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Volumn 2016, Issue , 2016, Pages

Lipoxin A4 Preconditioning Attenuates Intestinal Ischemia Reperfusion Injury through Keap1/Nrf2 Pathway in a Lipoxin A4 Receptor Independent Manner

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; CELL DEATH; CHEMICAL ACTIVATION; ENZYMES; FATTY ACIDS; LACTIC ACID; OXIDATIVE STRESS; OXYGEN; RATS;

EID: 84976384379     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2016/9303606     Document Type: Article
Times cited : (67)

References (43)
  • 1
    • 78650837682 scopus 로고    scopus 로고
    • Pretransplant predictors of survival after intestinal transplantation: Analysis of a single-center experience of more than 100 transplants
    • D. G. Farmer, R. S. Venick, J. Colangelo et al., "Pretransplant predictors of survival after intestinal transplantation: Analysis of a single-center experience of more than 100 transplants, " Transplantation, vol. 90, no. 12, pp. 1574-1580, 2010.
    • (2010) Transplantation , vol.90 , Issue.12 , pp. 1574-1580
    • Farmer, D.G.1    Venick, R.S.2    Colangelo, J.3
  • 2
    • 78651284857 scopus 로고    scopus 로고
    • Induction of intestinal ischemia reperfusion injury by portal vein outflowocclusion in rats
    • M. Vincenti, M. Behrends, K. Dang et al., "Induction of intestinal ischemia reperfusion injury by portal vein outflowocclusion in rats, " Journal of Gastroenterology, vol. 45, no. 11, pp. 1103-1110, 2010.
    • (2010) Journal of Gastroenterology , vol.45 , Issue.11 , pp. 1103-1110
    • Vincenti, M.1    Behrends, M.2    Dang, K.3
  • 3
    • 84948961687 scopus 로고    scopus 로고
    • Early tranexamic acid administration: A protective effect on gut barrier function following ischemia/reperfusion injury
    • M. E. Diebel, L.N. Diebel, C.W. Manke, D.M. Liberati, and J. R. Whittaker, "Early tranexamic acid administration: A protective effect on gut barrier function following ischemia/reperfusion injury, " The Journal of Trauma and Acute Care Surgery, vol. 79, no. 6, pp. 1015-1022, 2015.
    • (2015) The Journal of Trauma and Acute Care Surgery , vol.79 , Issue.6 , pp. 1015-1022
    • Diebel, M.E.1    Diebel, L.N.2    Manke, C.W.3    Liberati, D.M.4    Whittaker, J.R.5
  • 4
    • 9344226823 scopus 로고    scopus 로고
    • Depletion of intestinal resident macrophages prevents ischaemia reperfusion injury in gut
    • Y. Chen, V.C.H. Lui, N.V. Rooijen, andP. K.H. Tam, "Depletion of intestinal resident macrophages prevents ischaemia reperfusion injury in gut, " Gut, vol. 53, no. 12, pp. 1772-1780, 2004.
    • (2004) Gut , vol.53 , Issue.12 , pp. 1772-1780
    • Chen, Y.1    Lui, V.C.H.2    Rooijen, N.V.3    Tam, P.K.H.4
  • 5
    • 34250689537 scopus 로고    scopus 로고
    • Prevention of gastrointestinal complications in the critically ill patient
    • B. Martin, "Prevention of gastrointestinal complications in the critically ill patient, " AACN Advanced Critical Care, vol. 18, no. 2, pp. 158-166, 2007.
    • (2007) AACN Advanced Critical Care , vol.18 , Issue.2 , pp. 158-166
    • Martin, B.1
  • 6
    • 84958889692 scopus 로고    scopus 로고
    • Antioxidant potential of the methanol extract of Parquetina nigrescens mediates protection against intestinal ischemia-reperfusion injury in rats
    • F. J. Akinrinmade, A. S. Akinrinde, O. O. Soyemi, and A. A. Oyagbemi, "Antioxidant potential of the methanol extract of Parquetina nigrescens mediates protection against intestinal ischemia-reperfusion injury in rats, " Journal of Dietary Supplements, vol. 13, no. 4, pp. 420-432, 2016.
