Evolution of Sepsis Management: From Early Goal-Directed Therapy to Personalized Care

Advances in Surgery

Volumn 50, Issue 1, 2016, Pages 221-234

  Head, Lyndsay W ^a   Coopersmith, Craig M ^b  

^a EMORY UNIVERSITY HOSPITAL   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antibiotics; Early goal directed therapy; Fluids; Resuscitation; Sepsis; Sepsis bundles; Sepsis management; Surviving sepsis campaign

Indexed keywords

ANTIINFECTIVE AGENT; LACTIC ACID; VASOCONSTRICTOR AGENT;

BLOOD; FLUID THERAPY; HUMAN; MOTIVATION; PERSONALIZED MEDICINE; PROCEDURES; RESUSCITATION; SEPSIS;

ANTI-BACTERIAL AGENTS; FLUID THERAPY; GOALS; HUMANS; LACTIC ACID; PRECISION MEDICINE; RESUSCITATION; SEPSIS; VASOCONSTRICTOR AGENTS;

EID: 84977610490     PISSN: 00653411     EISSN: None     Source Type: Book Series    
DOI: 10.1016/j.yasu.2016.04.002     Document Type: Review

References (33)

1. [1] Kompanje, E.J., Jansen, T.C., van der Hoven, B., et al. The first demonstration of lactic acid in human blood in shock by Johann Joseph Scherer (1814-1869) in January 1843. Intensive Care Med 33:11 (2007), 1967–1971.
2. [2] American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20:6 (1992), 864–874.
3. [3] Levy, M.M., Fink, M.P., Marshall, J.C., et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 31:4 (2003), 1250–1256.
4. [4] Singer, M., Deutschman, C.S., Seymour, C.W., et al. The Third International Consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315:8 (2016), 801–810.
5. [5] Shankar-Hari, M., Phillips, G.S., Levy, M.L., et al. Developing a new definition and assessing new clinical criteria for septic shock: for the Third International Consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315:8 (2016), 775–787.
6. [6] Seymour, C.W., Liu, V.X., Iwashyna, T.J., et al. Assessment of clinical criteria for sepsis: for the Third International Consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315:8 (2016), 762–774.
7. [7] Angus, D.C., Seymour, C.W., Coopersmith, C.M., et al. A framework for the development and interpretation of different sepsis definitions and clinical criteria. Crit Care Med 44:3 (2016), e113–e121.
8. [8] Seymour, C.W., Coopersmith, C.M., Deutschman, C.S., et al. Application of a framework to assess the usefulness of alternative sepsis criteria. Crit Care Med 44:3 (2016), e122–e130.
9. [9] Gaieski, D.F., Edwards, J.M., Kallan, M.J., et al. Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med 41:5 (2013), 1167–1174.
10. [10] Lagu, T., Rothberg, M.B., Shieh, M.S., et al. Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007. Crit Care Med 40:3 (2012), 754–761.
11. [11] Zimmerman, J.E., Kramer, A.A., Knaus, W.A., Changes in hospital mortality for United States intensive care unit admissions from 1988 to 2012. Crit Care, 17(2), 2013, R81.
12. [12] Hotchkiss, R.S., Monneret, G., Payen, D., Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 13:12 (2013), 862–874.
13. [13] Limaye, A.P., Kirby, K.A., Rubenfeld, G.D., et al. Cytomegalovirus reactivation in critically ill immunocompetent patients. JAMA 300:4 (2008), 413–422.
14. [14] Martin, G.S., Mannino, D.M., Moss, M., The effect of age on the development and outcome of adult sepsis. Crit Care Med 34:1 (2006), 15–21.
15. [15] McConnell, K.W., McDunn, J.E., Clark, A.T., et al. Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses. Crit Care Med 38:1 (2010), 223–241.
16. [16] Danai, P.A., Moss, M., Mannino, D.M., et al. The epidemiology of sepsis in patients with malignancy. Chest 129:6 (2006), 1432–1440.
17. [17] Dellinger, R.P., Levy, M.M., Rhodes, A., et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 41:2 (2013), 580–637.
18. [18] Levy, M.M., Rhodes, A., Phillips, G.S., et al. Surviving sepsis campaign: association between performance metrics and outcomes in a 7.5-year study. Crit Care Med 43:1 (2015), 3–12.
19. [19] Rivers, E., Nguyen, B., Havstad, S., et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:19 (2001), 1368–1377.
20. [20] Yealy, D.M., Kellum, J.A., Huang, D.T., et al. A randomized trial of protocol-based care for early septic shock. N Engl J Med 370:18 (2014), 1683–1693.
21. [21] Peake, S.L., Delaney, A., Bailey, M., et al. Goal-directed resuscitation for patients with early septic shock. N Engl J Med 371:16 (2014), 1496–1506.
22. [22] Mouncey, P.R., Osborn, T.M., Power, G.S., et al. Trial of early, goal-directed resuscitation for septic shock. N Engl J Med 372:14 (2015), 1301–1311.
23. [23] Kaukonen, K.M., Bailey, M., Suzuki, S., et al. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA 311:13 (2014), 1308–1316.
24. [24] Marik, P.E., Baram, M., Vahid, B., Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares. Chest 134:1 (2008), 172–178.
25. [25] Asfar, P., Meziani, F., Hamel, J.F., et al. High versus low blood-pressure target in patients with septic shock. N Engl J Med 370:17 (2014), 1583–1593.
26. [26] Pope, J.V., Jones, A.E., Gaieski, D.F., et al. Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis. Ann Emerg Med 55:1 (2010), 40–46.
27. [27] Jones, A.E., Shapiro, N.I., Trzeciak, S., et al. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA 303:8 (2010), 739–746.
28. [28] Hebert, P.C., Wells, G., Blajchman, M.A., et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 340:6 (1999), 409–417.
29. [29] Holst, L.B., Haase, N., Wetterslev, J., et al. Lower versus higher hemoglobin threshold for transfusion in septic shock. N Engl J Med 371:15 (2014), 1381–1391.
30. [30] Kumar, A., Roberts, D., Wood, K.E., et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 34:6 (2006), 1589–1596.
31. [31] Raimundo, M., Crichton, S., Martin, J.R., et al. Increased fluid administration after early acute kidney injury is associated with less renal recovery. Shock 44:5 (2015), 431–437.
32. [32] Wong, H.R., Cvijanovich, N.Z., Anas, N., et al. Prospective testing and redesign of a temporal biomarker based risk model for patients with septic shock: implications for septic shock biology. EBioMedicine 2:12 (2015), 2087–2093.
33. [33] Wong, H.R., Cvijanovich, N.Z., Anas, N., et al. Developing a clinically feasible personalized medicine approach to pediatric septic shock. Am J Respir Crit Care Med 191:3 (2015), 309–315.