-
1
-
-
84858217865
-
Placebo-controlled trial of oral laquinimod for multiple sclerosis
-
COI: 1:CAS:528:DC%2BC38Xkt1yju7w%3D, PID: 22417253
-
Comi G, Jeffery D, Kappos L, et al. Placebo-controlled trial of oral laquinimod for multiple sclerosis. N Engl J Med. 2012;366:1000–9.
-
(2012)
N Engl J Med
, vol.366
, pp. 1000-1009
-
-
Comi, G.1
Jeffery, D.2
Kappos, L.3
-
2
-
-
0034624942
-
Linomide in relapsing and secondary progressive MS: part I: trial design and clinical results. North American Linomide Investigators
-
COI: 1:CAS:528:DC%2BD3cXktVCnurk%3D, PID: 10802775
-
Noseworthy JH, Wolinsky JS, Lublin FD, et al. Linomide in relapsing and secondary progressive MS: part I: trial design and clinical results. North American Linomide Investigators. Neurology. 2000;54:1726–33.
-
(2000)
Neurology
, vol.54
, pp. 1726-1733
-
-
Noseworthy, J.H.1
Wolinsky, J.S.2
Lublin, F.D.3
-
3
-
-
0034624943
-
Linomide in relapsing and secondary progressive Ms: part II: MRI results. MRI Analysis Center of the University of Texas-Houston, Health Science Center, and the North American Linomide Investigators
-
COI: 1:CAS:528:DC%2BD3cXktVCnurc%3D, PID: 10802777
-
Wolinsky JS, Narayana PA, Noseworthy JH, et al. Linomide in relapsing and secondary progressive Ms: part II: MRI results. MRI Analysis Center of the University of Texas-Houston, Health Science Center, and the North American Linomide Investigators. Neurology. 2000;54:1734–41.
-
(2000)
Neurology
, vol.54
, pp. 1734-1741
-
-
Wolinsky, J.S.1
Narayana, P.A.2
Noseworthy, J.H.3
-
4
-
-
0034003613
-
Linomide in the treatment of multiple sclerosis: MRI results from prematurely terminated phase-III trials
-
PID: 10773855
-
Tan IL, Lycklama a Nijeholt GJ, Polman CH, Ader HJ, Barkhof F. Linomide in the treatment of multiple sclerosis: MRI results from prematurely terminated phase-III trials. Mult Scler. 2000;6:99–104.
-
(2000)
Mult Scler
, vol.6
, pp. 99-104
-
-
Tan, I.L.1
Lycklama a Nijeholt, G.J.2
Polman, C.H.3
Ader, H.J.4
Barkhof, F.5
-
5
-
-
11144357311
-
Synthesis and biological evaluation of new 1,2-Dihydro-4-Hydroxy-2-Oxo-3-Quinolinecarboxamides for treatment of autoimmune disorders: structure-activity relationship
-
PID: 15056005
-
Jonsson S, Andersson G, Fex T, et al. Synthesis and biological evaluation of new 1,2-Dihydro-4-Hydroxy-2-Oxo-3-Quinolinecarboxamides for treatment of autoimmune disorders: structure-activity relationship. J Med Chem. 2004;47:2075–88.
-
(2004)
J Med Chem
, vol.47
, pp. 2075-2088
-
-
Jonsson, S.1
Andersson, G.2
Fex, T.3
-
6
-
-
0036710356
-
The new orally active immuno regulator laquinimod (Abr-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis
-
COI: 1:CAS:528:DC%2BD38XmvVWqtLo%3D, PID: 12225898
-
Brunmark C, Runstrom A, Ohlsson L, et al. The new orally active immuno regulator laquinimod (Abr-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2002;130:163–72.
-
(2002)
J Neuroimmunol
, vol.130
, pp. 163-172
-
-
Brunmark, C.1
Runstrom, A.2
Ohlsson, L.3
-
7
-
-
0029939467
-
Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system
-
COI: 1:CAS:528:DyaK28XivVyrs74%3D, PID: 8616884
-
Steinman L. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell. 1996;85:299–302.
-
(1996)
Cell
, vol.85
, pp. 299-302
-
-
Steinman, L.1
-
8
-
-
20444482731
-
Pathogenesis of multiple sclerosis
-
COI: 1:CAS:528:DC%2BD2MXlslWhtrg%3D, PID: 15891404
-
Prat A, Antel J. Pathogenesis of multiple sclerosis. Curr Opin Neurol. 2005;18:225–30.
