Stimulated release of a hyperpolarizing factor (ADHF) from mesenteric artery perivascular adipose tissue: Involvement of myocyte BKCa channels and adiponectin

British Journal of Pharmacology

Volumn 169, Issue 7, 2013, Pages 1500-1509

  Weston, A H ^a   Egner, I ^a   Dong, Y ^a   Porter, E L ^a   Heagerty, A M ^a   Edwards, G ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

3 adrenoceptors; adipocyte derived hyperpolarizing factor; adiponectin; adipose tissue; AMP kinase; BKCa channels; CL 316,243; iberiotoxin; membrane potential; vascular myocytes

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; 5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; 6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; ADIPOCYTE DERIVED HYPERPOLARIZING FACTOR; ADIPONECTIN; BETA 3 ADRENERGIC RECEPTOR; BIOLOGICAL FACTOR; CLOTRIMAZOLE; DORSOMORPHIN; GLIBENCLAMIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IBERIOTOXIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; N(G) METHYLARGININE; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIOLE; ARTICLE; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; ENZYME INHIBITION; HYPERPOLARIZATION; MALE; MESENTERIC ARTERY; MOUSE; MUSCLE CELL; NONHUMAN; PERIVASCULAR ADIPOSE TISSUE; PRIORITY JOURNAL; PROTEIN DETERMINATION; RAT;

Β3-ADRENOCEPTORS; 243; ADIPOCYTE-DERIVED HYPERPOLARIZING FACTOR; ADIPONECTIN; ADIPOSE TISSUE; AMP KINASE; BKCA CHANNELS; CL-316; IBERIOTOXIN; MEMBRANE POTENTIAL; VASCULAR MYOCYTES;

ADIPONECTIN; ADRENERGIC BETA-3 RECEPTOR AGONISTS; ANIMALS; DIOXOLES; GENE EXPRESSION REGULATION; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; MEMBRANE POTENTIALS; MESENTERIC ARTERIES; MICE; MICE, INBRED C57BL; MUSCLE CELLS; PYRONES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA-3; THIOPHENES; TRPM CATION CHANNELS;

EID: 84880274439     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12157     Document Type: Article

References (48)

