Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity

Experimental Gerontology

Volumn 82, Issue , 2016, Pages 166-174

  Deelen, Joris ^a,b   van den Akker, Erik B ^a,c   Trompet, Stella ^a   van Heemst, Diana ^a   Mooijaart, Simon P ^a   Slagboom, P Eline ^a   Beekman, Marian ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAX PLANCK INSTITUTE FOR BIOLOGY OF AGEING   (Germany)

^c DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

Biomarkers; Genetics; Healthy ageing; Human longevity

Indexed keywords

BIOLOGICAL MARKER; GLUCOSE; INSULIN; TRIACYLGLYCEROL; GLUCOSE BLOOD LEVEL;

ADULT; AGE; AGED; AGING; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; EUROPEAN; FEMALE; GENERAL PRACTITIONER; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; GLUCOSE BLOOD LEVEL; HEALTH STATUS; HUMAN; INSULIN BLOOD LEVEL; LIPID METABOLISM; LONGEVITY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PROGENY; SIBLING; SINGLE NUCLEOTIDE POLYMORPHISM; SPOUSE; TRIACYLGLYCEROL BLOOD LEVEL; BLOOD; GENETIC VARIATION; GENETICS; NETHERLANDS; STATISTICAL MODEL; VERY ELDERLY;

AGED, 80 AND OVER; BIOMARKERS; BLOOD GLUCOSE; FEMALE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INSULIN; LINEAR MODELS; LONGEVITY; MALE; NETHERLANDS; TRIGLYCERIDES;

EID: 84979642409     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2016.06.013     Document Type: Article

References (45)

