메뉴 건너뛰기




Volumn 3, Issue 1, 2014, Pages 29-39

Laquinimod Therapy in Multiple Sclerosis: A Comprehensive Review

Author keywords

Clinical trials; Disease modifying therapies; Laquinimod; Multiple sclerosis; Neurology; Neuroprotection

Indexed keywords

ALEMTUZUMAB; BLOOD CLOTTING FACTOR 5 LEIDEN; BRAIN DERIVED NEUROTROPHIC FACTOR; GADOLINIUM; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 4; LAQUINIMOD; NATALIZUMAB; PLACEBO; ROQUINIMEX; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84977139159     PISSN: 21938253     EISSN: 21936536     Source Type: Journal    
DOI: 10.1007/s40120-014-0017-6     Document Type: Review
Times cited : (13)

References (37)
  • 1
    • 84858217865 scopus 로고    scopus 로고
    • Placebo-controlled trial of oral laquinimod for multiple sclerosis
    • COI: 1:CAS:528:DC%2BC38Xkt1yju7w%3D, PID: 22417253
    • Comi G, Jeffery D, Kappos L, et al. Placebo-controlled trial of oral laquinimod for multiple sclerosis. N Engl J Med. 2012;366:1000–9.
    • (2012) N Engl J Med , vol.366 , pp. 1000-1009
    • Comi, G.1    Jeffery, D.2    Kappos, L.3
  • 2
    • 0034624942 scopus 로고    scopus 로고
    • Linomide in relapsing and secondary progressive MS: part I: trial design and clinical results. North American Linomide Investigators
    • COI: 1:CAS:528:DC%2BD3cXktVCnurk%3D, PID: 10802775
    • Noseworthy JH, Wolinsky JS, Lublin FD, et al. Linomide in relapsing and secondary progressive MS: part I: trial design and clinical results. North American Linomide Investigators. Neurology. 2000;54:1726–33.
    • (2000) Neurology , vol.54 , pp. 1726-1733
    • Noseworthy, J.H.1    Wolinsky, J.S.2    Lublin, F.D.3
  • 3
    • 0034624943 scopus 로고    scopus 로고
    • Linomide in relapsing and secondary progressive Ms: part II: MRI results. MRI Analysis Center of the University of Texas-Houston, Health Science Center, and the North American Linomide Investigators
    • COI: 1:CAS:528:DC%2BD3cXktVCnurc%3D, PID: 10802777
    • Wolinsky JS, Narayana PA, Noseworthy JH, et al. Linomide in relapsing and secondary progressive Ms: part II: MRI results. MRI Analysis Center of the University of Texas-Houston, Health Science Center, and the North American Linomide Investigators. Neurology. 2000;54:1734–41.
    • (2000) Neurology , vol.54 , pp. 1734-1741
    • Wolinsky, J.S.1    Narayana, P.A.2    Noseworthy, J.H.3
  • 4
    • 0034003613 scopus 로고    scopus 로고
    • Linomide in the treatment of multiple sclerosis: MRI results from prematurely terminated phase-III trials
    • PID: 10773855
    • Tan IL, Lycklama a Nijeholt GJ, Polman CH, Ader HJ, Barkhof F. Linomide in the treatment of multiple sclerosis: MRI results from prematurely terminated phase-III trials. Mult Scler. 2000;6:99–104.
    • (2000) Mult Scler , vol.6 , pp. 99-104
    • Tan, I.L.1    Lycklama a Nijeholt, G.J.2    Polman, C.H.3    Ader, H.J.4    Barkhof, F.5
  • 5
    • 11144357311 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of new 1,2-Dihydro-4-Hydroxy-2-Oxo-3-Quinolinecarboxamides for treatment of autoimmune disorders: structure-activity relationship
    • PID: 15056005
    • Jonsson S, Andersson G, Fex T, et al. Synthesis and biological evaluation of new 1,2-Dihydro-4-Hydroxy-2-Oxo-3-Quinolinecarboxamides for treatment of autoimmune disorders: structure-activity relationship. J Med Chem. 2004;47:2075–88.
    • (2004) J Med Chem , vol.47 , pp. 2075-2088
    • Jonsson, S.1    Andersson, G.2    Fex, T.3
  • 6
    • 0036710356 scopus 로고    scopus 로고
    • The new orally active immuno regulator laquinimod (Abr-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis
    • COI: 1:CAS:528:DC%2BD38XmvVWqtLo%3D, PID: 12225898
    • Brunmark C, Runstrom A, Ohlsson L, et al. The new orally active immuno regulator laquinimod (Abr-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2002;130:163–72.
    • (2002) J Neuroimmunol , vol.130 , pp. 163-172
    • Brunmark, C.1    Runstrom, A.2    Ohlsson, L.3
