Antimalarial actions of Lawsonia inermis, Tithonia diversifolia and Chromolaena odorata in combination

Journal of Ethnopharmacology

Volumn 191, Issue , 2016, Pages 188-194

  Afolayan, Funmilayo I D ^a,b   Adegbolagun, Olayemi M ^a   Irungu, Beatrice ^b   Kangethe, Lucy ^b   Orwa, Jennifer ^b   Anumudu, Chiaka I ^a  

^a UNIVERSITY OF IBADAN   (Nigeria)

^b KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

Author keywords

Antiplasmodial; Chromolaena odorata; Combination; Lawsonia inermis; Tithonia diversifolia

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ; CHLOROQUINE; CHROMOLAENA ODORATA EXTRACT; DICHLOROMETHANE; LAWSONIA INERMIS EXTRACT; METHANOL; PLANT EXTRACT; TITHONIA DIVERSIFOLIA EXTRACT; UNCLASSIFIED DRUG; SOLVENT;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG DETERMINATION; DRUG ISOLATION; DRUG POTENTIATION; DRUG SAFETY; DRUG SENSITIVITY; IC50; IN VITRO STUDY; IN VIVO STUDY; MALARIA FALCIPARUM; MOUSE; NONHUMAN; PLANT LEAF; PLASMODIUM BERGHEI INFECTION; SINGLE DRUG DOSE; ANIMAL; ASTERACEAE; CHEMISTRY; CHROMOLAENA; COMBINATION DRUG THERAPY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; DRUG RESISTANCE; GROWTH, DEVELOPMENT AND AGING; ISOLATION AND PURIFICATION; LAWSONIA INERMIS; MALARIA; MEDICINAL PLANT; PARASITOLOGY; PHYTOTHERAPY; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; TIME FACTOR; TOXICITY;

ANIMALS; ANTIMALARIALS; ASTERACEAE; CHROMOLAENA; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; LAWSONIA PLANT; MALARIA; METHANOL; METHYLENE CHLORIDE; MICE; PARASITIC SENSITIVITY TESTS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLANTS, MEDICINAL; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; SOLVENTS; TIME FACTORS;

EID: 84976288716     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2016.06.045     Document Type: Article

References (55)

