Mindfulness, Mechanisms and Meaning: Perspectives From the Cognitive Neuroscience of Addiction

Psychological Inquiry

Volumn 26, Issue 4, 2015, Pages 349-357

  McConnell, Patrick A ^a   Froeliger, Brett ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84948459402     PISSN: 1047840X     EISSN: None     Source Type: Journal    
DOI: 10.1080/1047840X.2015.1076701     Document Type: Note

References (83)

1. A.Alcaro,, & J.Panksepp, (2011). The SEEKING mind: Primal neuro-affective substrates for appetitive incentive states and their pathological dynamics in addictions and depression. Neuroscience & Behavioral Reviews, 35, 1805–1820.
2. S.Asensio,, M.J.Romero,, C.Palau,, A.Sanchez,, I.Senabre,, J.L.Morales,, … F.J.Romero, (2010). Altered neural response of the appetitive emotional system in cocaine addiction: An fMRI Study. Addiction Biology, 15, 504–516.
3. H.Augustus Diggs,, B.Froeliger,, J.M.Carlson,, & D.G.Gilbert, (2013). Smoker-nonsmoker differences in neural response to smoking-related and affective cues: An fMRI investigation. Psychiatry Research, 211, 85–87.
4. A.Azizian,, L.J.Nestor,, D.Payer,, J.R.Monterosso,, A.L.Brody,, & E.D.London, (2010). Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop task. Neuropsychopharmacology, 35, 775–782.
5. A.Barrós-Loscertales,, J.-C.Bustamante,, N.Ventura-Campos,, J.-J.Llopis,, M.-A.Parcet,, & C.Ávila, (2011). Lower activation in the right frontoparietal network during a counting Stroop task in a cocaine-dependent group. Psychiatry Research: Neuroimaging, 194, 111–118.
6. M.Beauregard,, & V.Paquette, (2006). Neural correlates of a mystical experience in Carmelite nuns. Neuroscience Letters, 405, 186–190.
7. A.T.Beck,, & B.A.Alford, (2009). Depression: Causes and treatment (2nd ed.). Philadelphia, PA: University of Pennsylvania Press.
8. K.C.Berridge,, T.E.Robinson,, & J.W.Aldridge, (2009). Dissecting components of reward: ‘Liking’, ‘wanting’, and learning. Current Opinion in Pharmacology, 9, 65–73.
9. B.Biswal,, F.Z.Yetkin,, V.M.Haughton,, & J.S.Hyde, (1995). Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magnetic Resonance in Medicine, 34, 537–541.
10. J.A.Brewer,, P.D.Worhunsky,, J.R.Gray,, Y.-Y.Tang,, J.Weber,, & H.Kober, (2011). Meditation experience is associated with differences in default mode network activity and connectivity. Proceedings of the National Academy of Sciences, 108, 20254–20259.
11. G.Bush,, P.Luu,, & M.I.Posner, (2000). Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Sciences, 4, 215–222.
12. G.Bush,, B.A.Vogt,, J.Holmes,, A.M.Dale,, D.Greve,, M.A.Jenike,, & B.R.Rosen, (2002). Dorsal anterior cingulate cortex: A role in reward-based decision making. Proceedings of the National Academy of Sciences, 99, 523–528.
13. Centers for Disease Control & Prevention. (2002). Annual smoking-attributable mortality, years of potential life lost, and economic costs—United States, 1995–1999. Morbidity and Mortality Weekly Report, 51, 300.
14. D.M.Cole,, C.F.Beckmann,, C.J.Long,, P.M.Matthews,, M.J.Durcan,, & J.D.Beaver, (2010). Nicotine replacement in abstinent smokers improves cognitive withdrawal symptoms with modulation of resting brain network dynamics. Neuroimage, 52, 590–599.
15. A.D.Craig, (2011). Significance of the insula for the evolution of human awareness of feelings from the body. Annals of the New York Academy of Sciences, 1225, 72–82.
16. A.Delle Fave,, F.Massimini,, & M.Bassi, (2011). Psychological selection and optimal experience. In A. Delle Fave (Ed.), Psychological Selection and Optimal Experience Across Cultures: Social Empowerment through Personal Growth, Cross-Cultural Advancements in Positive Psychology (Vol. 2, pp. 39–58). New York, NY: Springer.
