Cardiac Sympathetic Hyperactivity in Patients with Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea

COPD: Journal of Chronic Obstructive Pulmonary Disease

Volumn 13, Issue 6, 2016, Pages 706-711

  Taranto Montemurro, Luigi ^a,b   Messineo, Ludovico ^c   Perger, Elisa ^c   Salameh, Maroon ^c   Pini, Laura ^c   Corda, Luciano ^c   Ferliga, Mauro ^a   Tantucci, Claudio ^c  

^a Mellino Mellini Hospital Trust   (Italy)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF BRESCIA   (Italy)

Author keywords

autonomic activation; cardiovascular risk; Overlap Syndrome; sleep disordered breathing

Indexed keywords

ANTIDIABETIC AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; CARBON DIOXIDE; CARBON MONOXIDE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; OXYGEN;

ADULT; AGED; APNEA HYPOPNEA INDEX; ARTERIAL GAS; ARTICLE; BLOOD CARBON DIOXIDE TENSION; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMORBIDITY; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DIABETES MELLITUS; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HEART RATE; HEART RATE VARIABILITY; HUMAN; HYPERTENSION; ISCHEMIC CARDIOMYOPATHY; LUNG DIFFUSION CAPACITY; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MIDDLE AGED; MULTICHANNEL RECORDER; OXYGEN DESATURATION; PARASYMPATHETIC TONE; PRIORITY JOURNAL; RESIDUAL VOLUME; SLEEP DISORDERED BREATHING; SMOKING; SPIROMETRY; SYMPATHETIC TONE; TOTAL LUNG CAPACITY; WAKEFULNESS; ADRENERGIC SYSTEM; COMPARATIVE STUDY; COMPLICATION; ELECTROCARDIOGRAPHY; HEART; PATHOPHYSIOLOGY; SEVERITY OF ILLNESS INDEX; VERY ELDERLY; VITAL CAPACITY;

AGED; AGED, 80 AND OVER; ELECTROCARDIOGRAPHY; FORCED EXPIRATORY VOLUME; HEART; HEART RATE; HUMANS; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SEVERITY OF ILLNESS INDEX; SLEEP APNEA, OBSTRUCTIVE; SYMPATHETIC NERVOUS SYSTEM; TOTAL LUNG CAPACITY; VITAL CAPACITY;

EID: 84979073922     PISSN: 15412555     EISSN: 15412563     Source Type: Journal    
DOI: 10.1080/15412555.2016.1199668     Document Type: Article

References (45)

