The Efficacy Comparison of Tranexamic Acid for Reducing Blood Loss in Total Knee Arthroplasty at Different Dosage Time

Journal of Arthroplasty

Volumn 32, Issue 1, 2017, Pages 33-36

  Sun, Qi ^a   Yu, Xiao ^a   Nie, XiaoYang ^a   Gong, JinPeng ^a   Cai, Ming ^a  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

blood loss; different dosage time; intravenous administration; total knee arthroplasty; tranexamic acid

Indexed keywords

HEMOGLOBIN; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

AGED; ARTICLE; BLOOD TRANSFUSION; BLOOD VOLUME; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DOSE TIME EFFECT RELATION; DRUG EFFICACY; FEMALE; FOLLOW UP; HUMAN; INCIDENCE; INCISION; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; OPERATION DURATION; OPERATIVE BLOOD LOSS; POSTOPERATIVE HEMORRHAGE; PREOPERATIVE PERIOD; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TOTAL KNEE ARTHROPLASTY; BLOOD; BLOOD LOSS, SURGICAL; COMPARATIVE STUDY; INTRAVENOUS DRUG ADMINISTRATION; KNEE REPLACEMENT; MIDDLE AGED; OSTEOARTHRITIS, KNEE; TIME FACTOR; TOURNIQUET; TREATMENT OUTCOME;

ADMINISTRATION, INTRAVENOUS; AGED; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; FEMALE; HEMOGLOBINS; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; POSTOPERATIVE HEMORRHAGE; PROSPECTIVE STUDIES; TIME FACTORS; TOURNIQUETS; TRANEXAMIC ACID; TREATMENT OUTCOME;

EID: 84978795850     PISSN: 08835403     EISSN: 15328406     Source Type: Journal    
DOI: 10.1016/j.arth.2016.06.021     Document Type: Article

References (24)

1. 1 Lin, P.C., Hsu, C.H., Chen, W.S., et al. Does tranexamic acid save blood in minimally invasive total knee arthroplasty?. Clin Orthop Relat Res, 469(7), 2011, 1995.
2. 2 Jang, B., Kao, M., Bohm, M.T., et al. Intra-articular injection of tranexamic acid to reduce blood loss after total knee arthroplasty. J Orthop Surg (Hong Kong), 22(2), 2014, 146.
3. 3 Sarzaeem, M.M., Razi, M., Kazemian, G., et al. Comparing efficacy of three methods of tranexamic acid administration in reducing hemoglobin drop following total knee arthroplasty. J Arthroplasty, 29(8), 2014, 1521.
4. 4 Callaghan, J.J., O'Rourke, M.R., Liu, S.S., Blood management: issues and options. J Arthroplasty, 20(4 Suppl 2), 2005, 51.
5. 5 Patel, J.N., Spanyer, J.M., Smith, L.S., et al. Comparison of intravenous versus topical tranexamic acid in total knee arthroplasty: a prospective randomized study. J Arthroplasty, 29(8), 2014, 1528.
6. 6 Schreiber, G.B., Busch, M.P., Kleinman, S.H., et al. The risk of transfusion-transmitted viral infections. The Retrovirus Epidemiology Donor Study. N Engl J Med, 334(26), 1996, 1685.
7. 7 Veien, M., Sorensen, J.V., Madsen, F., et al. Tranexamic acid given intraoperatively reduces blood loss after total knee replacement: a randomized, controlled study. Acta Anaesthesiol Scand, 46(10), 2002, 1206.
8. 8 Kakar, P.N., Gupta, N., Govil, P., et al. Efficacy and safety of tranexamic acid in control of bleeding following TKR: a randomized clinical trial. Indian J Anaesth, 53(6), 2009, 667.
9. 9 Fu, D.J., Chen, C., Guo, L., et al. Use of intravenous tranexamic acid in total knee arthroplasty: a meta-analysis of randomized controlled trials. Chin J Traumatol, 16(2), 2013, 67.
10. 10 Gandhi, R., Evans, H.M., Mahomed, S.R., et al. Tranexamic acid and the reduction of blood loss in total knee and hip arthroplasty: a meta-analysis. BMC Res Notes, 6, 2013, 184.
11. 11 Tan, J., Chen, H., Liu, Q., et al. A meta-analysis of the effectiveness and safety of using tranexamic acid in primary unilateral total knee arthroplasty. J Surg Res, 184(2), 2013, 880.
12. 12 Dahuja, A., Dahuja, G., Jaswal, V., et al. A prospective study on role of tranexamic acid in reducing postoperative blood loss in total knee arthroplasty and its effect on coagulation profile. J Arthroplasty, 29(4), 2014, 733.
13. 13 Hourlier, H., Reina, N., Fennema, P., Single dose intravenous tranexamic acid as effective as continuous infusion in primary total knee arthroplasty: a randomised clinical trial. Arch Orthop Trauma Surg, 135(4), 2015, 465.
14. 14 Sabatini, L., Atzori, F., Revello, S., et al. Intravenous use of tranexamic acid reduces postoperative blood loss in total knee arthroplasty. Arch Orthop Trauma Surg, 134(11), 2014, 1609.
15. 15 Fiebig, E., Safety of the blood supply. Clin Orthop Relat Res(357), 1998, 6.
16. 16 Karaaslan, F., Karaoglu, S., Mermerkaya, M.U., et al. Reducing blood loss in simultaneous bilateral total knee arthroplasty: combined intravenous-intra-articular tranexamic acid administration. A prospective randomized controlled trial. Knee, 22(2), 2015, 131.
17. 17 Maniar, R.N., Kumar, G., Singhi, T., et al. Most effective regimen of tranexamic acid in knee arthroplasty: a prospective randomized controlled study in 240 patients. Clin Orthop Relat Res, 470(9), 2012, 2605.
18. 18 Fukuda, A., Hasegawa, M., Kato, K., et al. Effect of tourniquet application on deep vein thrombosis after total knee arthroplasty. Arch Orthop Trauma Surg, 127(8), 2007, 671.
19. 19 Reikeras, O., Clementsen, T., Time course of thrombosis and fibrinolysis in total knee arthroplasty with tourniquet application. Local versus systemic activations. J Thromb Thrombolysis, 28(4), 2009, 425.
20. 20 Rama, K.R., Apsingi, S., Poovali, S., et al. Timing of tourniquet release in knee arthroplasty. Meta-analysis of randomized, controlled trials. J Bone Joint Surg Am, 89(4), 2007, 699.
21. 21 Benoni, G., Fredin, H., Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients. J Bone Joint Surg Br, 78(3), 1996, 434.
22. 22 Kvederas, G., Porvaneckas, N., Andrijauskas, A., et al. A randomized double-blind clinical trial of tourniquet application strategies for total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc, 21(12), 2013, 2790.
23. 23 Reilly, T.J., Gradisar, I.A. Jr., Pakan, W., et al. The use of postoperative suction drainage in total knee arthroplasty. Clin Orthop Relat Res(208), 1986, 238.
24. 24 Gomez-Barrena, E., Ortega-Andreu, M., Padilla-Eguiluz, N.G., et al. Topical intra-articular compared with intravenous tranexamic acid to reduce blood loss in primary total knee replacement: a double-blind, randomized, controlled, noninferiority clinical trial. J Bone Joint Surg Am, 96(23), 2014, 1937.