Noninvasive Cardiovascular Risk Assessment of the Asymptomatic Diabetic Patient: The Imaging Council of the American College of Cardiology

JACC: Cardiovascular Imaging

Volumn 9, Issue 2, 2016, Pages 176-192

  Budoff, Matthew J ^a   Raggi, Paolo ^b   Beller, George A ^c   Berman, Daniel S ^d   Druz, Regina S ^e   Malik, Shaista ^f   Rigolin, Vera H ^g   Weigold, Wm Guy ^h   Soman, Prem ⁱ  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF VIRGINIA   (United States)

^d CEDARS SINAI MEDICAL CENTER   (United States)

^e DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g NORTHWESTERN UNIVERSITY   (United States)

^h WASHINGTON HOSPITAL CENTER   (United States)

ⁱ UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

coronary CT; diabetes; echocardiography; exercise testing; nuclear imaging

Indexed keywords

RADIOISOTOPE;

ARTERIAL WALL THICKNESS; ASYMPTOMATIC DISEASE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MAGNETIC RESONANCE; CARDIOVASCULAR RISK; CHRONIC KIDNEY DISEASE; CLASSIFICATION ALGORITHM; CLINICAL FEATURE; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY CALCIUM SCORE; CORONARY RISK; DIABETIC PATIENT; ECHOCARDIOGRAPHY; EXERCISE TEST; HIGH RISK PATIENT; HUMAN; ISCHEMIC HEART DISEASE; MEDICAL SOCIETY; NON INSULIN DEPENDENT DIABETES MELLITUS; NON INVASIVE PROCEDURE; PRACTICE GUIDELINE; PREDICTIVE VALUE; PREVALENCE; PRIORITY JOURNAL; REVIEW; SEX DIFFERENCE; STRATIFICATION; ALGORITHM; CARDIOLOGY; CARDIOVASCULAR DISEASES; CLINICAL PROTOCOL; DIABETES COMPLICATIONS; DIAGNOSTIC IMAGING; FEMALE; MALE; MORTALITY; PROCEDURES; PROGNOSIS; RISK ASSESSMENT; RISK FACTOR; UNITED STATES;

ALGORITHMS; ASYMPTOMATIC DISEASES; CARDIOLOGY; CARDIOVASCULAR DISEASES; CLINICAL PROTOCOLS; DIABETES COMPLICATIONS; DIAGNOSTIC IMAGING; EXERCISE TEST; FEMALE; HUMANS; MALE; PRACTICE GUIDELINES AS TOPIC; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RISK ASSESSMENT; RISK FACTORS; SEX FACTORS; SOCIETIES, MEDICAL; UNITED STATES;

EID: 84977631420     PISSN: 1936878X     EISSN: 18767591     Source Type: Journal    
DOI: 10.1016/j.jcmg.2015.11.011     Document Type: Review

References (147)

