HLA-DQ genotypes – but not immune markers – differ by ethnicity in patients with childhood onset type 1 diabetes residing in Belgium

Pediatric Diabetes

Volumn 17, Issue 5, 2016, Pages 342-350

  Stoupa, Athanasia ^a   Dorchy, Harry ^a  

^a HOP UNIV DES ENFANTS REINE FABIOLA   (Belgium)

Author keywords

antibodies; autoimmunity; ethnic groups; genotype; type 1 diabetes mellitus

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIBODY; C PEPTIDE; COMPLEMENT; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; COMPLEMENT COMPONENT CH50; HEMOGLOBIN A1C; HLA DQ ANTIGEN; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; INTRINSIC FACTOR; RHEUMATOID FACTOR; THYROID PEROXIDASE ANTIBODY; UNCLASSIFIED DRUG;

ADDISON DISEASE; ADOLESCENT; ADRENAL GLAND TISSUE; AFRICAN; AGE; AGE DISTRIBUTION; ANTIBODY SPECIFICITY; ARTICLE; AUTOIMMUNITY; BELGIUM; BLACK PERSON; CAUCASIAN; CHILD; CONTROLLED STUDY; DIABETIC KETOACIDOSIS; DISEASE ASSOCIATION; DISEASE DURATION; ENDOMYSIUM; ETHNIC DIFFERENCE; EUROPEAN; FEMALE; GENETIC SUSCEPTIBILITY; GENOTYPE; GLOMERULUS BASEMENT MEMBRANE; HAPLOTYPE; HIGH RISK PATIENT; HLA DQ GENE; HOMOZYGOSITY; HUMAN; HUMAN CELL; HUMAN TISSUE; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; MEGALOBLASTIC ANEMIA; ONSET AGE; PEDIATRIC HOSPITAL; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; STRIATED MUSCLE;

EID: 84977493337     PISSN: 1399543X     EISSN: 13995448     Source Type: Journal    
DOI: 10.1111/pedi.12293     Document Type: Article

References (33)