1. Abdullah, W.O., Unyah, N.Z., Hamat, R.A., Omar, B., Ghani, M.K.A., Rayani, M., Hatam, G.R., In vitro antiplasmodial activity and cytotoxicity of ten plants used as traditional. Med. Malays. Malays. J. Health Sci. 9 (2011), 5–8.
2. Abosi, A.O., Raseroka, B.H., In vivo antimalaria activity of Vernonia amygdalina. Br. J. Biomed. Sci. 60 (2003), 89–91.
3. Afolayan, F., Anumudu, C.I., Adegbolagun, O.M., Orwa, J.A., Irungu, B.N., Kangethe, L.N., Mathaura, C.N., Nwikwabe, M.N., Nyangacha R.M., Omar S.A., 2014. In vitro Antiplasmodial activity and Cytotoxicity of some Medicinal Plants indigenously used in Nigeria against Malaria. In: Proceedings of the 4th Walter Sisulu University International Research Conference. 17 – 19th August 2011. Directorate of Research Development, Walter Sisulu University, East London, Eastern Cape, South Africa.
4. Ahmed, S., Onocha, P.A., Antiemetic activity of Tithonia diversifolia (HEMSL.) A. Gray Leaves in copper sulfate induced Chick Emesis Model. AJPCT 1 (2013), 734–739.
5. Akala, H.M., Waters, C.N., Yenesew, A., Wanjala, C., Akenga, T.A., In vitro antiplasmodial and cyclin-dependent protein kinase (pfmrk) inhibitory activities of selected flavonoids in combination with Chloroquine (CQ) and Artemisinin. Res. Pharm. Biotechnol. 2 (2010), 40–50.
6. Ali, A.A.N., Al-rahwi, K., Lindequist, U., Some medicinal plants used in Yemeni Herbal Medicine to treat. Afr. J. Tradit. Complement. Altern. Med. 1 (2004), 72–76.
7. Barliana, M.I., Suradji, E.W., Abdulah, R., Diantini, A., Hatabu, T., Nakajima-Shimada, J., Koyama, H., Antiplasmodial properties of kaempferol-3-O-rhamnoside isolated from the leaves of Schima wallichii against Chloroquine-resistant Plasmodium Falciparum. Biomed. Rep. 2 (2014), 579–583.
8. Berenbaum, M.C., A method for testing for synergy with any number of agents. J. Infect. Dis. 137 (1978), 122–130.
9. Bukirwa, H., Orton, L., Artesunate plus mefloquine versus mefloquine for treating uncomplicated malaria. Cochrane Database Syst. Rev., 2005, CD004531, 10.1002/14651858.CD004531.pub2.
10. Chaudhary, G., Goyal, S., Poonia, P., Review Article Lawsonia inermis Linnaeus : a phytopharmacological review. IJPSDR 2 (2010), 91–98.
11. Chowdhury, M.M.H., Kubra, K., Ahmed, S.R., Antimicrobial, phytochemical and toxicological evaluation of Lawsonia inermis extracts against clinical isolates of pathogenic bacteria. Res. J. Med. Plant 8 (2014), 187–195.
12. Chou, T.C., Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol. Rev. 68 (2006), 621–681.
13. Desjardins, R.E., Canfield, R.E., Hayness, C.J., Chuby, J.D., Quantitative assessment of anti-malarial activity in vitro by an automated dilution technique. Antimicrob. Agents Chemother. 16 (1979), 710–718.
14. Elufioye, T.O., Agbedahunsi, J.M., Antimalarial activities of Tithonia diversifolia (Asteraceae) and Crossopteryx febrifuga (Rubiaceae) on mice in vivo. J. Ethnopharmacol. 93 (2004), 167–171.
15. Elufioye, T.O., Alatise, O.I., Fakoya, F.A., Agbedahunsi, J.M., Houghton, P.J., Toxicity studies of Tithonia diversifolia A. Gray (Asteraceae) in rats. J. Ethnopharmacol. 122 (2009), 410–415.
16. Essiett, U., Uriah, N., Comparative phytochemical and physicochemical properties of Aspilia Africana and Tithonia diversifolia leaves. Int. J. Mod. Biol. Med. 3 (2013), 113–122.
17. Ezeonwumelu, J.O.C., Omolo, R.G., Ajayi, A. M., Agwu, E., Tanayen, J.K., Oyewale, A.A., Adzu, B., Okoruwa, A.G., Ogbonnia, S.O., Studies of phytochemical screening, acute toxicity and anti-diarrhoeal effect of aqueous extract of Kenyan Tithonia diversifolia leaves in rats. Br. J. Pharmacol. Toxicol. 3 (2012), 127–134.
