Spatial expression patterns of peptide transporters in the human and rat gastrointestinal tracts, caco-2 in vitro cell culture model, and multiple human tissues

AAPS Journal

Volumn 3, Issue 1, 2001, Pages

  Herrera Ruiz, Dea ^a   Wang, Qing ^b   Cook, Thomas J ^a   Knipp, Gregory T ^a   Gudmundsson, Olafur S ^c   Smith, Ronald L ^a   Faria, Teresa N ^a  

^a RUTGERS UNIVERSITY   (United States)

^b GENENTECH INC   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

Caco 2 cells; Gi tract; HPT 1; Human digestive cdna panel; Human tissue cdna panel; Pept1; Peptide transport; PHT1; PTR3

Indexed keywords

EID: 52549097834     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Pauletti GM, Gangwar S, Knipp GT, et al. Structural requirements for intestinal absorption of peptide drugs. J Cont Rel. 1996;41:3-17.
2. Rosenberg SH, Kleiner! HD. Renin inhibitors. Pharm Biotechnol. 1998;11:7-28.
3. al-Obeidi F, Hruby VJ, Sawyer TK. Peptide and peptidomimetic libraries: molecular diversity and drug design. Mol Biotechnol. 1998;9:205-223.
4. Doring F, Walter J, Will J, et al. Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications. J Clin Invest. 1998;101:2761-2767.
5. Oh DM, Han HK, Amidon GL. Drug transport and targeting: intestinal transport. Pharm Biotechnol. 1999;12:59-88.
6. Hadley ME, Hruby VJ, Blanchard J, et al. Discovery and development of novel melanogenic drugs: Melatonin-I and -II. Pharm Biotechnol. 1998;11:575-595.
7. Barlow D, Satoh T. The design of peptide analogues for improved absorption. J Contr Rel. 1994;29:283-291.
8. Burton PS, Conradi RA, Ho NFH, Hilgers AR, Borchardt RT. How structural features influence the biomembrane permeability of peptides. J Pharm Sei. 1996;85:1336-1340.
9. Flicker G, Drewe J. Current concepts in intestinal peptide absorption. J Pept Sei. 1996;2:195-211.
10. Wang W, Borchardt RT, Wang B. Orally active peptidomimetic ROD analogs that are glycoprotein Ilb/IIIa antagonists. Curr Med Chem. 2000;7:437-453.
11. Bai JP, Amidon GL. Structural specificity of mucosal-cell transport and metabolism of peptide drugs: implication for oral peptide drug delivery. Pharm Res. 1992;9:969-978.
12. Yang CY, Dantzig AH, Pidgeon C. Intestinal peptide transport systems and oral drug availability. Pharm Res. 1999;16:1331-1343.
13. Meredith D, Boyd CAR. Structure and function of eukaryotic peptide transporters. Cell Mol Life Sei. 2000;57:754-778.
14. Liang R, Fei YJ, Prasad PD, et al. Human intestinal H+/peptide cotransporter: cloning, functional expression, and chromosomal localization. J Biol Chem. 1995;270:6456-6463.
15. Fei YJ, Kanai Y, Nussberger S, et al. Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature. 1994;368:563-566.
16. Dantzig AH, Hoskins JA, Tabas LB, et al. Association of intestinal peptide transport with a protein related to the cadherin superfamily. Science. 1994;264:430-433.
17. Ganapathy ME, Huang W, Wang H, Ganapathy V, Leibach FH. Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Biochem Biophys Res Commun. 1998;246:470-475.
18. Tamai I, Nakanishi T, Hayashi K, et al. The predominant contribution of oligopeptide transporter PepTl to intestinal absorption of beta-lactam antibiotics in the rat small intestine. J Pharm Pharmacol. 1997;49:796-801.
19. Audus KL, Bartel RL, Hidalgo IJ, Borchardt RT. The use of cultured epithelial and endothelial cells for drug transport and metabolism. Pharm Res. 1990;7:435-451.
20. Artursson P, Borchardt RT. Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond. Pharm Res. 1997;14:1655-1658.
21. Knipp GT, Ho NFH, Barsuhn CL, Borchardt RT. Delineation of paracellular diffusion in Caco-2 monolayers effect of perturbation on the transport of model compounds which vary in charge and size. J Pharm Sei. 1997;86:1105-1110.
