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Volumn 16, Issue 8, 2016, Pages 498-508

Combinatorial antibody libraries: New advances, new immunological insights

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY ENGINEERING; ANTIBODY LIBRARY; ANTIGEN BINDING; AUTOCRINE EFFECT; CELL FATE; COMBINATORIAL LIBRARY; DNA REPAIR; HEAVY CHAIN; HUMAN; IMMUNE SYSTEM; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; LIGHT CHAIN; PRIORITY JOURNAL; REVIEW; ANIMAL; CHEMISTRY; GENE LIBRARY; GENE VECTOR; GENETICS; IMMUNOLOGY; PROCEDURES; PROTEIN ENGINEERING; SYNTHETIC BIOLOGY;

EID: 84976908705     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri.2016.67     Document Type: Review
Times cited : (83)

References (55)
  • 1
    • 0005352170 scopus 로고
    • Dissociation of γ-globulin
    • Edelman, G. M. Dissociation of γ-globulin. J. Am. Chem. Soc. 81, 3155-3156 (1959
    • (1959) J. Am. Chem. Soc , vol.81 , pp. 3155-3156
    • Edelman, G.M.1
  • 2
    • 70449276523 scopus 로고
    • The hydrolysis of rabbit γ globulin and antibodies with crystalline papain
    • Porter, R. R. The hydrolysis of rabbit γ globulin and antibodies with crystalline papain. Biochem. J. 73, 119-126 (1959
    • (1959) Biochem. J. , vol.73 , pp. 119-126
    • Porter, R.R.1
  • 3
    • 0022558297 scopus 로고
    • Replacing the complementarity-determining regions in a human antibody with those from a mouse
    • Jones, P. T., Dear, P. H., Foote, J., Neuberger, M. S., & Winter, G. Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature 321, 522-525 (1986
    • (1986) Nature , vol.321 , pp. 522-525
    • Jones, P.T.1    Dear, P.H.2    Foote, J.3    Neuberger, M.S.4    Winter, G.5
  • 4
    • 84911390603 scopus 로고    scopus 로고
    • Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells
    • Romain, G., et al. Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells. Blood 124, 3241-3249 (2014
    • (2014) Blood , vol.124 , pp. 3241-3249
    • Romain, G.1
  • 5
    • 77951523463 scopus 로고    scopus 로고
    • Bispecific antibodies for cancer therapy: The light at the end of the tunnel?
    • Chames, P & Baty, D. Bispecific antibodies for cancer therapy: the light at the end of the tunnel? mAbs 1 539-547 2009
    • (2009) Mabs , vol.1 , pp. 539-547
    • Chames, P.1    Baty, D.2
  • 6
    • 84896925253 scopus 로고    scopus 로고
    • Emerging classes of armed antibody therapeutics against cancer
    • Hess, C., Venetz, D., & Neri, D. Emerging classes of armed antibody therapeutics against cancer. Med. Chem. Commun. 5, 408-431 (2014
    • (2014) Med. Chem. Commun , vol.5 , pp. 408-431
    • Hess, C.1    Venetz, D.2    Neri, D.3
  • 7
    • 84939622516 scopus 로고    scopus 로고
    • A general method for insertion of functional proteins within proteins via combinatorial selection of permissive junctions
    • Peng, Y. J., et al. A general method for insertion of functional proteins within proteins via combinatorial selection of permissive junctions. Chem. Biol. 22, 1134-1143 (2015
    • (2015) Chem Biol , vol.22 , pp. 1134-1143
    • Peng, Y.J.1
  • 8
    • 84882255351 scopus 로고    scopus 로고
    • Functional antibody CDR3 fusion proteins with enhanced pharmacological properties
    • Zhang, Y., et al. Functional antibody CDR3 fusion proteins with enhanced pharmacological properties. Angew. Chem. Int. Ed. Engl. 52, 8295-8298 (2013
    • (2013) Angew. Chem. Int. Ed. Engl , vol.52 , pp. 8295-8298
    • Zhang, Y.1
  • 9
    • 84886454533 scopus 로고    scopus 로고
    • An antibody CDR3 erythropoietin fusion protein
    • Zhang, Y., et al. An antibody CDR3 erythropoietin fusion protein. ACS Chem. Biol. 8, 2117-2121 (2013
    • (2013) ACS Chem. Biol , vol.8 , pp. 2117-2121
    • Zhang, Y.1
  • 10
  • 11
    • 84887433048 scopus 로고    scopus 로고
    • Network properties derived from deep sequencing of human B cell receptor repertoires delineate B cell populations
    • Bashford-Rogers, R. J. M., et al. Network properties derived from deep sequencing of human B cell receptor repertoires delineate B cell populations. Genome Res. 23, 1874-1884 (2013