1. 1 Engelgau, M.M., Geiss, L.S., Saaddine, J.B., et al. The evolving diabetes burden in the United States. Ann Intern Med 140 (2004), 945–950.
2. 2 Zimmet, P., Alberti, K.G., Shaw, J., Global and societal implications of the diabetes epidemic. Nature 414 (2001), 782–787.
3. 3 Sarwar, N., Gao, P., Seshasai, S.R., et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet 375 (2010), 2215–2222.
4. 4 Kannel, W.B., McGee, D.L., Diabetes and glucose tolerance as risk factors for cardiovascular disease: the Framingham study. Diabetes Care 2 (1979), 120–126.
5. 5 Gu, K., Cowie, C.C., Harris, M.I., Mortality in adults with and without diabetes in a national cohort of the US population, 1971–1993. Diabetes Care 21 (1998), 1138–1145.
6. 6 Haffner, S.M., Lehto, S., Rönnemaa, T., et al. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 339 (1998), 229–234.
7. 7 Natarajan, S., Liao, Y., Cao, G., Lipsitz, S.R., McGee, D.L., Sex differences in risk for coronary heart disease mortality associated with diabetes and established coronary heart disease. Arch Intern Med 163 (2003), 1735–1740.
8. 8 Pajunen, P., Koukkunen, H., Ketonen, M., et al. Myocardial infarction in diabetic and non-diabetic persons with and without prior myocardial infarction: the FINAMI Study. Diabetologia 48 (2005), 2519–2524.
9. 9 Hu, F.B., Stampfer, M.J., Solomon, C.G., et al. The impact of diabetes mellitus on mortality from all causes and coronary heart disease mortality in women: 20 years of follow-up. Arch Intern Med 161 (2001), 1717–1723.
10. 10 Natarajan, S., Liao, Y., Sinha, D., Cao, G., McGee, D.L., Lipsitz, S.R., Sex differences in the effect of diabetes duration on coronary heart disease mortality. Arch Intern Med 165 (2005), 430–435.
11. 11 Lotufo, P.A., Gaziano, J.M., Chae, C.U., et al. Diabetes and all cause and coronary heart disease mortality among US male physicians. Arch Intern Med 161 (2001), 242–247.
12. 12 Vaccaro, O., Eberly, L.E., Neaton, J.D., Yang, L., Riccardi, G., Stamler, J., Impact of diabetes and previous myocardial infarction on long-term survival: 25-year mortality follow-up of primary screeners of the Multiple Risk Factor Intervention Trial. Arch Intern Med 164 (2004), 1438–1443.
13. 13 Evans, J.M., Wang, J., Morris, A.D., Comparison of cardiovascular risk between patients with Type 2 diabetes and those who had myocardial infarction: cross-sectional and cohort studies. Br Med J 324 (2002), 939–942.
14. 14 Hu, G., Jousilahti, P., Qiao, Q., Katoh, S., Tuomilehto, J., Sex differences in cardiovascular and total mortality among diabetic and nondiabetic individuals with and without history of myocardial infarction. Diabetologia 48 (2005), 656–661.
15. 15 Bulugahapitiya, U., Siyambalapitiya, S., Sithole, J., Idris, I., Is diabetes a coronary risk equivalent? Systematic review and meta-analysis. Diabet Med 26 (2009), 142–148.
16. 16 American Diabetes Association. Standards of medical care in diabetes—2013. Diabetes Care 36:Suppl 1 (2013), S11–S66.
17. 17 Perk, J., De Backer, G., Gohlke, H., et al. European guidelines on cardiovascular disease prevention in clinical practice (version 2012): The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice. Eur Heart J 33 (2012), 1635–1701.
18. 18 Greenland, P., Bonow, R.O., Brundage, B.H., et al. ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography). J Am Coll Cardiol 49 (2007), 378–402.
19. 19 Greenland, P., Alpert, J.S., Beller, G.A., et al. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 56 (2010), 50–103.
20. 20 Curtis, J.M., Horton, E.S., Bahnson, J., et al. Prevalence and predictors of abnormal cardiovascular responses to exercise testing among individuals with type 2 diabetes: the Look AHEAD (Action for Health in Diabetes) study. Diabetes Care 33 (2010), 901–907.
21. 21 Turrini, F., Messora, R., Giovanardi, P., et al. Screening asymptomatic patients with diabetes for unknown coronary artery disease: does it reduce risk? An open-label randomized trial comparing a strategy based on exercise testing aimed at revascularization with management based on pharmacological/behavioural treatment of traditional risk factors. DADDY-D Trial (Does coronary Atherosclerosis Deserve to be Diagnosed and treated early in Diabetics?). Trials, 10, 2009, 119.
22. 22 Turrini, F., Scarlini, S., Mannucci, C., et al. Does coronary atherosclerosis deserve to be diagnosed and treated early in diabetic patients? The DADDY-D Trial. Screening diabetic patients for unknown coronary disease. Eur J Intern Med 26 (2015), 407–413.
23. 23 Banthia, S., Bergner, D.W., Chicos, A.B., et al. Detection of cardiovascular autonomic neuropathy using exercise testing in patients with type 2 diabetes mellitus. J Diabetes Complications 27 (2013), 64–69.