1. Franklin KA, Lindberg E. Obstructive sleep apnea is a common disorder in the population-a review on the epidemiology of sleep apnea. J Thorac Dis 2015; 7(8):1311–1322.
2. Halbert RJ, Natoli JL, Gano A, Badamgarav E, Buist AS, Mannino DM. Global burden of COPD:systematic review and meta-analysis. Eur Resp J 2006; 28:523–532.
3. Ioachimesc OC, Teodorescu M. Integrating the overlap of obstructive lung disease and obstructive sleep apnoea:OLDOSA syndrome. Respirology 2013; 18(3):421–431.
4. Marin JM, Soriano JB, Carrizo SJ, Boldova A, Celli BR. Outcomes in patients with chronic obstructive pulmonary disease and obstructive sleep apnea, the overlap syndrome. Am J Resp Crit Care Med 2010; 182:325–331.
5. Heindl S, Lehnert M, Criee CP, Hasenfuss G, Andreas S. Marked sympathetic activation in patients with chronic respiratory failure. Am J Resp Crit Care Med 2001; 164(4):597–601.
6. Bedard ME, Marquis K, Poirier P, Provencher S. Reduced heart rate variability in patients with chronic obstructive pulmonary disease independent of anticholinergic or beta-agonist medications. COPD 2010; 7(6):391–397.
7. Ashley C, Burton D, Sverrisdottir YB, Sander M, McKenzie DK, Macefield VG. Firing probability and mean firing rates of human muscle vasoconstrictor neurones are elevated during chronic asphyxia. J Physiol 2010; 588(Pt 4):701–712.
8. Stein PK, Nelson P, Rottman JN, Howard D, Ward SM, Kleiger RE, et al. Heart rate variability reflects severity of COPD in PiZ alpha1-antitrypsin deficiency. Chest 1998; 113(2):327–333.
9. MacNee W. Oxidants/antioxidants and COPD. Chest 2000; 117(5 Suppl 1):303S–317S.
10. Burtscher M, Haider T, Domej W, Linser T, Gatterer H, Faulhaber M, et al. Intermittent hypoxia increases exercise tolerance in patients at risk for or with mild COPD. Resp Physiol Neurobiol 2009; 165(1):97–103.
11. Raupach T, Bahr F, Herrmann P, Luethje L, Heusser K, Hasenfuss G, et al. Slow breathing reduces sympathoexcitation in COPD. Eur Resp J 2008; 32(2):387–392.
12. Zulli R, Donati P, Nicosia F, De Vecchi M, Tantucci C, Romanelli G, et al. Increased QT dispersion:a negative prognostic finding in chronic obstructive pulmonary disease. Intern Emerg Med 2006; 1(4):279–286.
13. Andreas S, Haarmann H, Klarner S, Hasenfuss G, Raupach T. Increased sympathetic nerve activity in COPD is associated with morbidity and mortality. Lung 2014; 192(2):235–241.
14. Short PM, Lipworth SI, Elder DH, Schembri S, Lipworth BJ. Effect of beta blockers in treatment of chronic obstructive pulmonary disease:a retrospective cohort study. BMJ 2011; 342:d2549.
15. Somers V, Dyken M, Clary M, Abboud F. Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 1995; 96:1897–1904.
16. Somers VK, Mark AL, Zavala DC, Abboud FM. Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans. J Appl Physiol (1985) 1989; 67(5):2101–2106.
17. Bradley TD, Tkacova R, Hall MJ, Ando S, Floras JS. Augmented sympathetic neural response to simulated obstructive apnoea in human heart failure. Clin Sci 2003; 104(3):231–238.
18. Seals DR, Suwarno NO, Dempsey JA. Influence of lung volume on sympathetic nerve discharge in normal humans. Circ Res 1990; 67(1):130–141.
19. Ge X, Han F, Huang Y, Zhang Y, Yang T, Bai C, et al. Is obstructive sleep apnea associated with cardiovascular and all-cause mortality? PLOS One 2013; 8(7).
20. Heart rate variability:standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 1996; 93(5):1043–1065.
21. Montano N, Ruscone T, Porta A, Lombardi F, Pagani M, Malliani A. Power spectrum analysis of heart rate variability to assess the changes in sympathovagal balance during graded orthostatic tilt. Circulation 1994; 90:1826–1831.
22. Berry RB, Budhiraja R, Gottlieb DJ, Gozal D, Iber C, Kapur VK, et al. Rules for scoring respiratory events in sleep:update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med 2012; 8(5):597–619.
23. Vestbo J, Hurd SS, Agusti AG, Jones PW, Vogelmeier C, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease:GOLD executive summary. Am J Resp Crit Care Med 2013; 187(4):347–365.
24. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease:GOLD executive summary. Am J Resp Crit Care Med 2007; 176(6):532–555.