    • (2013) Genome Res , vol.23 , pp. 1874-1884
    • Bashford-Rogers, R.J.M.1
  • 12
    • 84893831480 scopus 로고    scopus 로고
    • The promise and challenge of high-throughput sequencing of the antibody repertoire
    • Georgiou, G., et al. The promise and challenge of high-throughput sequencing of the antibody repertoire. Nat. Biotechnol. 32, 158-168 (2014
    • (2014) Nat. Biotechnol , vol.32 , pp. 158-168
    • Georgiou, G.1
  • 13
    • 33845726659 scopus 로고    scopus 로고
    • Manufacturing immunity to disease in a test tube: The magic bullet realized
    • Lerner, R. A. Manufacturing immunity to disease in a test tube: the magic bullet realized. Angew. Chem. Int. Ed. Engl. 45, 8106-8125 (2006
    • (2006) Angew. Chem. Int. Ed. Engl , vol.45 , pp. 8106-8125
    • Lerner, R.A.1
  • 14
    • 0013553762 scopus 로고
    • Cloning of the immunological repertoire in Escherichia coli for generation of monoclonal catalytic antibodies: Construction of a heavy-chain variable region-specific cDNA library
    • Sastry, L., et al. Cloning of the immunological repertoire in Escherichia coli for generation of monoclonal catalytic antibodies: construction of a heavy-chain variable region-specific cDNA library. Proc. Natl Acad. Sci. USA 86, 5728-5732 (1989
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 5728-5732
    • Sastry, L.1
  • 15
    • 1542698957 scopus 로고
    • Cloning immunoglobulin variable domains for expression by the polymerase chain reaction
    • Orlandi, R., Gussow, D. H., Jones, P. T., & Winter, G. Cloning immunoglobulin variable domains for expression by the polymerase chain reaction. Proc. Natl Acad. Sci. USA 86, 3833-3837 (1989
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 3833-3837
    • Orlandi, R.1    Gussow, D.H.2    Jones, P.T.3    Winter, G.4
  • 16
    • 0024833055 scopus 로고
    • Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda
    • Huse, W. D., et al. Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science 246, 1275-1281 (1989
    • (1989) Science , vol.246 , pp. 1275-1281
    • Huse, W.D.1
  • 17
    • 0025226085 scopus 로고
    • Phage antibodies: Filamentous phage displaying antibody variable domains
    • Mccafferty, J., Griffiths, A. D., Winter, G., & Chiswell, D. J. Phage antibodies: filamentous phage displaying antibody variable domains. Nature 348, 552-554 (1990
    • (1990) Nature , vol.348 , pp. 552-554
    • Mccafferty, J.1    Griffiths, A.D.2    Winter, G.3    Chiswell, D.J.4
  • 18
    • 0025838021 scopus 로고
    • Assembly of combinatorial antibody libraries on phage surfaces: The gene III site
    • Barbas, C. F., Kang, A. S., Lerner, R. A., & Benkovic, S. J. Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Proc. Natl Acad. Sci. USA 88, 7978-7982 (1991
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 7978-7982
    • Barbas, C.F.1    Kang, A.S.2    Lerner, R.A.3    Benkovic, S.J.4
  • 20
    • 73949101200 scopus 로고    scopus 로고
    • Twenty years of combinatorial antibody libraries, but how well do they mimic the immunoglobulin repertoire? Proc
    • Persson, M. A. A. Twenty years of combinatorial antibody libraries, but how well do they mimic the immunoglobulin repertoire? Proc. Natl Acad. Sci. USA 106, 20137-20138 (2009)
    • (2009) Natl Acad. Sci. USA , vol.106 , pp. 20137-20138
    • Persson, M.A.A.1
  • 21
    • 84979855211 scopus 로고    scopus 로고
    • Predominant autoantibody production by early human B cell precursors
    • Wolters Kluwer/ Lippincott Williams & Wilkins
    • Paul, W E. Fundamental Immunology (Wolters Kluwer/ Lippincott Williams & Wilkins 2008
    • (2008) Fundamental Immunology
    • Paul, W.E.1
  • 22
    • 0041689676 scopus 로고    scopus 로고
    • Wardemann, H., et al. Predominant autoantibody production by early human B cell precursors. Science 301, 1374-1377 (2003
    • (2003) Science , vol.301 , pp. 1374-1377
    • Wardemann, H.1
  • 23
    • 0033948368 scopus 로고    scopus 로고
