The effect of Astragalus as an adjuvant treatment in type 2 diabetes mellitus: A (preliminary) meta-analysis

Journal of Ethnopharmacology

Volumn 191, Issue , 2016, Pages 206-215

  Tian, Huiping ^a   Lu, Jun ^b   He, Hairong ^b   Zhang, Lu ^a   Dong, Yalin ^a   Yao, Hongping ^a   Feng, Weiyi ^a   Wang, Siwen ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b Department of Renal Transplantation Nephropathy Hospital First Affiliated Hospital Medical College   (China)

Author keywords

Adjuvant treatment; Astragalus; Meta analysis; Traditional chinese medicine; Type 2 diabetes mellitus

Indexed keywords

ASTRAGALUS EXTRACT; GLUCOSE; HEMOGLOBIN A1C; INSULIN; ANTIDIABETIC AGENT; BIOLOGICAL MARKER; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; PLANT EXTRACT;

ABSENCE OF SIDE EFFECTS; ADJUVANT THERAPY; ARTICLE; ASSESSMENT OF HUMANS; ASTRAGALUS (PLANT); DIET RESTRICTION; EXERCISE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HOMEOSTASIS MODEL ASSESSMENT INSULIN RESISTANCE; HUMAN; INSULIN RESISTANCE; META ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; POSTPRANDIAL STATE; RANDOMIZED CONTROLLED TRIAL (TOPIC); SENSITIVITY ANALYSIS; BLOOD; CHEMISTRY; COMBINATION DRUG THERAPY; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; ISOLATION AND PURIFICATION; MEDICINAL PLANT; METABOLISM; PHYTOTHERAPY; TREATMENT OUTCOME;

ASTRAGALUS PLANT; BIOMARKERS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DRUG THERAPY, COMBINATION; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; TREATMENT OUTCOME;

EID: 84976306088     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2016.05.062     Document Type: Article

References (30)

