Retrospective comparison of ephedrine and phenylephrine for the treatment of spinal anesthesia induced hypotension in pre-eclamptic patients

Current Medical Research and Opinion

Volumn 32, Issue 6, 2016, Pages 1083-1086

  Ituk, Unyime S ^a   Cooter, Mary ^b   Habib, Ashraf S ^b  

^a UNIVERSITY OF IOWA   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cesarean section; Hypotension; Pre eclampsia; Spinal anesthesia

Indexed keywords

BUPIVACAINE; EPHEDRINE; FENTANYL; HYPERTENSIVE FACTOR; MORPHINE; PHENYLEPHRINE; VASOCONSTRICTOR AGENT;

ACID BASE BALANCE; ADULT; APGAR SCORE; ARTERIAL PH; ARTICLE; CESAREAN SECTION; FEMALE; FETUS HEART; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; PREECLAMPSIA; RETROSPECTIVE STUDY; SPINAL ANESTHESIA; UMBILICAL ARTERY; ADVERSE EFFECTS; COMPARATIVE STUDY; OBSTETRIC ANESTHESIA; PRE-ECLAMPSIA; PREGNANCY; YOUNG ADULT;

ADULT; ANESTHESIA, OBSTETRICAL; ANESTHESIA, SPINAL; CESAREAN SECTION; EPHEDRINE; FEMALE; HUMANS; HYPOTENSION; PHENYLEPHRINE; PRE-ECLAMPSIA; PREGNANCY; RETROSPECTIVE STUDIES; VASOCONSTRICTOR AGENTS; YOUNG ADULT;

EID: 84977262298     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1185/03007995.2016.1159953     Document Type: Article

References (18)

1. Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R. Preeclampsia. Lancet 2010;376:631-44
2. Henke VG, Bateman BT, Leffert LR. Focused review: spinal anesthesia in severe preeclampsia. Anesth Analg 2013;117:686-93
3. Aya AG, Vialles N, Tanoubi I, et al. Spinal anesthesia-induced hypotension:a risk comparison between patients with severe preeclampsia and healthy women undergoing preterm cesarean delivery. Anesth Analg 2005;101:869-75
4. Johnson JW, Richards DS, Wagaman RA. The case for routine umbilical blood acid-base studies at delivery. Am J Obstet Gynecol 1990;162:621-5
5. Malin GL, Morris RK, Khan KS. Strength of association between umbilical cord pH and perinatal and long term outcomes: systematic review and meta-analysis. Br Med J 2010;340:c1471
6. Lee A, Ngan Kee WD, Gin T. Prophylactic ephedrine prevents hypotension during spinal anesthesia for Cesarean delivery but does not improve neonatal outcome: a quantitative systematic review. Can J Anaesth 2002;49:588-99
7. Veeser M, Hofmann T, Roth R, et al. Vasopressors for the management of hypotension after spinal anesthesia for elective caesarean section. Systematic review and cumulative meta-analysis. Acta Anaesthesiol Scand 2012;56:810-16
8. Ngan Kee WD, Khaw KS, Tan PE, et al. Placental transfer and fetal metabolic effects of phenylephrine and ephedrine during spinal anesthesia for cesarean delivery. Anesthesiology 2009;111:506-12
9. American Society of Anesthesiologists Task Force on Obstetric Anesthesia. Practice guidelines for obstetric anesthesia. Anesthesiology 2007;106:843-63
10. Habib AS. A review of the impact of phenylephrine administration on maternal hemodynamics and maternal and neonatal outcomes in women undergoing cesarean delivery under spinal anesthesia. Anesth Analg 2012;114:377-90
11. Lucas DN, Yentis SM, Kinsella SM, et al. Urgency of caesarean section:a new classification. J R Soc Med 2000;93:346-50
12. Saravanan S, Kocarev M, Wilson RC, et al. Equivalent dose of ephedrine and phenylephrine in the prevention of post-spinal hypotension in Caesarean section. Br J Anaesth 2006;96:95-9
13. Ngan Kee WD, Lee A, Khaw KS, et al. A randomized double-blinded comparison of phenylephrine and ephedrine infusion combinations to maintain blood pressure during spinal anesthesia for cesarean delivery: the effects on fetal acid-base status and hemodynamic control. Anesth Analg 2008;107:1295-302
14. Cooper DW, Carpenter M, Mowbray P, et al. Fetal and maternal effects of phenylephrine and ephedrine during spinal anesthesia for cesarean delivery. Anesthesiology 2002;97:1582-90
15. Cooper DW, Gibb SC, Meek T, et al. Effect of intravenous vasopressor on spread of spinal anaesthesia and fetal acid-base equilibrium. Br J Anaesth 2007;98:649-56
16. Aya AG, Mangin R, Vialles N, et al. Patients with severe preeclampsia experience less hypotension during spinal anesthesia for elective cesarean delivery than healthy parturients: a prospective cohort comparison. Anesth Analg 2003;97:867-72
17. James KS, McGrady E, Patrick A. Combined spinal-extradural anaesthesia for preterm and term caesarean section: is there a difference in local anaesthetic requirements? Br J Anaesth 1997;78:498-501
18. Ngan Kee WD, Khaw KS, Lau TK, et al. Randomised double-blinded comparison of phenylephrine vs ephedrine for maintaining blood pressure during spinal anaesthesia for non-elective Caesarean section. Anaesthesia 2008;63:1319-26