Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

Science

Volumn 352, Issue 6293, 2016, Pages 1542-1547

  Verba, Kliment A ^a   Wang, Ray Yu Ruei ^a   Arakawa, Akihiko ^b   Liu, Yanxin ^a   Shirouzu, Mikako ^b   Yokoyama, Shigeyuki ^b   Agard, David A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN 37; CYCLIN DEPENDENT KINASE 4; HEAT SHOCK PROTEIN 90; CDC37 PROTEIN, HUMAN; CDK4 PROTEIN, HUMAN; CELL CYCLE PROTEIN; CHAPERONIN; HSP90AB1 PROTEIN, HUMAN; MULTIPROTEIN COMPLEX;

BIOLOGICAL ANALYSIS; ENZYME; ENZYME ACTIVITY; EXPERIMENTAL STUDY; MOLECULAR ANALYSIS; PROTEIN; STABILIZATION;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL DEATH; COMPLEX FORMATION; CRYOELECTRON MICROSCOPY; DIMERIZATION; ENZYME ACTIVITY; ENZYME STABILITY; ENZYME STRUCTURE; HUMAN; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN HYDROLYSIS; PROTEIN PHOSPHORYLATION; PROTEIN UNFOLDING; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; PROTEIN SECONDARY STRUCTURE; SF9 CELL LINE; ULTRASTRUCTURE;

ANIMALS; CELL CYCLE PROTEINS; CHAPERONINS; CYCLIN-DEPENDENT KINASE 4; ENZYME STABILITY; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; PROTEIN STRUCTURE, SECONDARY; PROTEIN UNFOLDING; SF9 CELLS;

EID: 84976318037     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf5023     Document Type: Article

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