Zika virus: What do we know about the viral structure, mechanisms of transmission, and neurological outcomes?

Revista da Sociedade Brasileira de Medicina Tropical

Volumn 49, Issue 3, 2016, Pages 267-273

  Da Silva, Lucia Regina Cangussu ^a   De Souza, Adriano Miranda ^b  

^a Universidade Salgado de Oliveira   (Brazil)

^b FEDERAL UNIVERSITY OF JUIZ DE FORA   (Brazil)

Author keywords

Guillain Barre syndrome; Microcephaly; Neurological disorders; Transmission modes; Zika virus

Indexed keywords

ARTHROGRYPOSIS; BRAZIL; DISEASE TRANSMISSION; FLAVIVIRIDAE INFECTION; FLAVIVIRUS; GENE SEQUENCE; GLYCOSYLATION; GUILLAIN BARRE SYNDROME; HEAD CIRCUMFERENCE; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOCYTOCHEMISTRY; JAPANESE ENCEPHALITIS VIRUS; MICROCEPHALY; NEUROLOGIC DISEASE; NEUROPATHOLOGY; PATHOGENESIS; REVIEW; SEXUALLY TRANSMITTED DISEASE; SOUTH AND CENTRAL AMERICA; VECTOR CONTROL; VERTICAL TRANSMISSION; VIRUS MORPHOLOGY; VIRUS STRAIN; VIRUS TRANSMISSION; WEST NILE FEVER; ZIKA FEVER; ZIKA VIRUS; ADULT; CLASSIFICATION; COMPLICATION; NEWBORN; PHYSIOLOGY; TRANSMISSION; VIROLOGY;

ADULT; HUMANS; INFANT, NEWBORN; MICROCEPHALY; NERVOUS SYSTEM DISEASES; VIRAL STRUCTURES; ZIKA VIRUS; ZIKA VIRUS INFECTION;

EID: 84976632392     PISSN: 00378682     EISSN: None     Source Type: Journal    
DOI: 10.1590/0037-8682-0150-2016     Document Type: Review

References (87)

