Molecular modeling and structural analysis of nAChR variants uncovers the mechanism of resistance to snake toxins

Journal of Biomolecular Structure and Dynamics

Volumn 35, Issue 8, 2017, Pages 1654-1671

  Gunasekaran, D ^a   Sridhar, J ^a   Suryanarayanan, V ^b   Manimaran, N C ^a   Singh, Sanjeev Kumar ^b  

^a MADURAI KAMARAJ UNIVERSITY   (India)

^b ALAGAPPA UNIVERSITY   (India)

Author keywords

alpha neurotoxin; molecular docking and simulation; nicotinic acetylcholine receptors; snake bite; bungarotoxin

Indexed keywords

ALPHA BUNGAROTOXIN; ALPHA NEUROTOXIN; NEUROTOXIN; NICOTINIC RECEPTOR; SNAKE VENOM; UNCLASSIFIED DRUG; BUNGAROTOXIN; PROTEIN BINDING;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; COMPUTER MODEL; GLYCOSYLATION; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL; MUTATION; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; ALPHA HELIX; ANIMAL; BETA SHEET; CHEMISTRY; COLUBRIDAE; HEDGEHOG; HUMAN; METABOLISM; MONGOOSE; MOUSE; NAJA HAJE; PHYSIOLOGY; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; SHREW; SNAKEBITE; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BUNGAROTOXINS; COLUBRIDAE; CRYSTALLOGRAPHY, X-RAY; HEDGEHOGS; HERPESTIDAE; HUMANS; MICE; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; NAJA HAJE; NEUROTOXINS; PROTEIN BINDING; PROTEIN CONFORMATION, ALPHA-HELICAL; PROTEIN CONFORMATION, BETA-STRAND; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTORS, NICOTINIC; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SHREWS; SNAKE BITES; THERMODYNAMICS;

EID: 84978524779     PISSN: 07391102     EISSN: 15380254     Source Type: Journal    
DOI: 10.1080/07391102.2016.1190791     Document Type: Article

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