On the reconciliation of missing heritability for genome-wide association studies

European Journal of Human Genetics

Volumn 24, Issue 12, 2016, Pages 1810-1816

  Chen, Guo Bo ^a  

^a Evergreen Landscape and Architecture Studio   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HERITABILITY; HUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; BIOLOGICAL MODEL; PROCEDURES; QUANTITATIVE TRAIT; STANDARDS;

GENOME-WIDE ASSOCIATION STUDY; HUMANS; LINKAGE DISEQUILIBRIUM; MODELS, GENETIC; QUANTITATIVE TRAIT LOCI; QUANTITATIVE TRAIT, HERITABLE;

EID: 84979287927     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2016.89     Document Type: Article

References (19)

1. Falconer DS, Mackay TFC: Introduction to Quantitative Genetics. 4th edn. Pearson Education Limited: Harlow, UK, 1996.
2. Manolio TA, Collins FS, Cox NJ et al: Finding the missing heritability of complex diseases. Nature 2009; 461: 747-753.
3. Yang J, Benyamin B, McEvoy BP et al: Common SNPs explain a large proportion of the heritability for human height. Nat Genet 2010; 42: 565-569.
4. Lee SH, Wray NR, Goddard ME, Visscher PM: Estimating missing heritability for disease from genome-wide association studies. Am J Hum Genet 2011; 88: 294-305.
5. Golan D, Lander ES, Rosset S: Measuring missing heritability: Inferring the contribution of common variants. Proc Natl Acad Sci USA 2014; 111: E5272-E5281.
6. Visscher PM, Medland SE, Ferreira MAR et al: Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings. PLoS Genet 2006; 2: e41.
7. Chen X, Kuja-Halkola R, Rahman I et al: Dominant Genetic Variation and Missing Heritability for Human Complex Traits: Insights from Twin versus Genome-wide Common SNP Models. Am J Hum Genet 2015; 97: 708-714.
8. Lee JJ, Chow CC: Conditions for the validity of SNP-based heritability estimation. Hum Genet 2014; 133: 1011-1022.
9. de los Campos G, Sorensen D, Gianola D: Genomic Heritability: What Is It? PLoS Genet 2015; 11: e1005048.
10. Chen G-B: Estimating heritability of complex traits from genome-wide association studies using IBS-based Haseman-Elston regression. Front Genet 2014; 5: 107.
11. Moser G, Lee SH, Hayes BJ, Goddard ME, Wray NR, Visscher PM: Simultaneous Discovery, Estimation and Prediction Analysis of Complex Traits Using a Bayesian Mixture Model. PLoS Genet 2015; 11: e1004969.
12. Lynch M, Walsh B: Genetics and Analysis of Quantitative Traits. Sinauer Associates, Inc.: Sunderland, MA, USA, 1998.
13. Speed D, Hemani G, Johnson MR, Balding DJ: Improved Heritability Estimation from Genome-wide SNPs. Am J Hum Genet 2012; 91: 1011-1021.
14. Patterson HD, Thompson R: Recovery of inter-block information when block sizes are unequal. Biometrika 1971; 58: 545-554.
15. Gilmour AR, Thompson R, Cullis BR: Average information REML: an efficient in linear mixed models variance parameter estimation in linear mixed models. Biometrics 1995; 51: 1440-1450.
16. Bulmer MG: The effect of selection on genetic variability. Am Nat 1971; 105: 201-211.
17. Yang J, Ferreira T, Morris AP et al: Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat Genet 2012; 44: 369-375.
18. Hu Z, Yang R-C: Marker-based estimation of genetic parameters in genomics. PLoS One 2014; 9: e102715.
19. Yang J, Bakshi A, Zhu Z et al: Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. Nat Genet 2015; 47: 1114-1120.