    • (2016) Journal of Dietary Supplements , vol.13 , Issue.4 , pp. 420-432
    • Akinrinmade, F.J.1    Akinrinde, A.S.2    Soyemi, O.O.3    Oyagbemi, A.A.4
  • 7
    • 84934326305 scopus 로고    scopus 로고
    • Prophylactic ozone administration reduces intestinal mucosa injury induced by intestinal ischemia-reperfusion in the rat
    • Article ID 792016
    • O. Onal, F. Yetisir, A. E. S. Sarer et al., "Prophylactic ozone administration reduces intestinal mucosa injury induced by intestinal ischemia-reperfusion in the rat, " Mediators of Inflammation, vol. 2015, Article ID 792016, 8 pages, 2015.
    • (2015) Mediators of Inflammation 2015 , pp. 8
    • Onal, O.1    Yetisir, F.2    Sarer, A.E.S.3
  • 8
    • 84903880368 scopus 로고    scopus 로고
    • Propofol prevents lung injury after intestinal ischemia-reperfusion by inhibiting the interaction between mast cell activation and oxidative stress
    • W. Zhao, S. Zhou, W. Yao et al., "Propofol prevents lung injury after intestinal ischemia-reperfusion by inhibiting the interaction between mast cell activation and oxidative stress, " Life Sciences, vol. 108, no. 2, pp. 80-87, 2014.
    • (2014) Life Sciences , vol.108 , Issue.2 , pp. 80-87
    • Zhao, W.1    Zhou, S.2    Yao, W.3
  • 9
    • 34250359779 scopus 로고    scopus 로고
    • Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease
    • L. M. Aleksunes and J. E. Manautou, "Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease, " Toxicologic Pathology, vol. 35, no. 4, pp. 459-473, 2007.
    • (2007) Toxicologic Pathology , vol.35 , Issue.4 , pp. 459-473
    • Aleksunes, L.M.1    Manautou, J.E.2
  • 10
    • 67649402187 scopus 로고    scopus 로고
    • The Nrf2-Antioxidant response element signaling pathway and its activation by oxidative stress
    • T. Nguyen, P. Nioi, and C. B. Pickett, "The Nrf2-Antioxidant response element signaling pathway and its activation by oxidative stress, " The Journal of Biological Chemistry, vol. 284, no. 20, pp. 13291-13295, 2009.
    • (2009) The Journal of Biological Chemistry , vol.284 , Issue.20 , pp. 13291-13295
    • Nguyen, T.1    Nioi, P.2    Pickett, C.B.3
  • 11
    • 84884483748 scopus 로고    scopus 로고
    • IntestinalNF-E2-related factor-2 expression and antioxidant activity changes in rats undergoing orthotopic liver autotransplantation
    • M. Ge, X. Chi, A. Zhang et al., "IntestinalNF-E2-related factor-2 expression and antioxidant activity changes in rats undergoing orthotopic liver autotransplantation, " Oncology Letters, vol. 6, no. 5, pp. 1307-1312, 2013.
    • (2013) Oncology Letters , vol.6 , Issue.5 , pp. 1307-1312
    • Ge, M.1    Chi, X.2    Zhang, A.3
  • 13
  • 14
    • 84924274399 scopus 로고    scopus 로고
    • Lipoxin A4 mediates aortic contraction via rhoa/rho kinase, endothelial dysfunction and reactive oxygen species
    • C. F. Wenceslau, C. G. Mccarthy, T. Szasz, and R. C. Webb, "Lipoxin A4 mediates aortic contraction via rhoa/rho kinase, endothelial dysfunction and reactive oxygen species, " Journal of Vascular Research, vol. 51, no. 6, pp. 407-417, 2014.