25. Corda L, Novali M, Montemurro LT, La Piana GE, Redolfi S, Braghini A, et al. Predictors of nocturnal oxyhemoglobin desaturation in COPD. Resp Physiol Neurobiol 2011; 179(2–3):192–197.
26. Chhabra SK, Gupta M, Ramaswamy S, Dash DJ, Bansal V, Deepak KK. Cardiac Sympathetic Dominance and Systemic Inflammation in COPD. COPD 2015; 12(5):552–559.
27. Zamarrón C, Lado MJ, Teijeiro T, Morete E, Vila XA, Lamas PF. Heart rate variability in patients with severe chronic obstructive pulmonary disease in a home care program. Technol Health Care 2014; 22(1):91–98.
28. Camillo CA, Pitta F, Possani HV, Barbosa MV, Marques DS, Cavalheri V, et al. Heart rate variability and disease characteristics in patients with COPD. Lung 2008; 186(6):393–401.
29. Mazzuco A, Medeiros MW, Sperling MPR, Soares de Souza A, Alencar MCN, Arbex FF, et al. Relationship between linear and nonlinear dynamics of heart rate and impairment of lung function in COPD patients. Int J COPD 2015; 10:1651–1661.
30. Carvalho TD, Pastre CM, De Godoy MF, Fereira C, O Pitta F, De Abreu LC, et al. Fractal correlation property of heart rate variability in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2011; 6(6):23–28.
31. Kim YS, Kim SY, Park DY, Wu HW, Hwang GS, Kim HJ. Clinical implication of heart rate variability in obstructive sleep apnea syndrome patients. J Craniofac Surg 2015; 26(5):1592–1595.
32. Flevari A, Vagiakis E, Zakynthinos S. Heart rate variability is augmented in patients with positional obstructive sleep apnea, but only supine LF/HF index correlates with its severity. Sleep Breath 2015; 19(1):359–367.
33. Narkiewicz K, Montano N, Cogliati C, Van de Borne PJH, Dyken MED, Somers VK. Altered cardiovascular variability in obstructive sleep apnea. Circulation 1998; 98(11):1071–1077.
34. Shiina K, Tomiyama H, Takata Y, Yoshida M, Kato K, Saruhara H, et al. Effects of CPAP therapy on the sympathovagal balance and arterial stiffness in obstructive sleep apnea. Resp Med 2010; 106(6):911–916.
35. Roche F, Court-Fortune I, Pichot V, Duverney D, Costes F, Emonot A, et al. Reduced cardiac sympathetic autonomic tone after long-term nasal continuous positive airway pressure in obstructive sleep apnoea syndrome. Clin Physiol 1999; 19(2):127–134.
36. Palma JA, Iriarte J, Fernandez S, Alegre M, Valencia M, Artieda J, et al. Long-term continuous positive airway pressure therapy improves cardiac autonomic tone during sleep in patients with obstructive sleep apnea. Clin Autor Res 2015; 25(4):25–32.
37. Spaak J, Egri ZJ, Kubo T, Yu E, Ando SI, Kaneko Y, et al. Muscle sympathetic nerve activity during wakefulness in heart failure patients with and without sleep apnea. Hypertension 2005; 46:1327–1332.
38. Dempsey JA, Sheel AW, St Croix CM, Morgan BJ. Respiratory influences on sympathetic vasomotor outflow in humans. Resp Physiol Neurobiol 2002; 130:3–20.
39. Kwon J, Wolfe L, Lu B, Kalhan R. Hyperinflation is associated with lower sleep efficiency in COPD with co-existent obstructive sleep apnea. COPD 2015; 6:441–445.
40. Burton MD, Kazemi H. Neurotransmitters in central respiratory control. Respir Physiol 2000; 122(2–3):111–121.
41. Balachandran JS, Bakker JP, Rahangdale S, Yim-Yeh S, Mietus JE, Goldberger AL, et al. Effect of mild, asymptomatic obstructive sleep apnea on daytime heart rate variability and impedance cardiography measurements. Am J Cardiol 2012; 109(1):140–145.
42. Cheng ST, Wu YK, Yang MC, Huang CY, Huang HC, Chu WH, et al. Pulmonary rehabilitation improves heart rate variability at peak exercise, exercise capacity and health-related quality of life in chronic obstructive pulmonary disease. Heart Lung 43(3):249–255.
43. Idiaquez J, Santos I, Santin J, Del Rio R, Iturriaga R. Neurobehavioral and autonomic alterations in adults with obstructive sleep apnea. Sleep Med 2014; 15(11):1319–1323.
44. Haarmann H, Mohrlang C, Tschiesner U, Rubin DB, Bornemann T, Rüter K, et al. Inhaled β-agonist does not modify sympathetic activity in patients with COPD. BMC Pulm Med 2015; 15:46.
45. Wu YK, Huang CY, Yang MC, Huang GL, Chen SY, Lan CC. Effect of tiotropium on heart rate variability in stable chronic obstructive pulmonary disease patients. J Aerosol Med Pulm Drug Deliv 2015; 28(2):100–105.