Antiplasmodial and cytotoxic activities of Rwandan medicinal plants used in the treatment of malaria

Journal of Ethnopharmacology

Volumn 128, Issue 1, 2010, Pages 52-57

  Muganga, Raymond ^a,b   Angenot, L ^b   Tits, M ^b   Frederich M ^b  

^a UNIVERSITY OF RWANDA   (Rwanda)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Antiplasmodial activity; Cytotoxicity; Malaria; Rwandan medicinal plants; Selectivity index

Indexed keywords

ANTIMALARIAL AGENT; ARISTOLOCHIA ELAGANS EXTRACT; ARTEMISININ; CAMPTOTHECIN; CHLOROQUINE; CONYZA AEGYPTIACA EXTRACT; DICHLOROMETHANE; FUERSTIA AFRICANA EXTRACT; LACTATE DEHYDROGENASE; MARKHAMIA LUTEA EXTRACT; METHANOL; MICROGLOSSA PYRIFOLIA EXTRACT; MITRAGYNA RUBROSTIPULATA EXTRACT; PLANT EXTRACT; RUMEX ABYSSINICUS EXTRACT; RUMEX BEQUAERTII EXTRACT; SOLANECIO MANNII EXTRACT; TERMINALIA MOLLIS EXTRACT; TITHONIA DIVERSIFOLIA EXTRACT; TRIMERIA GRANDIFOLIA EXTRACT; UNCLASSIFIED DRUG; ZANTHOXYLUM CHALYBEUM EXTRACT;

ANTIPROTOZOAL ACTIVITY; ARISTOLOCHIA ELAGANS; ARISTOLOCHIACEAE; ARTICLE; BARK; CONTROLLED STUDY; CONYZA AEGYPTIACA; CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; FETUS; FLOWER; FUERSTIA AFRICANA; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LUNG FIBROBLAST; MALARIA; MARKHAMIA LUTEA; MEDICINAL PLANT; MICROGLOSSA PYRIFOLIA; MITRAGYNA RUBROSTIPULATA; OUTCOME ASSESSMENT; PLANT LEAF; PLANT ROOT; PLASMODIUM FALCIPARUM; RUMEX ABYSSINICUS; RUMEX BEQUAERTII; SOLANECIO MANNII; TERMINALIA MOLLIS; TITHONIA DIVERSIFOLIA; TRIMERIA GRANDIFOLIA; ZANTHOXYLUM CHALYBEUM;

ANTIMALARIALS; ANTINEOPLASTIC AGENTS; CELL LINE; HUMANS; MALARIA, FALCIPARUM; PLANT EXTRACTS; PLANTS, MEDICINAL; PLASMODIUM FALCIPARUM; RWANDA;

FUERSTIA AFRICANA; MICROGLOSSA PYRIFOLIA; PLASMODIUM FALCIPARUM; RUMEX ABYSSINICUS; SOLANECIO MANNII; TERMINALIA; TITHONIA DIVERSIFOLIA; ZANTHOXYLUM CHALYBEUM;

EID: 76749152886     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.12.023     Document Type: Article

References (37)

