Estrogenic Activity of Hyperforin in MCF-7 Human Breast Cancer Cells Transfected with Estrogen Receptor

Planta Medica

Volumn 82, Issue 16, 2016, Pages 1425-1430

  Kwon, Joseph ^a,b   Oh, Kyung Seo ^a,c   Cho, Se Young ^a,c   Bang, Mi Ae ^a,d   Kim, Hwan Seon ^c   Vaidya, Bipin ^c   Kim, Duwoon ^c  

^a Korea Basic Science Institute ^*

^b Korea Basic Science Institute (KBSI)   (South Korea)

^c Chonnam National University   (South Korea)

^d Jeonnam Biofood Technology Center   (South Korea)

Author keywords

Clusiaceae; estrogenic activity; hyperforin; Hypericum perforatum; Proteomics; St. John's wort

Indexed keywords

CHLOROGENIC ACID; CYCLIN D1; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; HYPERFORIN; HYPERICIN; HYPERIN; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEOME; QUERCETIN; ESTROGEN; PHLOROGLUCINOL; TERPENE;

ARTICLE; CELL PROLIFERATION; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ESTROGEN ACTIVITY; ESTROGEN RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; HYPERICUM PERFORATUM; MCF 7 CELL LINE; PLANT LEAF; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEOMICS; TRANSIENT TRANSFECTION; ANALOGS AND DERIVATIVES; CHEMISTRY; DNA RESPONSIVE ELEMENT; DRUG EFFECTS; GENETIC TRANSFECTION; MCF-7 CELL LINE;

CELL PROLIFERATION; ESTROGENS; HUMANS; MCF-7 CELLS; PHLOROGLUCINOL; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOME; RESPONSE ELEMENTS; TERPENES; TRANSFECTION;

EID: 84979709364     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0042-112594     Document Type: Article

References (51)

