Evidence of Hepatitis E virus breaking through the blood–brain barrier and replicating in the central nervous system

Journal of Viral Hepatitis

Volumn 23, Issue 11, 2016, Pages 930-939

  Shi, R ^a   Soomro, M H ^a   She, R ^a   Yang, Y ^a   Wang, T ^a   Wu, Q ^a   Li, H ^a   Hao, W ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

BBB; brain; hepatitis E virus; pathologic changes; spinal cord

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; PROTEIN ORF2; PROTEIN ZO1; UNCLASSIFIED DRUG; VIRAL PROTEIN; VIRUS RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM INFECTION; CHOROID PLEXUS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOPLASM; ENZYME LINKED IMMUNOSORBENT ASSAY; EPENDYMA CELL; GENOTYPE; HEPATITIS E VIRUS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INOCULATION; LYMPHOCYTIC INFILTRATION; MALE; MERIONES UNGUICULATUS; MICROGLIA; MYELIN SHEATH; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NONHUMAN; PERINEURAL INVASION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SPINAL CORD; UPREGULATION; VIRUS REPLICATION; VIRUS STRAIN; ANIMAL; CENTRAL NERVOUS SYSTEM; DISEASE MODEL; DNA SEQUENCE; GENETICS; GERBIL; GROWTH, DEVELOPMENT AND AGING; HEPATITIS E; ISOLATION AND PURIFICATION; PATHOLOGY; VIROLOGY;

ANIMALS; BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; DISEASE MODELS, ANIMAL; GERBILLINAE; HEPATITIS E; HEPATITIS E VIRUS; MALE; RNA, VIRAL; SEQUENCE ANALYSIS, DNA;

EID: 84977611734     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/jvh.12557     Document Type: Article

References (40)