24. 24 Georgoulias, P., Demakopoulos, N., Orfanakis, A., et al. Evaluation of abnormal heart-rate recovery after exercise testing in patients with diabetes mellitus: correlation with myocardial SPECT and chronotropic parameters. Nucl Med Commun 28 (2007), 165–171.
25. 25 Cheng, Y.J., Lauer, M.S., Earnest, C.P., et al. Heart rate recovery following maximal exercise testing as a predictor of cardiovascular disease and all-cause mortality in men with diabetes. Diabetes Care 26 (2003), 2052–2057.
26. 26 Naka, M., Hiramatsu, K., Aizawa, T., et al. Silent myocardial ischemia in patients with non-insulin-dependent diabetes mellitus as judged by treadmill exercise testing and coronary angiography. Am Heart J 123 (1992), 46–53.
27. 27 Chambless, L.E., Heiss, G., Folsom, A.R., et al. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987–1993. Am J Epidemiol 146 (1997), 483–494.
28. 28 Taylor, A.J., Kent, S.M., Flaherty, P.J., Coyle, L.C., Markwood, T.T., Vernalis, M.N., ARBITER: Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol: a randomized trial comparing the effects of atorvastatin and pravastatin on carotid intima medial thickness. Circulation 106 (2002), 2055–2060.
29. 29 Chambless, L.E., Folsom, A.R., Davis, V., et al. Risk factors for progression of common carotid atherosclerosis: the Atherosclerosis Risk in Communities Study, 1987–1998. Am J Epidemiol 155 (2002), 38–47.
30. 30 Burke, G.L., Evans, G.W., Riley, W.A., et al. Arterial wall thickness is associated with prevalent cardiovascular disease in middle-aged adults. The Atherosclerosis Risk in Communities (ARIC) Study. Stroke 26 (1995), 386–391.
31. 31 Goff, D.C. Jr., Lloyd-Jones, D.M., Bennett, G., et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 63:25 Pt B (2014), 2935–2959.
32. 32 Yeboah, J., McClelland, R.L., Polonsky, T.S., et al. Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals. JAMA 308 (2012), 788–795.
33. 33 Den Ruijter, H.M., Peters, S.A., Anderson, T.J., et al. Common carotid intima-media thickness measurements in cardiovascular risk prediction: a meta-analysis. JAMA 308 (2012), 796–803.
34. 34 Malik, S., Budoff, M.J., Katz, R., et al. Impact of subclinical atherosclerosis on cardiovascular disease events in individuals with metabolic syndrome and diabetes: the Multi-Ethnic Study of Atherosclerosis. Diabetes Care 34 (2011), 2285–2290.
35. 35 Rumberger, J.A., Simons, D.B., Fitzpatrick, L.A., Sheedy, P.F., Schwartz, R.S., Coronary artery calcium area by electron beam computed tomography and coronary atherosclerotic plaque area: a histopathologic correlative study. Circulation 92 (1995), 2157–2162.
36. 36 Detrano, R., Guerci, A.D., Carr, J.J., et al. Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med 358 (2008), 1336–1345.
37. 37 Budoff, M.J., Möhlenkamp, S., McClelland, R., et al. A comparison of outcomes with coronary artery calcium scanning in unselected populations: the Multi-Ethnic Study of Atherosclerosis (MESA) and Heinz Nixdorf RECALL study (HNR). J Cardiovasc Comput Tomogr 7 (2013), 182–191.
38. 38 Wong, N.D., Sciammarella, M.G., Polk, D., et al. The metabolic syndrome, diabetes, and subclinical atherosclerosis assessed by coronary calcium. J Am Coll Cardiol 41 (2003), 1547–1553.
39. 39 Mielke, C.H., Shields, J.P., Broemeling, L.D., Coronary artery calcium, coronary artery disease, and diabetes. Diabetes Res Clin Pract 53 (2001), 55–61.
40. 40 Schurgin, S., Rich, S., Mazzone, T., Increased prevalence of significant coronary artery calcification in patients with diabetes. Diabetes Care 24 (2001), 335–338.
41. 41 Khaleeli, E., Peters, S.R., Bobrowsky, K., Oudiz, R.J., Ko, J.Y., Budoff, M.J., Diabetes and the associated incidence of subclinical atherosclerosis and coronary artery disease: implications for management. Am Heart J 141 (2001), 637–644.
42. 42 Dabelea, D., Kinney, G., Snell-Bergeon, J.K., et al. Effect of type 1 diabetes on the gender difference in coronary artery calcification: a role for insulin resistance? The Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study. Diabetes 52 (2003), 2833–2839.
43. 43 Starkman, H.S., Cable, G., Hala, V., Hecht, H., Donnelly, C.M., Delineation of prevalence and risk factors for early coronary artery disease by electron beam computed tomography in young adults with type 1 diabetes. Diabetes Care 26 (2003), 433–436.
44. 44 Hokanson, J.E., Cheng, S., Snell-Bergeon, J.K., et al. A common promoter polymorphism in the hepatic lipase gene (LIPC-480C_T) is associated with an increase in coronary calcification in type 1 diabetes. Diabetes 51 (2002), 1208–1213.
45. 45 Snell-Bergeon, J.K., Hokanson, J.E., Jensen, L., et al. Progression of coronary artery calcification in type 1 diabetes: the importance of glycemic control. Diabetes Care 26 (2003), 2923–2928.
