Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Tang, Hai Bo ^a   Lu, Zhuan Ling ^a   Wei, Xian Kai ^a   Zhong, Tao Zhen ^a   Zhong, Yi Zhi ^a   Ouyang, Ling Xuan ^a   Luo, Yang ^a   Xing, Xing Wei ^a   Liao, Fang ^a   Peng, Ke Ke ^a   Deng, Chao Qian ^a   Minamoto, Nobuyuki ^a   Luo, Ting Rong ^a  

^a GUANGXI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; PROTEIN; SPHINGOMYELIN; TLR4 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 4; VIG1 PROTEIN, MOUSE;

ANIMAL; CELL LINE; DOG; HAMSTER; METABOLISM; MOUSE; PHYSIOLOGY; RABIES VIRUS; RAW 264.7 CELL LINE; VIRUS REPLICATION;

ANIMALS; CELL LINE; CHOLESTEROL; CRICETINAE; DOGS; MICE; PROTEINS; RABIES VIRUS; RAW 264.7 CELLS; SPHINGOMYELINS; TOLL-LIKE RECEPTOR 4; VIRUS REPLICATION;

EID: 84979581227     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep30529     Document Type: Article

References (36)

1. Anderson, A., Shwiff, S. A. The Cost of Canine Rabies on Four Continents. Transbound Emerg Dis. 24, doi: 10.1111/tbed.12168 (2013).
2. Kawai, T., Akira S. Pathogen recognition with Toll-like receptors. Curr Opin Immunol. 17(4), 338-344 (2005).
3. Johnson N. et al. Lyssavirus infection activates interferon gene expression in the brain. J Gen Virol. 87, 2663-2667 (2006).
4. Préhaud, C., Mégret, F., Lafage, M., Lafon, M. Virus infection switches TLR-3-positive human neurons to become strong producers of beta interferon. J Virol. 79(20), 12893-12904 (2005).
5. Saitoh, T. et al. Antiviral protein Viperin promotes Toll-like receptor 7-and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. Immunity. 34(3), 352-363 (2011).
6. Chin, K. C., Cresswell, P. Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. PNAS. 98, 15125-15130 (2001).
7. Ishii, K. J. et al. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat. Immunol. 7, 40-48 (2006).
8. Rivieccio, M. A. et al. TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5. J. Immunol. 177, 4735-4741 (2006).
9. Severa, M., Coccia, E. M., Fitzgerald K. A. Toll-like receptor-dependent and-independent viperin gene expression and counterregulation by PRDI-binding factor-1/BLIMP1. J. Biol. Chem. 281, 26188-26195 (2006).
10. Suh, H. S. et al. Astrocyte indoleamine 2, 3-dioxygenase is induced by the TLR3 ligand poly (I: C): mechanism of induction and role in antiviral response. J. Virol. 81, 9838-9850 (2007).
11. Boudinot, P. et al. Vesicular stomatitis virus and pseudorabies virus induce a vig1/cig5 homologue in mouse dendritic cells via different pathways. J. Gen. Virol. 81, 2675-2682 (2000).
12. Helbig, K. J., Lau, D. T., Semendric, L., Harley, H. A., Beard, M. R. Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector. Hepatology. 42, 702-710 (2005).
13. Wang, X., Hinson, E. R., Cresswell, P. The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts. Cell Host Microbe. 2, 96-105 (2007).
14. Mattijssen, S., Pruijn, G. J. Viperin, a key player in the antiviral response. Microbes Infect. 14(5), 419-426 (2012).
15. Helbig, K. J., Beard M. R. The role of viperin in the innate antiviral response. J Mol Biol. 426(6), 1210-1219 (2014).
16. Seo, J. Y., Yaneva, R., Cresswell, P. Viperin: A multifunctional, interferon-inducible protein that regulates virus replication. Cell Host Microbe. 10(6), 534-539 (2011).
17. Liu, Q. et al. Molecular epidemiology of rabies in Guangxi Province, south of China. J Clin Virol. 39(4), 295-303 (2007).
18. Tang, H. B. et al. Re-emergence of Rabies in the Guangxi Province of Southern China. PLoS Negl Trop Dis. 8(10), e3114 (2014).
19. Haldar, S., Paul, S., Joshi, N., Dasgupta, A., Chattopadhyay, K. The presence of the iron-sulfur motif is important for the conformational stability of the antiviral protein, Viperin. PLoS One. 7(2), e31797 (2012).
20. Hinson, E. R., Cresswell, P. The N-terminal amphipathic alpha-helix of viperin mediates localization to the cytosolic face of the endoplasmic reticulum and inhibitsprotein secretion. J Biol Chem. 284, 4705-4712 (2009).
21. Shaveta, G., Shi, J., Chow, V. T., Song, J. Structural characterization reveals that viperin is a radical S-ade-nosyl-L-methionine (SAM) enzyme. Biochem Biophys Res Commun. 391(3), 1390-1395 (2010).
22. Anderson, H. A., Chen, Y., Norkin, L. C. MHC class I molecules are enriched in caveolae but do not enter with simian virus 40. J Gen Virol. 79, 1469-1477 (1998).
23. Pelkmans, L., Kartenbeck. J., Helenius, A. Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER. Nat Cell Biol. 3(5), 473-483 (2001).
24. Kawai T. et al. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J. Immunol. 167, 5887-5894 (2001).
25. Haynes L. M. et al. Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus. J Virol. 75, 10730-10737(2001).
26. Kurt-Jones E. A. et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol. 1, 398-401(2000).
27. Rassa J. C. et al. Murine retroviruses activate B cells via interaction with toll-like receptor 4. PNAS. 99, 2281-2286 (2002).
28. Masayuki, I. i. et al. A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling. Mol Pharmacol. 69, 1288-1295 (2006).
29. Matsunaga, N., Tsuchimori, N., Matsumoto, T., Ii, M. TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules. Mol Pharmacol. 79, 34-41 (2011).
30. Yang, K. et al. Hsp90 Regulates Activation of Interferon Regulatory Factor 3 and TBK-1 Stabilization in Sendai Virus-infected Cells. Mol Biol Cell. 17, 1461-1471 (2006).
31. Nasr, N. et al. HIV-1 infection of human macrophages directly induces viperin which inhibits viral production. Blood. 120, 778-788 (2012).
32. Schafer, S. L., Lin, R., Moore, P. A., Hiscott, J., Pitha, P. M. Regulation of type I interferon gene expression by interferon regulatory factor-3. J. Biol. Chem. 273, 2714-2720 (1998).
33. Doyle, S. et al. IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity. 17(3), 251-263 (2002).
34. Ishikawa, Y., Samejima, T., Nunoya, T., Motohashi, T., Nomura, Y. Biological properties of the cell culture adapted RC-HL strain of rabies virus as a candidate strain for an inactivated vaccine. J. Jpn. Vet. Med. Assoc. 42, 637-643 (1989).
35. Sokol, F., Kuwert, E., Wiktor, T. J., Hummeler, K., Koprowski, H. Purification of rabies virus grown in tissue culture. J Virol. 2(8), 836-849 (1968).
36. Feng, L. et al. In vitro infection with classical swine fever virus inhibits the transcription of immune response genes. Virol J. 9, 175 (2012).