18. FDA, 1993. Red book II. Acute Oral Toxicity tests, pp. 113.
19. Gathirwa, J.W., Rukunga, G.M., Njagi, E.N.M., Omar, S.A., Mwitari, P.G., Guantai, A.N., Tolo, F.M., Kimani, C.W., Muthaura, C.N., Kirira, P.G., Ndunda, T.N., Amalemba, G., Mungai, G.M., Ndiege, I.O., The in vitro antiplasmodial and in vivo anti-malarial efficacy of combinations of some medicinal plants used traditionally for treatment of malaria by the Meru community in Kenya. J. Ethnopharmacol. 115 (2008), 223–231.
20. Gathirwa, J.W., Rukunga, G.M., Mwitari, P.G., Mwikwabe, N.M., Kimani, C.W., Muthaura, C.N., Kiboi, D.M., Nyangacha, R.M., Omar, S.A., Traditional herbal antimalarial therapy in Kilifi district, Kenya. J. Ethnopharmacol. 134 (2011), 434–442.
21. Gessler, M.C., Tanner, M., Chollet, J., Nkunya, M.H.H., Heinrick, M., Tanzanian medicinal plants used traditionally for the treatment of malaria: in vivo anti-malarial and in vitro cytotoxic activities. Phytother. Res. 9 (1995), 504–508.
22. Hajimehdipoor, H., Shahrestani, R., Shekarchi, M., Investigating the synergistic antioxidant effects of some flavonoid and phenolic compounds. RIJ 1 (2014), 35–40.
23. Idowu, O.A., Soniran, O.T., Ajana, O., Aworinde, D.O., Ethnobotanical survey of antimalarial plants used in Ogun State, Southwest Nigeria. Afr. J. Pharm. Pharmacol. 4 (2010), 55–60.
24. Iwu, M.M., Pharmacological Profile of Selected Medicinal Plants. Handbook of African Medicinal plants. 1993, CRC Press, Inc, Florida, 103–343.
25. Jutamaad, S., Noppamas, S., Aimon, S., Yodhathai, T., Toxicological and anti-malarial activity of eurycomalactone and Eurycoma longifolia Jack extract in mice. Thai J. Phytopharm. 5 (1998), 14–17.
26. Le Bras, J., Deloron, P., In vitro study of drug sensitivity of Plasmodium falciparum: an evaluation of a new semi-microtest. Am. J. Trop. Med. Hyg. 32 (1983), 447–451.
27. Ling, S.K., Abdul Rashih, A., Salbiah, M., Siti Asha, A.B., Mazura, M.P., Khoo, M.G.H, Vimala, S., Ong, B.K., Mastura, M., Nor Azah, M.A., 2007. Extraction and simultaneous detection of flavonoids in the leaves of Chromolaena odorata by RP-HPLC with DAD. Highlights of FRIM'S IRPA projects 2006, FRIM, Kaula Lumpur.
28. Lorke, D., A new approach to practical acute toxicity testing. Arch. Toxicol. 54 (1983), 275–287.
29. McFadden, R., Peterson, N., Interactions between drugs and four common medicinal herbs. Nurs. Stand 25 (2011), 65–68.
30. Muganga, R., Angenot, L., Tits, M., Frederich, M., Antiplasmodial and cytotoxic activity of Rwandan medicinal plants used in the treatment of malaria. J. Ethnopharmacol. 128 (2010), 52–57.
31. Nisit, P., Saisunee, L.B., Bconsom, L, B.J., Chemical Constituents and Biological Activities of Chromolaena odorata. Chiang Mai J. Sci. 32 (2005), 139–148.
32. Obafemi, C.A., Sulaimon, T.O., Akinpelu, D.A., Olugbade, T.A., 2006. Antimicrobial activity of extracts and a germacranolide-type sesquiterpene lactone from Tithonia diversifolia leaf extract, Vol. 5, pp. 1254–1258.
33. Onkaramurthy, M., Vee rapur, V.P., Thippeswamy, B.S., Reddy, T.N., Ravappa, H., Badami, S., Antidiabetic and anti-cataract effect of C. odorata Linn; in streptozotocin-induced diabetic rat. J. Ethnopharmacol. 145 (2013), 363–372.
34. Oyewole, I.O., Magaji, Z.J., Awoyinka, O.A., Biochemical and toxicological studies of aqueous extract of Tithonia diversifolia (Hemsl.) leaves in wister albino rats. J. Med. Plant Res. 1 (2007), 30–33.
35. Oyewole, I.O., Ibidapo, C.A., Moronkola, D.O., Oduola, A.O., Adeoye, G.O., Anyasor, G.N., Obansa, J.A., Antimalarial and repellent activities of Tithonia diversifolia (Hemsl) leaf extracts. J. Med. Plant Res. 2:8 (2008), 171–175.
