Fragment based discovery of arginine isosteres through REPLACE: Towards non-ATP competitive CDK inhibitors

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 1, 2014, Pages 616-622

  Premnath, Padmavathy Nandha ^a   Liu, Shu ^a   Perkins, Tracy ^a   Abbott, Jennifer ^a   Anderson, Erin ^a   McInnes, Campbell ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Anti tumor therapeutic; Cyclin dependent kinase; Drug discovery; Inhibitor; REPLACE

Indexed keywords

2 (3 ETHOXYPHENYL) ACETIC ACID; 2 (3 ISOBUTOXYPHENYL)ACETIC ACID; 2 (3 PROPOXYPHENYL)ACETIC ACID; ARGININE DERIVATIVE; CYCLIN DEPENDENT KINASE INHIBITOR; ETHYL 2 (3 ETHOXYPHENYL)ACETIC ACID; ISOBUTYL 2 (3 ISOBUTOXYPHENYL)ACETIC ACID; PHENYLACETIC CARBOXYLIC ACID DERIVATIVE; PICOLINIC ACID DERIVATIVE; PROPYL 2 (3 PROPOXYPHENYL)ACETIC ACID; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; DRUG POTENCY; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROPHOBICITY; MOLECULAR DOCKING; PREDICTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SOLID PHASE SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANTI-TUMOR THERAPEUTIC; CYCLIN DEPENDENT KINASE; DRUG DISCOVERY; INHIBITOR; REPLACE;

ARGININE; CYCLIN-DEPENDENT KINASE 2; CYCLINS; DRUG DISCOVERY; HUMANS; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891494110     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.10.039     Document Type: Article

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