46. 46 Berman, D.S., Wong, N.D., Gransar, H., et al. Relationship between stress-induced myocardial ischemia and atherosclerosis measured by coronary calcium tomography. J Am Coll Cardiol 44 (2004), 923–930.
47. 47 He, Z.X., Hedrick, T.D., Pratt, C.M., et al. Severity of coronary artery calcification by electron beam computed tomography predicts silent myocardial ischemia. Circulation 101 (2000), 244–251.
48. 48 Wong, N.D., Rozanski, A., Gransar, H., et al. Metabolic syndrome and diabetes are associated with an increased likelihood of inducible myocardial ischemia among patients with subclinical atherosclerosis. Diabetes Care 28 (2005), 1445–1450.
49. 49 Anand, D.V., Lim, E., Hopkins, D., et al. Risk stratification in uncomplicated type 2 diabetes: prospective evaluation of the combined use of coronary artery calcium imaging and selective myocardial perfusion scintigraphy. Eur Heart J 27 (2006), 713–721.
50. 50 Yeboah, J., Erbel, R., Delaney, J.C., et al. Development of a new diabetes risk prediction tool for incident coronary heart disease events: The Multi-Ethnic Study of Atherosclerosis and the Heinz Nixdorf Recall Study. Atherosclerosis 236 (2014), 411–417.
51. 51 Raggi, P., Shaw, L.J., Berman, D.S., Callister, T.Q., Prognostic value of coronary artery calcium screening in subjects with and without diabetes. J Am Coll Cardiol 43 (2004), 1663–1669.
52. 52 Moebus, S., Stang, A., Möhlenkamp, S., et al., for the Heinz Nixdorf Recall Study Group. Association of impaired fasting glucose and coronary artery calcification as a marker of subclinical atherosclerosis in a population-based cohort—results of the Heinz Nixdorf Recall Study. Diabetologia 52 (2009), 81–89.
53. 53 Lehmann, N., Möhlenkamp, S., Mahabadi, A.A., et al. Effect of smoking and other traditional risk factors on the onset of coronary artery calcification: results of the Heinz Nixdorf Recall study. Atherosclerosis 232 (2014), 339–345.
54. 54 Silverman, M.G., Blaha, M.J., Budoff, M.J., et al. Potential implications of coronary artery calcium testing for guiding aspirin use among asymptomatic individuals with diabetes. Diabetes Care 35 (2012), 624–626.
55. 55 Kronmal, R.A., McClelland, R.L., Detrano, R., et al. Risk factors for the progression of coronary artery calcification in asymptomatic subjects: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 115 (2007), 2722–2730.
56. 56 Erbel, R., Lehmann, N., Churzidse, S., et al., on behalf of the Heinz Nixdorf Recall Study Investigators. Progression of coronary artery calcification seems to be inevitable, but predictable—results of the Heinz Nixdorf Recall (HNR) study. Eur Heart J 35 (2014), 2960–2971.
57. 57 Pandey, A.K., Blaha, M.J., Sharma, K., et al. Family history of coronary heart disease and the incidence and progression of coronary artery calcification: Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 232 (2014), 369–376.
58. 58 Wong, N.D., Nelson, J.C., Granston, T., et al. Metabolic syndrome, diabetes, and incidence and progression of coronary calcium: the Multi-Ethnic Study of Atherosclerosis study. J Am Coll Cardiol Img 5 (2012), 358–366.
59. 59 Anand, D.V., Lim, E., Darko, D., et al. Determinants of progression of coronary artery calcification in type 2 diabetes: role of glycemic control and inflammatory/vascular calcification markers. J Am Coll Cardiol 50 (2007), 2218–2225.
60. 60 Budoff, M.J., Hokanson, J.E., Nasir, K., et al. Progression of coronary artery calcium predicts all-cause mortality. J Am Coll Cardiol Img 3 (2010), 1229–1236.
61. 61 Raggi, P., Cooil, B., Ratti, C., Callister, T.Q., Budoff, M., Progression of coronary calcification and occurrence of myocardial infarction in patients with and without diabetes mellitus. Hypertension 46 (2005), 238–243.
62. 62 Kiramijyan, S., Ahmadi, N., Isma'eel, H., et al. Impact of coronary artery calcium progression and statin therapy on clinical outcome in subjects with and without diabetes mellitus. Am J Cardiol 111 (2013), 356–361.
63. 63 Boudina, S., Abel, E.D., Diabetic cardiomyopathy revisited. Circulation 115 (2007), 3213–3223.
64. 64 Galderisi, M., Diastolic dysfunction and diabetic cardiomyopathy: evaluation by Doppler echocardiography. J Am Coll Cardiol 48 (2006), 1548–1551.
65. 65 Galderisi, M., Anderson, K.M., Wilson, P.W., Levy, D., Echocardiographic evidence for the existence of a distinct diabetic cardiomyopathy (The Framingham Heart Study). Am J Cardiol 68 (1991), 85–89.
66. 66 Devereux, R.B., Roman, M.J., Paranicas, M., et al. Impact of diabetes on cardiac structure and function: the Strong Heart Study. Circulation 101 (2000), 2271–2276.
67. 67 Di Cori, A., Di Bello, V., Miccoli, R., et al. Left ventricular function in normotensive young adults with well-controlled type 1 diabetes mellitus. Am J Cardiol 99 (2007), 84–90.