    • Repertoire selection by pre B cell receptors and B cell receptors, and genetic control of B cell development from immature to mature B cells
    • Melchers, F., et al. Repertoire selection by pre B cell receptors and B cell receptors, and genetic control of B cell development from immature to mature B cells. Immunol. Rev. 175, 33-46 (2000
    • (2000) Immunol. Rev , vol.175 , pp. 33-46
    • Melchers, F.1
  • 24
    • 0021818675 scopus 로고
    • Filamentous fusion phage: Novel expression vectors that display cloned antigens on the virion surface
    • Smith, G. P. Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science 228, 1315-1317 (1985
    • (1985) Science , vol.228 , pp. 1315-1317
    • Smith, G.P.1
  • 25
    • 0033506261 scopus 로고    scopus 로고
    • Ribosome display: An in vitro method for selection and evolution of antibodies from libraries
    • Schaffitzel, C., Hanes, J., Jermutus, L., & Pluckthun, A. Ribosome display: an in vitro method for selection and evolution of antibodies from libraries. J. Immunol. Methods 231, 119-135 (1999
    • (1999) J. Immunol. Methods , vol.231 , pp. 119-135
    • Schaffitzel, C.1    Hanes, J.2    Jermutus, L.3    Pluckthun, A.4
  • 27
    • 0033748716 scopus 로고    scopus 로고
    • Yeast surface display for directed evolution of protein expression, affinity, and stability
    • Boder, E. T., & Wittrup, K. D. Yeast surface display for directed evolution of protein expression, affinity, and stability. Methods Enzymol. 328, 430-444 (2000
    • (2000) Methods Enzymol , vol.328 , pp. 430-444
    • Boder, E.T.1    Wittrup, K.D.2
  • 28
    • 0031012062 scopus 로고    scopus 로고
    • Display of heterologous proteins on the surface of microorganisms: From the screening of combinatorial libraries to live recombinant vaccines
    • Georgiou, G., et al. Display of heterologous proteins on the surface of microorganisms: from the screening of combinatorial libraries to live recombinant vaccines. Nat. Biotechnol. 15, 29-34 (1997
    • (1997) Nat. Biotechnol , vol.15 , pp. 29-34
    • Georgiou, G.1
  • 29
    • 77958534289 scopus 로고    scopus 로고
    • Development of a novel mammalian cell surface antibody display platform
    • Zhou, C., Jacobsen, F. W., Cai, L., Chen, Q., & Shen, W. D. Development of a novel mammalian cell surface antibody display platform. mAbs 2, 508-518 (2010
    • (2010) Mabs , vol.2 , pp. 508-518
    • Zhou, C.1    Jacobsen, F.W.2    Cai, L.3    Chen, Q.4    Shen, W.D.5
  • 30
    • 84979849957 scopus 로고    scopus 로고
    • The top 25 best-selling drugs of 2014
    • Philippidis, A. The top 25 best-selling drugs of 2014. Genetic Engineering & Biotechnology News http:// www.genengnews.com/insight-and-intelligence/the-top- 25-best-selling-drugs-of-2014/77900383/#gsaccess 2015
    • (2015) Genetic Engineering & Biotechnology News
    • Philippidis, A.1
  • 31
    • 52649158251 scopus 로고    scopus 로고
    • Lentivirus display: Stable expression of human antibodies on the surface of human cells and virus particles
    • Taube, R., et al. Lentivirus display: stable expression of human antibodies on the surface of human cells and virus particles. PLoS ONE 3, e3181 (2008
    • (2008) PLoS ONE , vol.3 , pp. e3181
    • Taube, R.1
  • 32
    • 79957617682 scopus 로고    scopus 로고
    • High Affinity, developability and functional size: The holy grail of combinatorial antibody library generation
    • Ponsel, D., Neugebauer, J., Ladetzki-Baehs, K., & Tissot, K. High Affinity, developability and functional size: the holy grail of combinatorial antibody library generation. Molecules 16, 3675-3700 (2011
    • (2011) Molecules , vol.16 , pp. 3675-3700
    • Ponsel, D.1    Neugebauer, J.2    Ladetzki-Baehs, K.3    Tissot, K.4
  • 33
    • 84877897559 scopus 로고    scopus 로고
    • A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties
    • Tiller, T., et al A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties. mAbs 5 445-470 2013
    • (2013) Mabs , vol.5 , pp. 445-470
    • Tiller, T.1
  • 34
    • 0027199771 scopus 로고
    • Direct selection of antibodies that coordinate metals from semisynthetic combinatorial libraries