17. E.K.Diekhof,, P.Falkai,, & O.Gruber, (2008). Functional neuroimaging of reward processing and decision-making: A review of aberrant motivational and affective processing in addiction and mood disorders. Brain Research Reviews, 59, 164–184.
18. N.W.Duncan,, C.Wiebking,, B.Tiret,, M.Marjanska,, D.J.Hayes,, O.Lyttleton,, … G.Northoff, (2013). Glutamate concentration in the medial prefrontal cortex predicts resting-state cortical-subcortical functional connectivity in humans. PLoS One, 8(4), e60312.
19. M.D.Fox,, & M.Greicius, (2010). Clinical applications of resting state functional connectivity. Frontiers in Systems Neuroscience, 4, 1–13. http://doi.org/10.3389/fnsys.2010.00019
20. B.L.Fredrickson, (2004). The broaden-and-build theory of positive emotions. Philosophical Transactions-Royal Society of London Series B: Biological Sciences, 359(1449), 1367–1378.
21. B.Froeliger,, E.L.Garland,, R.Kozink,, L.Modlin,, N.-K.Chen,, F.J.McClernon,, … P.Sobin, (2012). Meditation-state functional connectivity (msFC): Strengthening of the dorsal attention network and beyond. Evidence-Based Complementary and Alternative Medicine: eCAM, 2012, 680407. http://doi.org/10.1155/2012/680407
22. B.Froeliger,, E.L.Garland,, L.A.Modlin,, & F.J.McClernon, (2012). Neurocognitive correlates of the effects of yoga meditation practice on emotion and cognition: A pilot study. Frontiers in Integrative Neuroscience, 6, 48. http://doi.org/10.3389/fnint.2012.00048
23. B.Froeliger,, P.A.McConnell,, N.Stankeviciute,, McClure, E. A., P.W.Kalivas,, & K.M.Gray, (in press). The effects of N-Acetylcysteine on frontostriatal resting-state functional connectivity, withdrawal symptoms and smoking abstinence: A double-blind, placebo-controlled fMRI study. Drug and Alcohol Dependence. doi:10.1016/j.drugalcdep.2015.09.021
24. B.Froeliger,, L.A.Modlin,, R.V.Kozink,, L.Wang,, E.L.Garland,, M.A.Addicott,, & F.J.McClernon, (2013). Frontoparietal attentional network activation differs between smokers and nonsmokers during affective cognition. Psychiatry Research, 211, 57–63.
25. B.Froeliger,, L.A.Modlin,, R.V.Kozink,, L.Wang,, & F.J.McClernon, (2012). Smoking abstinence and depressive symptoms modulate the executive control system during emotional information processing. Addiction Biology, 17, 668–679.
26. B.Froeliger,, L.Modlin,, L.Wang,, R.V.Kozink,, & F.J.McClernon, (2012). Nicotine withdrawal modulates frontal brain function during an affective Stroop task. Psychopharmacology, 220, 707–718.
27. H.Garavan,, J.N.Kaufman,, & R.Hester, (2008). Acute effects of cocaine on the neurobiology of cognitive control. Philosophical Transactions of the Royal Society B: Biological Sciences, 363, 3267–3276.
28. E.L.Garland,, C.A.Boettiger,, & M.O.Howard, (2011). Targeting cognitive-affective risk mechanisms in stress-precipitated alcohol dependence: An integrated, biopsychosocial model of automaticity, allostasis, and addiction. Medical Hypotheses, 76, 745–754.
29. E.L.Garland,, B.Fredrickson,, A.M.Kring,, D.P.Johnson,, P.S.Meyer,, & D.L.Penn, (2010). Upward spirals of positive emotions counter downward spirals of negativity: Insights from the broaden-and-build theory and affective neuroscience on the treatment of emotion dysfunctions and deficits in psychopathology. Clinical Psychology Review, 30, 849–864.