1. Campos GS, Bandeira AC, Sardi SI. Zika virus outbreak, Bahia, Brazil. Emerg Infect Dis 2015; 21:1885-1886.
2. Zanluca C, De Melo VCA, Mosimann ALP, dos Santos GIV, dos Santos CND, Luz K. First report of autochthonous transmission of Zika virus in Brazil. Mem Inst Oswaldo Cruz 2015; 110:569-572.
3. Musso D. Zika virus transmission from French Polynesia to Brazil. Emerg Infect Dis 2016; 21:1887.
4. Zammarchi L, Tappe D, Fortuna C, Remoli ME, Gunther S, Venturi G, et al. Zika virus infection in a traveller returning to Europe from Brazil, March 2015. Euro Surveill 2015; 20:1-3.
5. Ministério da Saúde. Brasil. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Monitoramento dos casos de dengue, febre de chikungunya e febre pelo vírus Zika até a Semana Epidemiológica 45, 2015. Bol Epidemiológico 2015; 46:1-9.
6. Fauci AS, Morens DM. Zika Virus in the Americas - Yet Another Arbovirus Threat. N Engl J Med 2016; 363:1-3.
7. Pan American Health Organization (PAHO). Epidemiological Alert Zika virus infection [Internet]. Epidemiological Alert Zika virus infection. 2015 [cited 2015 May 7]. Available from: http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&Itemid=270&gid=30078&lang=en
8. Henry R. Zika virus. Emerg Infect Dis 2014; 20:1090.
9. Duffy M, Chen T, Hancock T, Powers A, Kool J, Lanciotti R, et al. Zika Virus Outbreak on Yap Island, Federated States of Micronesia. N Engl J Med 2009; 360:2536-2543.
10. Cao-Lormeau VM. RE: Zika virus, French Polynesia, South Pacific, 2013. Emerg Infect Dis 2014; 20:1085-1086.
11. Musso D, Nhan T-X. Emergence of Zika Virus [Internet]. Vol. 4, Clinical Microbiology: Open Access. 2015. p. doi:10.4172/2327–5073.1000222. Available from: http://www.esciencecentral.org/journals/emergence-of-zika-virus-2327-5073-1000222.php?aid=61298
12. Musso D, Nilles EJ, Cao-Lormeau VM. Rapid spread of emerging Zika virus in the Pacific area. Clin Microbiol Infect 2014; 20:595-596.
13. Tappe D, Nachtigall S, Kapaun A, Schnitzler P, Gunther S, Schmidt- Chanasit J. Acute Zika virus infection after travel to Malaysian Borneo, September 2014. Emerg Infect Dis 2015; 21:911-913.
14. Waehre T, Magaard A TD. Zika Virus Infection after Travel to Tahiti, December 2013. Emerg Infect Dis J 2014; 20:1412-1413.
15. Kutsuna S, Kato Y, Takasaki T, Moi M, Kotaki A, Uemura H, et al. Two cases of Zika fever imported from French Polynesia to Japan, December to January 2013 [Internet]. Vol. 19, Eurosurveill. 2014. p. 20683. Available from: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20694
16. Fonseca K, Meatherall B, Zarra D, Drebot M, MacDonald J, Pabbaraju K, et al. Case report: First case of Zika virus infection in a returning Canadian traveler. Am J Trop Med Hyg 2014; 91:1035-1038.
17. Pyke AT, Daly MT, Cameron JN, Moore PR, Taylor CT, Hewitson GR, et al. Imported Zika Virus Infection from the Cook Islands into Australia, 2014 [Internet]. PLoS Currents. 2014. Available from: http://currents.plos.org/outbreaks/?p=38348
18. Tappe D, Rissland J, Gabriel M, Emmerich P, Günther S, Held G, et al. First case of laboratory-confirmed Zika virus infection imported into Europe, November 2013. Euro Surveill 2014; 19:20685.
19. Ministério da Saúde. Brasil. Secretaria de Vigilância em Saúde. Monitoramento dos casos de dengue, febre de chikungunya e febre pelo vírus Zika até a Semana Epidemiológica 8, 2016 [Internet]. Vol. 47, Boletim Epidemiológico. 2016 [cited 2016 Apr 7]. Available from: http://portalsaude.saude.gov.br/images/pdf/2016/janeiro/11/2015-053-para-substituir-na-p--gina.pdf
20. Sips GJ, Wilschut J, Smit JM. Neuroinvasive flavivirus infections. Rev Med Virol 2012; 22:69-87.
21. World Health Organization (WHO). Zika virus microcephaly and Guillain-Barré syndrome-Situation report 31 March 2016 [Internet]. 2016. p. 1-13. Available from: http://apps.who.int/iris/bitstream/10665/204718/1/zikasitrep_31Mar2016_eng.pdf?ua=1
22. Ministério da Saúde. Brasil. Instituto Evandro Chagas (IEC) comprova relação do Vírus Zika com a Microcefalia e diagnostica os primeiros óbitos relacionados ao vírus [Internet]. 2015 [cited 2016 Mar 13]. Available from: http://www.iec.gov.br/index.php/destaque/index/762