1. Nokoff N, Rewers M. Pathogenesis of type 1 diabetes: lessons from natural history studies of high-risk individuals. Ann N Y Acad Sci 2013: 1281: 1–15.
2. Vandewalle CL, Falorni A, Lernmark A et al. Associations of GAD65- and IA-2- autoantibodies with genetic risk markers in new-onset IDDM patients and their siblings. Belgian Diabetes Registry. Diabetes Care 1997: 20: 1547–1552.
3. Decochez K, Keymeulen B, Somers G et al. Use of an islet cell antibody assay to identify type 1 diabetic patients with rapid decrease in C-peptide levels after clinical onset. Belgian Diabetes Registry. Diabetes Care 2000: 23: 1072–1078.
4. van der, Auwera BJ, Schuit FC, Weets I et al. Relative and absolute HLA-DQA1-DQB1 linked risk for developing type I diabetes before 40 years of age in the Belgian population: implications for future prevention studies. Human Immunol 2002: 63: 40–50.
5. Bjornvold M, Undlien DE, Joner G et al. Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes. Diabetologia 2008: 51: 589–596.
6. Lipton RB, Drum M, Greeley SA, Danielson KK, Bell GI, Hagopian WA. HLA-DQ haplotypes differ by ethnicity in patients with childhood-onset diabetes. Pediatr Diabetes 2011: 12: 388–395.
7. Keskin M, Aygun A, Pehlivan S et al. Trends in the frequency of HLA DR-DQ haplotypes among children and adolescents with type 1 diabetes mellitus in the southest region of Turkey. J Clin Res Pediatr Endocrinol 2012: 4: 189–192.
8. Vehik K, Hamman RF, Lezotte D et al. Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes. Diabetes Care 2008: 31: 1392–1396.
9. Delli AJ, Lindblad B, Carlsson A et al. Type 1 diabetes patients born to immigrants to Sweden increase their native diabetes risk and differ from Swedish patients in HLA types and islet autoantibodies. BDD study group. Pediatr Diabetes 2010: 11: 513–520.
10. Black MH, Lawrence JM, Pihoker C et al. SEARCH for Diabetes in Youth Study Group HLA-associated phenotypes in youth with autoimmune diabetes. Pediatr Diabetes 2013: 14: 121–128.
11. Dorchy H, Vandewalle C, Decraene T, Nagy ZP, Schuit F, Gorus F. Genetic and immunological markers in European Caucasians and Mograbin Caucasians with type 1 (insulin-dependent) diabetes residing in Belgium. Pediatr Adolesc Endocrinol 1993: 23: 71–75.
12. Dorchy H, Lemiere B, Toussaint D, Gausset P. Islet-cell antibodies and organ-specific antibodies in diabetic children and adolescents. Relationship with age, age at onset, duration of diabetes, residual insulin secretion and retinopathy. Nouv Presse Med 1981: 10: 2795–2798.
13. Triolo TM, Armstrong TK, Mc Fann K et al. Additional autoimmune disease found in 33% of patients at Type 1 diabetes onset. Diabetes Care 2011: 34: 1211–1213.
14. Messaaoui A, Tenoutasse S, van der Auwera B, Melot C, Dorchy H. Autoimmune thyroid, celiac and Addison's diseases related to HLA-DQ types in young patients with Type 1 diabetes in Belgium. OJEMD 2012: 2: 70–73.
15. Cole TJ, Freeman JV, Preece MA. Body Mass Index reference curves for the UK 1990. Arch Dis Child 1995: 73: 17–24.
16. Wolfsdorf J, Craig ME, Daneman D et al. Diabetic ketoacidosis in children and adolescents with diabetes. Pediatr Diabetes 2009: 10: 118–133.
17. Vermeulen I, Weets I, Asanghanwa M et al. Contribution of antibodies against IA-2β and Zinc transporter 8 to classification of diabetes diagnosed under 40 years of age. Belgian Diabetes Registry. Diabetes Care 2011: 34: 1760–1765.
18. Van Laar JJ, Grishchenko M, Van Wouwe JP, Stronks K. Ethnic differences in the timely diagnosis of children with Type 1 diabetes mellitus in the Netherlands: clinical presentation at onset. Diabet Med 2007: 24: 296–302.
19. Redondo MJ, Rodriguez LM, Escalante M, O'brian Smith E, Balasubramanyam A, Haymond MW. Beta cell function and BMI in ethnically diverse children with newly diagnosed autoimmune type 1 diabetes. Pediatr Diabetes 2012: 13: 564–571.
20. Palmer JP. C-peptide in the natural history of Type 1 diabetes. Diabetes Metab Res Rev 2009: 25: 325–328.
21. Weets I, Truyen I, Verschraegen I et al. Belgian Diabetes Registry. Sex- and season-dependent differences in C-peptide levels at diagnosis of immune-mediated type 1 diabetes. Diabetologia 2006: 49: 1158–1162.
22. Dorchy H, Gorus F, vandewalle C et al. Belgian Diabetes Registry. Inaugural manifestations of type 1 diabetes mellitus in children, adolescents and adults younger than 40 years. Ann Pediatr 1998: 45: 543–548.
23. Dorchy H, Despontin M, Haumont D, Toussaint D, Loeb H. Residual insulin secretion in juvenile diabetes. Relationships with duration of diabetes, metabolic control and retinopathy. Arch Fr Pediatr 1982: 39: 145–148.
24. Erlich H, Valdes AM, Noble JA et al. Type 1 Diabetes Genetics Consortium. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 2008: 57: 1084–1092.
25. Noble JA, Valdes AM. Genetics of the HLA region in the prediction of type 1 diabetes. Curr Diab Rep 2011: 11: 533–542.
26. Noble JA, Johnson J, Lane JA et al. HLA class II genotyping of African American type 1 diabetic patients reveals associations unique to African haplotypes. Diabetes 2013: 62: 3292–3299.
27. Guerin V, Leniaud L, Pedron B, Guilmin-Crepon S, Tubiana-Rufi N, Sterkers G. HLA-associated genetic resistance and susceptibility to type 1 diabetes in French North Africans and French natives. Tissue Antigens 2007: 70: 214–218.
28. Izaabel H, H-J Garchon, Beaurain G et al. Distribution of HLA class II alleles and haplotypes in insulin-dependent Moroccan diabetics. Hum Immunol 1996: 49: 137–143.
29. Emery LM, Babu S, Bugawan TL et al. Newborn HLA-DR, DQ genotype screening: age- and ethnicity-specific type 1 diabetes risk estimates. Pediatr Diabetes 2005: 6: 136–144.
30. Damanhouri LH, Dromey JA, Christie MR et al. Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients. Diabet Med 2005: 22: 448–452.
31. Jonsdottir B, Andersson C, Carlsson A et al. Thyroid autoimmunity in relation to islet autoantibodies and HLA-DQ genotype in newly diagnosed type 1 diabetes in children and adolescents. Diabetologia 2013: 56: 1735–1742.
32. De Block CE, De Leeuw IH, Van Gaal LF. Autoimmune gastritis in type 1 diabetes: a clinically oriented review. J Clin Endocrinol Metab 2008: 93: 363–371.
33. De Block CE, De Leeuw IH, Rooman RL et al. Gastric parietal cell antibodies are associated with glutamic acid decarboxylase-65 antibodies and the HLA DQA1*0501-DQB1*0301 haplotype in Type 1 diabetes mellitus. BDR. Diab Med 2000: 17: 618–622.