22. Hu M, Chen J, Zhu Y, Dantzig AH, Stratford RE. Jr., Kuhfeld MT. Mechanism and kinetics of transcellular transport of a new betalactam antibiotic loracarbef across an intestinal epithelial membrane model system (Caco-2). Pharm Res. 1994;11:1405-1413.
23. Hu M, Zheng L, Chen J, et al. Mechanisms of transport of quinapril in Caco-2 cell monolayers: comparison with cephalexin. Pharm Res. 1995;12:1120-1125.
24. Snyder NJ, Tabas LB, Berry DM, Duckworth DC, Spry DO, Dantzig AH. Structure-activity relationship of carbacephalosporins and cephalosporins: antibacterial activity and interaction with the intestinal proton-dependent dipeptide transport carrier of Caco-2 cells. Antimicrob Agents Chemother. 1997;41:1649-1657.
25. Yang CY. Studies on the human intestinal di-/tripeptide transporter HPT-1 as a potential carrier for orally administered drugs [thesis]. West Lafayette, IN: Purdue University; 1998.
26. Steiner HY, Naider F, Becker JM. The PTR family: a new group of peptide transporters. Mol. Microbiol. 1995; 16:825-834
27. Graul RC, Sadee W. Sequence alignments of the H(+)-dependent oligopeptide transporter family PTR: Inferences on structure and function of the intestinal PLPT1 transporter. Pharm. Res. 1997; 14(4):388-400.
28. Botka CW, Witting TW, Graul RC, et al. Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics. AAPS PharmSci. 2000;2:l-22.
29. Yamashita T, Shimada S, Quo W, et al. Cloning and functional expression of a brain peptide/histidine transporter. J Biol Chem. 1997;272:10205-10211.
30. Herrera-Ruiz D, Wang Q, Ll-Toukhy N, Gudmundsson OS, and Knipp GT. Gene Expression of a Novel Oligopeptide Transporter in Rat and Human Tissues. 2001 Pharmaceutical Congress of the Americas, Orlando, Florida (March, 2001).
31. Walker WF, Hornberger DG. Anatomy and Dissection of the Rat. New York: W.H. Freeman Co; 1998.
32. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
33. Saito H, Okuda M., Terada T, Sasaki S, Inui K. Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney. J Pharmacol Exp Ther. 1995;275:1631-1637.
34. Erickson RH, Gum JR Jr, Lindstrom MM, McKean D, Kim YS. Regional expression and dietary regulation of rat small intestinal peptide and amino acid transporter mRNAs. Biochem Biophys Res Commun. 1995;216:249-257.
35. Knipp GT, Liu B, Audus KL, Fujii H, Ono T, Scares MJ. Fatty acid transport regulatory proteins in the developing rat placenta and in trophoblast cell culture models. Placenta. 2000;21:367-375.
36. Knipp GT, Audus KL, Scares MJ. Nutrient transport across the placenta. Adv Drug Del Rev. 1999;38:41-58.
37. Hui TY, Bernlohr DA. Fatty acid transporters in animal cells. Front Biosci. 1997;2:d222-d231.
38. Palacin M, Estevez R, Bertran J, Zorzano A. Molecular biology of mammalian plasma membrane amino acid transporters. Physiol Rev. 1998;78:969-1054.
39. Kahn BB, Flier JS, Regulation of glucose-transporter gene expression in vitro and in vivo. Diabetes Care. 1990;13:548-564.
40. Yao SYM, Ng AML, Muzyka WR, et al. Molecular cloning and functional characterization of nitrobenzylthioinosine (NBMPR)sensitive (es) and NBMPR-insensitive (ei) equilibrative nucleoside transporter proteins (rENTl and rENT2) from rat tissues. J Biol Chem. 1997;272:28423-28430.
41. Wang J, Schaner ME, Thomassen S, Su SF, Piquette-Miller M, Giacomini KM. Functional and molecular characteristics of Na+-dependent nucleoside transporters. Pharm Res. 1997; 14:1524-1532.
42. Miyamoto K-I, Shiraga T, Morita K, Yamamoto H, et al. Sequence, tissue distribution and developmental changes in rat intestinal oligopeptides transporter. Biochem Biophys Acta. 1996;1305:34-38.