23. Ministério da Saúde. Brasil. Secretaria de Vigilância em Saúde.Centro de Operações de Emergências em Saúde Pública sobre Microcefalias. Informe Epidemiológico no 25 - Semana Epidemiológica (SE) 18/2016 (01/05 a 07/05/2016) Monitoramento dos casos de microcefalia no Brasil. [Internet]. [cited 2016 May 13]. Available from: http://combateAedes.saude.gov.br/images/sala-desituacao/informe_microcefalia_epidemiologico25.pdf
24. Cauchemez S, Besnard M, Bompard P, Dub T, Guillemette-Artur P, Eyrolle-Guignot D, et al. Association between Zika virus and microcephaly in French Polynesia, 2013–15: a retrospective study. Lancet 2016; 6736:1-8.
25. Lanciotti RS, Kosoy OL, Laven JJ, Velez JO, Lambert AJ, Johnson AJ, et al. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis 2008; 14:1232-1239.
26. Blázquez AB, Escribano-Romero E, Merino-Ramos T, Saiz JC, Martín-Acebes MA. Stress responses in flavivirus-infected cells: Activation of unfolded protein response and autophagy. Front Microbiol 2014; 5:1-7.
27. Leis AA, Stokic DS. Neuromuscular Manifestations of West Nile Virus Infection. Front Neurol 2012; 3:1-10
28. Medeiros DBA, Nunes MRT, Vasconcelos PFC, Chang GJJ, Kuno G. Complete genome characterization of Rocio virus (Flavivirus: Flaviviridae), a Brazilian flavivirus isolated from a fatal case of encephalitis during an epidemic in São Paulo state. J Gen Virol 2007; 88:2237-2246.
29. Sirohi D, Chen Z, Sun L, Klose T, Pierson TC, Rossmann MG, et al. The 3.8 Å resolution cryo-EM structure of Zika virus. Science 2016; 5316:1-7.
30. Mlakar J, Korva M, Tul N, Popović M, Poljšak-Prijatelj M, Mraz J, et al. Zika virus associated with microcephaly. N Engl J Med 2016; 374:951-958.
31. Perera-Lecoin M, Meertens L, Carnec X, Amara A. Flavivirus entry receptors: An update. Viruses 2013; 6:69-88.
32. Beasley DWC, Whiteman MC, Zhang S, Huang CY, Schneider BS, Smith DR, et al. Envelope protein glycosylation status influences mouse neuroinvasion phenotype of genetic lineage 1 West Nile virus strains. J Virol 2005; 79:8339-8347.
33. Haddow AD, Schuh AJ, Yasuda CY, Kasper MR, Heang V, Huy R, et al. Genetic characterization of zika virus strains: Geographic expansion of the asian lineage. PLoS Negl Trop Dis 2012; 6:e1477.
34. Faye O, Freire CCM, Iamarino A, Faye O, de Oliveira JVC, Diallo M, et al. Molecular evolution of zika virus during its emergence in the 20th Century. PLoS Negl Trop Dis 2014; 8:e2636.
35. Piorkowski G, Richard P, Baronti C, Gallian P, Charrel R, Leparc- Goffart I, et al. Complete coding sequence of Zika virus from Martinique Outbreak in 2015. Genome Announc 2016; 2:e00500-514.
36. Calvet G, Aguiar RS, Melo AS, Sampaio SA, de Filippis I, Fabri A, et al. Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis 2016; 16:653-660.
37. Driggers RW, Ho C-Y, Korhonen EM, Kuivanen S, Jääskeläinen AJ, Smura T, et al. Zika Virus infection with prolonged maternal viremia and fetal brain abnormalities. N Engl J Med 2016; 374: 2142-2151.
38. Garcez PP, Correia Loiola E, Madeiro da Costa R, Higa LM, Trindade P, Delvecchio R, et al. Zika virus impairs growth in human neurospheres and brain organoids. Science 2016; 352:816-818.
39. Roth A, Mercier A, Lepers C, Hoy D, Duituturaga S, Benyon E, et al. Concurrent outbreaks of dengue, chikungunya and Zika virus infections – an unprecedented epidemic wave of mosquito-borne viruses in the Pacific 2012–2014. Euro Surveill 2014; 19:20929.
40. Diallo D, Sall AA, Diagne CT, Faye O, Faye O, Ba Y, et al. Zika virus emergence in mosquitoes in Southeastern Senegal, 2011. PLoS One 2014; 9:4-11.
41. Marcondes CB, Ximenes MF. Zika virus in Brazil and the danger of infestation by Aedes (Stegomyia) mosquitoes. Rev Soc Bras Med Trop 2015; 49:4-10.
42. Diagne CT, Diallo D, Faye O, Ba Y, Faye O, Gaye A, et al. Potential of selected Senegalese Aedes spp. mosquitoes (Diptera: Culicidae) to transmit Zika virus. BMC Infect Dis 2015; 15:492.
43. Ledermann JP, Guillaumot L, Yug L, Saweyog SC, Tided M, Machieng P, et al. Aedes hensilli as a potential vector of chikungunya and zika viruses. PLoS Negl Trop Dis 2014; 8:e3188.