68. 68 Ha, J.W., Lee, H.C., Kang, E.S., et al. Abnormal left ventricular longitudinal functional reserve in patients with diabetes mellitus: implications for detecting subclinical myocardial dysfunction using exercise tissue Doppler echocardiography. Heart 93 (2007), 1571–1576.
69. 69 Boyer, J.K., Thanigaraj, S., Schechtman, K.B., Perez, J.E., Prevalence of ventricular diastolic dysfunction in asymptomatic, normotensive patients with diabetes mellitus. Am J Cardiol 93 (2004), 870–875.
70. 70 Zabalgoitia, M., Ismaeil, M.F., Anderson, L., Maklady, F.A., Prevalence of diastolic dysfunction in normotensive, asymptomatic patients with well controlled type 2 diabetes mellitus. Am J Cardiol 87 (2001), 320–323.
71. 71 Kadappu, K.K., Boyd, A., Eshoo, S., et al. Changes in left atrial volume in diabetes mellitus: more than diastolic dysfunction?. Eur Heart J Cardiovasc Imaging 13 (2012), 1016–1023.
72. 72 Marwick, T.H., Case, C., Sawada, S., Vasey, C., Short, L., Lauer, M., Use of stress echocardiography to predict mortality in patients with diabetes and known or suspected coronary artery disease. Diabetes Care 25 (2002), 1042–1048.
73. 73 Elhendy, A., Adelaide, A.M., Mahoney, D.W., Pellikka, P.A., Prognostic stratification of diabetic patients by exercise echocardiography. J Am Coll Cardiol 37 (2001), 1551–1557.
74. 74 Cortigiani, L., Bigi, R., Sicari, R., Landi, P., Bovenzi, F., Picano, E., Prognostic value of pharmacological stress echocardiography in diabetic and nondiabetic patients with known or suspected coronary artery disease. J Am Coll Cardiol 47 (2006), 605–610.
75. 75 Hachamovitch, R., Kang, X., Amanullah, A.M., et al. Prognostic implications of myocardial perfusion single-photon emission computed tomography in the elderly. Circulation 120 (2009), 2197–2206.
76. 76 Acampa, W., Cantoni, V., Green, R., et al. Prognostic value of normal stress myocardial perfusion imaging in diabetic patients: a meta-analysis. J Nucl Cardiol 21 (2014), 893–902.
77. 77 Giri, S., Shaw, L.J., Murthy, D.R., et al. Impact of diabetes on the risk stratification using stress single-photon emission computed tomography myocardial perfusion imaging in patients with symptoms suggestive of coronary artery disease. Circulation 105 (2002), 32–40.
78. 78 Miller, T.D., Rajagopalan, N., Hodge, D.O., Frye, R.L., Gibbons, R.J., Yield of stress single-photon emission computed tomography in asymptomatic patients with diabetes. Am Heart J 147 (2004), 890–896.
79. 79 Rajagopalan, N., Miller, T.D., Hodge, D.O., Frye, R.L., Gibbons, R.J., Identifying high-risk asymptomatic diabetic patients who are candidates for screening stress single-photon emission computed tomography imaging. J Am Coll Cardiol 45 (2005), 43–49.
80. 80 Wackers, F.J., Young, L.H., Inzucchi, S.E., et al., for the Detection of Ischemia in Asymptomatic Diabetics Investigators. Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study. Diabetes Care 27 (2004), 1954–1961.
81. 81 Malhotra, S., Sharma, R., Kliner, D.E., Follansbee, W.P., Soman, P., Relationship between silent myocardial ischemia and coronary artery disease risk factors. J Nucl Cardiol 20 (2013), 731–738.
82. 82 Zellweger, M.J., Maraun, M., Osterhues, H.H., et al. Progression to overt or silent CAD in asymptomatic patients with diabetes mellitus at high coronary risk. Main findings of the prospective multicenter BARDOT trial with a pilot randomized treatment substudy. J Am Coll Cardiol Img 7 (2014), 1001–1010.
83. 83 Hachamovitch, R., Rozanski, A., Shaw, L.J., et al. Impact of ischaemia and scar on the therapeutic benefit derived from myocardial revascularization vs. medical therapy among patients undergoing stress-rest myocardial perfusion scintigraphy. Eur Heart J 32 (2011), 1012–1024.
84. 84 Navare, S.M., Mather, J.F., Shaw, L.J., Fowler, M.S., Heller, G.V., Comparison of risk stratification with pharmacologic and exercise stress myocardial perfusion imaging: a meta-analysis. J Nucl Cardiol 11 (2004), 551–561.
85. 85 Murthy, V.L., Masano, N., Foster, C.R., et al. Association between coronary vascular dysfunction and cardiac mortality in patients with and without diabetes mellitus. Circulation 126 (2012), 1858–1868.
86. 86 Sassa, S., Shimada, K., Yoshida, K., Tanaka, H., Jissho, S., Yoshikawa, J., Comparison of 64-slice multi-detector computed tomography coronary angiography between asymptomatic, type 2 diabetes mellitus and impaired glucose tolerance patients. J Cardiol 52 (2008), 133–139.
87. 87 Loffroy, R., Bernard, S., Serusclat, A., et al. Noninvasive assessment of the prevalence and characteristics of coronary atherosclerotic plaques by multidetector computed tomography in asymptomatic type 2 diabetic patients at high risk of significant coronary artery disease: a preliminary study. Arch Cardiovasc Dis 102 (2009), 607–615.