    • (2014) Journal of Vascular Research , vol.51 , Issue.6 , pp. 407-417
    • Wenceslau, C.F.1    McCarthy, C.G.2    Szasz, T.3    Webb, R.C.4
  • 15
    • 84864371713 scopus 로고    scopus 로고
    • Aspirin-Triggered lipoxin A4 attenuates lipopolysaccharide-induced intracellular ROS in BV2 microglia cells by inhibiting the function of NADPH oxidase
    • Y. Wu, H. Zhai, Y. Wang et al., "Aspirin-Triggered lipoxin A4 attenuates lipopolysaccharide-induced intracellular ROS in BV2 microglia cells by inhibiting the function of NADPH oxidase, " Neurochemical Research, vol. 37, no. 8, pp. 1690-1696, 2012.
    • (2012) Neurochemical Research , vol.37 , Issue.8 , pp. 1690-1696
    • Wu, Y.1    Zhai, H.2    Wang, Y.3
  • 16
    • 79953296864 scopus 로고    scopus 로고
    • Lipoxin A4 inhibits Porphyromonas gingivalis-induced aggregation and reactive oxygen species production by modulating neutrophil-platelet interaction and CD11b expression
    • E. Börgeson, J. Lönn, I. Bergström et al., "Lipoxin A4 inhibits Porphyromonas gingivalis-induced aggregation and reactive oxygen species production by modulating neutrophil-platelet interaction and CD11b expression, " Infection and Immunity, vol. 79, no. 4, pp. 1489-1497, 2011.
    • (2011) Infection and Immunity , vol.79 , Issue.4 , pp. 1489-1497
    • Börgeson, E.1    Lönn, J.2    Bergström, I.3
  • 17
    • 84948845353 scopus 로고    scopus 로고
    • LipoxinA4 attenuates cell invasion by inhibiting ROS/ERK/MMP pathway in pancreatic cancer
    • Article ID 6815727
    • L. Zong, J. Li, X. Chen et al., "LipoxinA4 attenuates cell invasion by inhibiting ROS/ERK/MMP pathway in pancreatic cancer, " OxidativeMedicine and Cellular Longevity, vol. 2016, Article ID 6815727, 9 pages, 2016.
    • (2016) OxidativeMedicine and Cellular Longevity 2016 , pp. 9
    • Zong, L.1    Li, J.2    Chen, X.3
  • 18
    • 33748707776 scopus 로고    scopus 로고
    • The lipoxin receptor ALX: Potent ligand-specific and stereoselective actions in vivo
    • N. Chiang, C. N. Serhan, S.-E. Dahĺen et al., "The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo, " Pharmacological Reviews, vol. 58, no. 3, pp. 463-487, 2006.
    • (2006) Pharmacological Reviews , vol.58 , Issue.3 , pp. 463-487
    • Chiang, N.1    Serhan, C.N.2    Dahĺen, S.-E.3
  • 19
    • 64849099379 scopus 로고    scopus 로고
    • Synthesis of lipoxin A4 by 5-lipoxygenase mediates PPARgamma-dependent, neuroprotective effects of rosiglitazone in experimental stroke
    • M. Sobrado, M. P. Pereira, I. Ballesteros et al., "Synthesis of lipoxin A4 by 5-lipoxygenase mediates PPARgamma-dependent, neuroprotective effects of rosiglitazone in experimental stroke, " The Journal of Neuroscience, vol. 29, no. 12, pp. 3875-3884, 2009.
    • (2009) The Journal of Neuroscience , vol.29 , Issue.12 , pp. 3875-3884
    • Sobrado, M.1    Pereira, M.P.2    Ballesteros, I.3
  • 20
    • 84930683202 scopus 로고    scopus 로고
    • Elevation of HO-1 expression mitigates intestinal ischemia-reperfusion injury and restores tight junction function in a rat liver transplantation model
    • Article ID 986075
    • X. Chi, W. Yao, H. Xia et al., "Elevation of HO-1 expression mitigates intestinal ischemia-reperfusion injury and restores tight junction function in a rat liver transplantation model, " Oxidative Medicine and Cellular Longevity, vol. 2015, Article ID 986075, 12 pages, 2015.