44. Bonaldo MC, Ribeiro IP, Lima NS, Santos AAC, Menezes LSR, Cruz SOD, et al. Isolation of infective Zika virus from urine and saliva of patients in Brazil. bioRxiv 2016; p. 045443. doi: http://dx.doi.org/10.1101/045443.
45. Leung GHY, Baird RW, Druce J, Anstey NM. Zika virus infection in Australia following a monkey bite in Indonesia. Southeast Asian J Trop Med Public Health 2015; 46:460-464.
46. Zeinad AK. Vírus do Nilo Ocidental – Nova ameaça à segurança transfusional ? Rev Bras Hematol Hemoter 2004; 26:114-121.
47. Gould E, Solomon T. Pathogenic flaviviruses. Lancet 2008; 371:500-509.
48. Petersen E, Wilson ME, Touch S, McCloskey B, Mwaba P, Bates M, et al. Unexpected and Rapid Spread of Zika Virus in The Americas - Implications for Public Health Preparedness for Mass Gatherings at the 2016 Brazil Olympic Games. Int J Infect Dis 2016; 44:11-15.
49. Dupont-Rouzeyrol M, O’Connor O, Calvez E, Daurès M, John M, Grangeon J-P, et al. Co-infection with Zika and Dengue Viruses in 2 Patients, New Caledonia, 2014. Emerg Infect Dis 2015; 21:381-382.
50. Musso D, Nhan T, Robin E, Roche C, Bierlaire D, Zisou K, et al. Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014. Euro Surveill 2014; 19:14-16.
51. Vasconcelos PFDC. Doença pelo vírus Zika: um novo problema emergente nas Américas? Rev Pan-Amazônica Saúde 2015; 6:9-10.
52. Ministério da Saúde. Brasil. Agência Nacional de Vigilância (ANVISA). Nota Técnica Conjunta no. 001/2015 CGSH/GGPBS/ GGMON. Critérios técnicos para gerenciamento do risco sanitário no uso de hemocomponentes em procedimentos transfusionais frente à situação de Emergência em Saúde Pública de Importância Nacional por casos de infecção por Vírus Zika no Brasil. [Internet]. 2015 [cited 2016 Mar 13]. p. 1-7. Available from: http://www.saude.ba.gov.br/novoportal/images/stories/
53. Musso D, Richard V, Broult J, Cao-Lormeau VM. Inactivation of dengue virus in plasma with amotosalen and ultraviolet A illumination. Transfusion 2014; 54:2924-2930.
54. Foy BD, Kobylinski KC, Foy JLC, Blitvich BJ, da Rosa AT, Haddow AD, et al. Probable Non-Vector-borne Transmission of Zika Virus, Colorado, USA. Emerg Infect Dis 2011; 17:880-882.
55. Musso D, Roche C, Robin E, Nhan T, Teissier A, Cao-Lormeau VM. Potential sexual transmission of Zika virus. Emerg Infect Dis 2015; 21:359-361.
56. Mansuy JM, Dutertre M, Mengelle C, Fourcade C, Marchou B, Delobel P, et al. Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen? Lancet Infect Dis 2016; 16:405.
57. Atkinson B, Hearn P, Afrough B, Lumley S, Carter D, Aarons EJ, et al. Detection of Zika virus in semen. Emerg Infect Dis 2016; 22:940.
58. Heymann DL, Hodgson A, Sall AA, Freedman DO, Staples JE, Althabe F, et al. Zika virus and microcephaly: why is this situation a PHEIC? Lancet 2016; 6736:1-3.
59. Besnard M, Lastère S, Teissier A, Cao-Lormeau VM, Musso D. Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014. Euro Surveill 2014; 19:pii=20751.
60. Dupont-Rouzeyrol M, Biron A, O’Connor O, Huguon E, Descloux E. Infectious Zika viral particles in breastmilk. Lancet 2016; 387:1051
61. Noronha L, Zanluca C, Azevedo MLV, Luz KG, Santos CND. Zika virus damages the human placental barrier and presents marked fetal neurotropism. Mem Inst Oswaldo Cruz 2016; 111:287-293.
62. Alves JAG, Câmara LMC, Costa FS, Rocha RS, Araújo MNT. Os macrófagos na placenta durante o trabalho de parto. Rev Bras Ginecol e Obs 2009; 31:89-93.
63. Tang Z, Abrahams VM, Mor G, Guller S. Placental Hofbauer cells and complications of pregnancy. Ann N Y Acad Sci 2011; 1221:103-108.
64. Martines RB, Bhatnagar J, Keating MK, Flannery LS, Muehlenbachs A, Gary J, et al. Notes from the Field: evidence of Zika virus infection in brain and placental tissues from two congenitally infected newborns and two fetal losses - Brazil, 2015. MMWR Morb Mortal Wkly Rep 2016; 65:159-160.
65. Wang H, Liang G. Epidemiology of Japanese encephalitis: past, present, and future prospects. Ther Clin Risk Manag 2015; 11: 435-438.
66. Rodrigues LC. Zika: the tragedy and the opportunities. Am J Public Health 2016; 106:582.
