Formation of membrane pores by gasdermin-N causes pyroptosis

Science China Life Sciences

Volumn 59, Issue 10, 2016, Pages 1071-1073

  Qi, Xiaopeng ^a  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; GSDMD PROTEIN, HUMAN; INFLAMMASOME; TUMOR PROTEIN;

ANIMAL; BIOLOGICAL MODEL; CELL MEMBRANE; CHEMISTRY; HUMAN; METABOLISM; POROSITY; PYROPTOSIS;

ANIMALS; CASPASES; CELL MEMBRANE; HUMANS; INFLAMMASOMES; MODELS, BIOLOGICAL; NEOPLASM PROTEINS; POROSITY; PYROPTOSIS;

EID: 84979658076     PISSN: 16747305     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11427-016-5109-3     Document Type: Article

References (9)

1. Aglietti, R.A., Estevez, A., Gupta, A., Ramirez, M.G., Liu, P.S., Kayagaki, N., Ciferri, C., Dixit, V.M., and Dueber, E.C. (2016). GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes. Proc Natl Acad Sci, USA 113, 7858–7863.
2. Ding, J., Wang, K., Liu, W., She, Y., Sun, Q., Shi, J., Sun, H., Wang, D.-C., and Shao, F. (2016). Pore-forming activity and structural autoinhibition of the gasdermin family. Nature 535, 111–116.
3. Hagar, J.A., Powell, D.A., Aachoui, Y., Ernst, R.K., and Miao, E.A. (2013). Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock. Science 341, 1250–1253.
4. Kayagaki, N., Stowe, I.B., Lee, B.L., O'Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q.T., Liu, P., Lill, J.R., Li, H., Wu, J., Kummerfeld, S., Zhang, J., Lee, W.P., Snipas, S.J., Salvesen, G.S., Morris, L.X., Fitzgerald, L., Zhang, Y., Bertram, E.M., Goodnow, C.C., and Dixit, V.M. (2015). Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526, 666–671.
5. Kayagaki, N., Wong, M.T., Stowe, I.B., Ramani, S.R., Gonzalez, L.C., Akashi-Takamura, S., Miyake, K., Zhang, J., Lee, W.P., Muszynski, A., Forsberg, L.S., Carlson, R.W., and Dixit, V.M. (2013). Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science 341, 1246–1249.
6. Man, S.M., and Kanneganti, T.-D. (2016). Converging roles of caspases in inflammasome activation, cell death and innate immunity. Nat Rev Immunol 16, 7–21.
7. Peraro, M.D., and van der Goot, F.G. (2016). Pore-forming toxins: ancient, but never really out of fashion. Nat Rev Micro 14, 77–92.
8. Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., and Shao, F. (2015). Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526, 660–665.
9. Shi, J., Zhao, Y., Wang, Y., Gao, W., Ding, J., Li, P., Hu, L., and Shao, F. (2014). Inflammatory caspases are innate immune receptors for intracellular LPS. Nature 514, 187–192.