88. 88 Choi, E.K., Chun, E.J., Choi, S.I., et al. Assessment of subclinical coronary atherosclerosis in asymptomatic patients with type 2 diabetes mellitus with single photon emission computed tomography and coronary computed tomography angiography. Am J Cardiol 104 (2009), 890–896.
89. 89 Rivera, J.J., Nasir, K., Choi, E.K., et al. Detection of occult coronary artery disease in asymptomatic individuals with diabetes mellitus using non-invasive cardiac angiography. Atherosclerosis 203 (2009), 442–448.
90. 90 Silva, J.D., Mota, P., Coelho, A., Catarino, R., Leitao-Marques, A., Incidence of subclinical atherosclerosis in asymptomatic type-2 diabetic patients: the potential of multi-slice computed tomography coronary angiography. Coron Artery Dis 22 (2011), 26–31.
91. 91 Kamimura, M., Moroi, M., Isobe, M., Hiroe, M., Role of coronary CT angiography in asymptomatic patients with type 2 diabetes mellitus. Int Heart J 53 (2012), 23–28.
92. 92 Nasti, R., Carbonara, O., di Santo Stefano, M.L., et al. Coronary artery disease is detectable by multi-slice computed tomography in most asymptomatic type 2 diabetic patients at high cardiovascular risk. Diab Vasc Dis Res 9 (2012), 10–17.
93. 93 Roos, C.J., Kharagjitsingh, A.V., Jukema, J.W., Bax, J.J., Scholte, A.J., Comparison by computed tomographic angiography—the presence and extent of coronary arterial atherosclerosis in South Asians versus Caucasians with diabetes mellitus. Am J Cardiol 113 (2014), 1782–1787.
94. 94 Zeina, A.R., Odeh, M., Rosenschein, U., Zaid, G., Barmeir, E., Coronary artery disease among asymptomatic diabetic and nondiabetic patients undergoing coronary computed tomography angiography. Coron Artery Dis 19 (2008), 37–41.
95. 95 Manfrini, O., Russo, V., Ciavarella, A., Ceroni, L., Montalti, M., Fattori, R., Coronary plaque quantification and composition in asymptomatic patients with type II diabetes mellitus. J Cardiovasc Med 13 (2012), 423–431.
96. 96 Halon, D.A., Dobrecky-Mery, I., Gaspar, T., et al. Pulse pressure and coronary atherosclerosis in asymptomatic type 2 diabetes mellitus: a 64 channel cardiac computed tomography analysis. Int J Cardiol 143 (2010), 63–71.
97. 97 Leem, J., Hee Koh, E., Jeong, E., et al. Prevalence of angiographically defined obstructive coronary artery disease in asymptomatic patients with type 2 diabetes according to the coronary calcium score. Intern Med 51 (2012), 3017–3023.
98. 98 Kwan, A.C., May, H.T., Cater, G., et al. Coronary artery plaque volume and obesity in patients with diabetes: the FACTOR-64 study. Radiology 272 (2014), 690–699.
99. 99 Choo, E.H., Kim, J.J., Hwang, B.H., et al. Status of hypertension and coronary stenosis in asymptomatic type 2 diabetic patients: analysis from Coronary Computed Tomographic Angiography Registry. Int J Cardiol 174 (2014), 282–287.
100. 100 Jeong, H.C., Kim, I., Park, K.H., et al. New strategy for detection of subclinical coronary atherosclerosis in asymptomatic patients with type 2 diabetes based on cardiac multi-detector computed tomography and treadmill test. Circ J 78 (2014), 671–678.
101. 101 Min, J.K., Dunning, A., Lin, F.Y., et al., for the CONFIRM Investigators. Age- and sex-related differences in all-cause mortality risk based on coronary computed tomography angiography findings results from the international multicenter CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry) of 23,854 patients without known coronary artery disease. J Am Coll Cardiol 58 (2011), 849–860.
102. 102 Muhlestein, J.B., Lappe, D.L., Lima, J.A., et al. Effect of screening for coronary artery disease using CT angiography on mortality and cardiac events in high-risk patients with diabetes: the FACTOR-64 randomized clinical trial. JAMA 312 (2014), 2234–2243.
103. 103 Taylor, A.J., Cerqueira, M., Hodgson, J.M., et al. ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 appropriate use criteria for cardiac computed tomography: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the Society of Cardiovascular Computed Tomography, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the American Society of Nuclear Cardiology, the North American Society for Cardiovascular Imaging, the Society for Cardiovascular Angiography and Interventions, and the Society for Cardiovascular Magnetic Resonance. J Am Coll Cardiol 56 (2010), 1864–1894.
104. 104 Velagaleti, R.S., Gona, P., Chuang, M.L., et al. Relations of insulin resistance and glycemic abnormalities to cardiovascular magnetic resonance measures of cardiac structure and function: the Framingham Heart Study. Circ Cardiovasc Imaging 3 (2010), 257–263.