67. World Health Organization (WHO). Assessment of infants with microcephaly in the context of Zika virus. 2016. p. 1-2. [Internet]; Available from: http://apps.who.int/iris/bitstream/10665/204475/1/WHO_ZIKV_MOC_16.3_eng.pdf?ua=1
68. Sarno M, Sacramento GA, Khouri R, do Rosário MS, Costa F, Archanjo G, et al. Zika virus infection and stillbirths: a case of hydrops fetalis, hydranencephaly and fetal demise. PLoS Negl Trop Dis 2016; 10:e0004517.
69. Schuler-Faccini L, Ribeiro EM, Feitosa IML, Horovitz DDG, Cavalcanti DP, Pessoa A, et al. Possible association between Zika virus infection and microcephaly - Brazil, 2015. MMWR Morb Mortal Wkly Rep 2016; 65:59-62.
70. Besnard M, Eyrolle-Guignot D, Guillemette-Artur P, Lastère S, Bost-Bezeaud F, Marcelis L, et al. Congenital cerebral malformations and dysfunction in fetuses and newborns following the 2013 to 2014 Zika virus epidemic in French Polynesia. Euro surveillance 2016; 21:30181.
71. Freitas BP, Dias JRO, Prazeres J, Sacramento GA, Ko AI, Maia M, et al. Ocular findings in infants with microcephaly associated with presumed Zika virus congenital infection in Salvador, Brazil. JAMA Ophthalmol 2016; 134:529-535.
72. Ventura CV, Maia M, Ventura BV, Van Der Linden V, Araújo EB, Ramos RC, et al. Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection. Arq Bras Oftalmol 2016; 79:1-3.
73. Adibi JJ, Marques ETA, Cartus A, Beigi RH. Teratogenic effects of the Zika virus and the role of the placenta. Lancet 2016; 6736:1-4.
74. Garcez PP, Nascimento J, Vasconcelos JM, Costa RM, Delvecchio R, Trindade P, et al. Combined proteome and transcriptome analyses reveal that Zika virus circulating in Brazil alters cell cycle and neurogenic programmes in human neurospheres. 2016 [Internet]. cited; May 9, 2016 Available from: https://doi.org/10.7287/peerj.preprints.2033v1.
75. Lebrun G, Chadda K, Reboux AH, Martinet O, Gauzère BA. Guillain-Barré syndrome after chikungunya infection. Emerg Infect Dis 2009; 15:495-496.
76. Oehler E, Watrin L, Larre P, Leparc-Goffart I, Lastere S, Valour F, et al. Zika virus infection complicated by Guillain-Barré syndrome--case report, French Polynesia, December 2013. Euro Surveill 2014; 19:7-9.
77. Nyati KK, Prasad KN. Role of cytokines and toll-like receptors in the immunopathogenesis of Guillain-Barré syndrome. Mediators Inflamm 2014; 2014:1-10. Article ID 758639.
78. Koga M, Gilbert M, Li J, Yuki N. Complex of GM1- and GD1alike lipo-oligosaccharide mimics GM1b, inducing anti-GM1b antibodies. PLoS One 2015; 10:e0124004.
79. Malkki H. CNS infections: Zika virus infection could trigger Guillain-Barré syndrome. Nat Rev Neurol 2016; 12:187.
80. Cao-Lormeau V-M, Blake A, Mons S, Lastère S, Roche C, Vanhomwegen J, et al. Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a casecontrol study. Lancet 2016; 387:1531-1539.
81. World Health Organization (WHO). Zika virus microcephaly and Guillain-Barré syndrome [Internet]. Vol. 2016. 2016. p. 1-13. Available from: http://who.int/emergencies/zika-virus/strategicresponse-framework.pdf?ua=1
82. Ribeiro GS, Kitron U. Zika virus pandemic: a human and public health crisis. Rev Soc Bras Med Trop 2016; 49:1-3.
83. Mécharles S, Herrmann C, Poullain P, Tran T, Deschamps N, Mathon G, et al. Case report acute myelitis due to Zika virus infection. Lancet 2016; 8:6736.
84. Brito CAA, Sobreira S, Cordeiro MT, Lucena-Silva N. Acute disseminated encephalomyelitis in classic dengue. Rev Soc Bras Med Trop 2007; 40:236-238.
85. Oliveira DB, Machado G, Almeida GMF, Ferreira PCP, Bonjardim CA, Trindade GS, et al. Infection of the central nervous system with dengue virus 3 genotype I causing neurological manifestations in Brazil. Rev Soc Bras Med Trop 2016; 49:125-129.
86. Sousa AM, Alvarenga MP, Alvarenga RMP. A cluster of transverse myelitis following dengue virus infection in the Brazilian Amazon Region. Trop Med Health 2014; 42:115-120.
87. Carteaux G, Maquart M, Bedet A, Contou D, Brugières P, Fourati S, et al. Zika virus associated with meningoencephalitis. N Engl J Med 2016; 374:1595-1596.