-
(2005)
Curr Opin Neurol
, vol.18
, pp. 225-230
-
-
Prat, A.1
Antel, J.2
-
9
-
-
79958770585
-
Insight into the mechanism of laquinimod action
-
PID: 21429524
-
Brück W, Wegner C. Insight into the mechanism of laquinimod action. J Neurol Sci. 2011;306:173–9.
-
(2011)
J Neurol Sci
, vol.306
, pp. 173-179
-
-
Brück, W.1
Wegner, C.2
-
10
-
-
4744340401
-
Laquinimod (Abr-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 Cytokine Tgf-Beta in Lewis Rats
-
COI: 1:CAS:528:DC%2BD2cXot1Wqtbo%3D, PID: 15465591
-
Yang JS, Xu LY, Xiao BG, Hedlund G, Link H. Laquinimod (Abr-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 Cytokine Tgf-Beta in Lewis Rats. J Neuroimmunol. 2004;156:3–9.
-
(2004)
J Neuroimmunol
, vol.156
, pp. 3-9
-
-
Yang, J.S.1
Xu, L.Y.2
Xiao, B.G.3
Hedlund, G.4
Link, H.5
-
11
-
-
77956649428
-
Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis
-
COI: 1:CAS:528:DC%2BC3cXhtFyisLfE, PID: 20684995
-
Wegner C, Stadelmann C, Pförtner R, et al. Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis. J Neuroimmunol. 2010;227:133–43.
-
(2010)
J Neuroimmunol
, vol.227
, pp. 133-143
-
-
Wegner, C.1
Stadelmann, C.2
Pförtner, R.3
-
12
-
-
77951218761
-
Laquinimod suppress antigen presentation in relapsing-remitting multiple sclerosis: in-vitro high-throughput gene expression study
-
COI: 1:CAS:528:DC%2BC3cXks1Sjsrg%3D, PID: 20347159
-
Gurevich M, Gritzman T, Orbach R, Tuller T, Feldman A, Achiron A. Laquinimod suppress antigen presentation in relapsing-remitting multiple sclerosis: in-vitro high-throughput gene expression study. J Neuroimmunol. 2010;221:87–94.
-
(2010)
J Neuroimmunol
, vol.221
, pp. 87-94
-
-
Gurevich, M.1
Gritzman, T.2
Orbach, R.3
Tuller, T.4
Feldman, A.5
Achiron, A.6
-
13
-
-
0034927081
-
Neurotrophins: roles in neuronal development and function
-
COI: 1:CAS:528:DC%2BD3MXls1ShsL4%3D, PID: 11520916
-
Huang EJ, Reichardt LF. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci. 2001;24:677–736.
-
(2001)
Annu Rev Neurosci
, vol.24
, pp. 677-736
-
-
Huang, E.J.1
Reichardt, L.F.2
-
14
-
-
83555174399
-
Modulation of autoimmune demyelination by laquinimod via induction of brain-derived neurotrophic factor
-
PID: 22152994
-
Thöne J, Ellrichmann G, Seubert S, et al. Modulation of autoimmune demyelination by laquinimod via induction of brain-derived neurotrophic factor. Am J Pathol. 2012;180:267–74.
-
(2012)
Am J Pathol
, vol.180
, pp. 267-274
-
-
Thöne, J.1
Ellrichmann, G.2
Seubert, S.3
-
15
-
-
79958768673
-
Effects of laquinimod on axon degeneration in autoimmune optic neuritis
-
Suhs K-W. Effects of laquinimod on axon degeneration in autoimmune optic neuritis. Mult Scler 2007;13:S7–S273.
-
(2007)
Mult Scler
, vol.13
, pp. 7-273
-
-
Suhs, K.-W.1
-
16
-
-
79951918131
-
Laquinimod: a promising oral medication for the treatment of relapsing-remitting multiple sclerosis
-
COI: 1:CAS:528:DC%2BC3MXit1Wku7o%3D, PID: 21306281
-
Thone J, Gold R. Laquinimod: a promising oral medication for the treatment of relapsing-remitting multiple sclerosis. Expert Opin Drug Metab Toxicol. 2011;7:365–70.
-
(2011)
Expert Opin Drug Metab Toxicol
, vol.7
, pp. 365-370
-
-
Thone, J.1
Gold, R.2
-
17
-
-
15244353263
-
Treatment with laquinimod reduces development of active MRI lesions in relapsing MS
-
COI: 1:CAS:528:DC%2BD2MXhvVShs7c%3D, PID: 15781813
-
Polman C, Barkhof F, Sandberg-Wollheim M, et al. Treatment with laquinimod reduces development of active MRI lesions in relapsing MS. Neurology. 2005;64:987–91.
