Restructuring reward processing with Mindfulness-Oriented Recovery Enhancement: novel therapeutic mechanisms to remediate hedonic dysregulation in addiction, stress, and pain

Annals of the New York Academy of Sciences

Volumn 1373, Issue 1, 2016, Pages 25-37

  Garland, Eric L ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

addiction; allostasis; mindfulness; reappraisal; reward; savoring

Indexed keywords

ADDICTION; ARTICLE; AUTOREGULATION; EXECUTIVE FUNCTION; HUMAN; INFORMATION PROCESSING; METACOGNITIVE AWARENESS; MINDFULNESS; MINDFULNESS ORIENTED RECOVERY ENHANCEMENT; PHYSIOLOGICAL STRESS; PSYCHOTHERAPY; REINFORCEMENT; REWARD; WORKING MEMORY;

EID: 84979523596     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/nyas.13034     Document Type: Article

References (61)

1. Farb, N.A., Z.V. Segal, H. Mayberg, et al. 2007. Attending to the present: mindfulness meditation reveals distinct neural modes of self-reference. Soc. Cogn. Affect. Neurosci. 2: 313–322.
2. Taylor, V., J. Grant, V. Daneault, et al. 2011. Impact of mindfulness on the neural responses to emotional pictures in experienced and beginner meditators. Neuroimage 57: 1524–1533.
3. Vago, D.R. & D.A. Silbersweig. 2012. Self-awareness, self-regulation, and self-transcendence (S-ART): a framework for understanding the neurobiological mechanisms of mindfulness. Front. Hum. Neurosci. 6: 296.
4. Garland, E.L. 2013. Mindfulness-Oriented Recovery Enhancement for Addiction, Stress, and Pain. Washington, DC: NASW Press.
5. Leknes, S. & I. Tracey. 2008. A common neurobiology for pain and pleasure. Nat. Rev. Neurosci. 9: 314–320.
6. Cabanac, M. 2010. “The dialectics of pleasure.” In Pleasures of the Brain. M.L. Kringelback & K.C. Berridge, Eds.: 113–124. Oxford: Oxford University Press.
7. Cabanac, M. 1979. Sensory pleasure. Q. Rev. Biol. 54: 1–29.
8. McFarland, D.J. & R.M. Sibly. 1975. The behavioural final common path. Philos. Trans. R. Soc. B Biol. Sci. 270: 265–293.
9. Frankfurt, H. 1971. Freedom of the will and the concept of a person. J. Philos. 67: 5–20.
10. Steklis, H.D. & R.D. Lane. 2012. “The unique human capacity for emotional awareness: psychological, neuroanatomical, comparative and evolutionary perspectives.” In Emotions of Animals and Humans. The Science of the Mind. S. Watanabe & S.A. Kuczaj, Eds: 165–205. Japan: Springer.
11. Volkow, N.D., J.S. Fowler & G.-J. Wang. 2004. The addicted human brain viewed in the light of imaging studies: brain circuits and treatment strategies. Neuropharmacology 47: 3–13.
12. Alcaro, A. & J. Panksepp. 2011. The SEEKING mind: primal neuro-affective substrates for appetitive incentive states and their pathological dynamics in addictions and depression. Neurosci. Biobehav. Rev. 35: 1805–1820.
13. Koob, G.F. & M. Le Moal. 2001. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 24: 97–129.
14. Koob, G.F. & M. Le Moal. 2008. Addiction and the brain antireward system. Annu. Rev. Psychol. 59: 29–53.
15. Pierce, R.C. & L. Vanderschuren. 2010. Kicking the habit: the neural basis of ingrained behaviors in cocaine addiction. Neurosci. Biobehav. Rev. 35: 212–219.
16. Tiffany, S.T. 1990. A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. Psychol. Rev. 97: 147–168.
17. Koob, G.F. & N.D. Volkow. 2009. Neurocircuitry of addiction. Neuropsychopharmacology 35: 217–238.
18. Yin, H.H. & B.J. Knowlton. 2006. The role of the basal ganglia in habit formation. Nat. Rev. Neurosci. 7: 464–476.
19. Berridge, K.C. 2007. The debate over dopamine's role in reward: the case for incentive salience. Psychopharmacology (Berl.) 191: 391–431.
20. Arnsten, A.F.T. 2009. Stress signalling pathways that impair prefrontal cortex structure and function. Nat. Rev. Neurosci. 10: 410–422.
21. Dias-Ferreira, E., J.C. Sousa, I. Melo, et al. 2009. Chronic stress causes frontostriatal reorganization and affects decision-making. Science 325: 621–625.
