Thyroid autoimmunity in relation to islet autoantibodies and HLA-DQ genotype in newly diagnosed type 1 diabetes in children and adolescents

Diabetologia

Volumn 56, Issue 8, 2013, Pages 1735-1742

  Jonsdottir, B ^a   Andersson, C ^a   Carlsson, A ^a   Delli, A ^a   Forsander, G ^b   Ludvigsson, J ^c   Marcus, C ^b   Samuelsson, U ^c   Ortqvist E ^b   Lernmark, A ^a   Ivarsson, S A ^a   Larsson, H Elding ^a  

^a LUND UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Autoimmune thyroid diseases; Diabetes mellitus; GAD65 autoantibodies; HLA genotype; IA 2 autoantibodies; Insulin autoantibodies; Thyroglobulin antibodies; Thyroid peroxidase antibodies; Type 1 diabetes; ZnT8 autoantibodies

Indexed keywords

ARGININE ZINC TRANSPORTER 8 AUTOANTIBODY; AUTOANTIBODY; GLUTAMIC ACID DECARBOXYLASE AUTOANTIBODY; GLUTAMINE ZINC TRANSPORTER 8 AUTOANTIBODY; HLA DQ ANTIGEN; INSULIN ANTIBODY; INSULINOMA ASSOCIATED PROTEIN 2 AUTOANTIBODY; PANCREAS ISLET CELL ANTIBODY; THYROGLOBULIN ANTIBODY; THYROID PEROXIDASE ANTIBODY; THYROID STIMULATING HORMONE AUTOANTIBODY; THYROXINE AUTOANTIBODY; TRYPTOPHAN ZINC TRANSPORTER 8 AUTOANTIBODY; UNCLASSIFIED DRUG;

ADOLESCENT; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BLOOD SAMPLING; CHILD; CONTROLLED STUDY; DIABETIC PATIENT; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HLA DQB1 GENE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; THYROID DISEASE;

ADOLESCENT; AUTOANTIBODIES; AUTOIMMUNITY; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; GENOTYPE; HLA-DQ ANTIGENS; HUMANS; INFANT; MALE; THYROID GLAND;

EID: 84879950516     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-2934-9     Document Type: Article

References (40)

