Statins and IL-1β, IL-10, and MPO Levels in Gingival Crevicular Fluid: Preliminary Results

Inflammation

Volumn 39, Issue 4, 2016, Pages 1547-1557

  Cicek Ari, Vuslat ^a   Ilarslan, Yagmur Deniz ^a   Erman, Baran ^a   Sarkarati, Bahram ^b   Tezcan, Ilhan ^a   Karabulut, Erdem ^a   Oz, Serife Gul ^a   Tanriover, Mine Durusu ^a   Sengun, Dilek ^a   Berker, Ezel ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b ABANT IZZET BAYSAL UNIVERSITY   (Turkey)

Author keywords

IL 10; IL 1 ; inflammation; periodontal diseases; statins

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 10; INTERLEUKIN 1BETA; MYELOPEROXIDASE; IL10 PROTEIN, HUMAN; PEROXIDASE;

ADULT; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD SAMPLING; CHRONIC PERIODONTITIS; CONTROLLED STUDY; DIET; DRUG EFFICACY; FEMALE; GINGIVITIS; HUMAN; HYPERLIPIDEMIA; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; METABOLIC PARAMETERS; PROTEIN BLOOD LEVEL; SAMPLING; BLOOD; CASE CONTROL STUDY; CHEMISTRY; COHORT ANALYSIS; DIET THERAPY; DRUG EFFECTS; HYPERLIPIDEMIAS; INFLAMMATION; PATHOLOGY; PERIODONTIUM;

CASE-CONTROL STUDIES; CHRONIC PERIODONTITIS; COHORT STUDIES; GINGIVAL CREVICULAR FLUID; GINGIVITIS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERLIPIDEMIAS; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-1BETA; PERIODONTIUM; PEROXIDASE;

EID: 84979031734     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-016-0390-7     Document Type: Article

References (34)