30. E.L.Garland,, B.Froeliger,, & M.O.Howard, (2013). Mindfulness training targets neurocognitive mechanisms of addiction at the attention-appraisal-emotion interface. Frontiers in Psychiatry, 4, 173. http://doi.org/10.3389/fpsyt.2013.00173
31. E.L.Garland,, B.Froeliger,, & M.O.Howard, (2014a). Effects of mindfulness-oriented recovery enhancement on reward responsiveness and opioid cue-reactivity. Psychopharmacology, 231, 3229–3238.
32. E.L.Garland,, B.Froeliger,, & M.O.Howard, (2014b). Neurophysiological evidence for remediation of reward processing deficits in chronic pain and opioid misuse following treatment with Mindfulness-Oriented Recovery Enhancement: Exploratory ERP findings from a pilot RCT. Journal of Behavioral Medicine, 38, 327–336.
33. E.L.Garland,, B.Froeliger,, & M.O.Howard, (2015). Neurophysiological evidence for remediation of reward processing deficits in chronic pain and opioid misuse following treatment with Mindfulness-Oriented Recovery Enhancement: Exploratory ERP findings from a pilot RCT. Journal of Behavioral Medicine, 38, 327–336.
34. K.A.Garrison,, T.A.Zeffiro,, D.Scheinost,, R.T.Constable,, & J.A.Brewer, (2015). Meditation leads to reduced default mode network activity beyond an active task. Cognitive, Affective, & Behavioral Neuroscience, 15(3), 712–720.
35. O.George,, & G.F.Koob, (2010). Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neuroscience & Biobehavioral Reviews, 35, 232–247.
36. R.Goldstein,, N.Alia-Klein,, D.Tomasi,, J.H.Carrillo,, T.Maloney,, P.A.Woicik,, … N.Volkow, (2009). Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addiction. Proceedings of the National Academy of Sciences, 106, 9453–9458.
37. R.Goldstein,, & N.Volkow, (2002). Drug addiction and its underlying neurobiological basis: Neuroimaging evidence for the involvement of the frontal cortex. The American Journal of Psychiatry, 159, 1642–1652.
38. R.Goldstein,, & N.Volkow, (2011). Dysfunction of the prefrontal cortex in addiction: Neuroimaging findings and clinical implications. Nature Reviews Neuroscience, 12, 652–669.
39. M.D.Greicius, (2008). Resting-state functional connectivity in neuropsychiatric disorders. Current Opinion in Neurology, 21, 424–430.
40. M.D.Greicius,, B.H.Flores,, V.Menon,, G.H.Glover,, H.B.Solvason,, H.Kenna,, … A.F.Schatzberg, (2007). Resting-state functional connectivity in major depression: Abnormally increased contributions from subgenual cingulate cortex and thalamus. Biological Psychiatry, 62, 429–437.
41. H.Gu,, B.J.Salmeron,, T.J.Ross,, X.Geng,, W.Zhan,, E.A.Stein,, & Y.Yang, (2010). Mesocorticolimbic circuits are impaired in chronic cocaine users as demonstrated by resting-state functional connectivity. Neuroimage, 53, 593–601.
42. J.P.Hamilton,, M.Farmer,, P.Fogelman,, & I.H.Gotlib, (2015). Depressive rumination, the default-mode network, and the dark matter of clinical neuroscience. Biological Psychiatry, 78(4), 224–230. doi: 10.1016/j.biopsych.2015.02.020
43. A.Hampshire,, S.R.Chamberlain,, M.M.Monti,, J.Duncan,, & A.M.Owen, (2010). The role of the right inferior frontal gyrus: Inhibition and attentional control. Neuroimage, 50, 1313–1319.
44. W.Hasenkamp,, & L.W.Barsalou, (2012). Effects of meditation experience on functional connectivity of distributed brain networks. Frontiers in Human Neuroscience, 6(38), 1–14. doi: 10.3389/fnhum.2012.00038
45. R.Hester,, & H.Garavan, (2009). Neural mechanisms underlying drug-related cue distraction in active cocaine users. Pharmacology Biochemistry and Behavior, 93, 270–277.
46. B.Hölzel,, S.W.Lazar,, T.Gard,, Z.Schuman-Olivier,, D.R.Vago,, & U.Ott, (2011). How does mindfulness meditation work? Proposing mechanisms of action from a conceptual and neural perspective. Perspectives on Psychological Science, 6, 537–559.