1. Balayan MS. Epidemiology of hepatitis E virus infection. J Viral Hepatitis 1997; 4(3): 155–165.
2. Perez-Gracia MT, Suay B, Mateos-Lindemann ML. Hepatitis E: an emerging disease. Infect Genet Evol 2014; 22: 40–59.
3. Xiao P, Li R, She R et al. Prevalence of hepatitis e virus in swine fed on kitchen residue. PLoS ONE 2012; 7(3): e33480.
4. Cencic A, Chingwaru W. Hepatitis E Virus (HEV) – An Emerging Viral Pathogen: Springer Netherlands 2010.
5. Akinori T, Shimizu YK, Torahiko T et al. Persistent infection of hepatitis E virus transmitted by blood transfusion in a patient with T-cell lymphoma. Hepatol Res 2007; 37(2): 113–120.
6. Hosseini Moghaddam SM. Hepatitis E Virus and Renal Transplantation. Hepat Mon 2011; 11(8): 599–600.
7. Williams TPE, Kasorndorkbua C, Halbur PG et al. Evidence of Extrahepatic Sites of Replication of the Hepatitis E Virus in a Swine Model. J Clin Microbiol 2001; 39(9): 3040–3046.
8. Billam P, Pierson FW, Li W, LeRoith T, Duncan RB, Meng XJ. Development and validation of a negative-strand-specific reverse transcription-PCR assay for detection of a chicken strain of hepatitis E virus: identification of nonliver replication sites. J Clin Microbiol 2008; 46(8): 2630–2634.
9. Bose PD, Das BC, Hazam RK, Kumar A, Medhi S, Kar P. Evidence of extrahepatic replication of hepatitis E virus in human placenta. J Gen Virol 2014; 95(Pt 6): 1266–1271.
10. Soomro MH, Shi R, She R et al. Antigen detection and apoptosis in Mongolian gerbil's kidney experimentally intraperitoneally infected by swine Hepatitis E virus. Virus Res 2015; 32(3): 588–593.
11. Woolson KL, Forbes A, Vine L et al. Extra-hepatic manifestations of autochthonous hepatitis E infection. Aliment Pharmacol Ther 2014; 40(11–12): 1282–1291.
12. Bazerbachi F, Haffar S, Garg SK, Lake JR. Extra-hepatic manifestations associated with hepatitis E virus infection: a comprehensive review of the literature. Gastroenterol Rep 2015; 4(1): 1–15.
13. Kausik M, Nidhi C. Acute transverse myelitis following hepatitis E virus infection. Indian Pediatr 2006; 43(43): 365–366.
14. Dalton HR, Kamar N, van Eijk JJ et al. Hepatitis E virus and neurological injury. Nat Rev Neurol 2016; 12(2): 77–85.
15. Fong F, Illahi M. Neuralgic amyotrophy associated with hepatitis E virus. Clin Neurol Neurosurg 2009; 111(2): 193–195.
16. Wu X, Liu K, Zhang HL. Guillain-Barre syndrome and encephalitis/encephalopathy associated with acute severe hepatitis E infection. Neurol Sci 2015; 36(1): 165–166.
17. Rianthavorn P, Thongmee C, Limpaphayom N, Komolmit P, Theamboonlers A, Poovorawan Y. The entire genome sequence of hepatitis E virus genotype 3 isolated from a patient with neuralgic amyotrophy. Scand J Infect Dis 2010; 42(5): 395–400.
18. Motte A, Franques J, Weitten T, Colson P. Hepatitis E-associated Parsonage-Turner syndrome, France. Clin Res Hepatol Gastroenterol 2014; 38(1): e11–e14.
19. Jha AK, Sandeep N, Subhash N, Arya S. Association of Bell's Palsy with Hepatitis E Virus Infection: a Rare Entity. J Clin Exp Hepatol 2012; 2(1): 88–90.
20. Kamar NBR, Bendall RP, Peron JM et al. Hepatitis E Virus and Neurologic Disorders. PMC 2011; 17(2): 173–179.
21. Chen XD, Zhou YT, Zhou JJ, Wang YW, Tong DM. Guillain-Barre syndrome and encephalitis/encephalopathy of a rare case of Northern China acute severe hepatitis E infection. Neurological sciences: official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2014; 35(9): 1461–1463.
22. Laura-Anne D, Elsa K, Shahram A et al. Neurologic disorders and hepatitis E, France, 2010. Emerg Infect Dis 2011; 17(8): 1510–1512.
23. Deroux A, Brion JP, Hyerle L et al. Association between hepatitis E and neurological disorders: two case studies and literature review. J Clin Virol 2014; 60(1): 60–62.
24. Yang Y, Shi R, She R et al. Effect of swine hepatitis E virus on the livers of experimentally infected Mongolian gerbils by swine hepatitis E virus. Virus Res 2015; 208: 171–179.
25. Sood A, Midha V, Sood N. Guillain-Barré syndrome with acute hepatitis E. Am J Gastroenterol 2000; 95(12): 3667–3668.
26. Perrin HB, Cintas P, Abravanel F et al. Neurologic Disorders in Immunocompetent Patients with Autochthonous Acute Hepatitis E. Emerg Infect Dis 2015; 21(11): 1928–1934.
27. Pischke S, Behrendt P, Bock CT, Jilg W, Manns MP, Wedemeyer H. Hepatitis E in Germany–an under-reported infectious disease. Dtsch Arztebl Int 2014; 111(35–36): 577–583.
28. Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ. Structure and function of the blood-brain barrier. Neurobiol Dis 2010; 37(1): 13–25.
29. Chang CM, Ng HK, Chan YW, Leung SY, Fong KY, Yu YL. Postinfectious myelitis, encephalitis and encephalomyelitis. Clin Exp Neurol 1992; 29(29): 250–262.
30. Saguna V, Yeung L, Moti C et al. West Nile virus infection modulates human brain microvascular endothelial cells tight junction proteins and cell adhesion molecules: transmigration across the in vitro blood-brain barrier. Virology 2009; 385(2): 425–433.
31. Suen WW, Prow NA, Hall RA, Bielefeldt-Ohmann H. Mechanism of West Nile virus neuroinvasion: a critical appraisal. Viruses 2014; 6(7): 2796–2825.
32. Liou ML, Hsu CY. Japanese encephalitis virus is transported across the cerebral blood vessels by endocytosis in mouse brain. Cell Tissue Res 1998; 293(3): 389–394.
33. Mishra MK, Dutta K, Saheb SK, Basu A. Understanding the molecular mechanism of blood-brain barrier damage in an experimental model of Japanese encephalitis: correlation with minocycline administration as a therapeutic agent. Neurochem Int 2009; 55(8): 717–723.
34. Hamm S, Dehouck B, Kraus J et al. Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts. Cell Tissue Res 2004; 315(2): 157–166.
35. Liu WY, Wang ZB, Zhang LC, Wei X, Li L. Tight junction in blood-brain barrier: an overview of structure, regulation, and regulator substances. CNS Neurosci Ther 2012; 18(8): 609–615.
36. Laskus T, Radkowski M, Adair DM, Wilkinson J, Scheck AC, Rakela J. Emerging evidence of hepatitis C virus neuroinvasion. AIDS 2005; 19(Suppl. 3): S140–S144.
37. Li WG, She RP, Wei HT et al. Prevalence of hepatitis E virus in swine under different breeding environment and abattoir in Beijing, China. Vet Microbiol 2009; 133(1–2): 75–83.
38. Meng XJ, Halbur PG, Shapiro MS et al. Genetic and experimental evidence for cross-species infection by swine hepatitis E virus. J Virol 1998; 72(12): 9714–9721.
39. Wang YC, Zhang HY, Xia NS et al. Prevalence, isolation, and partial sequence analysis of hepatitis E virus from domestic animals in China. J Med Virol 2002; 67(4): 516–21.
40. Lu L, Li C, Hagedorn CH. Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis. Rev Med Virol 2006; 16(1): 5–36.