Anti-obesity and anti-hepatosteatosis effects of dietary scopoletin in high-fat diet fed mice

Journal of Functional Foods

Volumn 25, Issue , 2016, Pages 433-446

  Ham, Ju Ri ^a   Lee, Hae In ^b   Choi, Ra Yeong ^a   Sim, Mi Ok ^c   Choi, Myung Sook ^d   Kwon, Eun Young ^d   Yun, Kyeong Won ^a   Kim, Myung Joo ^e   Lee, Mi Kyung ^a  

^a Sunchon National University   (South Korea)

^b Mokpo Marin Food Industry Research Center   (South Korea)

^c National Development Institute of Korea Medicine   (South Korea)

^d Kyungpook National University   (South Korea)

^e Suseong College   (South Korea)

Author keywords

High fat; Non alcoholic liver disease; Obesity; Scopoletin; Transcriptome

Indexed keywords

EID: 84978477123     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2016.06.026     Document Type: Article

References (71)

1. Acharyya S., Villalta S.A., Bakkar N., Bupha-Intr T., Janssen P.M., Carathers M., Guttridge D.C. Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. The Journal of Clinical Investigation 2007, 117(4):889-901.
2. American Institute of Nutrition Report of the American Institute of Nutrition ad hoc Committee on Standards for Nutritional Studies. The Journal of Nutrition 1977, 107:1340-1348.
3. Bentle L.A., Lardy H.A. Interaction of anions and divalent metal ions with phosphoenolpyruvate carboxykinase. The Journal of Biological Chemistry 1976, 251(10):2916-2921.
4. Bieber L., Abraham T., Helmrath T. A rapid spectrophotometric assay for carnitine palmitoyltransferase. Analytical Biochemistry 1972, 50(2):509-518.
5. Bonaterra G.A., Zugel S., Thogersen J., Walter S.A., Haberkorn U., Strelau J., Kinscherf R. Growth differentiation factor-15 deficiency inhibits atherosclerosis progression by regulating interleukin-6-dependent inflammatory response to vascular injury. Journal of the American Heart Association 2012, 1(6):e002550.
6. Bootcov M.R., Bauskin A.R., Valenzuela S.M., Moore A.G., Bansal M., He X.Y., Zhang H.P., Donnellan M., Mahler S., Pryor K., Walsh B.J., Nicholson R.C., Fairlie W.D., Por S.B., Robbins J.M., Breit S.N. MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proceedings of the National Academy of Sciences of the United States of America 1997, 94(21):11514-11519.
7. Carpinella M.C., Ferrayoli C.G., Palacios S.M. Antifungal synergistic effect of scopoletin, a hydroxycoumarin isolated from Melia azedarach L. fruits. Journal of Agricultural and Food Chemistry 2005, 53(8):2922-2927.
8. Catalan V., Gomez-Ambrosi J., Rodriguez A., Ramirez B., Silva C., Rotellar F., Gill M.J., Cienfuegos J.A., Salvador J., Frühbeck G. Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans. Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte" 2009, 87(8):803-813.
9. Chang T., Deng J., Chang Y., Lee C., Jung-Chun L., Lee M., Peng W.H., Huang S.S., Huang G. Ameliorative effects of scopoletin from Crossostephium chinensis against inflammation pain and its mechanisms in mice. Evidence-based Complementary and Alternative Medicine 2012, 2012:595603.
10. Chang W., Wu S., Xu K., Liao B., Wu J., Cheng A. Scopoletin protects against methylglyoxal-induced hyperglycemia and insulin resistance mediated by suppression of advanced glycation endproducts (AGEs) generation and anti-glycation. Molecules: A Journal of Synthetic Chemistry and Natural Product Chemistry 2015, 20(2):2786-2801.
11. Cho Y., Chung J.H., Do H.J., Jeon H.J., Jin T., Shin M. Effects of fisetin supplementation on hepatic lipogenesis and glucose metabolism in Sprague-Dawley rats fed on a high fat diet. Food Chemistry 2013, 139(1):720-727.
12. de Meijer V.E., Sverdlov D.Y., Le H.D., Popov Y., Puder M. Tissue-specific differences in inflammatory infiltrate and matrix metalloproteinase expression in adipose tissue and liver of mice with diet-induced obesity. Hepatology Research 2012, 42(6):601-610.
13. Davidson A.L., Arion W.J. Factors underlying significant underestimations of glucokinase activity in crude liver extracts: Physiological implications of higher cellular activity. Archives of Biochemistry and Biophysics 1987, 253(1):156-167.