36. Peters, W., Portus, J.H., Robinson, B.L., The chemotherapy of rodent malaria, XXII. The value of drug-resistant strains of Plasmodium berghei in screening for blood schizontocidal activity. Ann. Trop. Med. Parasitol. 69 (1975), 155–171.
37. Rajwar, S., Khatri, P., Diabetic effects of polyherbal formulation of Lawsonia inermis and Azadirachta indica. J. Drug Deliv. Ther. 3 (2013), 45–51.
38. Rasoanaivo, P., Deharo, E., Ratssimamanga-Urverg, S., Frappier, F., Guidelines for the non-clinical evaluation of the efficacy of traditional antimalarials. Wilcox, M., Bodeker, G., Rasoanaivo, P., (eds.) Traditional Medicinal Plants and Malaria, 2004, CPC Press, New York, 255–270.
39. Semwal, R.B., Semwal, D.K., Combrinck, S., Cartwright-Jones, C., Viljoen, A., Lawsonia inermis L. (henna): Ethnobotanical, phytochemical and pharmacological aspects. J. Ethnopharmacol. 155 (2014), 80–103.
40. Singh, V.B., Devaraja, R., Kanojia, N., Bishnoi, R., Kumar, S., Nayak, K.C., Verma, K.K., Tundwal, V., Effect of herbal medicine “Jod Aram” in Rheumatoid Arthritis Patients - Randomized Placebo Controlled Study. Indian Med. Gaz., 2014, 345–348.
41. Singh, D.K., Luqman, S., Lawsonia inermis (L): a perspective on anticancer potential of Mehndi Henna. Biomed. Res. Ther. 1 (2014), 112–120.
42. Sixsmith, D.G., Watkins, W.M., Chulay, J.D., Spencer, H.C., In vitro antimalarial activity of tetrahydrofoliate dehydrogenase inhibitors. Am. J. Trop. Med. Hyg. 33 (1984), 772–776.
43. Suleiman, E.A., Mohamed, E.A., In vitro activity of Lawsonia inermis (Henna ) on some pathogenic fungi. J. Mycol. 1 (2014), 1–5.
44. Tona, L., Kambu, K., Ngimbi, N., Cimanga, K., Vlietinck, A.J., Antiamoebic and phytochemical screening of some Congolese medicinal plants. J. Ethnopharmacol. 61 (1998), 57–65.
45. Trager, W., Jensen, J.B., Human malaria parasites in continuous culture. Science 193 (1976), 673–675.
46. Ukpai, O.M., Amaechi, E.C., Evaluation of in vivo antimalarial activity of the ethanolic leaf extracts of Chromolaena odorata and Cymbopogon citratus in mice. Nig. Niger. J. Biotechnol. 24 (2012), 27–34.
47. Vijayaraghavan, K., Ali, S.M., Manithi, R., Studies on phytochemical screening and antioxidant activity of Chromolaena odorata and Annona squamosa. Int. J. Innov. Res. Sci. Eng. Technol. 2 (2013), 7315–7321.
48. Vital, P.G., Rivera, W.L., Antimicrobial activity and cytotoxicity of Chromolaena odorata (L.F) King and Robinson and Uncaria perrottetii (A. Rich) Merr. extracts. J. Med. Plant Res. 3 (2009), 511–518.
49. Wang, X., Free radical scavenging activity of Chinese traditional four substances decoction (FSD) extracts. Afr. J. Pharm. Pharmacol. 6 (2012), 3113–3117.
50. World Health Organization: World Malaria Report. Geneva, Switzerland, 2008. 〈http://apps.who.int/malaria/wmr2008/〉. (Accessed 12.05.14).
51. World Health Organization (WHO): Malaria Facts sheet April 2016. 〈http://www.who.int/mediacentre/factsheets/fs094/en/〉 (Accessed 28.04.16).
52. Xu, X., Li, F., Zhang, X., Li, P., Zhang, X., Wu, Z., Li, D., (In vitro) (synergistic antioxidant activity and identification of antioxidant components from) Astragalus membranaceus and Paeonia lactiflora. PLoS One 9 (2014), 1–9 e96780.
53. Zhang, S., Qin, C., Safe, S.H., Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context. Environ. Health Perspect. 111 (2003), 1877–1882.
54. Zige, D.V., Ohimain, E.I., Nodu, M.B., Antibacterial activity of Ethanol, crude and water extract of Chromolaena odorata leaves on S. thyphi and E. coli. Greener J. Microbiol. Antimicrob. 1 (2013), 16–19.
55. Zumrutdal, E., Ozaslan, M., A miracle plant for the Herbal Pharmacy: Henna (Lawsonia inermis). Int. J. Pharm. 8 (2012), 483–489.