105. 105 Turkbey, E.B., Backlund, J.Y., Genuth, S., et al. Myocardial structure, function, and scar in patients with type 1 diabetes mellitus. Circulation 124 (2011), 1737–1746.
106. 106 Kwong, R.Y., Sattar, H., Wu, H., et al. Incidence and prognostic implication of unrecognized myocardial scar characterized by cardiac magnetic resonance in diabetic patients without clinical evidence of myocardial infarction. Circulation 118 (2008), 1011–1020.
107. 107 Schelbert, E.B., Cao, J.J., Sigurdsson, S., et al. Prevalence and prognosis of unrecognized myocardial infarction determined by cardiac magnetic resonance in older adults. JAMA 308 (2012), 890–896.
108. 108 Wong, T.C., Piehler, K., Meier, C.G., et al. Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality. Circulation 126 (2012), 1206–1216.
109. 109 Ng, A.C., Auger, D., Delgado, V., et al. Association between diffuse myocardial fibrosis by cardiac magnetic resonance contrast-enhanced T(1) mapping and subclinical myocardial dysfunction in diabetic patients: a pilot study. Circ Cardiovasc Imaging 5 (2012), 51–59.
110. 110 Jellis, C., Wright, J., Kennedy, D., et al. Association of imaging markers of myocardial fibrosis with metabolic and functional disturbances in early diabetic cardiomyopathy. Circ Cardiovasc Imaging 4 (2011), 693–702.
111. 111 Rijzewijk, L.J., van der Meer, R.W., Smit, J.W., et al. Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus. J Am Coll Cardiol 52 (2008), 1793–1799.
112. 112 Ng, A.C., Delgado, V., Bertini, M., et al. Myocardial steatosis and biventricular strain and strain rate imaging in patients with type 2 diabetes mellitus. Circulation 122 (2010), 2538–2544.
113. 113 Hammer, S., Snel, M., Lamb, H.J., et al. Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function. J Am Coll Cardiol 52 (2008), 1006–1012.
114. 114 Plein, S., Radjenovic, A., Ridgway, J.P., et al. Coronary artery disease: myocardial perfusion MR imaging with sensitivity encoding versus conventional angiography. Radiology 235 (2005), 423–430.
115. 115 Greenwood, J.P., Maredia, N., Younger, J.F., et al. Cardiovascular magnetic resonance and singlephoton emission computed tomography for diagnosis of coronary heart disease (CE-MARC): a prospective trial. Lancet 379 (2012), 453–460.
116. 116 Kannel, W.B., Metabolic risk factors for coronary heart disease in women: perspectives from the Framingham study. Am Heart J 114 (1987), 413–429.
117. 117 Marroquin, O.C., Kip, K.E., Kelley, D.E., et al. Metabolic syndrome modifies the cardiovascular risk associated with angiographic coronary artery disease in women. Circulation 109 (2004), 714–721.
118. 118 Helmut, H.O., Paradisi, G., Cronin, J., et al. Type II diabetes abrogates sex differences in endothelial function in premenopausal women. Circulation 101 (2000), 2040–2046.
119. 119 Tamis-Holland, J.E.T., Lu, J., Korykowski, M., et al. Sex differences in presentation and outcome among patients with type 2 diabetes and coronary artery disease treated with contemporary medical therapy with or without prompt revascularization. J Am Coll Cardiol 61 (2013), 1767–1776.
120. 120 Nicolini, E., Martegani, G., Maresca, A.M., et al. Left ventricular remodeling in patients with metabolic syndrome: influence of gender. Nutr Metab Cardiovasc Dis 23 (2013), 771–775.
121. 121 Berman, D., Kang, X., Hayes, S.W., et al. Adenosine myocardial perfusion single-photon emission computed tomography in women compared to men. J Am Coll Cardiol 41 (2003), 1125–1133.
122. 122 Budoff, M.J., Achenbach, S., Blumenthal, R.S., et al. Assessment of coronary artery disease by cardiac computed tomography, a scientific statement from the American Heart Association Committee on Cardiovascular Imaging and Intervention, Council on Cardiovascular Radiology and Intervention, and Committee on Cardiac Imaging, Council on Clinical Cardiology. Circulation 114 (2006), 1761–1791.
123. 123 Harjutsalo, V., Groop, P.H., Epidemiology and risk factors for diabetic kidney disease. Adv Chronic Kidney Dis 21 (2014), 260–266.
124. 124 Parving, H.-H., Mauer, M., Fioretto, P., Rossing, P., Ritz, E., Diabetic nephropathy. Taal, M., Chertow, G., Marsden, P., Skoreki, K., Yu, A.S.L., Brenner, B.M., (eds.) The Kidney, 9th Edition, 2012, Elsevier-Saunders, Philadelphia, 1411–1454.
125. 125 Jindal, A., Garcia-Touza, M., Jindal, N., Whaley-Connell, A., Sowers, J.R., Diabetic kidney disease and the cardiorenal syndrome: old disease, new perspectives. Endocrinol Metab Clin North Am 42 (2013), 789–808.
126. 126 Peev, V., Nayer, A., Contreras, G., Dyslipidemia, malnutrition, inflammation, cardiovascular disease and mortality in chronic kidney disease. Curr Opin Lipidol 25 (2014), 54–60.