1. Avery PJ, Patel SK, Ibrahim IM, Walker M, Keavney BD, (2011). Common variation in the adiponectin gene has an effect on systolic blood pressure. J Hum Hypertens 25: 719-724.
2. 3 receptors. A promising antidiabetic and antiobesity agent. J Med Chem 35: 3081-3084.
3. 3-adrenoceptors, in smooth muscle cells of rat small mesenteric arteries. Br J Pharmacol 146: 679-691.
4. Brochu-Gaudreau K, Rehfeldt C, Blouin R, Bordignon V, Murphy BD, Palin M-F, (2010). Adiponectin action from head to toe. Endocr 37: 11-32.
5. 3-adrenergic receptor agonist treatment of diet-induced obesity in mice. Endocrinology 138: 405-413.
6. Cool B, Zinker B, Chiou W, Kifle L, Cao N, Perham M, et al. (2006). Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab 3: 403-416.
7. 2+-activated nonselective cation channel in mouse sino-atrial node cells. Cardiovasc Res 73: 531-538.
8. Dolan JA, Muenkel HA, Burns MG, Pellegrino SM, Fraser CM, Pietri F, et al. (1994). Beta-3 adrenoceptor selectivity of the dioxolane dicarboxylate phenethanolamines. J Pharmacol Exp Ther 269: 1000-1006.
9. Dubrovska G, Verlohren S, Luft FC, Gollasch M, (2004). Mechanisms of ADRF release from rat aortic adventitial adipose tissue. Am J Physiol 286: H1107-H1113.
10. Edwards G, Zygmunt P, Högestätt E, Weston AH, (1996). Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein. Br J Pharmacol 119: 691-701.
11. 3 adrenoceptor activation. Proceedings of the British Pharmacological Society. Available at: http://www.pA2online.org/abstracts/ Vol8Issue1abst141P.pdf (accessed 02/04/2013).
12. Fang L, Zhao J, Chen Y, Ma T, Xu G, Tang C, et al. (2009). Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator. J Hypertens 27: 2174-2185.
13. Fésüs G, Dubrovska G, Gorzelniak K, Kluge R, Huang Y, Luft FC, et al. (2007). Adiponectin is a novel humoral vasodilator. Cardiovasc Res 75: 719-727.
14. 3-adrenoceptor agonist CL-316,243 on adiponectin, adiponectin receptors and tumor necrosis factor-α expressions in adipose tissues of obese diabetic KKAy mice. Eur J Pharmacol 584: 202-206.
15. Gao Y-J, Lu C, Su L-Y, Sharma AM, Lee RMKW, (2007). Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide. Br J Pharmacol 151: 323-331.
16. Garcia ML, Galvez A, Garcia-Calvo M, King VF, Vazquez J, Kaczorowski GJ, (1991). Use of toxins to study potassium channels. J Bioenerg Biomembr 23: 615-646.
17. Germack R, Starzec AB, Vassy R, Perret GY, (1997). Beta-adrenoceptor subtype expression and function in rat white adipocytes. Br J Pharmacol 120: 201-210.
18. Gollasch M, (2012). Vasodilator signals from perivascular adipose tissue. Br J Pharmacol 165: 633-642.
19. Göransson O, McBride A, Hawley SA, Ross FA, Shpiro N, Foretz M, et al. (2007). Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem 282: 32549-32560.
20. Greenstein AS, Khavandi K, Withers SB, Sonoyama K, Clancy O, Jeziorska M, et al. (2009). Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation 119: 1661-1670.
21. Guinamard R, Demion M, Launay P, (2010). Physiological roles of the TRPM4 channel extracted from background currents. Physiology 25: 155-164.
22. Kadowaki T, Yamauchi T, (2005). Adiponectin and adiponectin receptors. Endocr Rev 26: 439-451.
23. Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG, (2010). NC3Rs Reporting Guidelines Working Group. Br J Pharmacol 160: 1577-1579.
24. 2CR and involvement of microRNA-448-mediated repression of KLF5. Mol Endocrinol 24: 1978-1987.
25. 1-adrenoceptors, relax the rat isolated mesenteric artery. Br J Pharmacol 140: 3-12.
26. Löhn M, Dubrovska G, Lauterbach B, Luft FC, Gollasch M, Sharma AM, (2002). Periadventitial fat releases a vascular relaxing factor. FASEB J 16: 1057-1063.
27. Lynch FM, Withers SB, Yao Z, Werner ME, Edwards G, Weston AH, et al. (2013). Perivascular adipose tissue-derived adiponectin activates BKCa channels to induce anticontractile responses. Am J Physiol 304: H786-H795.
28. Ma K, Cabrero A, Saha PK, Kojima H, Li L, Chang BH-J, et al. (2002). Increased β-oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem 277: 34658-34661.
29. McGrath J, Drummond G, McLachlan E, Kilkenny C, Wainwright C, (2010). Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160: 1573-1576.
30. Michel MC, Ochodnicky P, Summers RJ, (2010). Tissue functions mediated by β3-adrenoceptors-findings and challenges. Naunyn-Schmied Arch Pharmacol 382: 103-108.
31. Moreno D, Knecht E, Viollet B, Sanz P, (2008). A-769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism. FEBS Lett 582: 2650-2654.
32. Morita H, Honda A, Inoue R, Ito Y, Abe K, Nelson MT, et al. (2007). Membrane stretch-induced activation of a TRPM4-like nonselective cation channel in cerebral artery myocytes. J Pharmacol Sci 103: 417-426.
33. Morrow VA, Foufelle F, Connell JMC, Petrie JR, Gould GW, Salt IP, (2003). Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells. J Biol Chem 278: 31629-31639.
34. 3-adrenoceptor agonist. Eur J Pharmacol 518: 71-76.
35. Ross FA, Rafferty JN, Dallas ML, Ogunbayo O, Ikematsu N, McClafferty H, et al. (2011). Selective expression in carotid body type I cells of a single splice variant of the large conductance calcium- and voltage-activated potassium channel confers regulation by AMP-activated protein kinase. J Biol Chem 286: 11929-11936.
36. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF, (1995). A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270: 26746-26749.
37. Schleifenbaum J, Köhn C, Voblova N, Dubrovska G, Zavarirskaya O, Gloe T, et al. (2010). Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide. J Hypertens 28: 1875-1882.
38. 1-containing complexes. Chem Biol 15: 1220-1230.
39. Stunes AK, Reseland JE, Hauso O, Kidd M, Tømmerås K, Waldum HL, et al. (2011). Adipocytes express a functional system for serotonin synthesis, reuptake and receptor activation. Diabetes Obes Metab 13: 551-558.
40. 1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle. Am J Physiol 297: C1041-C1052.
41. Triggle CR, Samuel SM, Ravishankar S, Marei I, Arunachalam G, Ding H, (2010). The endothelium: influencing vascular smooth muscle in many ways. Can J Physiol Pharmacol 90: 713-738.
42. Vennekens R, Nilius B, (2007). Insights into TRPM4 function, regulation and physiological role. Handb Exp Pharmacol 179: 269-285.
43. Verlohren S, Dubrovska G, Tsang SY, Essin K, Luft FC, Huang Y, et al. (2004). Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries. Hypertension 44: 271-276.
44. Xu A, Wang Y, Lam KSL, Vanhoutte PM, (2010). Vascular actions of adipokines molecular mechanisms and therapeutic implications. Adv Pharmacol 60: 229-255.
45. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, et al. (2002). Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8: 1288-1295.
46. Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M, et al. (2007). Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med 13: 332-339.
47. Zholos A, Johnson C, Burdyga T, Melanaphy D, (2011). TRPM channels in the vasculature. Adv Exp Med Biol 704: 707-729.
48. Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, et al. (2001). Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108: 1167-1174.