메뉴 건너뛰기




Volumn 441, Issue , 2017, Pages 116-123

Genes and proteins of the alternative steroid backdoor pathway for dihydrotestosterone synthesis are expressed in the human ovary and seem enhanced in the polycystic ovary syndrome

Author keywords

Adrenals; Androgen biosynthesis; Androgens; Classic and alternative backdoor pathway; Dihydrotestosterone; Human ovary; PCOS; Testis

Indexed keywords

ALDOSTERONE; ANDROGEN; ANDROSTANOLONE;

EID: 84979765631     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2016.07.029     Document Type: Article
Times cited : (61)

References (24)
  • 1
    • 7444233759 scopus 로고    scopus 로고
    • The backdoor pathway to dihydrotestosterone
    • Auchus, R.J., The backdoor pathway to dihydrotestosterone. Trends Endocrinol. Metab. 15 (2004), 432–438.
    • (2004) Trends Endocrinol. Metab. , vol.15 , pp. 432-438
    • Auchus, R.J.1
  • 2
    • 84876073490 scopus 로고    scopus 로고
    • Of marsupials and men: “Backdoor” dihydrotestosterone synthesis in male sexual differentiation
    • Biason-Lauber, A., Miller, W.L., Pandey, A.V., Fluck, C.E., Of marsupials and men: “Backdoor” dihydrotestosterone synthesis in male sexual differentiation. Mol. Cell Endocrinol. 371 (2013), 124–132.
    • (2013) Mol. Cell Endocrinol. , vol.371 , pp. 124-132
    • Biason-Lauber, A.1    Miller, W.L.2    Pandey, A.V.3    Fluck, C.E.4
  • 4
    • 0037902870 scopus 로고    scopus 로고
    • Beyond adrenal and ovarian androgen generation: increased peripheral 5alpha-reductase activity in women with polycystic ovary syndrome
    • Fassnacht, M., Schlenz, N., Schneider, S.B., Wudy, S.A., Allolio, B., Arlt, W., Beyond adrenal and ovarian androgen generation: increased peripheral 5alpha-reductase activity in women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 88 (2003), 2760–2766.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 2760-2766
    • Fassnacht, M.1    Schlenz, N.2    Schneider, S.B.3    Wudy, S.A.4    Allolio, B.5    Arlt, W.6
  • 5
    • 80051664435 scopus 로고    scopus 로고
    • Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation
    • Fluck, C.E., Meyer-Boni, M., Pandey, A.V., Kempna, P., Miller, W.L., Schoenle, E.J., Biason-Lauber, A., Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation. Am. J. Hum. Genet. 89 (2011), 201–218.
    • (2011) Am. J. Hum. Genet. , vol.89 , pp. 201-218
    • Fluck, C.E.1    Meyer-Boni, M.2    Pandey, A.V.3    Kempna, P.4    Miller, W.L.5    Schoenle, E.J.6    Biason-Lauber, A.7
  • 7
    • 33749567350 scopus 로고    scopus 로고
    • Variants in the 5α-reductase type 1 and type 2 genes are associated with the polycystic ovary syndrome and the severity of hirsutism in affected women
    • Goodarzi, M.O., Shah, N.A., Antoine, H.J., Pall, M., Guo, X., Azziz, R., Variants in the 5α-reductase type 1 and type 2 genes are associated with the polycystic ovary syndrome and the severity of hirsutism in affected women. J. Clin. Endocrinol. Metab. 91 (2006), 4085–4091.
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 4085-4091
    • Goodarzi, M.O.1    Shah, N.A.2    Antoine, H.J.3    Pall, M.4    Guo, X.5    Azziz, R.6
  • 14
    • 84858064955 scopus 로고    scopus 로고
    • Increased activation of the alternative “backdoor” pathway in patients with 21-hydroxylase deficiency; evidence from urinary steroid hormone analysis
    • Kamrath, C., Hochberg, Z., Hartmann, M.F., Remer, T., Wudy, S.A., Increased activation of the alternative “backdoor” pathway in patients with 21-hydroxylase deficiency; evidence from urinary steroid hormone analysis. J. Clin. Endocrinol. Metab. 97 (2012), E367–E375.