22. Shackman, A.J., T.V. Salomons, H.A. Slagter, et al. 2011. The integration of negative affect, pain and cognitive control in the cingulate cortex. Nat. Rev. Neurosci. 12: 154–167.
23. Tiffany, S.T. 2010. “Drug craving and affect.” In Substance Abuse and Emotion. J.D. Kassel, Ed.: 83–108. Washington, DC: American Psychological Association.
24. Sinha, R. 2008. Chronic stress, drug use, and vulnerability to addiction. Ann. N. Y. Acad. Sci. 1141: 105–130.
25. Lutz, A., H.A. Slagter, J.D. Dunne & R.J. Davidson. 2008. Attention regulation and monitoring in meditation. Trends Cogn. Sci. 12: 163–169.
26. Shizgal, P. & S.E. Hyman. 2012. “Homeostasis, motivational and addictive states.” In Principles of Neural Science, 5th ed. E.R. Kandel, J.H. Schwartz & T.M. Jessell, Eds.: 1095–1115. New York: McGraw Hill.
27. Sundararajan, L. 2008. Toward a reflexive positive psychology: insights from the Chinese Buddhist notion of emptiness. Theory Psychol. 18: 655–674.
28. Garland, E., B. Froeliger & M. Howard. 2014. Mindfulness training targets neurocognitive mechanisms of addiction at the attention–appraisal–emotion interface. Front. Psychiatry 4: 173.
29. Gross, J.J. 2015. Emotion regulation: current status and future prospects. Psychol. Inq. 26: 1–26.
30. Garland, E.L., N.A. Farb, P.R. Goldin & B.L. Fredrickson. 2015. Mindfulness broadens awareness and builds eudaimonic meaning: a process model of mindful positive emotion regulation. Psychol. Inq. 26: 293–314.
31. McConnell, P. & B.E. Froeliger. 2015. Mindfulness, mechanisms and meaning: perspectives from the cognitive neuroscience of addiction. Psychol. Inq. 26: 349–357.
32. Garland, E.L., N.A. Farb, P.R. Goldin & B.L. Fredrickson. 2015. The mindfulness-to-meaning theory: extensions, applications, and challenges at the attention–appraisal–emotion interface. Psychol. Inq. 26: 377–387.
33. Barrett, L.F. & W.K. Simmons. 2015. Interoceptive predictions in the brain. Nat. Rev. Neurosci. 16: 419–429.
34. Dahl, C.J., A. Lutz & R.J. Davidson. 2015. Reconstructing and deconstructing the self: cognitive mechanisms in meditation practice. Trends Cogn. Sci. 19: 515–523.
35. Bryant, F.B., E.D. Chadwick & K. Kluwe. 2011. Understanding the processes that regulate positive emotional experience: unsolved problems and future directions for theory and research on savoring. Int. J. Wellbeing 1: 107–126.
36. Frijda, N.H. & L. Sundararajan. 2007. Emotion refinement: a theory inspired by Chinese poetics. Perspect. Psychol. Sci. 2: 227–241.
37. Rinpoche, T.W. 2002. Healing with Form, Energy, and Light: The Five Elements in Tibetan Shamanism, Tantra, and Dzogchen. Ithaca, NY: Snow Lion Publications.
38. Dreyfus, G. 2011. Is mindfulness present-centred and non-judgmental? A discussion of the cognitive dimensions of mindfulness. Contemp. Buddhism 12: 41–54.
39. Garland, E.L., S.A. Gaylord, C.A. Boettiger & M.O. Howard. 2010. Mindfulness training modifies cognitive, affective, and physiological mechanisms implicated in alcohol dependence: results of a randomized controlled pilot trial. J. Psychoactive Drugs 42: 177–192.
40. Garland, E.L., E.G. Manusov, B. Froeliger, et al. 2014. Mindfulness-oriented recovery enhancement for chronic pain and prescription opioid misuse: results from an early-stage randomized controlled trial. J. Consult. Clin. Psychol. 82: 448.
41. Garland, E.L., A. Roberts-Lewis, C.D. Tronnier, et al. 2016. Mindfulness-Oriented Recovery Enhancement versus CBT for co-occurring substance dependence, traumatic stress, and psychiatric disorders: proximal outcomes from a pragmatic randomized trial. Behav. Res. Ther. 77: 7–16.
42. Eichberg, C., A. Mathew, J. Baddeley, et al. 2015. Mindfulness-oriented recovery enhancement (MORE): a novel smoking-cessation treatment focused on cognitive reappraisal and the savoring of naturalistic rewards. presentation. 16th Annual Frontiers in Neurosciences Research Day. Medical University of South Carolina. Charleston, SC.