    • (2015) Oxidative Medicine and Cellular Longevity 2015 , pp. 12
    • Chi, X.1    Yao, W.2    Xia, H.3
  • 21
    • 84930869497 scopus 로고    scopus 로고
    • Protective effects of butyrate on intestinal ischemia-reperfusion injury in rats
    • Y. Qiao, J. Qian, Q. Lu, Y. Tian, Q. Chen, andY. Zhang, "Protective effects of butyrate on intestinal ischemia-reperfusion injury in rats, "The Journal of Surgical Research, vol. 197, no. 2, pp. 324-330, 2015.
    • (2015) The Journal of Surgical Research , vol.197 , Issue.2 , pp. 324-330
    • Qiao, Y.1    Qian, J.2    Lu, Q.3    Tian, Y.4    Chen, Q.5    Zhang, Y.6
  • 22
    • 84877624393 scopus 로고    scopus 로고
    • Effect of lipoxin A4 onmyocardial ischemia reperfusion injury following cardiac arrest in a rabbit model
    • Z. Chen, Z. Wu, C. Huang et al., "Effect of lipoxin A4 onmyocardial ischemia reperfusion injury following cardiac arrest in a rabbit model, " Inflammation, vol. 36, no. 2, pp. 468-475, 2013.
    • (2013) Inflammation , vol.36 , Issue.2 , pp. 468-475
    • Chen, Z.1    Wu, Z.2    Huang, C.3
  • 23
    • 84862822042 scopus 로고    scopus 로고
    • BML-111, a lipoxin receptor agonist, protects haemorrhagic shock-induced acute lung injury in rats
    • J. Gong, S. Guo, H.-B. Li, S.-Y. Yuan, Y. Shang, and S.-L. Yao, "BML-111, a lipoxin receptor agonist, protects haemorrhagic shock-induced acute lung injury in rats, " Resuscitation, vol. 83, no. 7, pp. 907-912, 2012.
    • (2012) Resuscitation , vol.83 , Issue.7 , pp. 907-912
    • Gong, J.1    Guo, S.2    Li, H.-B.3    Yuan, S.-Y.4    Shang, Y.5    Yao, S.-L.6
  • 25
    • 0014864255 scopus 로고
    • Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal
    • C. J. Chiu, A. H. McArdle, R. Brown, H. J. Scott, and F.N. Gurd, "Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal, " Archives of Surgery, vol. 101, no. 4, pp. 478-483, 1970.
    • (1970) Archives of Surgery , vol.101 , Issue.4 , pp. 478-483
    • Chiu, C.J.1    McArdle, A.H.2    Brown, R.3    Scott, H.J.4    Gurd, F.N.5
  • 26
    • 84920063127 scopus 로고    scopus 로고
    • Dexmedetomidine protects against apoptosis induced by hypoxia/reoxygenation through the inhibition of gap junctions in NRK-52E cells
    • C. Luo, D. Yuan, W. Yao et al., "Dexmedetomidine protects against apoptosis induced by hypoxia/reoxygenation through the inhibition of gap junctions in NRK-52E cells, " Life Sciences, vol. 122, pp. 72-77, 2015.
    • (2015) Life Sciences , vol.122 , pp. 72-77
    • Luo, C.1    Yuan, D.2    Yao, W.3
  • 27
    • 84877604676 scopus 로고    scopus 로고
    • Involvement of K+ channel-dependant pathways in lipoxin A4-induced protective effects on hypoxia/reoxygenation injury of cardiomyocytes
    • X.-Q. Chen, S.-H. Wu, Y. Zhou, and Y.-R. Tang, "Involvement of K+ channel-dependant pathways in lipoxin A4-induced protective effects on hypoxia/reoxygenation injury of cardiomyocytes, " Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 88, no. 5, pp. 391-397, 2013.
    • (2013) Prostaglandins Leukotrienes and Essential Fatty Acids , vol.88 , Issue.5 , pp. 391-397
    • Chen, X.-Q.1    Wu, S.-H.2    Zhou, Y.3    Tang, Y.-R.4
  • 28
    • 84962173653 scopus 로고    scopus 로고
    • Hyperglycemia abrogates ischemic postconditioning cardioprotection by impairing AdipoR1/Caveolin-3/STAT3 signaling in diabetic rats
    • H. Li, W. Yao, Z. Liu et al., "Hyperglycemia abrogates ischemic postconditioning cardioprotection by impairing AdipoR1/Caveolin-3/STAT3 signaling in diabetic rats, " Diabetes, vol. 65, no. 4, pp. 942-955, 2016.