1. De Block CE, de Leeuw IH, Vertommen JJ et al (2001) Beta-cell, thyroid, gastric, adrenal and coeliac autoimmunity and HLA-DQ types in type 1 diabetes. Clin Exp Immunol 126:236-241
2. Eisenbarth GS (1986) Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med 314:1360-1368
3. Pearce EN, Farwell AP, Braverman LE (2003) Thyroiditis. N Engl J Med 348:2646-2655
4. Bizzaro N (2007) Autoantibodies as predictors of disease: the clinical and experimental evidence. Autoimmun Rev 6:325-333
5. Gorus FK, Goubert P, Semakula C et al (1997) IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. The Belgian Diabetes Registry. Diabetologia 40:95-99
6. Andersson C, Larsson K, Vaziri-Sani F et al (2011) The three ZNT8 autoantibody variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes. Autoimmunity 44:394-405
7. Wenzlau JM, Moua O, Sarkar SA et al (2008) SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes. Ann N Y Acad Sci 1150:256-259
8. Vaziri-Sani F, Delli AJ, Elding-Larsson H et al (2011) A novel triple mix radiobinding assay for the three ZnT8 (ZnT8-RWQ) autoantibody variants in children with newly diagnosed diabetes. J Immunol Methods 371:25-37
9. Chimienti F, Devergnas S, Favier A, Seve M (2004) Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 53:2330-2337
10. Murgia C, Devirgiliis C, Mancini E, Donadel G, Zalewski P, Perozzi G (2009) Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands. Nutr Metab Cardiovasc Dis 19:431-439
11. Sabbah E, Savola K, Kulmala P et al (1999) Diabetes-associated autoantibodies in relation to clinical characteristics and natural course in children with newly diagnosed type 1 diabetes. The Childhood Diabetes In Finland Study Group. J Clin Endocrinol Metab 84:1534-1539
12. Graham J, Hagopian WA, Kockum I et al (2002) Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes. Diabetes 51:1346-1355
13. Sumnik Z, Drevinek P, Snajderova M et al (2003) HLA-DQ polymorphisms modify the risk of thyroid autoimmunity in children with type 1 diabetes mellitus. J Pediatr Endocrinol Metabol 16:851-858
14. Hansen D, Bennedbaek FN, Hansen LK, Hoier-Madsen M, Jacobsen BB, Hegedus L (1999) Thyroid function, morphology and autoimmunity in young patients with insulin-dependent diabetes mellitus. Eur J Endocrinol 140:512-518
15. Delli AJ, Vaziri-Sani F, Lindblad B et al (2012) Zinc transporter 8 autoantibodies and their association with SLC30A8 and HLA-DQ genes differ between immigrant and Swedish patients with newly diagnosed type 1 diabetes in the Better Diabetes Diagnosis Study. Diabetes 61:2556-2564
16. Lampasona V, Schlosser M, Mueller PW et al (2011) Diabetes antibody standardization program: first proficiency evaluation of assays for autoantibodies to zinc transporter 8. Clin Chem 57:1693-1702
17. Mire-Sluis AR, Gaines Das R, Lernmark A (2000) The World Health Organization International Collaborative Study for islet cell antibodies. Diabetologia 43:1282-1292
18. Schlosser M, Mueller PW, Torn C, Bonifacio E, Bingley PJ (2010) Diabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies. Diabetologia 53:2611-2620
19. Andersson C, Vaziri-Sani F, Delli A et al (2013) Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet autoantibodies in childhood and adolescent type 1 diabetes. Pediatr Diabetes 14:97-105
20. Kiviniemi M, Hermann R, Nurmi J et al (2007) A high-throughput population screening system for the estimation of genetic risk for type 1 diabetes: an application for the TEDDY (the Environmental Determinants of Diabetes in the Young) study. Diabetes Technol Ther 9:460-472
21. Larsson HE, Lynch K, Lernmark B et al (2005) Diabetes-associated HLA genotypes affect birthweight in the general population. Diabetologia 48:1484-1491
22. Lynch KF, Lernmark B, Merlo J, Cilio CM, Ivarsson SA, Lernmark A (2008) Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotype. J Perinatol 28:211-217
23. Kordonouri O, Charpentier N, Hartmann R (2011) GADA positivity at onset of type 1 diabetes is a risk factor for the development of autoimmune thyroiditis. Pediatr Diabetes 12:31-33
24. Zeitlin AA, Heward JM, Newby PR et al (2008) Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. Genes Immun 9:358-363
25. Levin L, Ban Y, Concepcion E, Davies TF, Greenberg DA, Tomer Y (2004) Analysis of HLA genes in families with autoimmune diabetes and thyroiditis. Hum Immunol 65:640-647
26. Piatkowska E, Szalecki M (2011) Autoimmune thyroiditis in children and adolescents with type 1 diabetes. Pediatr Endocrinol Diabetes Metabol 17:173-177
27. Kordonouri O, Deiss D, Danne T, Dorow A, Bassir C, Gruters-Kieslich A (2002) Predictivity of thyroid autoantibodies for the development of thyroid disorders in children and adolescents with type 1 diabetes. Diabet Med 19:518-521
28. Barker JM, Yu J, Yu L et al (2005) Autoantibody 'subspecificity' in type 1 diabetes: risk for organ-specific autoimmunity clusters in distinct groups. Diabetes Care 28:850-855
29. Kakleas K, Paschali E, Kefalas N et al (2009) Factors for thyroid autoimmunity in children and adolescents with type 1 diabetes mellitus. Ups J Med Sci 114:214-220
30. McKenna MJ, Herskowitz R, Wolfsdorf JI (1990) Screening for thyroid disease in children with IDDM. Diabetes Care 13:801-803
31. Joseph J, Saroha V, Payne H et al (2011) Thyroid function at diagnosis of type I diabetes. Arch Dis Child 96:777-779
32. Perros P, McCrimmon RJ, Shaw G, Frier BM (1995) Frequency of thyroid dysfunction in diabetic patients: value of annual screening. Diabet Med 12:622-627
33. Kordonouri O, Klinghammer A, Lang EB, Gruters-Kieslich A, Grabert M, Holl RW (2002) Thyroid autoimmunity in children and adolescents with type 1 diabetes: a multicenter survey. Diabetes Care 25:1346-1350
34. Umpierrez GE, Latif KA, Murphy MB et al (2003) Thyroid dysfunction in patients with type 1 diabetes: a longitudinal study. Diabetes Care 26:1181-1185
35. Glastras SJ, Craig ME, Verge CF, Chan AK, Cusumano JM, Donaghue KC (2005) The role of autoimmunity at diagnosis of type 1 diabetes in the development of thyroid and celiac disease and microvascular complications. Diabetes Care 28:2170-2175
36. Tandon N, Zhang L, Weetman AP (1991) HLA associations with Hashimoto's thyroiditis. Clin Endocrinol (Oxf) 34:383-386
37. Awa WL, Boehm BO, Kapellen T et al (2010) HLA-DR genotypes influence age at disease onset in children and juveniles with type 1 diabetes mellitus. Eur J Endocrinol 163:97-104
38. Petrone A, Giorgi G, Mesturino CA et al (2001) Association of DRB1*04-DQB1*0301 haplotype and lack of association of two polymorphic sites at CTLA-4 gene with Hashimoto's thyroiditis in an Italian population. Thyroid 11:171-175
39. Golden B, Levin L, Ban Y, Concepcion E, Greenberg DA, Tomer Y (2005) Genetic analysis of families with autoimmune diabetes and thyroiditis: evidence for common and unique genes. J Clin Endocrinol Metab 90:4904-4911
40. Howson JM, Stevens H, Smyth DJ et al (2011) Evidence that HLA class I and II associations with type 1 diabetes, autoantibodies to GAD and autoantibodies to IA-2, are distinct. Diabetes 60:2635-2644