Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression

Oncotarget

Volumn 7, Issue 28, 2016, Pages 43256-43266

  Huang, Yen Sung ^a   Chang, Che Chang ^b   Lee, Szu Shuo ^c   Jou, Yuh Shan ^a,c   Shih, Hsiu Ming ^a,b,c  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c ACADEMIA SINICA   (Taiwan)

Author keywords

AKT; Breast cancer; HDAC3; LncRNA; Xist

Indexed keywords

HISTONE DEACETYLASE 3; JPX RNA; LONG UNTRANSLATED RNA; PH DOMAIN AND LEUCINE RICH REPEAT PHOSPHATASE 1; PHOSPHATASE; PROTEIN; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; SPEN PROTEIN; UNCLASSIFIED DRUG; X INACTIVATE SPECIFIC TRANSCRIPT; HISTONE DEACETYLASE; HOMEODOMAIN PROTEIN; NCOR2 PROTEIN, HUMAN; NUCLEAR PROTEIN; PHLPP1 PROTEIN, HUMAN; PHOSPHOPROTEIN PHOSPHATASE; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR; SMALL INTERFERING RNA; SPEN PROTEIN, HUMAN; XIST NON-CODING RNA;

ARTICLE; BREAST CANCER; CANCER CELL LINE; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; PROMOTER REGION; UPREGULATION; X CHROMOSOME INACTIVATION; ANIMAL; BREAST TUMOR; CELL SURVIVAL; FEMALE; GENE EXPRESSION REGULATION; GENETICS; INFORMATION PROCESSING; MCF-7 CELL LINE; METABOLISM; MOUSE; PATHOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TISSUE MICROARRAY; TUMOR SUPPRESSOR GENE;

ANIMALS; BREAST NEOPLASMS; CELL SURVIVAL; DATASETS AS TOPIC; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GENES, TUMOR SUPPRESSOR; HISTONE DEACETYLASES; HOMEODOMAIN PROTEINS; HUMANS; MCF-7 CELLS; MICE; NUCLEAR PROTEINS; NUCLEAR RECEPTOR CO-REPRESSOR 2; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; RNA, LONG NONCODING; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TISSUE ARRAY ANALYSIS; UP-REGULATION; X CHROMOSOME INACTIVATION;

EID: 84978698535     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.9673     Document Type: Article

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