  • 7
    • 0029939467 scopus 로고    scopus 로고
    • Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system
    • COI: 1:CAS:528:DyaK28XivVyrs74%3D, PID: 8616884
    • Steinman L. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell. 1996;85:299–302.
    • (1996) Cell , vol.85 , pp. 299-302
    • Steinman, L.1
  • 8
    • 20444482731 scopus 로고    scopus 로고
    • Pathogenesis of multiple sclerosis
    • COI: 1:CAS:528:DC%2BD2MXlslWhtrg%3D, PID: 15891404
    • Prat A, Antel J. Pathogenesis of multiple sclerosis. Curr Opin Neurol. 2005;18:225–30.
    • (2005) Curr Opin Neurol , vol.18 , pp. 225-230
    • Prat, A.1    Antel, J.2
  • 9
    • 79958770585 scopus 로고    scopus 로고
    • Insight into the mechanism of laquinimod action
    • PID: 21429524
    • Brück W, Wegner C. Insight into the mechanism of laquinimod action. J Neurol Sci. 2011;306:173–9.
    • (2011) J Neurol Sci , vol.306 , pp. 173-179
    • Brück, W.1    Wegner, C.2
  • 10
    • 4744340401 scopus 로고    scopus 로고
    • Laquinimod (Abr-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 Cytokine Tgf-Beta in Lewis Rats
    • COI: 1:CAS:528:DC%2BD2cXot1Wqtbo%3D, PID: 15465591
    • Yang JS, Xu LY, Xiao BG, Hedlund G, Link H. Laquinimod (Abr-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 Cytokine Tgf-Beta in Lewis Rats. J Neuroimmunol. 2004;156:3–9.
    • (2004) J Neuroimmunol , vol.156 , pp. 3-9
    • Yang, J.S.1    Xu, L.Y.2    Xiao, B.G.3    Hedlund, G.4    Link, H.5
  • 11
    • 77956649428 scopus 로고    scopus 로고
    • Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis
    • COI: 1:CAS:528:DC%2BC3cXhtFyisLfE, PID: 20684995
    • Wegner C, Stadelmann C, Pförtner R, et al. Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis. J Neuroimmunol. 2010;227:133–43.
    • (2010) J Neuroimmunol , vol.227 , pp. 133-143
    • Wegner, C.1    Stadelmann, C.2    Pförtner, R.3
  • 12
    • 77951218761 scopus 로고    scopus 로고
    • Laquinimod suppress antigen presentation in relapsing-remitting multiple sclerosis: in-vitro high-throughput gene expression study
    • COI: 1:CAS:528:DC%2BC3cXks1Sjsrg%3D, PID: 20347159
    • Gurevich M, Gritzman T, Orbach R, Tuller T, Feldman A, Achiron A. Laquinimod suppress antigen presentation in relapsing-remitting multiple sclerosis: in-vitro high-throughput gene expression study. J Neuroimmunol. 2010;221:87–94.
    • (2010) J Neuroimmunol , vol.221 , pp. 87-94
    • Gurevich, M.1    Gritzman, T.2    Orbach, R.3    Tuller, T.4    Feldman, A.5    Achiron, A.6
  • 13
    • 0034927081 scopus 로고    scopus 로고
    • Neurotrophins: roles in neuronal development and function
    • COI: 1:CAS:528:DC%2BD3MXls1ShsL4%3D, PID: 11520916
    • Huang EJ, Reichardt LF. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci. 2001;24:677–736.
    • (2001) Annu Rev Neurosci , vol.24 , pp. 677-736
    • Huang, E.J.1    Reichardt, L.F.2
  • 14
    • 83555174399 scopus 로고    scopus 로고
    • Modulation of autoimmune demyelination by laquinimod via induction of brain-derived neurotrophic factor
    • PID: 22152994
    • Thöne J, Ellrichmann G, Seubert S, et al. Modulation of autoimmune demyelination by laquinimod via induction of brain-derived neurotrophic factor. Am J Pathol. 2012;180:267–74.
    • (2012) Am J Pathol , vol.180 , pp. 267-274
    • Thöne, J.1    Ellrichmann, G.2    Seubert, S.3
  • 15
    • 79958768673 scopus 로고    scopus 로고
    • Effects of laquinimod on axon degeneration in autoimmune optic neuritis
    • Suhs K-W. Effects of laquinimod on axon degeneration in autoimmune optic neuritis. Mult Scler 2007;13:S7–S273.
    • (2007) Mult Scler , vol.13 , pp. 7-273
    • Suhs, K.-W.1
  • 16
    • 79951918131 scopus 로고    scopus 로고
    • Laquinimod: a promising oral medication for the treatment of relapsing-remitting multiple sclerosis
    • COI: 1:CAS:528:DC%2BC3MXit1Wku7o%3D, PID: 21306281