1. Beekman, M., Blauw, G.J., Houwing-Duistermaat, J.J., Brandt, B.W., Westendorp, R.G., Slagboom, P.E., Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies. J. Gerontol. A Biol. Sci. Med. Sci. 61:4 (2006), 355–362.
2. Bos, S.D., Beekman, M., Maier, A.B., Karsdal, M.A., Kwok, W.Y., Bay-Jensen, A.C., et al. Metabolic health in families enriched for longevity is associated with low prevalence of hand osteoarthritis and influences OA biomarker profiles. Ann. Rheum. Dis. 72:10 (2013), 1669–1674.
3. Broer, L., Buchman, A.S., Deelen, J., Evans, D.S., Faul, J.D., Lunetta, K.L., et al. GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. J. Gerontol. A Biol. Sci. Med. Sci. 70:1 (2015), 110–118.
4. Cheverud, J.M., A simple correction for multiple comparisons in interval mapping genome scans. Heredity (Edinb) 87:Pt 1 (2001), 52–58.
5. Christensen, K., McGue, M., Petersen, I., Jeune, B., Vaupel, J.W., Exceptional longevity does not result in excessive levels of disability. Proc. Natl. Acad. Sci. U. S. A. 105:36 (2008), 13274–13279.
6. Cruchaga, C., Kauwe, J.S., Harari, O., Jin, S.C., Cai, Y., Karch, C.M., et al. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron 78:2 (2013), 256–268.
7. Deelen, J., Beekman, M., Codd, V., Trompet, S., Broer, L., Hagg, S., et al. Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers. Int. J. Epidemiol. 43:3 (2014), 878–886.
8. Deelen, J., Beekman, M., Uh, H.W., Broer, L., Ayers, K.L., Tan, Q., et al. Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Hum. Mol. Genet. 23:16 (2014), 4420–4432.
9. Deelen, J., Beekman, M., Capri, M., Franceschi, C., Slagboom, P.E., Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges. BioEssays 35:4 (2013), 386–396.
10. Finch, C.E., Tanzi, R.E., Genetics of aging. Science (New York, N.Y.) 278:5337 (1997), 407–411.
11. Friedewald, W.T., Levy, R.I., Fredrickson, D.S., Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18:6 (1972), 499–502.
12. Herskind, A.M., McGue, M., Holm, N.V., Sorensen, T.I., Harvald, B., Vaupel, J.W., The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900. Hum. Genet. 97:3 (1996), 319–323.
13. Hjelmborg, J.vB., Iachine, I., Skytthe, A., Vaupel, J.W., McGue, M., Koskenvuo, M., et al. Genetic influence on human lifespan and longevity. Hum. Genet. 119:3 (2006), 312–321.
14. Ingelsson, E., Langenberg, C., Hivert, M.F., Prokopenko, I., Lyssenko, V., Dupuis, J., et al. Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans. Diabetes 59:5 (2010), 1266–1275.
15. Kirkwood, T.B., Cordell, H.J., Finch, C.E., Speed-bumps ahead for the genetics of later-life diseases. Trends Genet. 27:10 (2011), 387–388.
16. Lara, J., Cooper, R., Nissan, J., Ginty, A.T., Khaw, K.T., Deary, I.J., et al. A proposed panel of biomarkers of healthy ageing. BMC medicine, 13, 2015, 222.
17. Li, J., Ji, L., Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity (Edinb) 95:3 (2005), 221–227.
18. Liu, J., Zeng, F.F., Liu, Z.M., Zhang, C.X., Ling, W.H., Chen, Y.M., Effects of blood triglycerides on cardiovascular and all-cause mortality: a systematic review and meta-analysis of 61 prospective studies. Lipids Health Dis., 12, 2013, 159.
19. Marquardt, A., Stohr, H., White, K., Weber, B.H., cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics 66:2 (2000), 175–183.
20. Martin-Ruiz, C., von, Z.T., Biomarkers of healthy ageing: expectations and validation. Proc. Nutr. Soc. 73:3 (2014), 422–429.
21. Martin-Ruiz, C., Jagger, C., Kingston, A., Collerton, J., Catt, M., Davies, K., et al. Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85 + study. Mech. Ageing Dev. 132:10 (2011), 496–502.
22. Moeller, M., Hirose, M., Mueller, S., Roolf, C., Baltrusch, S., Ibrahim, S., et al. Inbred mouse strains reveal biomarkers that are pro-longevity, antilongevity or role switching. Aging Cell 13:4 (2014), 729–738.
23. Mooijaart, S.P., Berbee, J.F., van, H.D., Havekes, L.M., de Craen, A.J., Slagboom, P.E., et al. ApoE plasma levels and risk of cardiovascular mortality in old age. PLoS Med., 3(6), 2006, e176.
24. Murray, C.J., Atkinson, C., Bhalla, K., Birbeck, G., Burstein, R., Chou, D., et al. The state of US health, 1990–2010: burden of diseases, injuries, and risk factors. JAMA 310:6 (2013), 591–608.
25. Njajou, O.T., Hsueh, W.C., Blackburn, E.H., Newman, A.B., Wu, S.H., Li, R., et al. Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study. J. Gerontol. A Biol. Sci. Med. Sci. 64:8 (2009), 860–864.
26. Noordam, R., de Craen, A.J., Pedram, P., Maier, A.B., Mooijaart, S.P., van, P.J., et al. Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study. CMAJ 184:18 (2012), E963–E968.
27. Nyholt, D.R., A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am. J. Hum. Genet. 74:4 (2004), 765–769.
28. Perls, T., Shea-Drinkwater, M., Bowen-Flynn, J., Ridge, S.B., Kang, S., Joyce, E., et al. Exceptional familial clustering for extreme longevity in humans. J. Am. Geriatr. Soc. 48:11 (2000), 1483–1485.
29. Pyorala, M., Miettinen, H., Laakso, M., Pyorala, K., Plasma insulin and all-cause, cardiovascular, and noncardiovascular mortality: the 22-year follow-up results of the Helsinki policemen study. Diabetes Care 23:8 (2000), 1097–1102.
30. Rozing, M.P., Mooijaart, S.P., Beekman, M., Wijsman, C.A., Maier, A.B., Bartke, A., et al. C-reactive protein and glucose regulation in familial longevity. Age (Dordr.) 33:4 (2011), 623–630.
31. Rozing, M.P., Westendorp, R.G., de Craen, A.J., Frolich, M., Heijmans, B.T., Beekman, M., et al. Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study. J. Gerontol. A Biol. Sci. Med. Sci. 65:4 (2010), 365–368.
32. Rozing, M.P., Westendorp, R.G., Frolich, M., de Craen, A.J., Beekman, M., Heijmans, B.T., et al. Human insulin/IGF-1 and familial longevity at middle age. Aging (Albany NY) 1:8 (2009), 714–722.
33. Sala, M., Kroft, L.J., Roell, B., van der Grond, J., Slagboom, P.E., Mooijaart, S.P., et al. Association of liver enzymes and computed tomography markers of liver steatosis with familial longevity. PLoS One, 9(3), 2014, e91085.
34. Schoenmaker, M., de Craen, A.J., de Meijer, P.H., Beekman, M., Blauw, G.J., Slagboom, P.E., et al. Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. European journal of human genetics: EJHG. 14:1 (2006), 79–84.
35. Scott, R.A., Lagou, V., Welch, R.P., Wheeler, E., Montasser, M.E., Luan, J., et al. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat. Genet. 44:9 (2012), 991–1005.
36. Shiels, P.G., Improving precision in investigating aging: why telomeres can cause problems. J. Gerontol. A Biol. Sci. Med. Sci. 65:8 (2010), 789–791.
37. Sprott, R.L., Biomarkers of aging and disease: introduction and definitions. Exp. Gerontol. 45:1 (2010), 2–4.
38. Stijntjes, M., de Craen, A.J., van, H.D., Meskers, C.G., van Buchem, M.A., Westendorp, R.G., et al. Familial longevity is marked by better cognitive performance at middle age: the Leiden Longevity Study. PLoS One, 8(3), 2013, e57962.
39. Terry, D.F., Sebastiani, P., Andersen, S.L., Perls, T.T., Disentangling the roles of disability and morbidity in survival to exceptional old age. Arch. Intern. Med. 168:3 (2008), 277–283.
40. Vaarhorst, A.A., Beekman, M., Suchiman, E.H., van, H.D., Houwing-Duistermaat, J.J., Westendorp, R.G., et al. Lipid metabolism in long-lived families: the Leiden longevity study. Age (Dordr.) 33:2 (2011), 219–227.
41. van Vlijmen, B.J., van den Maagdenberg, A.M., Gijbels, M.J., van der Boom, H., HogenEsch, H., Frants, R.R., et al. Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice. J. Clin. Invest. 93:4 (1994), 1403–1410.
42. Welter, D., MacArthur, J., Morales, J., Burdett, T., Hall, P., Junkins, H., et al. The NHGRI GWAS catalog, a curated resource of SNP-trait associations. Nucleic Acids Res. 42:Database issue (2014), D1001–D1006.
43. Westendorp, R.G., van, H.D., Rozing, M.P., Frolich, M., Mooijaart, S.P., Blauw, G.J., et al. Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: the Leiden Longevity Study. J. Am. Geriatr. Soc. 57:9 (2009), 1634–1637.
44. Wijsman, C.A., van, H.D., Rozing, M.P., Slagboom, P.E., Beekman, M., de Craen, A.J., et al. Homocysteine and familial longevity: the Leiden Longevity Study. PLoS One, 6(3), 2011, e17543.
45. Willer, C.J., Schmidt, E.M., Sengupta, S., Peloso, G.M., Gustafsson, S., Kanoni, S., et al. Discovery and refinement of loci associated with lipid levels. Nat. Genet. 45:11 (2013), 1274–1283.