An investigation of the usability of solid lipid nanoparticles radiolabelled with Tc-99m as imaging agents in liver-spleen scintigraphy

Journal of Biomedical Nanotechnology

Volumn 12, Issue 7, 2016, Pages 1501-1509

  Eroglu, Hayrettin ^a   Yenilmez, Ayse ^a  

^a ATATÜRK UNIVERSITY   (Turkey)

Author keywords

Imaging Agents; Liver; Rabbit; Radiolabeled; Solid Lipid Nanoparticle; Spleen; Tc 99m

Indexed keywords

FOURIER TRANSFORM INFRARED SPECTROSCOPY; HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; LIVER; MICROEMULSIONS; NANOPARTICLES; NANOTECHNOLOGY; NUCLEAR MEDICINE; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION ANALYSIS;

IMAGING AGENT; RABBIT; RADIOLABELED; SOLID LIPID NANOPARTICLE (SLN); SPLEEN;

THERMOGRAVIMETRIC ANALYSIS;

SOLID LIPID NANOPARTICLE; SURFACTANT; TECHNETIUM 99M; LIPID; NANOPARTICLE; RADIOPHARMACEUTICAL AGENT; TECHNETIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CRYSTAL STRUCTURE; DRUG ACCUMULATION; EXPERIMENTAL RABBIT; FREEZE DRYING; HEART; IN VIVO STUDY; INFRARED SPECTROSCOPY; INVESTIGATIVE PROCEDURES; ISOTOPE LABELING; LASER DIFFRACTION; LIVER; LIVER SCINTISCANNING; LIVER SPLEEN SCINTIGRAPHY; LUNG; MALE; MICROEMULSION; NEW ZEALAND RABBIT; NONHUMAN; RADIOACTIVITY; REFRACTION INDEX; SCANNING ELECTRON MICROSCOPY; SPLEEN; SPLEEN SCINTISCANNING; TEMPERATURE; THERMOGRAVIMETRY; THIN LAYER CHROMATOGRAPHY; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION; ZETA POTENTIAL; ANIMAL; CHEMISTRY; DIAGNOSTIC IMAGING; LEPORIDAE; METABOLISM; PROCEDURES; SCINTISCANNING; TISSUE DISTRIBUTION;

ANIMALS; LIPIDS; LIVER; LUNG; MALE; NANOPARTICLES; RABBITS; RADIONUCLIDE IMAGING; RADIOPHARMACEUTICALS; SPLEEN; TECHNETIUM; TISSUE DISTRIBUTION;

EID: 84976500212     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2016.2286     Document Type: Article

References (24)