1. Genco, R.J. 1992. Host responses in periodontal diseases: current concepts. Journal of Periodontology 63: 338–55.
2. Okada, H., and S. Murakami. 1998. Cytokine expression in periodontal health and disease. Critical Reviews in Oral Biology and Medicine 9: 248–66.
3. Loos, B.G., J. Craandijk, F.J. Hoek, P.M. Wertheim-van Dillen, and U. van der Velden. 2000. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. Journal of Periodontology 71: 1528–34.
4. Quist-Paulsen, P. 2010. Statins and inflammation: an update. Current Opinion in Cardiology 25: 399–405.
5. Horiuchi, N., and T. Maeda. 2006. Statins and bone metabolism. Oral Diseases 12: 85–101.
6. Mundy, G., R. Garrett, S. Harris, J. Chan, D. Chen, G. Rossini, et al. 1999. Stimulation of bone formation in vitro and in rodents by statins. Science 286: 1946–9.
7. Lindy, O., K. Suomalainen, M. Makela, and S. Lindy. 2008. Statin use is associated with fewer periodontal lesions: a retrospective study. BMC Oral Health 8: 16.
8. Saxlin, T., L. Suominen-Taipale, M. Knuuttila, P. Alha, and P. Ylostalo. 2009. Dual effect of statin medication on the periodontium. Journal of Clinical Periodontology 36: 997–1003.
9. Saver, B.G., P.P. Hujoel, J. Cunha-Cruz, and G. Maupome. 2007. Are statins associated with decreased tooth loss in chronic periodontitis? Journal of Clinical Periodontology 34: 214–9.
10. Meisel, P., H.K. Kroemer, M. Nauck, B. Holtfreter, and T. Kocher. 2014. Tooth loss, periodontitis, and statins in a population-based follow-up study. Journal of Periodontology 85: e160–8.
11. Sangwan, A., S. Tewari, H. Singh, R.K. Sharma, and S.C. Narula. 2013. Periodontal status and hyperlipidemia: statin users versus non-users. Journal of Periodontology 84: 3–12.
12. Fentoglu, O., B.K. Koroglu, H. Hicyilmaz, T. Sert, M. Ozdem, R. Sutcu, et al. 2011. Pro-inflammatory cytokine levels in association between periodontal disease and hyperlipidaemia. Journal of Clinical Periodontology 38: 8–16.
13. Suresh, S., S. Narayana, P. Jayakumar, U. Sudhakar, and V. Pramod. 2013. Evaluation of anti-inflammatory effect of statins in chronic periodontitis. Indian Journal of Pharmacology 45: 391–4.
14. Ebersole, J.L., R.E. Singer, B. Steffensen, T. Filloon, and K.S. Kornman. 1993. Inflammatory mediators and immunoglobulins in GCF from healthy, gingivitis and periodontitis sites. Journal of Periodontal Research 28: 543–6.
15. Stashenko, P., J.J. Jandinski, P. Fujiyoshi, J. Rynar, and S.S. Socransky. 1991. Tissue levels of bone resorptive cytokines in periodontal disease. Journal of Periodontology 62: 504–9.
16. de Araujo Junior, R.F., T.O. Souza, L.M. de Moura, K.P. Torres, L.B. de Souza, S. Alves Mdo, et al. 2013. Atorvastatin decreases bone loss, inflammation and oxidative stress in experimental periodontitis. PloS One 8, e75322.
17. Moore, K.W., A. O’Garra, R. de Waal Malefyt, P. Vieira, and T.R. Mosmann. 1993. Interleukin-10. Annual Review of Immunology 11: 165–90.
18. Cassatella, M.A., L. Meda, S. Bonora, M. Ceska, and G. Constantin. 1993. Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide. Journal of Experimental Medicine 178: 2207–11.
19. Lacraz, S., L.P. Nicod, R. Chicheportiche, H.G. Welgus, and J.M. Dayer. 1995. IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes. Journal of Clinical Investigation 96: 2304–10.
20. Li, J.J., and C.H. Fang. 2005. Effects of 4 weeks of atorvastatin administration on the antiinflammatory cytokine interleukin-10 in patients with unstable angina. Clinical Chemistry 51: 1735–8.
21. Tekin, A., N. Sezgin, M.T. Katircibasi, G. Tekin, Y. Colkesen, A.T. Sezgin, et al. 2008. Short-term effects of fluvastatin therapy on plasma interleukin-10 levels in patients with chronic heart failure. Coronary Artery Disease 19: 513–9.
22. Sorsa, T., L. Tjaderhane, Y.T. Konttinen, A. Lauhio, T. Salo, H.M. Lee, et al. 2006. Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation. Annali Medici 38: 306–21.
23. Steinberg, D., S. Parthasarathy, T.E. Carew, J.C. Khoo, and J.L. Witztum. 1989. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. New England Journal of Medicine 320: 915–24.
24. Davignon, J., R.F. Jacob, and R.P. Mason. 2004. The antioxidant effects of statins. Coronary Artery Disease 15: 251–8.
25. Loe, H., and J. Silness. 1963. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontologica Scandinavica 21: 533–51.
26. Silness, J., and H. Loe. 1964. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontologica Scandinavica 22: 121–35.
27. Ainamo, J., and I. Bay. 1975. Problems and proposals for recording gingivitis and plaque. International Dental Journal 25: 229–35.
28. Suzuki, K., H. Ota, S. Sasagawa, T. Sakatani, and T. Fujikura. 1983. Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Analytical Biochemistry 132: 345–52.
29. Laufs, U., V. La Fata, J. Plutzky, and J.K. Liao. 1998. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 97: 1129–35.
30. Cunha-Cruz, J., B. Saver, G. Maupome, and P.P. Hujoel. 2006. Statin use and tooth loss in chronic periodontitis patients. Journal of Periodontology 77: 1061–6.
31. de Lima Oliveira, A.P., M. de Faveri, L.C. Gursky, M.J. Mestnik, M. Feres, A.D. Haffajee, et al. 2012. Effects of periodontal therapy on GCF cytokines in generalized aggressive periodontitis subjects. Journal of Clinical Periodontology 39: 295–302.
32. Cao, C.F., and Q.T. Smith. 1989. Crevicular fluid myeloperoxidase at healthy, gingivitis and periodontitis sites. Journal of Clinical Periodontology 16: 17–20.
33. Nizam, N., P. Gumus, J. Pitkanen, T. Tervahartiala, T. Sorsa, and N. Buduneli. 2014. Serum and salivary matrix metalloproteinases, neutrophil elastase, myeloperoxidase in patients with chronic or aggressive periodontitis. Inflammation 37: 1771–8.
34. Dalcico, R., A.M. de Menezes, O.B. Deocleciano, R.B. Oria, M.L. Vale, R.A. Ribeiro, et al. 2013. Protective mechanisms of simvastatin in experimental periodontal disease. Journal of Periodontology 84: 1145–57.