Benzamide capped peptidomimetics as non-ATP competitive inhibitors of CDK2 using the REPLACE strategy

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 15, 2016, Pages 3754-3760

  Premnath, Padmavathy Nandha ^a,b   Craig, Sandra N ^a   Liu, Shu ^a,c   McInnes, Campbell ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF NEW ENGLAND   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cyclin dependent kinase; Cyclin groove; Inhibitor; Protein protein interaction; REPLACE

Indexed keywords

BENZAMIDE DERIVATIVE; BENZOIC ACID DERIVATIVE; CYCLIN A; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 2 INHIBITOR; CYCLIN DEPENDENT KINASE 4; PEPTIDOMIMETIC AGENT; BENZAMIDE; CDK2 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; ENZYME INHIBITION; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HUMAN; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

BENZAMIDES; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; PEPTIDOMIMETICS; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84978501329     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.05.067     Document Type: Article

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