    • (2016) Diabetes , vol.65 , Issue.4 , pp. 942-955
    • Li, H.1    Yao, W.2    Liu, Z.3
  • 29
    • 84929170284 scopus 로고    scopus 로고
    • Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activatingNrf2 andBrg1
    • H. Li, W. Yao, M. G. Irwin et al., "Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activatingNrf2 andBrg1, " Free Radical Biology &Medicine, vol. 84, pp. 311-321, 2015.
    • (2015) Free Radical Biology &Medicine , vol.84 , pp. 311-321
    • Li, H.1    Yao, W.2    Irwin, M.G.3
  • 30
    • 84896129738 scopus 로고    scopus 로고
    • Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model
    • Article ID 258567
    • W. Yao, G. Luo, G. Zhu et al., "Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model, " Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID 258567, 9 pages, 2014.
    • (2014) Oxidative Medicine and Cellular Longevity 2014 , pp. 9
    • Yao, W.1    Luo, G.2    Zhu, G.3
  • 31
  • 32
    • 84937762523 scopus 로고    scopus 로고
    • Higenamine regulatesNrf2-HO-1-Hmgb1 axis and attenuates intestinal ischemiareperfusion injury in mice
    • C. Liu, C. Zhu, G. Wang, R. Xu, and Y. Zhu, "Higenamine regulatesNrf2-HO-1-Hmgb1 axis and attenuates intestinal ischemiareperfusion injury in mice, " Inflammation Research, vol. 64, no. 6, pp. 395-403, 2015.
    • (2015) Inflammation Research , vol.64 , Issue.6 , pp. 395-403
    • Liu, C.1    Zhu, C.2    Wang, G.3    Xu, R.4    Zhu, Y.5
  • 33
    • 4644309384 scopus 로고    scopus 로고
    • Lipoxins and novel 15-epi-lipoxin analogs display potent antiinflammatory actions after oral administration
    • G. Bannenberg, R.-L. Moussignac, K. Gronert et al., "Lipoxins and novel 15-epi-lipoxin analogs display potent antiinflammatory actions after oral administration, " British Journal of Pharmacology, vol. 143, no. 1, pp. 43-52, 2004.
    • (2004) British Journal of Pharmacology , vol.143 , Issue.1 , pp. 43-52
    • Bannenberg, G.1    Moussignac, R.-L.2    Gronert, K.3
  • 35
    • 84859164095 scopus 로고    scopus 로고
    • A lipoxin A4 analog ameliorates blood-brain barrier dysfunction and reduces MMP-9 expression in a rat model of focal cerebral ischemia-reperfusion injury
    • Y. Wu, Y.-P. Wang, P. Guo et al., "A lipoxin A4 analog ameliorates blood-brain barrier dysfunction and reduces MMP-9 expression in a rat model of focal cerebral ischemia-reperfusion injury, " Journal of Molecular Neuroscience, vol. 46, no. 3, pp. 483-491, 2012.
    • (2012) Journal of Molecular Neuroscience , vol.46 , Issue.3 , pp. 483-491
    • Wu, Y.1    Wang, Y.-P.2    Guo, P.3
  • 36
    • 84880277197 scopus 로고    scopus 로고
    • BML-111 attenuates hemorrhagic shock-induced acute lung injury through inhibiting activation of mitogen-Activated protein kinase pathway in rats
    • H.-B. Li, G.-Z. Wang, J. Gong et al., "BML-111 attenuates hemorrhagic shock-induced acute lung injury through inhibiting activation of mitogen-Activated protein kinase pathway in rats, " The Journal of Surgical Research, vol. 183, no. 2, pp. 710-719, 2013.