1. Heldring N Pike A Andersson S Matthews J Cheng G Hartman J Tujague M Ström A Treuter E Warner M Gustafsson J A Estrogen receptors: how do they signal and what are their targets Physiol Rev 2007 87 905 931
2. Nilsson S Mäkelä S Treuter E Tujague M Thomsen J Andersson G Enmark E Pettersson K Warner M Gustafsson J A Mechanisms of estrogen action Physiol Rev 2001 81 1535 1565
3. Marino M Galluzzo P Ascenzi P Estrogen signaling multiple pathways to impact gene transcription Curr Genomics 2006 7 497 508
4. Dalal P K Agarwal M Postmenopausal syndrome Indian J Psychiatry 2015 57 S222 S232
5. Zanetta G M Webb M J Li H Keeney G L Hyperestrogenism: a relevant risk factor for the development of cancer from endometriosis Gynecol Oncol 2000 79 18 22
6. Grodstein F Manson J E Colditz G A Willett W C Speizer F E Stampfer M J A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease Ann Intern Med 2000 133 933 941
7. Moreira A C Silva A M Santos M S Sardão V A Phytoestrogens as alternative hormone replacement therapy in menopause: What is real, what is unknown J Steroid Biochem Mol Biol 2014 143 61 71
8. Warren M P A comparative review of the risks and benefits of hormone replacement therapy regimens Am J Obstet Gynecol 2004 190 1141 1167
9. Davis S R Lambrinoudaki I Lumsden M Mishra G D Pal L Rees M Santoro N Simoncini T Menopause Nat Rev Dis Primers 2015 1 15004
10. Chen C L Weiss N S Newcomb P Barlow W White E Hormone replacement therapy in relation to breast cancer JAMA 2002 287 734 741
11. Borrelli F Ernst E Alternative and complementary therapies for the menopause Maturitas 2010 66 333 343
12. Boué S M Tilghman S L Elliott S Zimmerman M C Williams K Y Payton-Stewart F Miraflor A P Howell M H Shih B Y Carter-Wientjes C H Segar C Beckman B S Wiese T E Cleveland T E McLachlan J A Burow M E Identification of the potent phytoestrogen glycinol in elicited soybean (Glycine max) Endocrinology 2009 150 2446 2453
13. Henry L A Witt D M Resveratrol: phytoestrogen effects on reproductive physiology and behavior in female rats Horm Behav 2002 41 220 228
14. Adlercreutz H Phytoestrogens: epidemiology and a possible role in cancer protection Environ Health Perspect 1995 103 103 112
15. Mense S M Hei T K Ganju R K Bhat H K Phytoestrogens and breast cancer prevention: possible mechanisms of action Environ Health Perspect 2008 116 426 433
16. Tamir S Eizenberg M Somjen D Izrael S Vaya J Estrogen-like activity of glabrene and other constituents isolated from licorice root J Steroid Biochem Mol Biol 2001 78 291 298
17. Kostelac D Rechkemmer G Briviba K Phytoestrogens modulate binding response of estrogen receptors α and β to the estrogen response element J Agric Food Chem 2003 51 7632 7635
18. Kuiper G G Lemmen J G Carlsson B Corton J C Safe S H van der Saag P T van der Burg B Gustafsson J A Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β Endocrinology 1998 139 4252 4263
19. Boué S M Wiese T E Nehls S Burow M E Elliott S Carter-Wientjes C H Shih B Y McLachlan J A Cleveland T E Evaluation of the estrogenic effects of legume extracts containing phytoestrogens J Agric Food Chem 2003 51 2193 2199
20. Lee Y M Kim J B Bae J H Lee J S Kim P S Jang H H Kim H R Estrogen-like activity of aqueous extract from Agrimonia pilosa Ledeb. in MCF-7 cells BMC Complement Altern Med 2012 12 260
21. Liu J Burdette J E Xu H Gu C van Breemen R B Bhat K PL Booth N Constantinou A I Pezzuto J M Fong H HS Farnsworth N R Bolton J L Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms J Agric Food Chem 2001 49 2472 2479
22. Overk C R Yao P Chadwick L R Nikolic D Sun Y Cuendet M A Deng Y Hedayat A Pauli G F Farnsworth N R Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense) J Agric Food Chem 2005 53 6246 6253
23. Lee H Y Park S H Chae S W Soung N K Oh M J Kim J S Kim Y O Chae H J Aqueous ginseng extract has a preventive role in RANKL-induced osteoclast differentiation and estrogen deficiency-induced osteoporosis J Funct Foods 2015 13 192 203
24. Zhu Y Xu J Li Z Xie S Zhou J Guo X Zhou X Li G Zhong R Ma A Ginsenoside Rh2 suppresses growth of uterine leiomyoma in vitro and in vivo and may regulate ERα/c-Src/p38 MAPK activity J Funct Foods 2015 18 Part A 73 82
25. Grube B Walper A Wheatley D St. John's wort extract: efficacy for menopausal symptoms of psychological origin Adv Ther 1999 16 177 186
26. Hunt E Lester C Lester E Tackett R Effect of St. John's wort on free radical production Life Sci 2001 69 181 190