    • Barbas, C. F., Rosenblum, J. S., & Lerner, R. A. Direct selection of antibodies that coordinate metals from semisynthetic combinatorial libraries. Proc. Natl Acad. Sci. USA 90, 6385-6389 (1993
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 6385-6389
    • Barbas, C.F.1    Rosenblum, J.S.2    Lerner, R.A.3
  • 35
    • 43149109969 scopus 로고    scopus 로고
    • Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies
    • Kashyap, A. K., et al. Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies. Proc. Natl Acad. Sci. USA 105, 5986-5991 (2008
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 5986-5991
    • Kashyap, A.K.1
  • 36
    • 58049198443 scopus 로고    scopus 로고
    • Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells
    • Throsby, M., et al. Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells. PLoS ONE 3, e3942 2008
    • (2008) PLoS ONE , vol.3 , pp. e3942
    • Throsby, M.1
  • 37
    • 62049083943 scopus 로고    scopus 로고
    • Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
    • Sui, J. H., et al. Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nat. Struct. Mol. Biol. 16, 65-273 (2009
    • (2009) Nat. Struct. Mol. Biol , vol.16 , pp. 65-273
    • Sui, J.H.1
  • 38
    • 79952640176 scopus 로고    scopus 로고
    • Rare antibodies from combinatorial libraries suggests an S.O.S component of the human immunological repertoire
    • Lerner, R. A. Rare antibodies from combinatorial libraries suggests an S.O.S. component of the human immunological repertoire. Mol. Biosyst. 7, 1004-1012 (2011
    • (2011) Mol. Biosyst , vol.7 , pp. 1004-1012
    • Lerner, R.A.1
  • 39
    • 64849114224 scopus 로고    scopus 로고
    • Antibody recognition of a highly conserved influenza virus epitope
    • Ekiert, D. C., et al. Antibody recognition of a highly conserved influenza virus epitope. Science 324, 246-251 (2009
    • (2009) Science , vol.324 , pp. 246-251
    • Ekiert, D.C.1
  • 40
    • 84866122029 scopus 로고    scopus 로고
    • Highly conserved protective epitopes on influenza B viruses
    • Dreyfus, C., et al. Highly conserved protective epitopes on influenza B viruses. Science 337, 1343-1348 (2012
    • (2012) Science , vol.337 , pp. 1343-1348
    • Dreyfus, C.1
  • 41
    • 0033783032 scopus 로고    scopus 로고
    • Receptor binding and membrane fusion in virus entry: The influenza hemagglutinin
    • Skehel, J. J., & Wiley, D. C. Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin. Annu. Rev. Biochem. 69, 531-569 (2000
    • (2000) Annu. Rev. Biochem , vol.69 , pp. 531-569
    • Skehel, J.J.1    Wiley, D.C.2
  • 42
    • 0025439518 scopus 로고
    • The protection: The unit of humoral immunity selected by evolution
    • Cohn, M., & Langman, R. E. The protection: the unit of humoral immunity selected by evolution. Immunol. Rev. 115, 7-147 (1990
    • (1990) Immunol. Rev , vol.115 , pp. 7-147
    • Cohn, M.1    Langman, R.E.2
  • 43
    • 0026791975 scopus 로고
    • The immune system evolved to discriminate infectious nonself from noninfectious self
    • Janeway, C. A. The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol. Today 13, 11-16 (1992
    • (1992) Immunol. Today , vol.13 , pp. 11-16
    • Janeway, C.A.1
  • 44
    • 84866949036 scopus 로고    scopus 로고
    • Structural and genetic basis for development of broadly neutralizing influenza antibodies
    • Lingwood, D., et al. Structural and genetic basis for development of broadly neutralizing influenza antibodies. Nature 489, 566-570 (2012
    • (2012) Nature , vol.489 , pp. 566-570
    • Lingwood, D.1
  • 45
    • 84922225958 scopus 로고    scopus 로고
    • Rapid development of broadly influenza neutralizing antibodies through redundant mutations
    • Pappas, L., et al. Rapid development of broadly influenza neutralizing antibodies through redundant mutations. Nature 516, 418-422 (2014
    • (2014) Nature , vol.516 , pp. 418-422
    • Pappas, L.1
  • 46
    • 84946742981 scopus 로고    scopus 로고
    • Agonist antibody that induces human malignant cells to kill one another
