Folic acid supplementation in postpolypectomy patients in a randomized controlled trial increases tissue folate concentrations and reduces aberrant DNA biomarkers in colonic tissues adjacent to the former polyp site

Journal of Nutrition

Volumn 146, Issue 5, 2016, Pages 933-939

  O'Reilly, Sharleen L ^a,d   McGlynn, Angela P ^b   McNulty, Helene ^b   Reynolds, John ^c,e   Wasson, Gillian R ^b   Molloy, Anne M ^a   Strain, J J ^b   Weir, Donald G ^a   Ward, Mary ^b   McKerr, George ^b   Scott, John M ^a   Downes, C Stephen ^b  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF ULSTER   (United Kingdom)

^c DEAKIN UNIVERSITY   (Australia)

^d DEAKIN UNIVERSITY   (Australia)

^e MONASH UNIVERSITY   (Australia)

Author keywords

Colon cancer; Colonocyte; DNA methylation; Field cancerization; Folate; Uracil misincorporation

Indexed keywords

BIOLOGICAL MARKER; DNA; FOLIC ACID; PLACEBO; URACIL; VITAMIN B COMPLEX;

ADENOMATOUS POLYP; ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; COLON; COLON POLYP; COLONOSCOPY; COMET ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; DNA METHYLATION; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HUMAN TISSUE; MALE; MICROBIOLOGY; MIDDLE AGED; POLYPECTOMY; POSTOPERATIVE CARE; RANDOMIZED CONTROLLED TRIAL; SUPPLEMENTATION; TISSUE LEVEL; ADENOMATOUS POLYPS; AGED; BLOOD; COLONIC NEOPLASMS; COMPLICATION; DIETARY SUPPLEMENT; DNA DAMAGE; DRUG EFFECTS; FOLIC ACID DEFICIENCY; GENETICS; INTESTINE MUCOSA; METABOLISM; OBESITY; PATHOLOGY; POLYP;

ADENOMATOUS POLYPS; AGED; BIOMARKERS; BODY MASS INDEX; COLON; COLONIC NEOPLASMS; COLONOSCOPY; COMET ASSAY; DIETARY SUPPLEMENTS; DNA; DNA DAMAGE; DNA METHYLATION; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; HUMANS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; OBESITY; POLYPS; URACIL; VITAMIN B COMPLEX;

EID: 84978916647     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.115.222547     Document Type: Article

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