Discontinuation and restarting in patients on statin treatment: Prospective open cohort study using a primary care database

BMJ (Online)

Volumn 353, Issue , 2016, Pages

  Vinogradova, Yana ^a   Coupland, Carol ^a   Brindle, Peter ^b,c   Hippisley Cox, Julia ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b Bristol Clinic   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ADULT; AGED; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DRUG USE; DRUG WITHDRAWAL; ETHNICITY; FEMALE; FOLLOW UP; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRESCRIPTION; PRIMARY PREVENTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETREATMENT; SECONDARY PREVENTION; TREATMENT DURATION; TREATMENT WITHDRAWAL; UNITED KINGDOM; CARDIOVASCULAR DISEASES; FACTUAL DATABASE; MALE; MEDICATION COMPLIANCE; MEDICATION THERAPY MANAGEMENT; MIDDLE AGED; PRIMARY HEALTH CARE; PROCEDURES; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME;

AGED; CARDIOVASCULAR DISEASES; COHORT STUDIES; DATABASES, FACTUAL; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MEDICATION ADHERENCE; MEDICATION THERAPY MANAGEMENT; MIDDLE AGED; OUTCOME AND PROCESS ASSESSMENT (HEALTH CARE); PRIMARY HEALTH CARE; PRIMARY PREVENTION; PROSPECTIVE STUDIES; SECONDARY PREVENTION; UNITED KINGDOM;

EID: 84977192298     PISSN: 09598146     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.i3305     Document Type: Article

References (42)