14. Do G., Kwon E., Kim E., Kim H., Choi M. Hepatic transcription response to high-fat treatment in mice: Microarray comparison of individual vs. pooled RNA samples. Biotechnology Journal 2010, 5(9):970-973.
15. Duarte N., Coelho I.C., Patarrão R.S., Almeida J.I., Penha-Gonçalves C., Macedo M.P., Macedo M.P. How inflammation impinges on NAFLD: A role for Kupffer cells. BioMed Research International 2015, 2015:984578.
16. Firuzi O., Miri R., Tavakkoli M., Saso L. Antioxidant therapy: Current status and future prospects. Current Medicinal Chemistry 2011, 18(25):3871-3888.
17. Folch J., Lees M., Sloane-Stanley G. A simple method for the isolation and purification of total lipids from animal tissues. Journal of Biological Chemistry 1957, 226(1):497-509.
18. Forino M., Tartaglione L., Dell'Aversano C., Ciminiello P. NMR-based identification of the phenolic profile of fruits of Lycium barbarum (goji berries). isolation and structural determination of a novel N-feruloyl tyramine dimer as the most abundant antioxidant polyphenol of goji berries. Food Chemistry 2016, 194:1254-1259.
19. Ganji S.H., Kashyap M.L., Kamanna V.S. Niacin inhibits fat accumulation, oxidative stress, and inflammatory cytokine IL-8 in cultured hepatocytes: Impact on non-alcoholic fatty liver disease. Metabolism: Clinical and Experimental 2015, 64(9):982-990.
20. Gawrieh S., Baye T.M., Carless M., Wallace J., Komorowski R., Kleiner D.E., Andris D., Makladi B., Cole R., Charlton M., Curran J., Dyer T.D., Charlesworth J., Wilke R., Blangero J., Kissebah A.H., Olivier M. Hepatic gene networks in morbidly obese patients with nonalcoholic fatty liver disease. Obesity Surgery 2010, 20(12):1698-1709.
21. Gnonlonfin B.G., Gbaguidi F., Gbenou J.D., Sanni A., Brimer L. Changes in scopoletin concentration in cassava chips from four varieties during storage. Journal of the Science of Food and Agriculture 2011, 91(13):2344-2347.
22. Gummesson A., Jernås M., Svensson P., Larsson I., Glad C.A., Schéle E., Gripeteg L., Sjöholm K., Lystig T.C., Sjöström L., Carlsson B., Fagerberg B., Carlsson L.M. Relations of adipose tissue CIDEA gene expression to basal metabolic rate, energy restriction, and obesity: Population-based and dietary intervention studies. The Journal of Clinical Endocrinology & Metabolism 2007, 92(12):4759-4765.
23. Hernandez Vera R., Vilahur G., Ferrer-Lorente R., Pena E., Badimon L. Platelets derived from the bone marrow of diabetic animals show dysregulated endoplasmic reticulum stress proteins that contribute to increased thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology 2012, 32(9):2141-2148.
24. Hsiao E.C., Koniaris L.G., Zimmers-Koniaris T., Sebald S.M., Huynh T.V., Lee S.J. Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury. Molecular and Cellular Biology 2000, 20(10):3742-3751.
25. Ikejima K., Takei Y., Honda H., Hirose M., Yoshikawa M., Zhang Y., Lang T., Fukuda T., Yamashina S., Kitamura T., Sato N. Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Gastroenterology 2002, 122(5):1399-1410.
26. Im J., Ki H., Xin M., Kwon S., Kim Y.H., Kim D., Hong S., Jin J., Lee Y. Anti-obesity effect of Triticum aestivum sprout extract in high-fat-diet-induced obese mice. Bioscience, Biotechnology, and Biochemistry 2015, 1-8. ahead-of-print.
27. Inoue N., Shimano H., Nakakuki M., Matsuzaka T., Nakagawa Y., Yamamoto T., Sato R., Takahashi A., Sone H., Yahagi N., Suzuki H., Toyoshima H., Yamada N. Lipid synthetic transcription factor SREBP-1a activates p21WAF1/CIP1, a universal cyclin-dependent kinase inhibitor. Molecular and Cellular Biology 2005, 25(20):8938-8947.
28. Issell B.F., Franke A., Fielding R.M. Pharmacokinetic study of Noni fruit extract. Journal of Dietary Supplements 2008, 5(4):373-382.
29. Jang S., Kim M., Choi M., Kwon E., Lee M. Inhibitory effects of ursolic acid on hepatic polyol pathway and glucose production in streptozotocin-induced diabetic mice. Metabolism: Clinical and Experimental 2010, 59(4):512-519.
30. Ku B.J., Kim T.H., Lee J.H., Buras E.D., White L.D., Stevens R.D., Ilkayeva O.R., Bain J.R., Newgard C.B., DeMayo F.J., Jeong J.W. Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis. PLoS ONE 2012, 7(8). e42915.