47. B.Hölzel,, & U.Ott, (2006). Relationships between meditation depth, absorption, meditation practice, and mindfulness: A latent variable approach. Journal of Transpersonal Psychology, 38, 179–199.
48. L.E.Hong,, H.Gu,, Y.Yang,, T.J.Ross,, B.J.Salmeron,, B.Buchholz,, … E.A.Stein, (2009). Association of nicotine addiction and nicotine's actions with separate cingulate cortex functional circuits. Archives of General Psychiatry, 66, 431–441.
49. A.Jamal,, I.T.Agaku,, E.O'Connor,, B.A.King,, J.B.Kenemer,, & L.Neff, (2014). Current cigarette smoking among adults—United States, 2005–2013. MMWR Morbidity and Mortality Weekly Report, 63, 1108–1112.
50. J.H.Jang,, W.H.Jung,, D.-H.Kang,, M.S.Byun,, S.J.Kwon,, C.-H.Choi,, & J.S.Kwon, (2011). Increased default mode network connectivity associated with meditation. Neuroscience Letters, 487, 358–362.
51. T.Jao,, C.-W.Li,, P.E.Vértes,, C.W.Wu,, S.Achard,, C.-H.Hsieh,, … E.Bullmore, (2015). Large-scale functional brain network reorganization during Taoist meditation. Brain Connectivity. doi:10.1089/brain.2014.0318
52. Z.Josipovic, (2014). Neural correlates of nondual awareness in meditation. Annals of the New York Academy of Sciences, 1307, 9–18.
53. Z.Josipovic,, I.Dinstein,, J.Weber,, & D.J.Heeger, (2011). Influence of meditation on anti-correlated networks in the brain. Frontiers in Human Neuroscience 5, 183. http://doi.org/10.3389/fnhum.2011.00183
54. R.Kalisch, (2009). The functional neuroanatomy of reappraisal: Time matters. Neuroscience & Biobehavioral Reviews, 33, 1215–1226.
55. P.W.Kalivas, (2009). The glutamate homeostasis hypothesis of addiction. Nature Reviews Neuroscience, 10, 561–572.
56. Y.Kang,, J.Gruber,, & J.R.Gray, (2013). Mindfulness and de-automatization. Emotion Review 5, 192–201.
57. L.G.Kiken,, & N.J.Shook, (2011). Looking up: Mindfulness increases positive judgments and reduces negativity bias. Social Psychological and Personality Science, 2(4), 425–431.
58. G.F.Koob,, & M.Le Moal, (1997). Drug abuse: Hedonic homeostatic dysregulation. Science, 278(5335), 52–58.
59. G.F.Koob,, & M.Le Moal, (2001). Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology, 24, 97–129.
60. G.F.Koob,, & N.Volkow, (2010). Neurocircuitry of addiction. Neuropsychopharmacology, 35, 217–238.
61. R.V.Kozink,, A.M.Lutz,, J.E.Rose,, B.Froeliger,, & F.J.McClernon, (2010). Smoking withdrawal shifts the spatiotemporal dynamics of neurocognition. Addiction Biology, 15, 480–490.
62. M.L.Kringelbach,, & K.C.Berridge, (2009). Towards a functional neuroanatomy of pleasure and happiness. Trends in Cognitive Sciences, 13, 479–487.
63. N.Ma,, Y.Liu,, N.Li,, C.-X.Wang,, H.Zhang,, X.-F.Jiang,, … D.-R.Zhang, (2010). Addiction related alteration in resting-state brain connectivity. Neuroimage, 49, 738–744.
64. J.C.Motzkin,, A.Baskin-Sommers,, J.P.Newman,, K.A.Kiehl,, & M.Koenigs, (2014). Neural correlates of substance abuse: Reduced functional connectivity between areas underlying reward and cognitive control. Human Brain Mapping, 35, 4282–4292.
65. N.H.Naqvi,, & A.Bechara, (2010). The insula and drug addiction: An interoceptive view of pleasure, urges, and decision-making. Brain Structure and Function, 214, 435–450.