43. Froeliger, B., A. Mathew, C. Eichberg, et al. Under review. Restructuring reward mechanisms in nicotine addiction: a pilot fMRI study of mindfulness oriented recover enhancement in cigarette smokers.
44. Garland, E.L., A. Beck, P. Hansen, et al. 2015. Integrated Mindfulness-oriented recovery enhancement and physical health intervention for obese cancer survivors: preliminary results from a pilot randomized controlled trial. Poster presentation. 12th International Conference of the Society for Integrative Oncology. November 15, 2015. Boston, MA.
45. Garland, E.L. & M.O. Howard. 2013. Mindfulness-oriented recovery enhancement reduces pain attentional bias in chronic pain patients. Psychother. Psychosom. 82: 311–318.
46. Garland, E.L., B. Froeliger & M.O. Howard. 2014. Effects of Mindfulness-Oriented Recovery Enhancement on reward responsiveness and opioid cue-reactivity. Psychopharmacology (Berl.) 231: 3229–3238.
47. Garland, E.L., B. Froeliger & M.O. Howard. 2014. Neurophysiological evidence for remediation of reward processing deficits in chronic pain and opioid misuse following treatment with Mindfulness-Oriented Recovery Enhancement: exploratory ERP findings from a pilot RCT. J. Behav. Med. 38: 327–336.
48. Garland, E.L. 2015. Mindfulness-oriented recovery enhancement modulates neurocognitive mechanisms and reward system function in addiction, stress, and pain. Presentation. Advances in Meditation Research: Genetics, Neuroscience and Clinical Applications. Memorial Sloan Kettering Cancer Center. September 24, 2015. New York, NY.
49. Garland, E.L. 2014. Dismantling mindfulness-based cognitive therapy for recurrent depression implicates lack of differential efficacy for mindfulness training. Evid. Based Ment. Health 17: 94–94.
50. Collins, L.M., S.A. Murphy, V.N. Nair & V.J. Strecher. 2005. A strategy for optimizing and evaluating behavioral interventions. Ann. Behav. Med. 30: 65–73.
51. Garland, E.L., N. Geschwind, F. Peeters & M. Wichers. 2015. Mindfulness training promotes upward spirals of positive affect and cognition: multilevel and autoregressive latent trajectory modeling analyses. Front. Psychol. 6: 15.
52. Maturana, H. & F. Varela. 1987. The Tree of Knowledge: The Biological Roots of Human Understanding. Boston, MA: Shambala.
53. Garland, E.L. 2007. The meaning of mindfulness: a second-order cybernetics of stress, metacognition, and coping. Complement. Health Pract. Rev. 12: 15–30.
54. Lazarus, R. & S. Folkman. 1984. Stress, Appraisal, and Coping. New York: Springer.
55. Damasio, A.R. 1998. Investigating the biology of consciousness. Philos. Trans. R. Soc. Lond. B Biol. Sci. 353: 1879–1882.
56. Vygotsky, L.S. 1978. Mind in Society: The Development of Higher Psychological Processes. Cambridge, MA: Harvard University Press.
57. Ellsworth, P.C. & K.R. Scherer. 2003. “Appraisal processes in emotion.” In Handbook of Affective Sciences. R.J. Davidson, K.R. Scherer & H.H. Goldsmith, Eds.: 572–595. New York: Oxford University Press.
58. McEwen, B.S. 2000. Allostasis and allostatic load: implications for neuropsychopharmacology. Neuropsychopharmacology 22: 108–124.
59. Brosschot, J.F., B. Verkuil & J.F. Thayer. 2010. Conscious and unconscious perseverative cognition: is a large part of prolonged physiological activity due to unconscious stress? J. Psychosom. Res. 69: 407–416.
60. Moss, A.C., J.A Erskine, I.P. Albery, et al. 2015. To suppress, or not to suppress? That is repression: controlling intrusive thoughts in addictive behaviour. Addict. Behav. 44: 65–70.
61. Baker, T.B., M.E. Piper, D.E. McCarthy, et al. 2004. Addiction motivation reformulated: an affective processing model of negative reinforcement. Psychol. Rev. 111: 33–51.