31. Lazarow P.B. Assay of peroxisomal beta-oxidation of fatty acids. Methods in Enzymology 1981, 72:315-319.
32. Lee H., Lee M. Coordinated regulation of scopoletin at adipose tissue-liver axis improved alcohol-induced lipid dysmetabolism and inflammation in rats. Toxicology Letters 2015, 237(3):210-218.
33. Lee H., Seo K., Yun K.W., Kim M., Lee M. Comparative study of the hepatoprotective efficacy of Artemisia iwayomogi and Artemisia capillaris on ethanol-administered mice. Journal of Food Science 2011, 76(9):T207-T211.
34. - δδCT method. Methods : A Companion to Methods in Enzymology 2001, 25(4):402-408.
35. Machado M., Cortez-Pinto H. Non-alcoholic fatty liver disease and insulin resistance. European Journal of Gastroenterology & Hepatology 2005, 17(8):823-826.
36. Mandukhail S.U., Aziz N., Gilani A.H. Studies on antidyslipidemic effects of Morinda citrifolia (Noni) fruit, leaves and root extracts. Lipids in Health and Disease 2010, 9:88.
37. Marra F., Bertolani C. Adipokines in liver diseases. Hepatology (Baltimore, Md.) 2009, 50(3):957-969.
38. Matsumoto S., Mizutani M., Sakata K., Shimizu B. Molecular cloning and functional analysis of the ortho-hydroxylases of p-coumaroyl coenzyme A/feruloyl coenzyme A involved in formation of umbelliferone and scopoletin in sweet potato, Ipomoea batatas (L.) lam. Phytochemistry 2012, 74:49-57.
39. Matsusue K., Kusakabe T., Noguchi T., Takiguchi S., Suzuki T., Yamano S., Gonzalez F.J. Hepatic steatosis in leptin-deficient mice is promoted by the PPARγ target gene Fsp27. Cell Metabolism 2008, 7(4):302-311.
40. Mishkinsky J.S., Goldschmied A., Joseph B., Ahronson Z., Sulman F.G. Hypoglycaemic effect of Trigonella foenum graecum and Lupinus termis (leguminosae) seeds and their major alkaloids in alloxan-diabetic and normal rats. Archives Internationales de Pharmacodynamie et de Therapie 1974, 210(1):27-37.
41. Nayak S., Shettigar R. Morinda citrifolia: A review. Journal of Pharmacy Research 2010, 3(8):1872-1874.
42. Nepokroeff C.M., Lakshmanan M.R., Porter J.W. Fatty-acid synthase from rat liver. Methods in Enzymology 1975, 35:37-44.
43. Netzer N., Gatterer H., Faulhaber M., Burtscher M., Pramsohler S., Pesta D. Hypoxia, oxidative stress and fat. Biomolecules 2015, 5(2):1143-1150.
44. Newgard C.B., McGarry J.D. Metabolic coupling factors in pancreatic β-cell signal transduction. Annual Review of Biochemistry 1995, 64(1):689-719.
45. Nieschulz O., Schmersahl P. On choleretic agents from Artemisia abrotanum L. Arzneimittel-Forschung 1968, 18(10):1330-1336.
46. Ojewole J., Adesina S. Mechanism of the hypotensive effect of scopoletin isolated from the fruit of Tetrapleura tetraptera. Planta Medica 1983, 49(9):46-50.
47. Pandy V., Narasingam M., Kunasegaran T., Murugan D.D., Mohamed Z. Effect of Noni (Morinda citrifolia Linn.) fruit and its bioactive principles scopoletin and rutin on rat vas deferens contractility: An ex vivo study. TheScientificWorldJournal 2014, 2014:909586.
48. Puri V., Ranjit S., Konda S., Nicoloro S.M., Straubhaar J., Chawla A., Chouinard M., Lin C., Burkart A., Corvera S., Perugini R.A., Czech M.P. Cidea is associated with lipid droplets and insulin sensitivity in humans. Proceedings of the National Academy of Sciences of the United States of America 2008, 105(22):7833-7838.
49. Raso G.M., Simeoli R., Russo R., Iacono A., Santoro A., Paciello O., Ferrante M.C., Conani R.B., Calignano A., Meli R. Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet. PLoS ONE 2013, 8(7). e68626.
50. Reagan-Shaw S., Nihal M., Ahmad N. Dose translation from animal to human studies revisited. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 2008, 22(3):659-661.
51. Renaud H.J., Cui J.Y., Lu H., Klaassen C.D. Effect of diet on expression of genes involved in lipid metabolism, oxidative stress, and inflammation in mouse liver-insights into mechanisms of hepatic steatosis 2014.
52. Russell D.W., Setchell K.D. Bile acid biosynthesis. Biochemistry 1992, 31(20):4737-4749.