1. Bordoloi M., Barua N.C., Ghosh A.C. An artemisinic acid analogue from Tithonia diversifolia. Phytochemistry 1996, 41:557-559.
2. Capasso F. Medicinal plants: an approach to the study of naturally occurring drugs. Journal of Ethnopharmacology 1985, 13:111-113.
3. Elufioye T.O., Alatise O.I., Fakoya F.A., Agbedahunsi J.M., Houghton P.J. Toxicity studies of Tithonia diversifolia A. Gray (Asteraceae) in rats. Journal of Ethnopharmacology 2009, 122:410-415.
4. Fanello C.I., Karema C., Van Doren W., Van Overmeir C., Ngamije D., Alessandro U. A randomized trial to assess the safety and efficacy of artemether-lumefantrine (Coartem®) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwanda. Transactions of the Royal Society of Tropical Medicine and Hygiene 2007, 101:344-350.
5. Fiot, J., 2005. Etude ethnopharmacologique de Mitragyna inermis (Willd.) O. Kuntze et Gueria senegalensis J.F. Gmel, deux plantes issues de la médecine traditionnelle Africaine. Ph.D. Thesis. Université de la Méditerranée (Aix-Marseille II), pp. 185-187.
6. Frédérich M., De Pauw M.C., Prosperi C., Tits M., Brandt V., Penelle J., Hayette M.P., De Mol P., Angenot L. Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja. Journal of Natural Products 2001, 64:12-16.
7. Gessler M.C, Nkuya M.H.H., Mwasumbi L.B., Heinrich M., Tanner M. Screening of Tanzanian medicinal plants for antimalarial activity. Acta Tropica 1994, 56:65-77.
8. Gessler M.C., Nkuya M.H.H., Msuya D.C., Mwasumbi L.B., Schär A., Heinrich M., Tanner M. Traditional healers in Tanzania: the treatment of malaria with plant remedies. Journal of Ethnopharmacology 1995, 48:131-144.
9. Goffin E., Ziemons E., De Mol P., Do Ceu de Madureira M., Martins A.P., Proença da Cunha A., Philippe G., Tits M., Angenot A., Frédérich M. In vitro antiplasmodial activity of Tithonia diversifolia and identification of its main active constituent: tagitinin C. Planta Medica 2002, 68:543-545.
10. Hakizamungu E., Weri M. L'usage de plantes médicinales dans le traitement du paludisme en médicine traditionnelle Rwandaise. Bulletin de Médecine et Pharmacie 1988, 2:11-17.
11. Jonville M.C., Kodja H., Humeau L., Fournel J., De Mol P., Cao M., Angenot L., Frédérich M. Screening of medicinal plants from Reunion Island for antimalarial and cytotoxic activity. Journal of Ethnopharmacology 2008, 8:382-386.
12. Jou J.H., Li C.Y., Schelonka E.P., Lin C.H., Wu T.S. Analysis of the analogues of aristolochic acid and aristolactam in the plant of Aristolochia genus by HPLC. Journal of Food and Drug Analysis 2004, 12:40-45.
13. Kamuhabwa A., Nshimo C., de Witte P. Cytotoxicity of some medicinal plant extracts used in Tanzanian traditional medicine. Journal of Ethnopharmacology 2000, 70:143-149.
14. Kenmogne M., Prost E., Harakat D., Jacquier M.J., Frédérich M., Sondengam L.B., Zèches M., Waffo-Téguo P. Five labdane diterpenoids from the seeds of Aframomum zambesiacum. Phytochemistry 2006, 67:433-438.
15. Kernan M.R., Amarquaye A., Chen J.L., Chan J., Sesin D.F., Parkinson, Ye Z.J., Barret M., Bales C., Stoddard C.A., Sloan B., Blanc P., Limbach C., Mrisho S., Rozhon E.J. Antiviral phenylpropanoid glycosides from the medicinal plant Markhamia lutea. Journal of Natural Products 1998, 61:564-570.
16. Koch A., Orljala J., Mutiso P.C., Soejarto D.D. An antimalarial abietane diterpene from Fuerstia Africana T.C.E. Fries. Biomedical Systematics and Ecology 2006, 34:270-272.
17. Köhler I., Jenett-Siems K., Kraft C., Siems K., Abbiw D., Bienzle U., Eich E. Herbal remedies traditionally used against malaria in Ghana: bioassay-guided fractionation of Microglossa pyrifolia. Zeitschrift für Naturforschung 2002, 57:1022-1027.
18. Lacroix D., Prado S., Deville A., Krief S., Dumontet V., Kasenene J., Mouray E., Bories C., Bodo B. Hydroperoxy-cycloartane triterpenoids from the leaves of Markhamia lutea, a plant ingested by wild chimpanzees. Phytochemistry 2009, 70:1239-1245.
19. Maregesi S.M., Pieters L., Ngassapa O.D., Apers S., Vingerhoets R., Cos P., Vanden Berghe D.A., Vlietinck A.J. Screening of some Tanzanian medicinal plants from Bunda district for antibacterial, antifungal and antiviral activities. Journal of Ethnopharmacology 2008, 119:58-66.