    • Thone J, Gold R. Laquinimod: a promising oral medication for the treatment of relapsing-remitting multiple sclerosis. Expert Opin Drug Metab Toxicol. 2011;7:365–70.
    • (2011) Expert Opin Drug Metab Toxicol , vol.7 , pp. 365-370
    • Thone, J.1    Gold, R.2
  • 17
    • 15244353263 scopus 로고    scopus 로고
    • Treatment with laquinimod reduces development of active MRI lesions in relapsing MS
    • COI: 1:CAS:528:DC%2BD2MXhvVShs7c%3D, PID: 15781813
    • Polman C, Barkhof F, Sandberg-Wollheim M, et al. Treatment with laquinimod reduces development of active MRI lesions in relapsing MS. Neurology. 2005;64:987–91.
    • (2005) Neurology , vol.64 , pp. 987-991
    • Polman, C.1    Barkhof, F.2    Sandberg-Wollheim, M.3
  • 18
    • 78449302875 scopus 로고    scopus 로고
    • Oral laquinimod in patients with relapsing-remitting multiple sclerosis: 36-week double-blind active extension of the multi-centre, randomized, double-blind, parallel-group placebo-controlled study
    • COI: 1:STN:280:DC%2BC3cblvVygtQ%3D%3D, PID: 20834039
    • Comi G, Abramsky O, Arbizu T, et al. Oral laquinimod in patients with relapsing-remitting multiple sclerosis: 36-week double-blind active extension of the multi-centre, randomized, double-blind, parallel-group placebo-controlled study. Mult Scler. 2010;16:1360–6.
    • (2010) Mult Scler , vol.16 , pp. 1360-1366
    • Comi, G.1    Abramsky, O.2    Arbizu, T.3
  • 19
    • 45249107267 scopus 로고    scopus 로고
    • Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study
    • COI: 1:STN:280:DC%2BD1cvgsVegtQ%3D%3D, PID: 18572078
    • Comi G, Pulizzi A, Rovaris M, et al. Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study. Lancet. 2008;371:2085–92.
    • (2008) Lancet , vol.371 , pp. 2085-2092
    • Comi, G.1    Pulizzi, A.2    Rovaris, M.3
  • 21
    • 84977108120 scopus 로고    scopus 로고
    • Clinicaltrials.gov. The efficacy and safety and tolerability of laquinimod in subjects with relapsing remitting multiple sclerosis (RRMS) (CONCERTO). (last accessed April 9, 2014)
    • Clinicaltrials.gov. The efficacy and safety and tolerability of laquinimod in subjects with relapsing remitting multiple sclerosis (RRMS) (CONCERTO). http://clinicaltrials.gov/show/NCT01707992 (last accessed April 9, 2014).
  • 22
    • 84863549344 scopus 로고    scopus 로고
    • Overview of treatment options in multiple sclerosis
    • PID: 22795209
    • Waubant E. Overview of treatment options in multiple sclerosis. J Clin Psychiatry. 2012;73:e22.
    • (2012) J Clin Psychiatry , vol.73 , pp. 22
    • Waubant, E.1
  • 24
    • 0008678962 scopus 로고    scopus 로고
    • Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The multiple sclerosis collaborative research group (MSCRG)’
    • COI: 1:CAS:528:DyaK28XisFyrsLY%3D, PID: 8602746
    • Jacobs LD, Cookfair DL, Rudick RA, et al. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The multiple sclerosis collaborative research group (MSCRG)’. Ann Neurol. 1996;39:285–94.
    • (1996) Ann Neurol , vol.39 , pp. 285-294
    • Jacobs, L.D.1    Cookfair, D.L.2    Rudick, R.A.3
  • 25
    • 0027418515 scopus 로고
    • Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis I. Clinical results of a multicenter, randomized, double‐blind, placebo-controlled trial
    • IFNB Multiple Sclerosis Study Group. Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis I. Clinical results of a multicenter, randomized, double‐blind, placebo-controlled trial. Neurology. 1993;43:655.
    • (1993) Neurology , vol.43 , pp. 655
    • IFNB Multiple Sclerosis Study Group1
  • 26
    • 84874508209 scopus 로고    scopus 로고
    • Oral available agents in the treatment of relapsing remitting multiple sclerosis: an overview of merits and culprits
    • PID: 23459383
    • Thone J, Ellrichmann G. Oral available agents in the treatment of relapsing remitting multiple sclerosis: an overview of merits and culprits. Drug Healthc Patient Saf. 2013;5:37–47.
