D-ASPARTATE; SCHIZOPHRENIA; SIGNAL TRANSDUCTION;

EID: 84938900420     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep12984     Document Type: Article

References (34)

1. Picchioni, M. M. & Murray, R. M. Schizophrenia. BMJ 335, 91-95 (2007).
2. Hunsberger, J. G., Austin, D. R., Chen, G. & Manji, H. K. MicroRNAs in mental health: from biological underpinnings to potential therapies. Neuromolecular Med 11, 173-182 (2009).
3. Forero, D. A., van der Ven, K., Callaerts, P. & Del-Favero, J. miRNA genes and the brain: implications for psychiatric disorders. Hum Mutat 31, 1195-1204 (2010).
4. Bartel, D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297 (2004).
5. Zhu, Y., Kalbfleisch, T., Brennan, M. D. & Li, Y. A MicroRNA gene is hosted in an intron of a schizophrenia-susceptibility gene. Schizophr Res 109, 86-89 (2009).
6. Miller, B. H. & Wahlestedt, C. MicroRNA dysregulation in psychiatric disease. Brain Res 1338, 89-99 (2010).
7. Kantrowitz, J. T. & Javitt, D. C. N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: the final common pathway on the road to schizophrenia? Brain Res Bull 83, 108-121 (2010).
8. Kocerha, J. et al. MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction. Proc Natl Acad Sci USA 106, 3507-3512 (2009).
9. Cheng, H. Y. et al. microRNA modulation of circadian-clock period and entrainment. Neuron 54, 813-829 (2007).
10. Beveridge, N. J., Tooney, P. A., Carroll, A. P., Tran, N. & Cairns, M. J. Down-regulation of miR-17 family expression in response to retinoic acid induced neuronal differentiation. Cell Signal 21, 1837-1845 (2009).
11. Nudelman, A. S. et al. Neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132, in vivo. Hippocampus 20, 492-498 (2010).
12. Miller, B. H. et al. MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function. Proc Natl Acad Sci USA 109, 3125-3130 (2012).
13. Kim, A. H. et al. MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders. Schizophr Res 124, 183-191 (2010).
14. Beveridge, N. J., Gardiner, E., Carroll, A. P., Tooney, P. A. & Cairns, M. J. Schizophrenia is associated with an increase in cortical microRNA biogenesis. Mol Psychiatry 15, 1176-1189 (2010).
15. Mishra, P. J. & Bertino, J. R. MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine. Pharmacogenomics 10, 399-416 (2009).
16. Shi, Y. Y. & He, L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 15, 97-98 (2005).
17. Moore, J. H. Computational analysis of gene-gene interactions using multifactor dimensionality reduction. Expert Rev Mol Diagn 4, 795-803 (2004).
18. Hahn, L. W., Ritchie, M. D. & Moore, J. H. Multifactor dimensionality reduction software for detecting gene-gene and geneenvironment interactions. Bioinformatics 19, 376-382 (2003).
19. Ritchie, M. D., Hahn, L. W. & Moore, J. H. Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genet Epidemiol 24, 150-157 (2003).
20. Moore, J. H. & White, B. C. Tuning ReliefF for genome-wide genetic analysis. Lect Notes Comput Sc 4447, 166-175 (2007).
21. Noble, W. S. How does multiple testing correction work? Nat Biotechnol 27, 1135-1137 (2009).
22. Han, J. et al. Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell 125, 887-901 (2006).
23. Diederichs, S. & Haber, D. A. Sequence variations of microRNAs in human cancer: alterations in predicted secondary structure do not affect processing. Cancer Res 66, 6097-6104 (2006).
24. Wu, M. et al. Genetic variations of microRNAs in human cancer and their effects on the expression of miRNAs. Carcinogenesis 29, 1710-1716 (2008).
25. Calin, G. A. et al. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 353, 1793-1801 (2005).
26. Pullmann, R. Jr. et al. Differential stability of thymidylate synthase 3?-untranslated region polymorphic variants regulated by AUF1. J Biol Chem 281, 23456-23463 (2006).
27. Allen, N. C. et al. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet 40, 827-834 (2008).
28. Demontis, D. et al. Association of GRIN1 and GRIN2A-D with schizophrenia and genetic interaction with maternal herpes simplex virus-2 infection affecting disease risk. Am J Med Genet B Neuropsychiatr Genet 156B, 913-922 (2011).
29. Di Maria, E. et al. Variations in the NMDA receptor subunit 2B gene (GRIN2B) and schizophrenia: a case-control study. Am J Med Genet B Neuropsychiatr Genet 128B, 27-29 (2004).
30. Ohtsuki, T. et al. Mutation analysis of the NMDAR2B (GRIN2B) gene in schizophrenia. Mol Psychiatry 6, 211-216 (2001).
31. Paoletti, P. & Neyton, J. NMDA receptor subunits: function and pharmacology. Curr Opin Pharmacol 7, 39-47 (2007).
32. Mueller, H. T. & Meador-Woodruff, J. H. NR3A NMDA receptor subunit mRNA expression in schizophrenia, depression and bipolar disorder. Schizophr Res 71, 361-370 (2004).
33. Gulli, R. et al. A putative regulatory subunit (NR3A) of the NMDA receptor complex as candidate gene for susceptibility to schizophrenia: a case-control study. Psychiatr Genet 17, 355-356 (2007).
34. Shen, Y. C. et al. Exomic sequencing of the ionotropic glutamate receptor N-methyl-D-aspartate 3A gene (GRIN3A) reveals no association with schizophrenia. Schizophr Res 114, 25-32 (2009).