Controlled bile acid exposure to oesophageal mucosa causes up-regulation of nuclear γ-H2AX possibly via iNOS induction

Bioscience Reports

Volumn 36, Issue 4, 2016, Pages

  Jiang, Bo ^a,b   Zhao, Shengqian ^a   Tao, Zhen ^b   Wen, Jin ^a   Yang, Yancheng ^a   Zheng, Yin ^a   Yan, Hongling ^a   Sheng, Ying ^a   Gao, Aimin ^a  

^a The 159th Hospital of PLA   (China)

^b JINAN MILITARY GENERAL HOSPITAL   (China)

Author keywords

Dysplasia; Genotoxic stress; Metaplasia; Oesophageal adenocarcinoma; Preneoplastic lesion

Indexed keywords

BILE ACID; GAMMA HISTONE H2AX; HISTONE H2AX; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC ACID; RECEPTOR PROTEIN; TGR5 PROTEIN; UNCLASSIFIED DRUG; AMINOGUANIDINE; G PROTEIN COUPLED RECEPTOR; GPBAR1 PROTEIN, HUMAN; GUANIDINE DERIVATIVE; H2AFX PROTEIN, HUMAN; HISTONE; NITRIC OXIDE; NOS2 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; ESOPHAGUS MUCOSA; HISTONE PHOSPHORYLATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; PROTEIN EXPRESSION; UPREGULATION; BARRETT ESOPHAGUS; CELL CULTURE; DNA DAMAGE; DRUG EFFECTS; EPITHELIUM; ESOPHAGUS; GASTROESOPHAGEAL REFLUX; MALE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; TRANSCRIPTION INITIATION;

BARRETT ESOPHAGUS; BILE ACIDS AND SALTS; CELLS, CULTURED; DNA DAMAGE; EPITHELIUM; ESOPHAGEAL MUCOSA; ESOPHAGUS; GASTROESOPHAGEAL REFLUX; GUANIDINES; HISTONES; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RECEPTORS, G-PROTEIN-COUPLED; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84979578344     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20160124     Document Type: Article

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