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1
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Neurobehavioral effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions
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1 Capuron, L., Gumnick, J.F., Musselman, D.L., Lawson, D.H., Reemsnyder, A., Nemeroff, C.B., Miller, A.H., Neurobehavioral effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions. Neuropsychopharmacology 26 (2002), 643–652.
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Capuron, L.1
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The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)
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3 Raison, C.L., Miller, A.H., The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D). Mol Psychiatry 18 (2013), 15–37.
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This paper demonstrates that an evolutionary advantageous process, namely behavioural changes during inflammation, is an important pathomechanism in the development of social stress-induced depression.
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4•• Miller, A.H., Raison, C.L., The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat Rev Immunol 16 (2015), 22–34 This paper demonstrates that an evolutionary advantageous process, namely behavioural changes during inflammation, is an important pathomechanism in the development of social stress-induced depression.
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Miller, A.H.1
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Is there a role for adjuvant high-dose interferon-alpha-2b in the management of melanoma?
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5 Sabel, M.S., Sondak, V.K., Is there a role for adjuvant high-dose interferon-alpha-2b in the management of melanoma?. Drugs 63 (2003), 1053–1058.
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9 Lotrich, F.E., Psychiatric clearance for patients started on interferon-alpha-based therapies. Am J Psychiatry 170 (2013), 592–597.
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Hepatitis C infection, antiviral treatment and mental health: a European expert consensus statement
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10 Schaefer, M., Capuron, L., Friebe, A., Diez-Quevedo, C., Robaeys, G., Neri, S., Foster, G.R., Kautz, A., Forton, D., Pariante, C.M., Hepatitis C infection, antiviral treatment and mental health: a European expert consensus statement. J Hepatol 57 (2012), 1379–1390.
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Schaefer, M.1
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Subtypes of depressive symptoms and inflammatory biomarkers: an exploratory study on a sample of HIV-positive patients
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11 Norcini Pala, A., Steca, P., Bagrodia, R., Helpman, L., Colangeli, V., Viale, P., Wainberg, M.L., Subtypes of depressive symptoms and inflammatory biomarkers: an exploratory study on a sample of HIV-positive patients. Brain Behav Immun, 2016.
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Norcini Pala, A.1
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12
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Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals?
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12 Capuron, L., Fornwalt, F.B., Knight, B.T., Harvey, P.D., Ninan, P.T., Miller, A.H., Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals?. J Affect Disord 119 (2009), 181–185.
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Capuron, L.1
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Interleukin-6 promoter polymorphism interacts with pain and life stress influencing depression phenotypes
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13 Kovacs, D., Eszlari, N., Petschner, P., Pap, D., Vas, S., Kovacs, P., Gonda, X., Bagdy, G., Juhasz, G., Interleukin-6 promoter polymorphism interacts with pain and life stress influencing depression phenotypes. J Neural Transm (Vienna) 123 (2016), 541–548.
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15 Kovacs, P., Panczel, G., Borbola, K., Juhasz, G., Liszkay, G., Psychological changes in melanoma patients during ipilimumab treatment compared to low-dose interferon alpha therapy — a follow-up study of first experiences. Pathol Oncol Res 20 (2014), 939–944.
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17 Garbe, C., Radny, P., Linse, R., Dummer, R., Gutzmer, R., Ulrich, J., Stadler, R., Weichenthal, M., Eigentler, T., Ellwanger, U., et al. Adjuvant low-dose interferon {alpha}2a with or without dacarbazine compared with surgery alone: a prospective-randomized phase III DeCOG trial in melanoma patients with regional lymph node metastasis. Ann Oncol 19 (2008), 1195–1201.
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18 Raison, C.L., Capuron, L., Miller, A.H., Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 27 (2006), 24–31.
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Interferon-alpha acutely impairs whole-brain functional connectivity network architecture — a preliminary study
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An elegant pharmacological brain MRI study demonstrated that the first dose of IFN-alpha in hepatitis C patients can disconnect functionally coupled brain regions within hours.
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19•• Dipasquale, O., Cooper, E.A., Tibble, J., Voon, V., Baglio, F., Baselli, G., Cercignani, M., Harrison, N.A., Interferon-alpha acutely impairs whole-brain functional connectivity network architecture — a preliminary study. Brain Behav Immun, 2015 An elegant pharmacological brain MRI study demonstrated that the first dose of IFN-alpha in hepatitis C patients can disconnect functionally coupled brain regions within hours.
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Dipasquale, O.1
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IFN-alpha-induced cortical and subcortical glutamate changes assessed by magnetic resonance spectroscopy
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20 Haroon, E., Woolwine, B.J., Chen, X., Pace, T.W., Parekh, S., Spivey, J.R., Hu, X.P., Miller, A.H., IFN-alpha-induced cortical and subcortical glutamate changes assessed by magnetic resonance spectroscopy. Neuropsychopharmacology 39 (2014), 1777–1785.
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Anterior cingulate activation and error processing during interferon-alpha treatment
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21 Capuron, L., Pagnoni, G., Demetrashvili, M., Woolwine, B.J., Nemeroff, C.B., Berns, G.S., Miller, A.H., Anterior cingulate activation and error processing during interferon-alpha treatment. Biol Psychiatry 58 (2005), 190–196.
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22 Miller, A.H., Maletic, V., Raison, C.L., Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry 65 (2009), 732–741.
