Apigenin suppresses colorectal cancer cell proliferation, migration and invasion via inhibition of the Wnt/β-catenin signaling pathway

Oncology Letters

Volumn 11, Issue 5, 2016, Pages 3075-3080

  Xu, Min ^a   Wang, Shusheng ^a   Song, Yu ^a   Yao, Jianhua ^a   Huang, Kun ^a   Zhu, Xiaojue ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Apigenin; Colorectal cancer cell; TOP FOP flash; Wnt catenin signaling pathway

Indexed keywords

APIGENIN; BETA CATENIN; WNT PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; COLORECTAL CANCER; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; INTESTINE CRYPT; LUCIFERASE ASSAY; MALE; MOUSE; MTT ASSAY; NONHUMAN; PROTEIN ISOLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPECTROPHOTOMETRY; WESTERN BLOTTING; WOUND HEALING;

EID: 84976897434     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2016.4331     Document Type: Article

References (32)

1. Arend RC, Londoño-Joshi AI, Straughn JM Jr and Buchsbaum DJ: The Wnt/β-catenin pathway in ovarian cancer: A review. Gynecol Oncol 131: 772-779, 2013.
2. Noguti J, DE Moura CF, Hossaka TA, Franco M, Oshima CT, Dedivitis RA and Ribeiro DA: The role of canonical WNT signaling pathway in oral carcinogenesis: A comprehensive review. Anticancer Res 32: 873-878, 2012.
3. Pecina-Slaus N: Wnt signal transduction pathway and apoptosis: A review. Cancer Cell Int 10: 22, 2010.
4. Moon RT, Brown JD and Torres M: WNTs modulate cell fate and behavior during vertebrate development. Trends Genet 13: 157-162, 1997.
5. Behrens J: Control of beta-catenin signaling in tumor development. Ann NY Acad Sci 910: 21-35, 2000.
6. Chesire DR, Ewing CM, Sauvageot J, Bova GS and Isaacs WB: Detection and analysis of beta-catenin mutations in prostate cancer. Prostate 45: 323-334, 2000.
7. Polakis P: The oncogenic activation of beta-catenin. Curr Opin Genet Dev 9: 15-21, 1999.
8. Birt DF, Mitchell D, Gold B, Pour P and Pinch HC: Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid. Anticancer Res 17: 85-91, 1997.
9. Caltagirone S, Rossi C, Poggi A, Ranelletti FO, Natali PG, Brunetti M, Aiello FB and Piantelli M: Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. Int J Cancer 87: 595-600, 2000.
10. Wang IK, Lin-Shiau SY and Lin JK: Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer 35: 1517-1525, 1999.
11. Wang W, Heideman L, Chung CS, Pelling JC, Koehler KJ and Birt DF: Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines. Mol Carcinog 28: 102-110, 2000.
12. Yin F, Giuliano AE, Law RE and Van Herle AJ: Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells. Anticancer Res 21: 413-420, 2001.
13. Zhu Y, Mao Y, Chen H, Lin Y, Hu Z, Wu J, Xu X, Xu X, Qin J and Xie L: Apigenin promotes apoptosis, inhibits invasion and induces cell cycle arrest of T24 human bladder cancer cells. Cancer Cell Int 13: 54, 2013.
14. Wang YJ, Zhou SM, Xu G and Gao YQ: Interference of Phenylethanoid Glycosides from Cistanche tubulosa with the MTT Assay. Molecules 20: 8060-8071, 2015.
15. Feliciangeli S, Bendahhou S, Sandoz G, Gounon P, Reichold M, Warth R, Lazdunski M, Barhanin J and Lesage F: Does sumoylation control K2P1/TWIK1 background K+ channels? Cell 130: 563-569, 2007.
16. Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, van Es JH, Abo A, Kujala P, Peters PJ and Clevers H: Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459: 262-265, 2009.