    • (2013) The Journal of Surgical Research , vol.183 , Issue.2 , pp. 710-719
    • Li, H.-B.1    Wang, G.-Z.2    Gong, J.3
  • 37
    • 85027953990 scopus 로고    scopus 로고
    • BML-111 attenuates acute lung injury in endotoxemic mice
    • M. Tang, L. Chen, B. Li et al., "BML-111 attenuates acute lung injury in endotoxemic mice, " The Journal of Surgical Research, vol. 200, no. 2, pp. 619-630, 2016.
    • (2016) The Journal of Surgical Research , vol.200 , Issue.2 , pp. 619-630
    • Tang, M.1    Chen, L.2    Li, B.3
  • 38
    • 84938983720 scopus 로고    scopus 로고
    • LipoxinA4 activatesNrf2 pathway and ameliorates cell damage in cultured cortical astrocytes exposed to oxygen-glucose deprivation/reperfusion insults
    • L. Wu, H.-H. Li, Q. Wu et al., "LipoxinA4 activatesNrf2 pathway and ameliorates cell damage in cultured cortical astrocytes exposed to oxygen-glucose deprivation/reperfusion insults, " Journal of Molecular Neuroscience, vol. 56, no. 4, pp. 848-857, 2015.
    • (2015) Journal of Molecular Neuroscience , vol.56 , Issue.4 , pp. 848-857
    • Wu, L.1    Li, H.-H.2    Wu, Q.3
  • 39
    • 84938765962 scopus 로고    scopus 로고
    • The Keap1/Nrf2 pathway in health and disease: From the bench to the clinic
    • M. A. O'Connell and J. D. Hayes, "The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic, " Biochemical Society Transactions, vol. 43, pp. 687-689, 2015.
    • (2015) Biochemical Society Transactions , vol.43 , pp. 687-689
    • O'Connell, M.A.1    Hayes, J.D.2
  • 40
    • 84883093951 scopus 로고    scopus 로고
    • Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs
    • T. Satoh, S. R. McKercher, and S. A. Lipton, "Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs, " Free Radical Biology & Medicine, vol. 65, pp. 645-657, 2013.
    • (2013) Free Radical Biology & Medicine , vol.65 , pp. 645-657
    • Satoh, T.1    McKercher, S.R.2    Lipton, S.A.3
  • 41
    • 84925488240 scopus 로고    scopus 로고
    • Lipoxin A4 suppresses lipopolysaccharide-induced hela cell proliferation and migration via NFkappaB pathway
    • H. Hao, F. Xu, J. Hao et al., "Lipoxin A4 suppresses lipopolysaccharide-induced hela cell proliferation and migration via NFkappaB pathway, " Inflammation, vol. 38, pp. 400-408, 2015.
    • (2015) Inflammation , vol.38 , pp. 400-408
    • Hao, H.1    Xu, F.2    Hao, J.3
  • 42
    • 84881443730 scopus 로고    scopus 로고
    • LipoxinA4 preconditioning and postconditioning protect myocardial ischemia/reperfusion injury in rats
    • Article ID 231351
    • Q. Zhao, L. Shao, X. Hu et al., "LipoxinA4 preconditioning and postconditioning protect myocardial ischemia/reperfusion injury in rats, " Mediators of Inflammation, vol. 2013, Article ID 231351, 13 pages, 2013.
    • (2013) Mediators of Inflammation 2013 , pp. 13
    • Zhao, Q.1    Shao, L.2    Hu, X.3
  • 43
    • 84918817969 scopus 로고    scopus 로고
    • Lipoxin A4 suppresses the development of endometriosis in an ALX receptor-dependent manner via the p38 MAPK pathway
    • R. Wu, W. Zhou, S. Chen et al., "Lipoxin A4 suppresses the development of endometriosis in an ALX receptor-dependent manner via the p38 MAPK pathway, " British Journal of Pharmacology, vol. 171, no. 21, pp. 4927-4940, 2014.
    • (2014) British Journal of Pharmacology , vol.171 , Issue.21 , pp. 4927-4940
    • Wu, R.1    Zhou, W.2    Chen, S.3


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