    • (2012) J. Clin. Endocrinol. Metab. , vol.97 , pp. E367-E375
    • Kamrath, C.1    Hochberg, Z.2    Hartmann, M.F.3    Remer, T.4    Wudy, S.A.5
  • 15
    • 84899536851 scopus 로고    scopus 로고
    • Simultaneous measurement of thirteen steroid hormones in women with polycystic ovary syndrome and control women using liquid chromatography-tandem mass spectrometry
    • Keefe, C.C., Godman, M.M., Zhang, K., Clarke, N., Reitz, R.E., Welt, C.K., Simultaneous measurement of thirteen steroid hormones in women with polycystic ovary syndrome and control women using liquid chromatography-tandem mass spectrometry. PLoS One, 9, 2014, e93805.
    • (2014) PLoS One , vol.9 , pp. e93805
    • Keefe, C.C.1    Godman, M.M.2    Zhang, K.3    Clarke, N.4    Reitz, R.E.5    Welt, C.K.6
  • 16
    • 79951665862 scopus 로고    scopus 로고
    • The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders
    • Miller, W.L., Auchus, R.J., The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocr. Rev. 32 (2011), 81–151.
    • (2011) Endocr. Rev. , vol.32 , pp. 81-151
    • Miller, W.L.1    Auchus, R.J.2
  • 20
    • 0034287545 scopus 로고    scopus 로고
    • Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones
    • Penning, T.M., Burczynski, M.E., Jez, J.M., Hung, C.F., Lin, H.K., Ma, H., Moore, M., Palackal, N., Ratnam, K., Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. Biochem. J. 351 (2000), 67–77.
    • (2000) Biochem. J. , vol.351 , pp. 67-77
    • Penning, T.M.1    Burczynski, M.E.2    Jez, J.M.3    Hung, C.F.4    Lin, H.K.5    Ma, H.6    Moore, M.7    Palackal, N.8    Ratnam, K.9
  • 21
    • 0346186090 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
    • Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group, Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum. Reprod. 19 (2004), 41–47.
    • (2004) Hum. Reprod. , vol.19 , pp. 41-47
    • Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group1
  • 23
    • 84969794976 scopus 로고    scopus 로고
    • Evidence for increased 5α-reductase activity during early childhood in daughters of women with polycystic ovary syndrome
    • Torchen, L.C., Idkowiak, J., Fogel, N.R., O'Neil, D.M., Shackleton, C.H.L., Arlt, W., Dunaif, A., Evidence for increased 5α-reductase activity during early childhood in daughters of women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 101 (2016), 2069–2075, 10.1210/jc.2015-3926.
    • (2016) J. Clin. Endocrinol. Metab. , vol.101 , pp. 2069-2075
    • Torchen, L.C.1    Idkowiak, J.2    Fogel, N.R.3    O'Neil, D.M.4    Shackleton, C.H.L.5    Arlt, W.6    Dunaif, A.7
  • 24
    • 0037317265 scopus 로고    scopus 로고
    • 5alpha-androstane-3alpha,17beta-diol is formed in tammar wallaby pouch young testes by a pathway involving 5alpha-pregnane-3alpha,17alpha-diol-20 one as a key intermediate
    • Wilson, J.D., Auchus, R.J., Leihy, M.W., Guryev, O.L., Estabrook, R.W., Osborn, S.M., Shaw, g, Renfree, M.B., 5alpha-androstane-3alpha,17beta-diol is formed in tammar wallaby pouch young testes by a pathway involving 5alpha-pregnane-3alpha,17alpha-diol-20 one as a key intermediate. Endocrinology 144 (2003), 575–580.
    • (2003) Endocrinology , vol.144 , pp. 575-580
    • Wilson, J.D.1    Auchus, R.J.2    Leihy, M.W.3    Guryev, O.L.4    Estabrook, R.W.5    Osborn, S.M.6    Shaw, G.7    Renfree, M.B.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.