Intravenous use of tranexamic acid reduces postoperative blood loss in total knee arthroplasty

Archives of Orthopaedic and Trauma Surgery

Volumn 134, Issue 11, 2014, Pages 1609-1614

  Sabatini, Luigi ^a   Atzori, Francesco ^a   Revello, Stefano ^a   Scotti, Luca ^b   Debiasi, Fabrizio ^b   Massè, Alessandro ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b SAN LUIGI GONZAGA HOSPITAL   (Italy)

Author keywords

Blood transfusions; Fibrin sealant; Total knee replacement; Tranexamic acid

Indexed keywords

FIBRIN GLUE; HEMOGLOBIN; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT; HEMOSTATIC AGENT;

AGED; ARTICLE; BLOOD TRANSFUSION; COMPARATIVE STUDY; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DRUG EFFICACY; DRUG SAFETY; FEMALE; FEVER; HEMATOMA; HEMOGLOBIN BLOOD LEVEL; HUMAN; KNEE PROSTHESIS; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE HEMORRHAGE; RETROSPECTIVE STUDY; STATISTICAL MODEL; STUDENT T TEST; TOTAL KNEE REPLACEMENT; WOUND INFECTION; INTRAVENOUS DRUG ADMINISTRATION; KNEE ARTHROPLASTY; OPERATION DURATION; PROCEDURES; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME;

AGED; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; BLOOD TRANSFUSION; FEMALE; FIBRIN TISSUE ADHESIVE; HEMOGLOBINS; HEMOSTATICS; HUMANS; INJECTIONS, INTRAVENOUS; MALE; OPERATIVE TIME; POSTOPERATIVE HEMORRHAGE; RETROSPECTIVE STUDIES; TRANEXAMIC ACID; TREATMENT OUTCOME;

EID: 84919787657     PISSN: 09368051     EISSN: 14343916     Source Type: Journal    
DOI: 10.1007/s00402-014-2081-x     Document Type: Article

References (26)

1. Zhang H, Chen J, Chen F, Que W (2012) The effect of tranexamic acid on blood loss and use of blood products in total knee arthroplasty: a meta-analysis. Knee Surg Sports Traumatol Arthrosc 20:1742–1752
2. Lemaire R (2008) Strategies for blood management in orthopaedic and trauma surgery. J. Bone Joint Surg 90:1128–1136
3. Tai TW, Chang CW (2012) Effects of tourniquet use on blood loss and soft tissue damage in total knee arthroplasty: a randomized controlled trial. J. Bone Joint Surg Am 94(24):2209–2215
4. Everts PA, Davilee RJ, Oosterbos CJ (2007) Autologous platelet gel and fibrin sealant enhance the efficacy of total knee arthroplasty: improved range of motion, decreased length of stay and a reduced incidence of arthrofibrosis. Knee Surg Sports Traumatol Arthrosc 15(7):888–894
5. Curtin WA, Wang GJ, Goodman NC, Abbott RD, Spotnitz WD (1999) Reduction of hemorrhage after knee arthroplasty using cryo-based fibrin sealant. J Arthroplast 14(4):481–487
6. Flynn JC, Csenesitz TA (1979) Present status of intraoperative blood recovery during orthopaedics surgery. Jefferson Orthop J 8:22–25
7. Cowell HR (1987) Prior deposit of autologous blood for transfusion. J. Bone Joint Surg 69(3):319
8. Spahn DR, Casutt M (2012) Eliminated blood transfusion: new aspects and perspectives. Anestesiology 13(3):145–151
9. Sabatini L, Trecci A, Imarisio D, Uslenghi MD, Bianco G, Scagnelli R (2012) Fibrin tissue adhesive reduces postoperative blood loss in total knee arthroplasty. J. Orthop Traumatol 13(3):145–151
10. Good L, Peterson E, Lisander B (2003) Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement. Br J Anaesth 90:596–599
11. Sasanuma H, Sekiya H, Takatoku K et al (2011) Efficients strategy for controlling postoperative hemorrhage in total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 19(7):921–925
12. Blackwell Science Ltd (2000) Guidelines for the clinical use of red cell transfusions. Br J Haematol 93:242–255
13. Sehat KR, Evans R, Newman JH (2000) How much blood is really lost in total knee arthroplasty: correct blood loss management should take hidden loss into account. Knee 7:151–155
14. Sehat KR, Evans R, Newman JH (2004) Hidden blood loss following hip and knee arthroplasty: correct management of blood loss should take hidden loss into account. JBJS (Br) 86B:561–565
15. Everts PA, Devilee RJ, Brown Mahoney C (2006) Platelet gel and fibrin sealant reduce allogenic blood transfusions in total knee arthroplasty. Acta Anaesthesiolo Scand 50(5):593–599
16. Tanaka N, Sakahashi H, Sato E, Hirose K, Ishioma T et al (2006) Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. J Bone Joint Surg Br 88:49–53
17. Kakar PN, Gupta N, Govil P, Shah V (2009) Efficacy and safety of tranexamic acid in control of bleeding following TKR: a randomized clinical trial. Indian J Anaesth 53(6):667–671
18. Camarasa MA, Olle G, Serra-Prat M, Martin A et al (2006) Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement; a randomized clinical trial. Br J Anaesth 96:576–582
19. Huang F, Wu D, Ma G, Yin Z, Wang Q et al (2014) The use of tranexamic acid to reduce blood loss amd transfusion in major orthopaedic surgery: a meta-analysis. J Surg Res I36:318–327
20. Charoencholvanich K, Siriwattanasakul P (2011) Tranexamic acid reduces bood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clin Orthop Relat Res 469(10):2874–2880
21. Ortega-Andreu M, Perez Charzanowska H, Figueredo R, Gomaez Barrena E (2011) Blood loss control with two doses of tranexamic acid in a multimodal protocol for total knee arthroplasty. Open Orthop J 5:44–48
22. Kim TK, Chang CB, Koh IJ (2013) Practical issues for the use of tranexamic acid in total knee arthroplasty: a systematic review. Knee Surg Sports Traumatol Arthrosc 22(8):1849–1858 (Epub ahead of print)
23. Tan J, Chen H, Liu Q, Chen C, Huang W (2013) A meta-analysis of the effectiveness and safety of using tranexamic acid in primary unilateral total knee arthroplasty. J Surg Res 184(2):880–887
24. Charoencholvanich K, Siriwattanasakul P, Narkbunnam R et al (2012) Temporary clamping of drain combined with tranexamic acid reduce blood loss after total knee arthroplasty: a prospective randomized controlled trial. BMC Musculoskelet Disord 13:124
25. Irisson E, Hemon Y, Pauly V, Parratte S et al (2012) Tranexamic acid reduces blood loss and financial cost in primary total hip and knee replacement surgery. Orthop Traumatol Surg res 98:477–483
26. Franchini M, Regis D, Gandini G, Corallo F (2016) Preoperative autologous blood donation in primary total knee arthroplasty: the experience of the transfusion centre of Verona. Blood Transfus 4:189–195