53. San-Miguel B., Crespo I., Kretzmann N.A., Mauriz J.L., Marroni N., Tunon M.J., Gonzalez-Gallego J. Glutamine prevents fibrosis development in rats with colitis induced by 2,4,6-trinitrobenzene sulfonic acid. The Journal of Nutrition 2010, 140(6):1065-1071.
54. Seo K., Choi M., Jung U.J., Kim H., Yeo J., Jeon S., Lee M. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice. Molecular Nutrition & Food Research 2008, 52(9):995-1004.
55. Seo K., Jeong H., Yun K. Antimicrobial activity and chemical components of two plants, Artemisia capillaris and Artemisia iwayomogi, used as Korean herbal Injin. Journal of Ecology and Environment 2010, 33(2):141-147.
56. Shaw C., Chen C., Hsu C., Chen C., Tsai Y. Antioxidant properties of scopoletin isolated from Sinomonium acutum. Phytotherapy Research 2003, 17(7):823-825.
57. Shoelson S.E., Lee J., Goldfine A.B. Inflammation and insulin resistance. The Journal of Clinical Investigation 2006, 116(7):1793-1801.
58. Sim M., Ham J.R., Lee H., Seo K., Lee M. Long-term supplementation of umbelliferone and 4-methylumbelliferone alleviates high-fat diet induced hypertriglyceridemia and hyperglycemia in mice. Chemico-Biological Interactions 2014, 216:9-16.
59. Subramanian S., Goodspeed L., Wang S., Kim J., Zeng L., Ioannou G.N., Yeh M.M., Kowdley K.V., O'Brien K.D., Pennathur S., Chait A. Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice. Journal of Lipid Research 2011, 52(9):1626-1635.
60. Takasaki M., Honma T., Yanaka M., Sato K., Shinohara N., Ito J., Tanaka Y., Tsuduki T., Ikeda I. Continuous intake of a high-fat diet beyond one generation promotes lipid accumulation in liver and white adipose tissue of female mice. The Journal of Nutritional Biochemistry 2012, 23(6):640-645.
61. VerHague M.A., Cheng D., Weinberg R.B., Shelness G.S. Apolipoprotein A-IV expression in mouse liver enhances triglyceride secretion and reduces hepatic lipid content by promoting very low density lipoprotein particle expansion. Arteriosclerosis, Thrombosis, and Vascular Biology 2013, 33(11):2501-2508.
62. Vernon G., Baranova A., Younossi Z. Systematic review: The epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Alimentary Pharmacology & Therapeutics 2011, 34(3):274-285.
63. 2+-dependent phosphatidate phosphohydrolase in pulmonary glycerolipid biosynthesis. Biochimica et Biophysica Acta 1984, 796(3):364-372.
64. Wang X., Ren Q., Wu T., Guo Y., Liang Y., Liu S. Ezetimibe prevents the development of non-alcoholic fatty liver disease induced by high-fat diet in C57BL/6J mice. Molecular Medicine Reports 2014, 10(6):2917-2923.
65. Watanabe M., Houten S.M., Wang L., Moschetta A., Mangelsdorf D.J., Heyman R.A., Moore D.D., Auwerx J. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. The Journal of Clinical Investigation 2004, 113(10):1408-1418.
66. Woo M., Jeon S., Kim H., Lee M., Shin S., Shin Y.C., Park Y.B., Choi M. Fucoxanthin supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration in high-fat fed C57BL/6N mice. Chemico-Biological Interactions 2010, 186(3):316-322.
67. Xu X., Park J.G., So J.S., Hur K.Y., Lee A.H. Transcriptional regulation of apolipoprotein A-IV by the transcription factor CREBH. Journal of Lipid Research 2014, 55(5):850-859.
68. Yang R., Lee M., Hu H., Pollin T.I., Ryan A.S., Nicklas B.J., Snitker S., Horenstein R.B., Hull K., Goldberg N.H., Goldberg A.P., Shuldiner A.R., Fried S.K., Gong D.W. Acute-phase serum amyloid A: An inflammatory adipokine and potential link between obesity and its metabolic complications. PLoS Medicine 2006, 3(6):e287.
69. Yoon Y., Chung M.Y., Hwang J., Han M.S., Goo T., Yun E. Allomyrina dichotoma (Arthropoda: Insecta) larvae confer resistance to obesity in mice fed a high-fat diet. Nutrients 2015, 7(3):1978-1991.
70. Zhang L., Yang B., Yu B. Paeoniflorin protects against nonalcoholic fatty liver disease induced by a high-fat diet in mice. Biological and Pharmaceutical Bulletin 2015, 38(7):1005-1011.
71. Zhou L., Xu L., Ye J., Li D., Wang W., Li X., Wu L., Wang H., Guan F., Li P. Cidea promotes hepatic steatosis by sensing dietary fatty acids. Hepatology (Baltimore, Md.) 2012, 56(1):95-107.