Endothelial restoration of receptor activity-modifying protein 2 is sufficient to rescue lethality, but survivors develop dilated cardiomyopathy

Hypertension

Volumn 68, Issue 3, 2016, Pages 667-677

  Kechele, Daniel O ^a   Dunworth, William P ^b   Trincot, Claire E ^b   Wetzel Strong, Sarah E ^a   Li, Manyu ^a   Ma, Hong ^a   Liu, Jiandong ^a   Caron, Kathleen M ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

calcitonin receptor like receptor; cardiomyopathy, dilated; endothelium; G protein coupled receptor; hypotensionreceptor activity modifying protein

Indexed keywords

ADRENOMEDULLIN RECEPTOR; CALCITONIN RECEPTOR; CALCITONIN RECEPTOR LIKE RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLUCAGON RECEPTOR; PARATHYROID HORMONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; RECEPTOR ACTIVITY MODIFYING PROTEIN 2; VASCULAR ENDOTHELIAL CADHERIN; MEMBRANE PROTEIN; RAMP2 PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR FUNCTION; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; FEMALE; HYPOTENSION; LETHALITY; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; UPREGULATION; ANALYSIS OF VARIANCE; ANIMAL; C57BL MOUSE; CARDIAC MUSCLE; DISEASE MODEL; GENETICS; HOMEOSTASIS; METABOLISM; MORTALITY; NONPARAMETRIC TEST; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; SIGNAL TRANSDUCTION; SURVIVOR; TRANSGENIC MOUSE;

ANALYSIS OF VARIANCE; ANIMALS; CARDIOMYOPATHY, DILATED; DISEASE MODELS, ANIMAL; HOMEOSTASIS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCARDIUM; RANDOM ALLOCATION; RECEPTOR ACTIVITY-MODIFYING PROTEIN 2; RECEPTORS, ADRENOMEDULLIN; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC; SURVIVORS;

EID: 84978112058     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.116.07191     Document Type: Article

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