Autophagy inhibition dysregulates TBK1 signaling and promotes pancreatic inflammation

Cancer Immunology Research

Volumn 4, Issue 6, 2016, Pages 520-530

  Yang, Shenghong ^a,b   Imamura, Yu ^c,d,e   Jenkins, Russell W ^a,b   Canadas, Israel ^a,b   Kitajima, Shunsuke ^a,b   Aref, Amir ^a   Brannon, Arthur ^f   Oki, Eiji ^e   Castoreno, Adam ^b   Zhu, Zehua ^a,b   Thai, Tran ^a,b   Reibel, Jacob ^a   Qian, Zhirong ^a,g,h   Ogino, Shuji ^a,g,h   Kwong, Kwok ^a   Baba, Hideo ^c   Kimmelman, Alec C ^a   Magliano, Marina Pasca Di ^f   Barbie, David A ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c KUMAMOTO UNIVERSITY   (Japan)

^d CANCER INSTITUTE HOSPITAL   (Japan)

^e KYUSHU UNIVERSITY   (Japan)

^f UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

^h HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY PROTEIN 3; AUTOPHAGY PROTEIN 5; AUTOPHAGY PROTEIN 7; BECLIN 1; CERULETIDE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HISTONE DEACETYLASE 6; INTERLEUKIN 1BETA; INTERLEUKIN 6; K RAS PROTEIN; MOMELOTINIB; NBR1 PROTEIN; NDP52 PROTEIN; OPTN PROTEIN; PHOSPHOTRANSFERASE; PROGRAMMED DEATH 1 LIGAND 1; PROTEIN; RAB7 PROTEIN; RANTES; RUXOLITINIB; TANK BINDING KINASE 1; UNCLASSIFIED DRUG; ATG5 PROTEIN, MOUSE; AUTOPHAGY RELATED PROTEIN 5; BENZAMIDE DERIVATIVE; CCL5 PROTEIN, MOUSE; CD274 PROTEIN, MOUSE; CYTOKINE; KRAS2 PROTEIN, MOUSE; N-(CYANOMETHYL)-4-(2-((4-(4-MORPHOLINYL)PHENYL)AMINO)-4-PYRIMIDINYL)BENZAMIDE; PROTEIN P21; PROTEIN SERINE THREONINE KINASE; PYRIMIDINE DERIVATIVE; TBK1 PROTEIN, MOUSE;

ADENOCARCINOMA CELL LINE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DYSPLASIA; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE DELETION; GENE REPRESSION; IMMUNOHISTOCHEMISTRY; MOUSE; NEUTROPHIL; NONHUMAN; PANCREAS ADENOCARCINOMA; PANCREATIC TISSUE; PANCREATITIS; SELECTIVE AUTOPHAGY; SIGNAL TRANSDUCTION; TISSUE SECTION; TUMOR SPHEROID; ACUTE DISEASE; ADENOCARCINOMA; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL TRANSFORMATION; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; METABOLISM; PANCREAS TUMOR; PATHOLOGY; PHYSIOLOGY; TUMOR CELL CULTURE;

ACUTE DISEASE; ADENOCARCINOMA; ANIMALS; ANTIGENS, CD274; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN 5; BENZAMIDES; CELL TRANSFORMATION, NEOPLASTIC; CERULETIDE; CHEMOKINE CCL5; CYTOKINES; ENZYME ACTIVATION; GENE DELETION; MICE; PANCREATIC NEOPLASMS; PANCREATITIS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS P21(RAS); PYRIMIDINES; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 84976556738     PISSN: 23266066     EISSN: 23266074     Source Type: Journal    
DOI: 10.1158/2326-6066.CIR-15-0235     Document Type: Article

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