66. N.H.Naqvi,, D.Rudrauf,, H.Damasio,, & A.Bechara, (2007). Damage to the insula disrupts addiction to cigarette smoking. Science, 315, 531–534.
67. National Institute on Drug Abuse. (2015). Nationwide trends. Retrieved from http://www.drugabuse.gov/publications/drugfacts/nationwide-trends
68. D.E.Payer,, M.D.Lieberman,, & E.D.London, (2010). Neural Correlates of Affect Processing and aggression in methamphetamine dependence. Archives of General Psychiatry, 2010, 2154.
69. M.E.Raichle,, A.M.MacLeod,, A.Z.Snyder,, W.J.Powers,, D.A.Gusnard,, & G.L.Shulman, (2001). A default mode of brain function. Proceedings of the National Academy of Sciences, 98, 676–682.
70. J.Richiardi,, A.Altmann,, A.-C.Milazzo,, C.Chang,, M.M.Chakravarty,, T.Banaschewski,, … C.Büchel, (2015). Correlated gene expression supports synchronous activity in brain networks. Science, 348, 1241–1244.
71. T.E.Robinson,, & K.C.Berridge, (2008). Review. The incentive sensitization theory of addiction: Some current issues. Philosophical Transactions of the Royal Society B: Biological Sciences, 363(1507), 3137–3146.
72. A.Shallcross,, J.Gross,, P.Visvanathan,, N.Kumar,, A.Palfrey,, B.Ford,, … K.Goode, (2015). Relapse prevention in major depressive disorder: Mindfulness-based cognitive therapy versus an active control condition. Journal of Consulting and Clinical Psychology, 83, 964–975.
73. A.Shmuel,, & D.A.Leopold, (2008). Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: Implications for functional connectivity at rest. Human Brain Mapping, 29, 751–761.
74. R.Simon,, & M.Engström, (2015). The default mode network as a biomarker for monitoring the therapeutic effects of meditation. Frontiers in Psychology, 6, 776.
75. R.Sinha,, C.Lacadie,, P.Skudlarski,, R.Fulbright,, B.Rounsaville,, T.Kosten,, & B.Wexler, (2005). Neural activity associated with stress-induced cocaine craving: A functional magnetic resonance imaging study. Psychopharmacology, 183, 171–180.
76. M.Sperduti,, P.Martinelli,, & P.Piolino, (2012). A neurocognitive model of meditation based on activation likelihood estimation (ALE) meta-analysis. Consciousness and Cognition, 21, 269–276.
77. R.N.Spreng,, & D.L.Schacter, (2012). Default network modulation and large-scale network interactivity in healthy young and old adults. Cerebral Cortex, 22, 2610–2621.
78. M.T.Sutherland,, M.J.McHugh,, V.Pariyadath,, & E.A.Stein, (2012). Resting state functional connectivity in addiction: Lessons learned and a road ahead. Neuroimage, 62, 2281–2295.
79. Y.-Y.Tang,, B.K.Hölzel,, & M.I.Posner, (2015). The neuroscience of mindfulness meditation. Nature Reviews Neuroscience, 16, 213–225.
80. Y.-Y.Tang,, M.K.Rothbart,, & M.I.Posner, (2012). Neural correlates of establishing, maintaining, and switching brain states. Trends in Cognitive Sciences, 16, 330–337.
81. V.A.Taylor,, V.Daneault,, J.Grant,, G.Scavone,, E.Breton,, S.Roffe-Vidal,, … H.Benali, (2012). Impact of meditation training on the default mode network during a restful state. Social Cognitive and Affective Neuroscience, 8(1), 4–14. http://doi.org/10.1093/scan/nsr087
82. D.R.Vago,, & D.A.Silbersweig, (2012). Self-awareness, self-regulation, and self-transcendence (S-ART): A framework for understanding the neurobiological mechanisms of mindfulness. Frontiers in Human Neuroscience 6, 296. http://doi.org/10.3389/fnhum.2012.00296
83. A.Verdejo-Garcia,, & A.Bechara, (2009). A somatic marker theory of addiction. Neuropharmacology, 56(Suppl. 1), 48–62.