Dual effect of statin medication on the periodontium

Journal of Clinical Periodontology

Volumn 36, Issue 12, 2009, Pages 997-1003

  Saxlin, Tuomas ^a   Suominen Taipale, Liisa ^b   Knuuttila, Matti ^a,c   Alha, Pirkko ^b   Ylöstalo, Pekka ^a  

^a UNIVERSITY OF OULU   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c OULU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Periodontal infection; Statin medication

Indexed keywords

ATORVASTATIN; HEPTANOIC ACID DERIVATIVE; HYPOCHOLESTEROLEMIC AGENT; PYRROLE DERIVATIVE; SIMVASTATIN;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; DRUG EFFECT; FEMALE; GINGIVITIS; HUMAN; IMMUNOMODULATION; MALE; MIDDLE AGED; PERIODONTAL POCKET; PERIODONTICS; PERIODONTIUM; REGRESSION ANALYSIS; RISK FACTOR; TOOTH PLAQUE;

ADULT; AGED; ANTICHOLESTEREMIC AGENTS; DENTAL PLAQUE; FEMALE; GINGIVITIS; HEPTANOIC ACIDS; HUMANS; IMMUNOMODULATION; MALE; MIDDLE AGED; PERIODONTAL INDEX; PERIODONTAL POCKET; PERIODONTIUM; PYRROLES; REGRESSION ANALYSIS; RISK FACTORS; SIMVASTATIN;

EID: 73149098120     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2009.01484.x     Document Type: Article

References (26)

1. Aromaa, A. Koskinen, S. (eds) 2004) Health and Functional Capacity in Finland. Baseline Results of the Health 2000 Health Examination Survey. Helsinki : Publications of the National Public Health Institute B12/2004.
2. Bergström, J. Preber, H. (1994) Tobacco use as a risk factor. Journal of Periodontology 65, 545 550.
3. Cunha-Cruz, J., Saver, B., Maupome, G. Hujoel, P. P. (2006) Statin use and tooth loss in chronic periodontitis patients. Journal of Periodontology 77, 1061 1066.
4. Hujoel, P. P., Drangsholt, M., Spiekerman, C. DeRouen, T. A. (2002) Periodontitis-systemic disease associations in the presence of smoking - causal or coincidental? Periodontology 2000 30, 51 60.
5. Ikeda, U. Shimada, K. (1999) Statins and monocytes. Lancet 353, 2070.
6. Jain, M. K. Ridker, P. M. (2005) Anti-inflammatory effects of statins: clinical evidence and basic mechanisms. Nature Reviews Drug Discovery 4, 977 987.
7. Kwak, B., Mulhaupt, F., Myit, S. Mach, F. (2000) Statins as a newly recognised type of immunomodulator. Nature Medicine 6, 1399 1402.
8. Lewsey, J. D., Gilthorpe, M. S., Bulman, J. S. Bedi, R. (2000) Is modelling dental caries a "normal" thing to do? Community Dental Health 17, 212 217.
9. Libby, P. (2002) Inflammation in atherosclerosis. Nature 420, 868 874.
10. Lindy, O., Suomalainen, K., Mäkelä, M. Lindy, S. (2008) Statin use is associated with fewer periodontal lesions: a retrospective study. BMC Oral Health 8, 16.
11. Lösche, W., Karapetow, F., Pohl, A., Pohl, C. Kocher, T. (2000) Plasma lipid and blood glucose levels in patients with destructive periodontal disease. Journal of Clinical Periodontology 27, 537 541.
12. Luan, Z., Chase, A. J. Newby, A. C. (2003) Statins inhibit secretion of metalloproteinases-1, -2, -3 and -9 from vascular smooth muscle cells and macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology 23, 769 775.
13. Matsuura, E., Kobayashi, K., Tabuchi, M. Lopez, L. R. (2006) Oxidative modification of low-density lipoprotein and immune regulation of atherosclerosis. Progress in Lipid Research 45, 466 486.
14. Nibali, L., D'Aiuto, F., Griffiths, G., Patel, K., Suvan, J. Tonetti, M. S. (2007) Severe periodontitis is associated with systemic inflammation and a dysmetabolic status: a case-control-study. Journal of Clinical Periodontology 34, 931 937.
15. Noack, B., Jachmann, I., Roscher, S., Sieber, L., Kopprasch, S., Luck, C., Hanefeld, M. Hoffmann, T. (2000) Metabolic diseases and their possible link to risk indicators of periodontitis. Journal of Periodontology 71, 898 903.
16. Ridker, P. M., Rifai, N., Pfeffer, M. A., Sacks, F. Braunwald, E. (1999) Long-term effects of pravastatin on plasma concentration of C-reactive protein. Circulation 100, 230 235.
17. Rosenson, R. S., Tangney, C. C. Casey, L. C. (1999) Inhibition of proinflammatory cytokine production by pravastatin. Lancet 353, 983 984.
18. Sakoda, K., Yamamoto, M., Negishi, Y., Liao, J. K., Node, K. Izumi, Y. (2006) Simvastatin decreases IL-6 and IL-8 production in epithelial cells. Journal of Dental Research 85, 520 523.
19. Saxlin, T., Suominen-Taipale, L., Kattainen, A., Marniemi, J., Knuuttila, M. Ylöstalo, P. (2008) Association between serum lipid levels and periodontal infection. Journal of Clinical Periodontology 35, 1040 1047.
20. Schönbeck, U. Libby, P. (2004) Inflammation, immunity, and HMG-CoA reductase inhibitors: statins as anti-inflammatory agents? Circulation 109, II-18 II-26.
21. Seto, H., Ohba, H., Togunaga, K., Hama, H., Horibe, M. Nagata, T. (2008) Topical administration of simvastatin recovers alveolar bone loss in rats. Journal of Periodontal Research 43, 261 267.
22. Silness, J. Löe, H. (1964) Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta Odontologica Scandinavia 22, 121 135.
23. Vaziri, H., Naserhojjati-Roodsari, R., Tahsili-Fahadan, N., Khojasteh, A., Mashhadi-Abbas, F., Eslami, B. Dehpour, A. R. (2007) Effect of simvastatin administration on periodontitis-associated bone loss in ovariectomized rats. Journal of Periodontology 78, 1561 1567.
24. Vehkalahti, M., Knuuttila, M. Hausen, H. (2004) Kliinisten mittausten laadun varmista minen (Quality assurance of clinical examinations). In : Suominen-Taipale, L., Nordblad, A., Vehkalahti, M. Aromaa, A. (eds). Suomalaisten Aikuisten Suunterveys, Terveys 2000-Tutkimus (Oral Health of Finnish Adults, Health 2000 Health Examination Survey), pp. 24 32. Helsinki : Publications of the National Public Health Institute B 16/2004.
25. Vehkalahti, M., Knuuttila, M. Hausen, H. (2008) Quality assurance. In Suominen-Taipale, L., Nordblad, A., Vehkalahti, M. Aromaa, A. (eds). Oral Health in the Finnish Adult Population, Health 2000 Survey, pp. 17 20. Helsinki : Publications of the National Public Health Institute B 25/2008.
26. Weitz-Schmidt, G., Welzenbach, K., Brinkmann, V., Kamata, T., Kallen, J., Bruns, C., Cottens, S., Takada, Y. Hommel, U. (2001) Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nature Medicine 7, 687 692.