17. Miao L, Xiong X, Lin Y, Cheng Y, Lu J, Zhang J and Cheng N: MiR-203 inhibits tumor cell migration and invasion via caveolin-1 in pancreatic cancer cells. Oncol Lett 7: 658-662, 2014.
18. Schuijers J, Junker JP, Mokry M, Hatzis P, Koo BK, Sasselli V, van der Flier LG, Cuppen E, van Oudenaarden A and Clevers H: Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts. Cell stem cell 16: 158-170, 2015.
19. Osada T, Chen M, Yang XY, Spasojevic I, Vandeusen JB, Hsu D, Clary BM, Clay TM, Chen W, Morse MA and Lyerly HK: Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations. Cancer Res 71: 4172-4182, 2011.
20. Shen X, Ying H and Yue BY: Wnt activation by wild type and mutant myocilin in cultured human trabecular meshwork cells. PLoS One 7: e44902, 2012.
21. Haggar FA and Boushey RP: Colorectal cancer epidemiology: Incidence, mortality, survival and risk factors. Clin Colon Rectal Surg 22: 191-197, 2009.
22. Blair V, Kahokehr A and Sammour T: Cancer in Māori: Lessons from prostate, colorectal and gastric cancer and progress in hereditary stomach cancer in New Zealand. ANZ J Surg 83: 42-48, 2013.
23. Lazarova DL, Chiaro C, Wong T, Drago E, Rainey A, O’Malley S and Bordonaro M: CBP Activity Mediates Effects of the histone deacetylase inhibitor butyrate on WNT activity and apoptosis in colon cancer cells. J Cancer 4: 481-490, 2013.
24. Chong KY, Hsu CJ, Hung TH, Hu HS, Huang TT, Wang TH, Wang C, Chen CM, Choo KB and Tseng CP: Wnt pathway activation and ABCB1 expression account for attenuation of proteasome inhibitor-mediated apoptosis in multidrug-resistant cancer cells. Cancer Biol Ther 16: 149-159, 2015.
25. Jang GB, Hong IS, Kim RJ, Lee SY, Park SJ, Lee ES, Park JH, Yun CH, Chung JU, Lee KJ, et al: Wnt/beta-catenin small-molecule inhibitor CWP232228 preferentially inhibits the growth of breast cancer stem-like cells. Cancer Res 75: 1691-1702, 2015.
26. Hall CL, Zhang H, Baile S, Ljungman M, Kuhstoss S and Keller ET: p21CIP-1/WAF-1 induction is required to inhibit prostate cancer growth elicited by deficient expression of the Wnt inhibitor Dickkopf-1. Cancer research 70: 9916-9926, 2010.
27. Lin C, Lu W, Zhang W, Londoño-Joshi AI, Buchsbaum DJ, Bu G and Li Y: The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells. PLoS One 8: e58102, 2013.
28. Sack U, Walther W, Scudiero D, Selby M, Aumann J, Lemos C, Fichtner I, Schlag PM, Shoemaker RH and Stein U: S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells. Mol Biol Cell 22: 3344-3354, 2011.
29. Seo HS, Ku JM, Choi HS, Woo JK, Jang BH, Shin YC and Ko SG: Induction of caspase-dependent apoptosis by apigenin by inhibiting STAT3 signaling in HER2-overexpressing MDA-MB-453 breast cancer cells. Anticancer Res 34: 2869-2882, 2014.
30. Wu DG, Yu P, Li JW, Jiang P, Sun J, Wang HZ, Zhang LD, Wen MB and Bie P: Apigenin potentiates the growth inhibitory effects by IKK-β-mediated NF-κB activation in pancreatic cancer cells. Toxicol Lett 224: 157-164, 2014.
31. Chunhua L, Donglan L, Xiuqiong F, Lihua Z, Qin F, Yawei L, Liang Z, Ge W, Linlin J, Ping Z, et al: Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT. J Nutr Biochem 24: 1766-1775, 2013.
32. Wang QR, Yao XQ, Wen G, Fan Q, Li YJ, Fu XQ, Li CK and Sun XG: Apigenin suppresses the growth of colorectal cancer xenografts via phosphorylation and up-regulated FADD expression. Oncol Lett 2: 43-47, 2011.