A Physiologically Based Pharmacokinetic Model for Ganciclovir and Its Prodrug Valganciclovir in Adults and Children

AAPS Journal

Volumn 18, Issue 6, 2016, Pages 1453-1463

  Lukacova, V ^a   Goelzer, P ^b   Reddy, M ^c   Greig, G ^d   Reigner, B ^d   Parrott, N ^d  

^a Simulations Plus Inc   (United States)

^b TEVA PHARMACEUTICALS   (Israel)

^c ARRAY BIOPHARMA INC   (United States)

^d F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

esterases; pediatrics; permeability limited distribution; physiologically based pharmacokinetic models

Indexed keywords

ESTERASE; GANCICLOVIR; VALGANCICLOVIR; ANTIVIRUS AGENT; PRODRUG;

ACTIVE TRANSPORT; AREA UNDER THE CURVE; ARTICLE; BLOOD FLOW; COMPUTER MODEL; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG PENETRATION; DRUG RESEARCH; DRUG SOLUBILITY; DRUG TRANSPORT; EXPERIMENTAL MODEL; IN VITRO STUDY; INTESTINE; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; LIVER; MAXIMUM PLASMA CONCENTRATION; ORAL DRUG ADMINISTRATION; PHYSICAL CHEMISTRY; PREDICTION; RENAL CLEARANCE; SIMULATION; SOFTWARE; ADULT; ANALOGS AND DERIVATIVES; ANIMAL; BIOLOGICAL MODEL; BLOOD; CHILD; HUMAN;

ADULT; ANIMALS; ANTIVIRAL AGENTS; CHILD; GANCICLOVIR; HUMANS; MODELS, BIOLOGICAL; PRODRUGS;

EID: 84979587972     PISSN: None     EISSN: 15507416     Source Type: Journal    
DOI: 10.1208/s12248-016-9956-4     Document Type: Article

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