27. Tripathi Y B Pandey E Role of alcoholic extract of shoot of Hypericum perforatum Linn on lipid peroxidation and various species of free radicals in rats Indian J Exp Biol 1999 37 567 571
28. Barnes J Anderson L A Phillipson J D St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties J Pharm Pharmacol 2001 53 583 600
29. Chatterjee S S Bhattacharya S K Wonnemann M Singer A Müller W E Hyperforin as a possible antidepressant component of hypericum extracts Life Sci 1998 63 499 510
30. Koeberle A Rossi A Bauer J Dehm F Verotta L Northoff H Sautebin L Werz O Hyperforin, an anti-inflammatory constituent from St. John's wort, inhibits microsomal prostaglandin E2 synthase-1 and suppresses prostaglandin E2 formation in vivo Front Pharmacol 2011 2 7
31. Meruelo D Lavie G Lavie D Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin Proc Natl Acad Sci U S A 1988 85 5230 5234
32. Butterweck V Mechanism of action of St John's wort in depression CNS Drugs 2003 17 539 562
33. 1H-NMR and HPLC-MS/MS-based global/targeted metabolomic evaluation of Hypericum perforatum L. intervention for menopause J Funct Foods 2015 17 722 741
34. Harris D Besselink E Henning S Go V Heber D Phytoestrogens induce differential estrogen receptor alpha-or beta-mediated responses in transfected breast cancer cells Exp Biol Med (Maywood) 2005 230 558 568
35. Wakeling A E Dukes M Bowler J A potent specific pure antiestrogen with clinical potential Cancer Res 1991 51 3867 3873
36. Howell A Osborne C K Morris C Wakeling A E ICI 182, 780 (Faslodex™) Cancer 2000 89 817 825
37. Lucas T FG Royer C Siu E R Lazari M FM Porto C S Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat Sertoli cells Biol Reprod 2010 83 307 317
38. Royer C Lucas T FG Lazari M FM Porto C S 17Beta-estradiol signaling and regulation of proliferation and apoptosis of rat Sertoli cells Biol Reprod 2012 86 108
39. Rochefort H Garcia M Glondu M Laurent V Liaudet E Rey J M Roger P Cathepsin D in breast cancer: mechanisms and clinical applications, a 1999 overview Clin Chim Acta 2000 291 157 170
40. Fung K Samara E Wong C Metwalli A Krlin R Bane B Liu C Yang J Pitha J Culkin D Increased expression of type 2 3α-hydroxysteroid dehydrogenase/type 5 17β-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma Endocr Relat Cancer 2006 13 169 180
41. Rižner T L Penning T M Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism Steroids 2014 79 1 37
42. McCarty M F Barroso-Aranda J Contreras F Genistein and phycocyanobilin may prevent hepatic fibrosis by suppressing proliferation and activation of hepatic stellate cells Med Hypotheses 2009 72 330 332
43. Ambruso D R Ellison M A Thurman G W Leto T L Peroxiredoxin 6 translocates to the plasma membrane during neutrophil activation and is required for optimal NADPH oxidase activity Biochim Biophys Acta 2012 1823 306 315
44. Nadal-Serrano M Sastre-Serra J Pons D G Miro A M Oliver J Roca P The ERalpha/ERbeta ratio determines oxidative stress in breast cancer cell lines in response to 17Beta-estradiol J Cell Biochem 2012 113 3178 3185
45. Compton D A Luo C Mutation of the predicted p34cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle and block mitosis J Cell Sci 1995 108 621 633
46. Cirak C Radusiene J Stanius Z Camas N Caliskan O Odabas M S Secondary metabolites of Hypericum orientale L. growing in Turkey: variation among populations and plant parts Acta Physiol Plant 2012 34 1313 1320
47. Felekkis K N Narsimhan R P Near R Castro A F Zheng Y Quilliam L A Lerner A AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner Mol Cancer Res 2005 3 32 41
48. Mirebeau-Prunier D Le Pennec S Jacques C Gueguen N Poirier J Malthiery Y Savagner F Estrogen-related receptor α and PGC-1-related coactivator constitute a novel complex mediating the biogenesis of functional mitochondria FEBS J 2010 277 713 725
49. Chou J Lin J H Brenot A Kim J W Provot S Werb Z GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression Nat Cell Biol 2013 15 201 213
50. Nakagawa Y Suzuki T Tayama S Metabolism and toxicity of benzophenone in isolated rat hepatocytes and estrogenic activity of its metabolites in MCF-7 cells Toxicology 2000 156 27 36
51. Jeong E H Vaidya B Cho S Y Park M A Kaewintajuk K Kim S R Oh M J Choi J S Kwon J Kim D Identification of regulators of the early stage of viral hemorrhagic septicemia virus infection during curcumin treatment Fish Shellfish Immunol 2015 45 184 193