1. Trusler D. Statin prescriptions in UK now total a million each week. BMJ 2011;343:d4350. doi:10.1136/bmj.d4350.
2. Stone NJ, Robinson JG, Lichtenstein AH, et al. American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines [corrections in: J Am Coll Cardiol 2015;66:2812 and J Am Coll Cardiol 2014;63:3024-5]. J Am Coll Cardiol 2014;63(25, Part B):2889-934. doi:10.1016/j. jacc.2013.11.002.
3. National Institute for Health and Care Excellence. Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease. Clinical guideline 181.NICE, 2014.
4. National Institute for Health and Care Excellence. Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease. Clinical guideline 67. NICE, 2008.
5. Mihaylova B, Emberson J, Blackwell L, et al. Cholesterol Treatment Trialists' (CTT) Collaborators. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet 2012;380:581-90. doi:10.1016/S0140-6736(12)60367-5.
6. Taylor F, Huffman MD, Macedo AF, et al. Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 2013;1:CD004816.
7. Abramson JD, Rosenberg HG, Jewell N, Wright JM. Should people at low risk of cardiovascular disease take a statin [correction in: BMJ 2014;348:g3329]? BMJ 2013;347:f6123. doi:10.1136/bmj.f6123.
8. Malhotra A. Saturated fat is not the major issue [correction in: BMJ 2014;348:g3332]. BMJ 2013;347:f6340. doi:10.1136/bmj.f6340.
9. Prasad V. Statins, primary prevention, and overall mortality. Ann Intern Med 2014;160:867-9. doi:10.7326/M13-2974.
10. Hippisley-Cox J, Parker C, Coupland C, Vinogradova Y. Inequalities in the primary care of patients with coronary heart disease and serious mental health problems: a cross-sectional study. Heart 2007;93:1256-62.doi:10.1136/hrt.2006.110171.
11. Hippisley-Cox J, Pringle M, Crown N, Meal A, Wynn A. Sex inequalities in ischaemic heart disease in general practice: cross sectional survey. BMJ 2001;322:832. doi:10.1136/bmj.322.7290.832.
12. Hippisley-Cox J, Coupland C. Unintended effects of statins in men and women in England and Wales: population based cohort study using the QResearch database. BMJ 2010;340:c2197. doi:10.1136/bmj. c2197.
13. Sattar N, Preiss D, Murray HM, et al. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet 2010;375:735-42. doi:10.1016/S0140-6736(09)61965-6.
14. Smeeth L, Hubbard R, Fletcher AE. Cataract and the use of statins: a case-control study. QJM 2003;96:337-43. doi:10.1093/qjmed/hcg064.
15. Lemstra M, Blackburn D, Crawley A, Fung R. Proportion and risk indicators of nonadherence to statin therapy: a meta-analysis. Can J Cardiol 2012;28:574-80. doi:10.1016/j.cjca.2012.05.007.
16. Mann DM, Woodard M, Muntner P, Falzon L, Kronish I. Predictors of non-adherence to statins: a systematic review and meta-analysis. Annals Pharmacother 2010;44:1410-21.
17. Brookhart MA, Patrick AR, Schneeweiss S, et al. Physician follow-up and provider continuity are associated with long-term medication adherence: a study of the dynamics of statin use. Arch Intern Med 2007;167:847-52. doi:10.1001/archinte.167.8.847.
18. Caspard H, Chan AK, Walker AM. Compliance with a statin treatment in a usual-care setting: retrospective database analysis over 3 years after treatment initiation in health maintenance organization enrollees with dyslipidemia. Clin Ther 2005;27:1639-46. doi:10.1016/j.clinthera.2005.10.005.
19. Zhang H, Plutzky J, Skentzos S, et al. Discontinuation of statins in routine care settings: a cohort study. Ann Intern Med 2013;158:526-34.doi:10.7326/0003-4819-158-7-201304020-00004.
20. Vinogradova Y, Coupland C, Brindle P, Hippisley-Cox J. Patients who discontinued statin treatment: a protocol for cohort study using primary care data. BMJ Open 2015;5:e008701. doi: 10.1136/bmjopen-2015-008701.
21. Daskalopoulou SS, Delaney JAC, Filion KB, Brophy JM, Mayo NE, Suissa S. Discontinuation of statin therapy following an acute myocardial infarction: a population-based study. Eur Heart J 2008;29:2083-91. doi:10.1093/eurheartj/ehn346.
22. Jones PH, Davidson MH, Stein EA, et al. STELLAR Study Group. Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR∗Trial). Am J Cardiol 2003;92:152-60. doi:10.1016/S0002-9149(03)00530-7.
23. Royal Pharmaceutical Society of Great Britain, British Medical Association. British National Formulary 66.Pharmaceutical Press, 2013.
24. Royston P. Multiple imputation of missing values. Stata J 2004;4:227-41.
25. Steyerberg EW, van Veen M. Imputation is beneficial for handling missing data in predictive models. J Clin Epidemiol 2007;60:979. doi:10.1016/j.jclinepi.2007.03.003.
26. Svensson E, Nielsen RB, Hasvold P, Aarskog P, Thomsen RW. Statin prescription patterns, adherence, and attainment of cholesterol treatment goals in routine clinical care: a Danish population-based study. Clin Epidemiol 2015;7:213-23.
27. Casula M, Tragni E, Catapano AL. Adherence to lipid-lowering treatment: the patient perspective.Patient prefer adherence 2012;6:805-14.
28. Rosenbaum D, Dallongeville J, Sabouret P, Bruckert E. Discontinuation of statin therapy due to muscular side effects: a survey in real life. Nutr Metab Cardiovasc Dis 2013;23:871-5. doi:10.1016/j. numecd.2012.04.012.
29. Pastori D, Polimeni L, Baratta F, Pani A, Del Ben M, Angelico F. The efficacy and safety of statins for the treatment of non-alcoholic fatty liver disease. Dig Liver Dis 2015;47:4-11. doi:10.1016/j. dld.2014.07.170.
30. Young RP, Hopkins R, Eaton TE. Pharmacological actions of statins: potential utility in COPD. Eur Respir Rev 2009;18:222-32. doi:10.1183/09059180.00005309.
31. Ingebrigtsen TS, Marott JL, Nordestgaard BG, Lange P, Hallas J, Vestbo J. Statin use and exacerbations in individuals with chronic obstructive pulmonary disease. Thorax 2015;70:33-40. doi:10.1136/thoraxjnl-2014-205795.
32. Jensen MT, Andersen HU, Rossing P, Jensen JS. Statins are independently associated with increased HbA1c in type 1 diabetes-The Thousand & 1 Study. Diabetes Res Clin Pract 2016;111:51-7. doi:10.1016/j.diabres.2015.10.022.
33. Nielsen SF, Nordestgaard BG. Negative statin-related news stories decrease statin persistence and increase myocardial infarction and cardiovascular mortality: a nationwide prospective cohort study. Eur Heart J 2016;37:908-16. doi:10.1093/eurheartj/ehv641.
34. Warren JR, Falster MO, Fox D, Jorm L. Factors influencing adherence in long-term use of statins. Pharmacoepidemiol Drug Saf 2013;22:1298-307. doi:10.1002/pds.3526.
35. Mauskop A, Borden WB. Predictors of statin adherence. Curr Cardiol Rep 2011;13:553-8. doi:10.1007/s11886-011-0221-2.
36. Schedlbauer A, Davies P, Fahey T. Interventions to improve adherence to lipid lowering medication. Cochrane Database Syst Rev 2010;(3):CD004371.
37. Larsen J, Andersen M, Kragstrup J, Gram LF. High persistence of statin use in a Danish population: compliance study 1993-1998. Br J Clin Pharmacol 2002;53:375-8. doi:10.1046/j.1365-2125.2002.01563.x.
38. Ferrajolo, C., Arcoraci, V., Sullo, M.G., Rafaniello, C., Sportiello, L., Ferrara, R., Cannata, A., Pagliaro, C., Tari, M.G., Caputi, A.P., Rossi, F., Trifirò, G., Capuano, A.Pattern of statin use in southern Italian primary care: Can prescription databases be used for monitoring long-term adherence to the treatment?.PLoS ONE 9(7),2014.
39. Halava H, Korhonen MJ, Huupponen R, et alLifestyle factors as predictors of nonadherence to statin therapy among patients with and without cardiovascular comorbidities. CMAJ 2014;186:E449-56.
40. Mancini GBJ, Tashakkor AY, Baker S, et al. Diagnosis, prevention, and management of statin adverse effects and intolerance: Canadian Working Group Consensus update. Can J Cardiol 2013;29:1553-68. doi:10.1016/j.cjca.2013.09.023.
41. Granger BB, McBroom K, Bosworth HB, Hernandez A, Ekman I. The meanings associated with medicines in heart failure patients. Eur J Cardiovasc Nurs 2013;12:276-83. doi:10.1177/1474515112447734.
42. Harrison TN, Derose SF, Cheetham TC, et al. Primary nonadherence to statin therapy: patients' perceptions. Am J Manag Care 2013;19:e133-9.