1. H. S. Kaş, Ilaçtaşiyicipartiküler sistemler, Kontrollü Salim Sistemleri, edited by A. Z. Gürsoy, Kontrollü Salim Sistemleri Derneǧi Yayini, Istanbul (2002), pp. 65-102.
2. O. C. Farokhzad and R. Langer, Nanomedicine: Developing smarter therapeutic and diagnostic modalities. Adv. Drug Deliv. Rev. 58, 1456 (2006).
3. A. Z. Wang, R. Langer, and O. C. Farokhzad, Nanoparticle delivery of cancer drugs. Annu. Rev. Med. 63, 185 (2012).
4. B. B. C. Youan, Impact of nano science and nanotechnology on controlled drugdelivery. Nanomedicine 3, 401 (2008).
5. M. E. Gindy and R. K. Prud'homme, Multifunctional nanoparticles for imaging, delivery and targeting in cancer therapy. Expert Opin. Drug Deliv. 6, 865 (2009).
6. K. Kim, J. H. Kim, H. Park, Y. S. Kim, K. Park, H. Nam, S. Lee, J. H. Park, R. W. Park, I. S. Kim, K. Choi, S. Y. Kim, K. Park, and I. C. Kwon, Tumor-homing multifunctional nanoparticles for cancer theragnosis: Simultaneous diagnosis, drug delivery, and therapeutic monitoring. J. Control Release 146, 219 (2010).
7. S. Rai, R. Paliwal, P. N. Gupta, K. Khatri, A. K. Goyal, B. Vaidya, and S. P. Vyas, Solid lipid nanoparticles (SLNs) as a rising tool in drug delivery science: One step up in nanotechnology. Curr. Nanosci. 4, 30 (2008).
8. E. Andreozzi, J. W. Seo, K. Ferrara, and A. Louie, Novel method to label solid lipid nanoparticles with 64cu for positron emission tomography imaging. Bioconjug. Chem. 22, 808 (2011).
9. N. Kathe, B. Henriksen, and H. Chauhan, Physicochemical characterization techniques for solid lipid nanoparticles: Principles and limitations. Drug Dev. Ind. Pharm. 40, 1565 (2014).
10. A. E. H. de Mendoza, M. A. Campanero, F. Mollinedo, and M. J. Blanco-Prieto, Lipid nanomedicines for anticancer drug therapy. J. Biomed. Nanotechnol. 5, 323 (2009).
11. M. A. Videira, M. F. Botelho, A. C. Santos, L. F. Gouveia, J. J. de Lima, and A. J. Almeida, Lymphatic uptake of pulmonary delivered radiolabelled solid lipid nanoparticles. J. Drug Target 10, 607 (2002).
12. V. Kakkar, S. K. Muppu, K. Chopra, and I. P. Kaur, Curcumin loaded solid lipid nanoparticles: An efficient formulation approach for cerebral ischemic reperfusion injury in rats. Eur. J. Pharm. Biopharm. 85, 339 (2013).
13. I. Banerjee, K. De, S. Chattopadhyay, A. K. Bandyopadhyay, and M. Misra, An easy and effective method for radiolabelling of solid lipid nanoparticles. J. Radioanal. Nucl. Chem. 302, 837 (2014).
14. K. J. Harrington, S. Mohammadtaghi, P. S. Uster, D. Glass, A. M. Peters, R. G. Vile, and J. S. W. Stewart, Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes. Clin. Cancer Res. 7, 243 (2001).
15. S. A. Wissing, O. Kayser, and R. H. Müller, Solid lipid nanoparticles for parenteral drug delivery. Adv. Drug Deliv. Rev. 56, 1257 (2004).
16. G. B. Saha, Fundamentals of Nuclear Pharmacy, 6rd edn., SpringerVerlag, New York (2010), p. 83
17. V. Kakkar, A. K. Mishra, K. Chuttani, and I. P. Kaur, Proof of concept studies to confirm the delivery of curcumin loaded solid lipid nanoparticles (C-SLNs) to brain. Int. J. Pharm. 448, 354 (2013).
18. D. Nesseem, Formulation of sunscreens with enhancement sun protection factor response based on solid lipid nanoparticles. Int. J. Cosmet. Sci. 33, 70 (2011).
19. M. Demirel ve Y. Yazan, Katilipit nanopartiküller (SLN), FABAD J. Pharm. Sci. 25, 167 (2000).
20. P. V. Pople and K. K. Singh, Development and evaluation of colloidal modified nanolipid carrier: Application to topical delivery of tacrolimus. Eur. J. Pharm. Biopharm. 79, 82 (2011).
21. K. Manjunath, J. S. Reddy, and V. Venkateswarlu, Solid lipid nanoparticles as drug delivery systems. Methods Find. Exp. Clin. Pharmacol. 27, 127 (2005).
22. M. H. Aburahma and S. M. Badr-Eldin, Compritol 888 ATO: A multifunctional lipid excipient in drug delivery systems and nanopharmaceuticals. Expert Opin. Drug Deliv. 11, 1865 (2014).
23. R. H. Muller, K. Mader, and S. Gohla, Solid lipid nanoparticles (SLN) for controlled drug delivery-A review of the state of the art. European Journal of Pharmaceutics and Biopharmaceutics 50, 161 (2000).
24. E. B. Souto, W. Mehnert, and R. H. Muller, Polymorphic behaviour of Compritol888 ATO as bulk lipid and as SLN and NLC. J. Microencapsul. 23, 417 (2006).