    • Yea, K., et al. Agonist antibody that induces human malignant cells to kill one another. Proc. Natl Acad. Sci. USA 112, E6158-E6165 2015
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. E6158-E6165
    • Yea, K.1
  • 47
    • 84877871396 scopus 로고    scopus 로고
    • Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells
    • Xie, J., Zhang, H. K., Yea, K., & Lerner, R. A. Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells. Proc. Natl Acad. Sci. USA 110, 8099-8104 (2013
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 8099-8104
    • Xie, J.1    Zhang, H.K.2    Yea, K.3    Lerner, R.A.4
  • 48
    • 84894499829 scopus 로고    scopus 로고
    • Prevention of cell death by antibodies selected from intracellular combinatorial libraries
    • Xie, J., et al. Prevention of cell death by antibodies selected from intracellular combinatorial libraries. Chem. Biol. 21, 274-283 (2014
    • (2014) Chem. Biol , vol.21 , pp. 274-283
    • Xie, J.1
  • 49
    • 84883822712 scopus 로고    scopus 로고
    • Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections
    • Yea, K., et al. Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections. Proc. Natl Acad. Sci. USA 110, 14966-14971 (2013
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 14966-14971
    • Yea, K.1
  • 50
    • 84921508928 scopus 로고    scopus 로고
    • Selection of multiple agonist antibodies from intracellular combinatorial libraries reveals that cellular receptors are functionally pleiotropic
    • Yea, K., Xie, J., Zhang, H., Zhang, W., & Lerner, R. A. Selection of multiple agonist antibodies from intracellular combinatorial libraries reveals that cellular receptors are functionally pleiotropic. Curr. Opin. Chem. Biol. 26, 1-7 (2015
    • (2015) Curr. Opin. Chem. Biol , vol.26 , pp. 1-7
    • Yea, K.1    Xie, J.2    Zhang, H.3    Zhang, W.4    Lerner, R.A.5
  • 51
    • 84866847222 scopus 로고    scopus 로고
    • Selection of antibodies that regulate phenotype from intracellular combinatorial antibody libraries
    • Zhang, H. K., Wilson, I. A., & Lerner, R. A. Selection of antibodies that regulate phenotype from intracellular combinatorial antibody libraries. Proc. Natl Acad. Sci. USA 109, 15728-15733 (2012
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 15728-15733
    • Zhang, H.K.1    Wilson, I.A.2    Lerner, R.A.3
  • 52
    • 84878241266 scopus 로고    scopus 로고
    • Selecting agonists from single cells infected with combinatorial antibody libraries
    • Zhang, H. K., et al. Selecting agonists from single cells infected with combinatorial antibody libraries. Chem. Biol. 20, 734-741 (2013
    • (2013) Chem. Biol , vol.20 , pp. 734-741
    • Zhang, H.K.1
  • 53
    • 84946768226 scopus 로고    scopus 로고
    • Antibodies from combinatorial libraries use functional receptor pleiotropism to regulate cell fates
    • Lerner, R. A., et al. Antibodies from combinatorial libraries use functional receptor pleiotropism to regulate cell fates. Q. Rev. Biophys. 48, 389-394 (2015
    • (2015) Q. Rev. Biophys , vol.48 , pp. 389-394
    • Lerner, R.A.1
  • 54
    • 84887037302 scopus 로고    scopus 로고
    • Selecting antagonistic antibodies that control differentiation through inducible expression in embryonic stem cells
    • Melidoni, A. N., Dyson, M. R., Wormald, S., & McCafferty, J. Selecting antagonistic antibodies that control differentiation through inducible expression in embryonic stem cells. Proc. Natl Acad. Sci. USA 110, 17802-17807 (2013
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 17802-17807
    • Melidoni, A.N.1    Dyson, M.R.2    Wormald, S.3    McCafferty, J.4
  • 55
    • 0026556127 scopus 로고
    • Human combinatorial antibody libraries to hepatitis B surface antigen
    • Zebedee, S. L., et al. Human combinatorial antibody libraries to hepatitis B surface antigen. Proc. Natl Acad. Sci. USA 89, 3175- 3179 (1992).
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 3175-3179
    • Zebedee, S.L.1


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