1. Chen, J.H., Huang, G.R., Shi, Y.X., Effect of Huangqi injection on early diabetic nephropathy. Zhongguo Wu Zhen Xue ZA Zhi, 2003, 1156–1158.
2. Chinese Pharmacopoeia Commission, Chinese Pharmacopoeia, Section on Chinese Medicine, Notes for Clinicians, 2015, China Medical Science Press, Beijing, 302–303.
3. Fu, J., Wang, Z., Huang, L., Zheng, S., Wang, D., Chen, S., Zhang, H., Yang, S., Review of the botanical characteristics, phytochemistry, and pharmacology of Astragalus membranaceus (Huangqi). Phytother. Res. 28 (2014), 1275–1283.
4. Higgins, J.P., Thompson, S.G., Quantifying heterogeneity in a meta-analysis. Stat. Med. 21 (2002), 1539–1558.
5. Higgins, J.P.T., Green, S., 2011. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. 〈 http://handbook.cochrane.org/〉.
6. International Diabetes Federation, 2015. IDF Diabetes Atlas-7th edition. 〈 http://www.diabetesatlas.org/〉.
7. Kohnert, K.D., Augstein, P., Zander, E., Heinke, P., Peterson, K., Freyse, E.J., Hovorka, R., Salzsieder, E., Glycemic variability correlates strongly with postprandial beta-cell dysfunction in a segment of type 2 diabetic patients using oral hypoglycemic agents. Diabetes Care 32 (2009), 1058–1062.
8. Li, L., The treatment of Huangqi in diabetic nephropathy. Zhongguo Shi Yong Yi Yao, 2008, 103–104.
9. Liu, M., Wu, K., Mao, X., Wu, Y., Ouyang, J., Astragalus polysaccharide improves insulin sensitivity in KKAy mice: regulation of PKB/GLUT4 signaling in skeletal muscle. J. Ethnopharmacol. 127 (2010), 32–37.
10. Liu, S., Zhang, M.X., Yang, X.F., Liu, L.Z., The influence of irbesartan combination with Astragalus injection on connective tissue growth factor in elderly diabetic nephropathy patients. Zhongguo Lao Nian Xue ZA Zhi 35 (2015), 108–110.
11. Mei, J., Analysis on medication rule in Diabetes Ⅱ Patients treated with Traditional Chinese Medicine. Zhongguo Shi Yan Fang Ji Xue ZA Zhi 18 (2012), 290–291.
12. Pang, F., Clinical research of Astragalus in improvement of insulin resistance and insulin secretion in type 2 diabetes mellitus. Zhongguo Yi Yao Dao Kan 15:118 (2013), 1420–1421.
13. Patel, A., MacMahon, S., Chalmers, J., Neal, B., Billot, L., Woodward, M., Marre, M., Cooper, M., Glasziou, P., Grobbee, D., Hamet, P., Harrap, S., Heller, S., Liu, L., Mancia, G., Mogensen, C.E., Pan, C., Poulter, N., Rodgers, A., Williams, B., Bompoint, S., de Galan, B.E., Joshi, R., Travert, F., Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N. Engl. J. Med. 358 (2008), 2560–2572.
14. Sterne, J.A., Egger, M., Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J. Clin. Epidemiol. 54 (2001), 1046–1055.
15. Stolar, M., Glycemic control and complications in type 2 diabetes mellitus. Am. J. Med., 123, 2010 S3-11.
16. Stumvoll, M., Goldstein, B.J., van Haeften, T.W., Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365 (2005), 1333–1346.
17. Tang, A.H., Shi, W., Tang, N., Hao, X.B., Liu, C.H., A clinical study of Huangqi injection on simple diabetic retinopathy. Zhejiang Zhong Yi ZA Zhi, 2003, 40–41.
18. Tao, S.J., Yin, Z.N., Tan, H., The influence of injection Astragalus membranaceus on serum and urine TGFβ1 in diabetic nephropathy patients and clinical significance. Zhongguo Xian Dai Yi Xue ZA Zhi, 2003, 49–51.
19. Taylor, R., Type 2 diabetes: etiology and reversibility. Diabetes Care 36 (2013), 1047–1055.
20. Wang, N., Zhang, D., Mao, X., Zou, F., Jin, H., Ouyang, J., Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes. Mol. Cell. Endocrinol. 307 (2009), 89–98.
21. Wang, X.X., Li, M., Yan, M., Liu, Z.D., Lu, Z.J., Tang, P., Effect of Astragalus-supplemented enteral nutrition on metabolism in type-2 diabetic patients with ischemic stroke. Chang Wai Yu Chang Nei Ying Yang 57 (2007), 108–110.
22. Wang, Y., Guo, L.P., Shang, H.C., Fu, J., Fu, S.F., Literature analysis on 560 cases of adverse drug reaction/events of Astragalus injection. Zhong Yi ZA Zhi v. 52 (2011), 779–783.
23. Wang, Z.Y., Zhang, Q.L., Astragalus injection combined with western medicine in the treatment of insulin resistance in type 2 diabetes in 60 cases. Shaanxi Zhong Yi, 2006, 1535–1537.
24. Wu, J.B., The adjuvant treatment of Huangqi in type 2 diabetes. Zhongguo Yi xue Gong Cheng, 19, 2011 139+141.
25. Wu, J.R., Wang, K.H., Ji, K., Zhang, D., Zhang, X.M., Yang, B., Feng, R.B., Medication rules for treating diabetes based on data mining. Zhongguo Shi Yan Fang Ji Xue ZA Zhi 21 (2015), 214–217.
26. Zeng, F., The effect of Astragalus injection on renal lesion and plasma endothelin in diabetes mellitus. Jiangxi Zhong Yi Yao, 2005, 26–27.
27. Zhang, K., Pugliese, M., Pugliese, A., Passantino, A., Biological active ingredients of traditional Chinese herb Astragalus membranaceus on treatment of diabetes: a systematic review. Mini Rev. Med. Chem. 15 (2015), 315–329.
28. Zhao, J.H., Clinical effect analysis of Huangqi on adjuvant treatment in type 2 diabetes. Shi Yong Lin Chuang Yi Yao ZA Zhi 14 (2010), 60–61.
29. Zhou, H., The effect of Astragalus injection on albumin excrete rate in diabetic nephropathy patients. Zhongguo Zhong Yi Ji Zheng, 2004, 668.
30. Zhou, L., Zhang, S.H., Yu, Z., Zou, K.L., A clinical study on the influence of Radix Astragali for diabetic insulin resistance and serum adiponectin. Xin Zhong Yi, 2007, 82–83 88.