127. 127 Halter, J.B., Musi, N., McFarland Horne, F., et al. Diabetes and cardiovascular disease in older adults: current status and future directions. Diabetes 63 (2014), 2578–2589.
128. 128 Blacher, J., Guerin, A.P., Pannier, B., et al. Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease. Hypertension 38 (2001), 938–942.
129. 129 Raggi, P., Boulay, A., Chasan-Taber, S., et al. Cardiac calcification in adult hemodialysis patients: a link between end-stage renal disease and cardiovascular disease?. J Am Coll Cardiol 39 (2002), 695–701.
130. 130 Block, G.A., Spiegel, D.M., Ehrlich, J., et al. Effects of sevelamer and calcium on coronary artery calcification in patients new to hemodialysis. Kidney Int 68 (2005), 1815–1824.
131. 131 Qunibi, W.Y., Abouzahr, F., Mizani, M.R., et al. Cardiovascular calcification in Hispanic Americans (HA) with chronic kidney disease (CKD) due to type 2 diabetes. Kidney Int 68 (2005), 271–277.
132. 132 Russo, D., Palmiero, G., De Blasio, A.P., et al. Coronary artery calcification in patients with CRF not undergoing dialysis. Am J Kidney Dis 44 (2004), 1024–1030.
133. 133 London, G.M., Guerin, A.P., Marchais, S.J., Metivier, F., Pannier, B., Adda, H., Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dial Transplant 18 (2003), 1731–1740.
134. 134 Nakamura, S., Ishibashi-Ueda, H., Niizuma, S., Yoshihara, F., Horio, T., Kawano, Y., Coronary calcification in patients with chronic kidney disease and coronary artery disease. Clin J Am Soc Nephrol 4 (2009), 1892–1900.
135. 135 Budoff, M.J., Rader, D.J., Reilly, M.P., et al. Relationship of estimated GFR and coronary artery calcification in the CRIC (Chronic Renal Insufficiency Cohort) Study. Am J Kidney Dis 58 (2011), 519–526.
136. 136 He, J., Reilly, M., Yang, W., et al., for the CRIC Investigators. Risk factors for coronary artery calcium among patients with chronic kidney disease (from the Chronic Renal Insufficiency Cohort Study). Am J Cardiol 110 (2012), 1735–1741.
137. 137 Kramer, H., Toto, R., Peshock, R., Cooper, R., Victor, R., Association between chronic kidney disease and coronary artery calcification: the Dallas Heart Study. J Am Soc Nephrol 16 (2005), 507–513.
138. 138 Kestenbaum, B., Adeney, K., de Boer, I.H., Ix, J., Shlipak, M., Siscovick, D., Incidence and progression of coronary calcification in chronic kidney disease: the Multi-Ethnic Study of Atherosclerosis. Kidney International 76 (2009), 991–998.
139. 139 Adeseun, G.A., Xie, D., Wang, X., et al. Carotid plaque, carotid intima-media thickness, and coronary calcification equally discriminate prevalent cardiovascular disease in kidney disease. Am J Nephrol 36 (2012), 342–347.
140. 140 Shantouf, R.S., Budoff, M.J., Ahmadi, N., et al. Total and individual coronary artery calcium scores as independent predictors of mortality in hemodialysis patients. Am J Nephrol 31 (2010), 419–425.
141. 141 Block, G.A., Raggi, P., Bellasi, A., Kooniega, L., Spiegel, D.M., Mortality effect of coronary calcification and phosphate binder choice in incident hemodialysis patients. Kidney Int 71 (2007), 438–441.
142. 142 Di Iorio, B., Bellasi, A., Russo, D., for the INDEPENDENT Study Investigators. Mortality in kidney disease patients treated with phosphate binders: a randomized study. Clin J Am Soc Nephrol 7 (2012), 487–493.
143. 143 Hendel, R.C., Berman, D.S., Di Carli, M.F., et al. ACCF/ASNC/ACR/AHA/ASE/SCCT/SCMR/SNM 2009 app-ropriate use criteria for cardiac radionuclide imaging: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the American Society of Nuclear Cardiology, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the Society of Cardiovascular Computed Tomography, the Society for Cardiovascular Magnetic Resonance, and the Society of Nuclear Medicine. J Am Coll Cardiol 53 (2009), 2201–2229.
144. 144 Stone, N.J., Robinson, J.G., Lichtenstein, A.H., et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 63:25 Pt B (2014), 2889–2934.
145. 145 Wolk, M.J., Bailey, S.R., Doherty, J.U., et al. ACCF/AHA/ASE/ASNC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2013 multimodality appropriate use criteria for the detection and risk assessment of stable ischemic heart disease: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons. J Am Coll Cardiol 63 (2014), 380–406.
146. 146 Park, G.M., Lee, S.W., Cho, Y.R., et al. Coronary computed tomographic angiographic findings in asymptomatic patients with type 2 diabetes mellitus. Am J Cardiol 113 (2014), 765–771.
147. 147 Scholte, A.J., Schuijf, J.D., Kharagjitsingh, A.V., et al. Different manifestations of coronary artery disease by stress SPECT myocardial perfusion imaging, coronary calcium scoring, and multislice CT coronary angiography in asymptomatic patients with type 2 diabetes mellitus. J Nucl Cardiol 15 (2008), 503–509.