-
(2005)
Neurology
, vol.64
, pp. 987-991
-
-
Polman, C.1
Barkhof, F.2
Sandberg-Wollheim, M.3
-
18
-
-
78449302875
-
Oral laquinimod in patients with relapsing-remitting multiple sclerosis: 36-week double-blind active extension of the multi-centre, randomized, double-blind, parallel-group placebo-controlled study
-
COI: 1:STN:280:DC%2BC3cblvVygtQ%3D%3D, PID: 20834039
-
Comi G, Abramsky O, Arbizu T, et al. Oral laquinimod in patients with relapsing-remitting multiple sclerosis: 36-week double-blind active extension of the multi-centre, randomized, double-blind, parallel-group placebo-controlled study. Mult Scler. 2010;16:1360–6.
-
(2010)
Mult Scler
, vol.16
, pp. 1360-1366
-
-
Comi, G.1
Abramsky, O.2
Arbizu, T.3
-
19
-
-
45249107267
-
Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study
-
COI: 1:STN:280:DC%2BD1cvgsVegtQ%3D%3D, PID: 18572078
-
Comi G, Pulizzi A, Rovaris M, et al. Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study. Lancet. 2008;371:2085–92.
-
(2008)
Lancet
, vol.371
, pp. 2085-2092
-
-
Comi, G.1
Pulizzi, A.2
Rovaris, M.3
-
21
-
-
84977108120
-
-
Clinicaltrials.gov. The efficacy and safety and tolerability of laquinimod in subjects with relapsing remitting multiple sclerosis (RRMS) (CONCERTO). (last accessed April 9, 2014)
-
Clinicaltrials.gov. The efficacy and safety and tolerability of laquinimod in subjects with relapsing remitting multiple sclerosis (RRMS) (CONCERTO). http://clinicaltrials.gov/show/NCT01707992 (last accessed April 9, 2014).
-
-
-
-
22
-
-
84863549344
-
Overview of treatment options in multiple sclerosis
-
PID: 22795209
-
Waubant E. Overview of treatment options in multiple sclerosis. J Clin Psychiatry. 2012;73:e22.
-
(2012)
J Clin Psychiatry
, vol.73
, pp. 22
-
-
Waubant, E.1
-
24
-
-
0008678962
-
Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The multiple sclerosis collaborative research group (MSCRG)’
-
COI: 1:CAS:528:DyaK28XisFyrsLY%3D, PID: 8602746
-
Jacobs LD, Cookfair DL, Rudick RA, et al. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The multiple sclerosis collaborative research group (MSCRG)’. Ann Neurol. 1996;39:285–94.
-
(1996)
Ann Neurol
, vol.39
, pp. 285-294
-
-
Jacobs, L.D.1
Cookfair, D.L.2
Rudick, R.A.3
-
25
-
-
0027418515
-
Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis I. Clinical results of a multicenter, randomized, double‐blind, placebo-controlled trial
-
IFNB Multiple Sclerosis Study Group. Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis I. Clinical results of a multicenter, randomized, double‐blind, placebo-controlled trial. Neurology. 1993;43:655.
-
(1993)
Neurology
, vol.43
, pp. 655
-
-
IFNB Multiple Sclerosis Study Group1
-
26
-
-
84874508209
-
Oral available agents in the treatment of relapsing remitting multiple sclerosis: an overview of merits and culprits
-
PID: 23459383
-
Thone J, Ellrichmann G. Oral available agents in the treatment of relapsing remitting multiple sclerosis: an overview of merits and culprits. Drug Healthc Patient Saf. 2013;5:37–47.
-
(2013)
Drug Healthc Patient Saf
, vol.5
, pp. 37-47
-
-
Thone, J.1
Ellrichmann, G.2
-
27
-
-
80054734945
-
Oral treatment for multiple sclerosis
-
COI: 1:CAS:528:DC%2BC3MXhtlOks7jK, PID: 22014437
-
Killestein J, Rudick RA, Polman CH. Oral treatment for multiple sclerosis. Lancet Neurol. 2011;10:1026–34.
-
(2011)
Lancet Neurol
, vol.10
, pp. 1026-1034
-
-
Killestein, J.1
Rudick, R.A.2
Polman, C.H.3
-
28
-
-
76149093586
-
A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
-
COI: 1:CAS:528:DC%2BC3cXhvVWltr4%3D, PID: 20089952
-
Kappos L, Radue EW, O’Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med. 2010;362:387–401.
-
(2010)
N Engl J Med
, vol.362
, pp. 387-401
-
-
Kappos, L.1
Radue, E.W.2
O’Connor, P.3
-
29
-
-
84881550415
-
Fingolimod versus intramuscular interferon in patient subgroups from transforms
-
COI: 1:CAS:528:DC%2BC3sXht1GgtL7K, PID: 23632946
-
Cohen JA, Barkhof F, Comi G, et al. Fingolimod versus intramuscular interferon in patient subgroups from transforms. J Neurol. 2013;260:2023–32.