    • (2013) Drug Healthc Patient Saf , vol.5 , pp. 37-47
    • Thone, J.1    Ellrichmann, G.2
  • 27
    • 80054734945 scopus 로고    scopus 로고
    • Oral treatment for multiple sclerosis
    • COI: 1:CAS:528:DC%2BC3MXhtlOks7jK, PID: 22014437
    • Killestein J, Rudick RA, Polman CH. Oral treatment for multiple sclerosis. Lancet Neurol. 2011;10:1026–34.
    • (2011) Lancet Neurol , vol.10 , pp. 1026-1034
    • Killestein, J.1    Rudick, R.A.2    Polman, C.H.3
  • 28
    • 76149093586 scopus 로고    scopus 로고
    • A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
    • COI: 1:CAS:528:DC%2BC3cXhvVWltr4%3D, PID: 20089952
    • Kappos L, Radue EW, O’Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med. 2010;362:387–401.
    • (2010) N Engl J Med , vol.362 , pp. 387-401
    • Kappos, L.1    Radue, E.W.2    O’Connor, P.3
  • 29
    • 84881550415 scopus 로고    scopus 로고
    • Fingolimod versus intramuscular interferon in patient subgroups from transforms
    • COI: 1:CAS:528:DC%2BC3sXht1GgtL7K, PID: 23632946
    • Cohen JA, Barkhof F, Comi G, et al. Fingolimod versus intramuscular interferon in patient subgroups from transforms. J Neurol. 2013;260:2023–32.
    • (2013) J Neurol , vol.260 , pp. 2023-2032
    • Cohen, J.A.1    Barkhof, F.2    Comi, G.3
  • 31
    • 80053533877 scopus 로고    scopus 로고
    • Randomized trial of oral teriflunomide for relapsing multiple sclerosis
    • PID: 21991951
    • O’Connor P, Wolinsky JS, Confavreux C, et al. Randomized trial of oral teriflunomide for relapsing multiple sclerosis. N Engl J Med. 2011;365:1293–303.
    • (2011) N Engl J Med , vol.365 , pp. 1293-1303
    • O’Connor, P.1    Wolinsky, J.S.2    Confavreux, C.3
  • 33
    • 84977167063 scopus 로고    scopus 로고
    • Clinicaltrials.gov. A study comparing the effectiveness and safety of teriflunomide and interferon beta-1a in patients with relapsing multiple sclerosis (TENERE). (last accessed April 9, 2014)
    • Clinicaltrials.gov. A study comparing the effectiveness and safety of teriflunomide and interferon beta-1a in patients with relapsing multiple sclerosis (TENERE). http://clinicaltrials.gov/show/NCT00883337 (last accessed April 9, 2014).
  • 34
    • 84884339141 scopus 로고    scopus 로고
    • Clinical efficacy of BG-12 (Dimethyl Fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the define study
    • COI: 1:CAS:528:DC%2BC3sXhsVeis7%2FO, PID: 23797999
    • Bar-Or A, Gold R, Kappos L, et al. Clinical efficacy of BG-12 (Dimethyl Fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the define study. J Neurol. 2013;260:2297–305.
    • (2013) J Neurol , vol.260 , pp. 2297-2305
    • Bar-Or, A.1    Gold, R.2    Kappos, L.3
  • 35
    • 84884337463 scopus 로고    scopus 로고
    • Clinical efficacy of BG-12 (Dimethyl Fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the confirm study
    • COI: 1:CAS:528:DC%2BC3sXhsVeisrbN, PID: 23749293
    • Hutchinson M, Fox RJ, Miller DH, et al. Clinical efficacy of BG-12 (Dimethyl Fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the confirm study. J Neurol. 2013;260:2286–96.
    • (2013) J Neurol , vol.260 , pp. 2286-2296
    • Hutchinson, M.1    Fox, R.J.2    Miller, D.H.3
  • 36
    • 68349107070 scopus 로고    scopus 로고
    • Imaging outcomes for neuroprotection and repair in multiple sclerosis trials
    • Barkhof F, Calabresi P, Miller D, Reingold S. Imaging outcomes for neuroprotection and repair in multiple sclerosis trials. Nat Rev Neurol. 2009;5(256–266):39.
    • (2009) Nat Rev Neurol , vol.5 , Issue.256-266 , pp. 39
    • Barkhof, F.1    Calabresi, P.2    Miller, D.3    Reingold, S.4
  • 37
    • 74249102004 scopus 로고    scopus 로고
    • Emerging multiple sclerosis oral therapies
    • PID: 20038763
    • Rammohan K, Shoemaker J. Emerging multiple sclerosis oral therapies. Neurology. 2010;74:s47–53.
    • (2010) Neurology , vol.74 , pp. 47-53
    • Rammohan, K.1    Shoemaker, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.