Paracetamol and pain: The kiloton problem

European Journal of Hospital Pharmacy

Volumn 23, Issue 4, 2016, Pages 187-188

  Moore, R Andrew ^a   Moore, Nicholas ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 1; IBUPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL;

ACUTE LIVER FAILURE; CARDIOVASCULAR DISEASE; CLINICAL TRIAL (TOPIC); DRUG SAFETY; EDITORIAL; GASTROINTESTINAL DISEASE; HUMAN; MORTALITY; OSTEOARTHRITIS; PAIN; QUALITY OF LIFE; SYSTEMATIC REVIEW (TOPIC);

EID: 84979209177     PISSN: 20479956     EISSN: 20479964     Source Type: Journal    
DOI: 10.1136/ejhpharm-2016-000952     Document Type: Editorial

References (23)

1. Gulmez SE, Larrey D, Pageaux GP, et al. Transplantation for acute liver failure in patients exposed to NSAIDs or paracetamol (acetaminophen): the multinational case-population SALT study. Drug Saf 2013;36:135-44.
2. Prescribing & Medicines Team. Prescription cost analysis England 2014. Health and Social Care Information Centre, 2015.
3. Proprietary Association of Great Britain. http://www.pagb.co.uk/media/pdfs/Hawtonparacetamolstudy8.2.13.pdf (accessed 18 Mar 2015).
4. Axelrod, J. Journey of a late blooming biochemical neuroscientist. J Biol Chem 2003;278:1-13.
5. Hinz B, Brune K. Paracetamol and cyclooxygenase inhibition: is there a cause for concern? Ann Rheum Dis 2012;71:20-5.
6. Moore RA, Derry S, Wiffen PJ, et al. Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions. Eur J Pain 2015;19:1213-23.
7. Moore RA, Derry S, Aldington D, et al. Single dose oral analgesics for acute postoperative pain in adults - an overview of Cochrane reviews. Cochrane Database Syst Rev 2015;9:CD008659.
8. Machado GC, Maher CG, Ferreira PH, et al. Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials. BMJ 2015;350:h1225.
9. Williams CM, Maher CG, Latimer J, et al. Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial. Lancet 2014;384:1586-96.
10. Hazlewood G, van der Heijde DM, Bombardier C. Paracetamol for the management of pain in inflammatory arthritis: a systematic literature review. J Rheumatol Suppl 2012;90:11-16.
11. van Walsem A, Pandhi S, Nixon RM, et al. Relative benefit-risk comparing diclofenac to other traditional non-steroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors in patients with osteoarthritis or rheumatoid arthritis: a network meta-analysis. Arthritis Res Ther 2015;17:66.
12. da Costa BR, Reichenbach S, Keller N, et al. Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet 2016; (March 17, epub ahead of print)
13. Roberts E, Delgado Nunes V, Buckner S. Paracetamol: not as safe as we thought? A systematic literature review of observational studies. Ann Rheum Dis 2016;75:552-9.
14. Gulmez SE, Larrey D, Pageaux GP, et al. Liver transplant associated with paracetamol overdose: results from the seven-country SALT study. Br J Clin Pharmacol 2015;80:599-606.
15. Doherty M, Hawkey C, Goulder M, et al. A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain. Ann Rheum Dis 2011;70:1534-41.
16. Moore N, Van Ganse E, Le Parc J, et al. The PAIN study: Paracetamol, Aspirin and Ibuprofen New tolerability study. A large scale, randomized clinical trial comparing the tolerability of aspirin, ibuprofen and paracetamol for short-term analgesia. Clin Drug Invest 1999;18:89-98.
17. Moore RA, Derry S, Aldington D, et al. Adverse events associated with single dose oral analgesics for acute postoperative pain in adults - an overview of Cochrane reviews. Cochrane Database Syst Rev 2015;10:CD011407.
18. Tanner T, Aspley S, Munn A, et al. The pharmacokinetic profile of a novel fixed-dose combination tablet of ibuprofen and paracetamol. BMC Clin Pharmacol 2010;10:10.
19. Moore R, Derry S, Taylor RS, et al. The costs and consequences of adequately managed chronic non-cancer pain and chronic neuropathic pain. Pain Pract 2014;14:79-94.
20. Moore RA, Straube S, Aldington D. Pain measures and cut-offs - 'no worse than mild pain' as a simple, universal outcome. Anaesthesia 2013;68:400-12.
21. Moore A, Derry S, Eccleston C, et al. Expect analgesic failure; pursue analgesic success. BMJ 2013;346:f2690.
22. Conaghan PG, Peloso PM, Everett SV, et al. Inadequate pain relief and large functional loss among patients with knee osteoarthritis: evidence from a prospective multinational longitudinal study of osteoarthritis real-world therapies. Rheumatology (Oxford) 2015;54:270-7.
23. Lin HY, Cheng TT, Wang JH. Etoricoxib improves pain, function and quality of life: results of a real-world effectiveness trial. Int J Rheum Dis 2010;13:144-50.