-
(2013)
J Neurol
, vol.260
, pp. 2023-2032
-
-
Cohen, J.A.1
Barkhof, F.2
Comi, G.3
-
30
-
-
77953634709
-
Oral fingolimod for relapsing-remitting multiple sclerosis Evaluation of
-
Doggrell SA. Oral fingolimod for relapsing-remitting multiple sclerosis Evaluation of: Kappos L, Radue E-M, O’Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 2010;362:387–401; and Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 2010;362:402–15. Expert Opin Pharmacother. 2010;11(10):1777–81.
-
(2010)
Kappos L, Radue E-M, O’Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 2010;362:387–401; and Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 2010;362:402–15. Expert Opin Pharmacother
, vol.11
, Issue.10
, pp. 1777-1781
-
-
Doggrell, S.A.1
-
31
-
-
80053533877
-
Randomized trial of oral teriflunomide for relapsing multiple sclerosis
-
PID: 21991951
-
O’Connor P, Wolinsky JS, Confavreux C, et al. Randomized trial of oral teriflunomide for relapsing multiple sclerosis. N Engl J Med. 2011;365:1293–303.
-
(2011)
N Engl J Med
, vol.365
, pp. 1293-1303
-
-
O’Connor, P.1
Wolinsky, J.S.2
Confavreux, C.3
-
32
-
-
84885848919
-
The efficacy and safety of teriflunomide in patients with relapsing MS: results from tower, a phase III, placebo-controlled study. Lyon
-
Kappos L, Comi G, Confavreux C. The efficacy and safety of teriflunomide in patients with relapsing MS: results from tower, a phase III, placebo-controlled study. Lyon, France: 28th Congress of the European committee for research and treatment in multiple sclerosis (ECTRIMS); 2012.
-
(2012)
France: 28th Congress of the European committee for research and treatment in multiple sclerosis (ECTRIMS)
-
-
Kappos, L.1
Comi, G.2
Confavreux, C.3
-
33
-
-
84977167063
-
-
Clinicaltrials.gov. A study comparing the effectiveness and safety of teriflunomide and interferon beta-1a in patients with relapsing multiple sclerosis (TENERE). (last accessed April 9, 2014)
-
Clinicaltrials.gov. A study comparing the effectiveness and safety of teriflunomide and interferon beta-1a in patients with relapsing multiple sclerosis (TENERE). http://clinicaltrials.gov/show/NCT00883337 (last accessed April 9, 2014).
-
-
-
-
34
-
-
84884339141
-
Clinical efficacy of BG-12 (Dimethyl Fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the define study
-
COI: 1:CAS:528:DC%2BC3sXhsVeis7%2FO, PID: 23797999
-
Bar-Or A, Gold R, Kappos L, et al. Clinical efficacy of BG-12 (Dimethyl Fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the define study. J Neurol. 2013;260:2297–305.
-
(2013)
J Neurol
, vol.260
, pp. 2297-2305
-
-
Bar-Or, A.1
Gold, R.2
Kappos, L.3
-
35
-
-
84884337463
-
Clinical efficacy of BG-12 (Dimethyl Fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the confirm study
-
COI: 1:CAS:528:DC%2BC3sXhsVeisrbN, PID: 23749293
-
Hutchinson M, Fox RJ, Miller DH, et al. Clinical efficacy of BG-12 (Dimethyl Fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the confirm study. J Neurol. 2013;260:2286–96.
-
(2013)
J Neurol
, vol.260
, pp. 2286-2296
-
-
Hutchinson, M.1
Fox, R.J.2
Miller, D.H.3
-
36
-
-
68349107070
-
Imaging outcomes for neuroprotection and repair in multiple sclerosis trials
-
Barkhof F, Calabresi P, Miller D, Reingold S. Imaging outcomes for neuroprotection and repair in multiple sclerosis trials. Nat Rev Neurol. 2009;5(256–266):39.
-
(2009)
Nat Rev Neurol
, vol.5
, Issue.256-266
, pp. 39
-
-
Barkhof, F.1
Calabresi, P.2
Miller, D.3
Reingold, S.4
-
37
-
-
74249102004
-
Emerging multiple sclerosis oral therapies
-
PID: 20038763
-
Rammohan K, Shoemaker J. Emerging multiple sclerosis oral therapies. Neurology. 2010;74:s47–53.
-
(2010)
Neurology
, vol.74
, pp. 47-53
-
-
Rammohan, K.1
Shoemaker, J.2
|