20. Maregesi S., Van Miert S., Pannecouque C., Haddad M.H.F., Hermans N., Wright C.W., Vlietinck A.J., Apers S., Pieters L. Screening of Tanzanian medicinal plants against Plasmodium falciparum and human immunodeficiency virus. Planta Medica 2009, 10 1055/s-0029-1186024.
21. Maude R.J., Pontavornpinyo W., Saralamba S., Aguas R., Yeung S., Dondorp A., Day N.P.J., White N.J., White L.J. The last man standing is the most resistant: eliminating artemisinin-resistant malaria in Cambodia. Malaria Journal 2009, 8:31-131.
22. Mukazayire M.J., Allaeys V., Buc Calderon P., Stévigny C., Bigendako M.J., Duez P. Evaluation of the hepatotoxic and hepatoprotective effect of Rwandese herbal drugs on in vivo (guinea pigs barbiturate-induced sleeping time) and in vitro (rat precision-cut liver slices, PCLS) models. Experimental Toxicology and Pathology 2009, (Available online 3 June 2009). 10.1016/j.etp.2009.04.005.
23. Muthaura C.N., Rukunga G.M., Chhabra S.C., Omar S.A., Guantai A.N., Gathirwa J.W., Tolo F.M., Mwitari P.G., Keter L.K., Kirira P.G., Kimani C.W., Mungai G.M., Mjagi E.N.M. Antimalarial activity of some plants traditionally used in Meru district of Kenya. Phytotherapy Research 2007, 21:860-867.
24. Neuwinger H.D. African Ethnobotany. Poison and Drugs 1996, Chapman & Hall, Weinheim, Germany.
25. Nortier L.J., Martinez M., Schmeiser H.H., Arlt V.M., Bieler C.A., Petein M., Depierreux M.F., Paul L.D., Abramowicz D., Vereerstraeten P., Vanherweghem J.L. Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia Fangchi). New England Journal of Medicine 2000, 342:1682-1692.
26. Pink R., Hudson A., Mouriès M.A., Bendig M. Opportunities and challenges in antiparasitic drug discovery. Nature Reviews /Drug Discovery 2005, 4:727-740.
27. PNILP (National Malarial Control Program in Rwanda) Plan de lutte contre les épidémies du paludisme au Rwanda 2005-2010 2005, (Visiting time, October 2009). http://moh.gov.rw/index.php%3Foption=com_docman%26task=doc_download%26gid=97%26Itemid=14.
28. Rukunga G.M., Gathirwa J.W., Omar S.A., Muregi F.W., Muthaura C.N., Kirira P.G., Mungai G.M., Kofi-Tsekpo W.M. Anti-plasmodial activity of the extracts of some Kenyan medicinal plants. Journal of Ethnopharmacology 2009, 121:282-285.
29. Rwanda News Agency Le traitement avec de nouveaux antipaludiques, moins effectif à l'est du Rwanda 2009, (Visiting time, October 2009). http://www.rnanews.com/index.php%3Foption=com_content%26task=view%26id=971%26Itemid=31.
30. Rwangabo P.C. La médecine traditionnelle au Rwanda 1993, Karthala, Paris, pp. 74-185.
31. Stevigny C., Block S., Pauw-Gillet M.C., de Hoffmann E., Llabres G., Adjakidje V., Quetin-Leclercq J. Cytotoxic aporphine alkaloids from Cassytha filiformis. Planta Medica 2002, 68:1042-1044.
32. Tabuti J.R. Herbal medicines used in the treatment of malaria in Budiope county, Uganda. Journal of Ethnopharmacology 2008, 116:33-42.
33. Valsaraj R., Pushpangadan P., Smitt U.W., Adsersen A., Christensen S.B., Sittie A., Nyman U., Nielsen C., Olsen C.E. New anti-HIV-1, antimalarial and antifungal compounds from Terminalia bellerica. Journal of Natural Products 1997, 60:739-742.
34. Vanherweghem J.L, Depierreux M., Tielemans C., Abramowicz D., Dratwa M., Jadoul M., Richard C., Vandervelde D., Verbeelen D., Vanhaelen-Fastre R., Vanhaelen M. Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet 1993, 341:387-391.
35. World Health Organisation (WHO) World Malaria Report 2008, (Visiting time: October 2009). http://www.who.int/malaria/wmr2008.
36. Zirihi G.N., Mambu L., Guédé-Guina F., Bodo B., Grellier P. In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria. Journal of Ethnopharmacology 2005, 98:281-285.
37. Zongo C., Akomo E.F., Savadogo A., Obame L.C., Koudou J., Traore A.S. In vitro antibacterial properties of total alkaloids extract from Mitragyna inermis (Willd.) O. Kuntze, a West African traditional medicinal plant. Asian Journal of Plant Sciences 2009, 8:172-177.