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Miller, A.H.1
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23 D'Mello, C., Le, T., Swain, M.G., Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation. J Neurosci 29 (2009), 2089–2102.
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24 Torres-Platas, S.G., Cruceanu, C., Chen, G.G., Turecki, G., Mechawar, N., Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides. Brain Behav Immun 42 (2014), 50–59.
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25 Cattaneo, A., Macchi, F., Plazzotta, G., Veronica, B., Bocchio-Chiavetto, L., Riva, M.A., Pariante, C.M., Inflammation and neuronal plasticity: a link between childhood trauma and depression pathogenesis. Front Cell Neurosci, 9, 2015, 40.
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26 Vecsei, L., Szalardy, L., Fulop, F., Toldi, J., Kynurenines in the CNS: recent advances and new questions. Nat Rev Drug Discov 12 (2013), 64–82.
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27 Tavares, R.G., Tasca, C.I., Santos, C.E., Alves, L.B., Porciuncula, L.O., Emanuelli, T., Souza, D.O., Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes. Neurochem Int 40 (2002), 621–627.
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28 Raison, C.L., Demetrashvili, M., Capuron, L., Miller, A.H., Neuropsychiatric adverse effects of interferon-alpha: recognition and management. CNS Drugs 19 (2005), 105–123.
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29 Leonard, B., Maes, M., Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neurosci Biobehav Rev 36 (2012), 764–785.
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30 Romano, E., Kusio-Kobialka, M., Foukas, P.G., Baumgaertner, P., Meyer, C., Ballabeni, P., Michielin, O., Weide, B., Romero, P., Speiser, D.E., Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients. Proc Natl Acad Sci U S A 112 (2015), 6140–6145.
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31 Thomas, G., Tacke, R., Hedrick, C.C., Hanna, R.N., Nonclassical patrolling monocyte function in the vasculature. Arterioscler Thromb Vasc Biol 35 (2015), 1306–1316.
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33 Smith, K.J., Norris, S., O'Farrelly, C., O'Mara, S.M., Risk factors for the development of depression in patients with hepatitis C taking interferon-alpha. Neuropsychiatr Dis Treat 7 (2011), 275–292.
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34 Moieni, M., Irwin, M.R., Jevtic, I., Olmstead, R., Breen, E.C., Eisenberger, N.I., Sex differences in depressive and socioemotional responses to an inflammatory challenge: implications for sex differences in depression. Neuropsychopharmacology 40 (2015), 1709–1716.
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35 Juhasz, G., Gonda, X., Hullam, G., Eszlari, N., Kovacs, D., Lazary, J., Pap, D., Petschner, P., Elliott, R., Deakin, J.F., et al. Variability in the effect of 5-HTTLPR on depression in a large European population: the role of age, symptom profile, type and intensity of life stressors. PLoS One, 10, 2015 e0116316.
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36 Lotrich, F.E., Ferrell, R.E., Rabinovitz, M., Pollock, B.G., Risk for depression during interferon-alpha treatment is affected by the serotonin transporter polymorphism. Biol Psychiatry 65 (2009), 344–348.
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37 Udina, M., Moreno-Espana, J., Navines, R., Gimenez, D., Langohr, K., Gratacos, M., Capuron, L., de la Torre, R., Sola, R., Martin-Santos, R., Serotonin and interleukin-6: the role of genetic polymorphisms in IFN-induced neuropsychiatric symptoms. Psychoneuroendocrinology 38 (2013), 1803–1813.
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This study used whole genome expression data and pathway analysis methods to show that interferon α/β signalling pathway is upregulated in recurrent MDD patients compared to controls.
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38•• Mostafavi, S., Battle, A., Zhu, X., Potash, J.B., Weissman, M.M., Shi, J., Beckman, K., Haudenschild, C., McCormick, C., Mei, R., et al. Type I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing. Mol Psychiatry 19 (2014), 1267–1274 This study used whole genome expression data and pathway analysis methods to show that interferon α/β signalling pathway is upregulated in recurrent MDD patients compared to controls.
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Effects of IL1B single nucleotide polymorphisms on depressive and anxiety symptoms are determined by severity and type of life stress
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A further support that genetic variants in the inflammatory pathway, namely polymorphisms in the IL1B gene, increase the risk of depressive and anxiety symptoms in the face of stressful life events.
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39• Kovacs, D., Eszlari, N., Petschner, P., Pap, D., Vas, S., Kovacs, P., Gonda, X., Juhasz, G., Bagdy, G., Effects of IL1B single nucleotide polymorphisms on depressive and anxiety symptoms are determined by severity and type of life stress. Brain Behav Immun 56 (2016), 96–104 A further support that genetic variants in the inflammatory pathway, namely polymorphisms in the IL1B gene, increase the risk of depressive and anxiety symptoms in the face of stressful life events.
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40
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Neuronal nitric oxide synthase (NOS1) polymorphisms interact with financial hardship to affect depression risk
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40 Sarginson, J.E., Deakin, J.F., Anderson, I.M., Downey, D., Thomas, E., Elliott, R., Juhasz, G., Neuronal nitric oxide synthase (NOS1) polymorphisms interact with financial hardship to affect depression risk. Neuropsychopharmacology 39 (2014), 2857–2866.
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41
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41 Deinzer, R., Granrath, N., Stuhl, H., Twork, L., Idel, H., Waschul, B., Herforth, A., Acute stress effects on local Il-1beta responses to pathogens in a human in vivo model. Brain Behav Immun 18 (2004), 458–467.
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