Spironolactone prevents endothelial nitric oxide synthase uncoupling and vascular dysfunction induced by β-adrenergic overstimulation

Hypertension

Volumn 68, Issue 3, 2016, Pages 726-735

  Victorio, Jamaira A ^a   Clerici, Stefano P ^a   Palacios, Roberto ^b   Alonso, María J ^b   Vassallo, Dalton V ^c   Jaffe, Iris Z ^d   Rossoni, Luciana V ^e   Davel, Ana P ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSIDAD REY JUAN CARLOS   (Spain)

^c FEDERAL UNIVERSITY OF ESPÍRITO SANTO   (Brazil)

^d TUFTS MEDICAL CENTER   (United States)

^e UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

adipose tissue; aorta; losartan; mineralocorticoid receptor

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; ALDOSTERONE; ANGIOTENSIN 1 RECEPTOR; CORTICOSTERONE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEAT SHOCK PROTEIN 90; ISOPRENALINE; LOSARTAN; MINERALOCORTICOID RECEPTOR; NITRIC OXIDE; PHENYLEPHRINE; SPIRONOLACTONE; SUPEROXIDE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVITY; GENOMICS; HEART VENTRICLE HYPERTROPHY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR DISEASE; VASOCONSTRICTION; ANALYSIS OF VARIANCE; ANIMAL; CARDIOMEGALY; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; METABOLISM; RANDOMIZATION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; ROLE PLAYING; WISTAR RAT;

ADIPOSE TISSUE; ANALYSIS OF VARIANCE; ANIMALS; CARDIOMEGALY; DISEASE MODELS, ANIMAL; ISOPROTERENOL; LOSARTAN; MALE; NITRIC OXIDE SYNTHASE TYPE III; RANDOM ALLOCATION; RATS; RATS, WISTAR; RECEPTORS, MINERALOCORTICOID; RENIN-ANGIOTENSIN SYSTEM; ROLE; SPIRONOLACTONE; VASOCONSTRICTION;

EID: 84978761809     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.116.07911     Document Type: Article

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